-
1
-
-
0035479838
-
Genetic control of skeletal development
-
Wagner, E.F. & Karsenty, G. Genetic control of skeletal development. Curr. Opin. Genet. Dev. 11, 527-532 (2001).
-
(2001)
Curr. Opin. Genet. Dev
, vol.11
, pp. 527-532
-
-
Wagner, E.F.1
Karsenty, G.2
-
2
-
-
38849178302
-
Building bone to reverse osteoporosis and repair fractures
-
Khosla, S., Westendorf, J.J. & Oursler, M.J. Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest. 118, 421-428 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 421-428
-
-
Khosla, S.1
Westendorf, J.J.2
Oursler, M.J.3
-
3
-
-
34447132814
-
Skeletal remodeling in health and disease
-
Zaidi, M. Skeletal remodeling in health and disease. Nat. Med. 13, 791-801 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 791-801
-
-
Zaidi, M.1
-
4
-
-
28544439444
-
The role of the immune system in the pathophysiology of osteoporosis
-
Clowes, J.A., Riggs, B.L. & Khosla, S. The role of the immune system in the pathophysiology of osteoporosis. Immunol. Rev. 208, 207-227 (2005).
-
(2005)
Immunol. Rev
, vol.208
, pp. 207-227
-
-
Clowes, J.A.1
Riggs, B.L.2
Khosla, S.3
-
5
-
-
31044432767
-
Pathogenesis of osteoporosis: Concepts, conflicts, and prospects
-
Raisz, L.G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J. Clin. Invest. 115, 3318-3325 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 3318-3325
-
-
Raisz, L.G.1
-
6
-
-
33646396235
-
Estrogen deficiency and bone loss: An inflammatory tale
-
Weitzmann, M.N. & Pacifici, R. Estrogen deficiency and bone loss: an inflammatory tale. J. Clin. Invest. 116, 1186-1194 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1186-1194
-
-
Weitzmann, M.N.1
Pacifici, R.2
-
7
-
-
0043267732
-
Genetic regulation of osteoclast development and function
-
Teitelbaum, S.L. & Ross, F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4, 638-649 (2003).
-
(2003)
Nat. Rev. Genet
, vol.4
, pp. 638-649
-
-
Teitelbaum, S.L.1
Ross, F.P.2
-
8
-
-
27944480412
-
Pathophysiology of age-related bone loss and osteoporosis
-
Khosla, S. & Riggs, B.L. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol. Metab. Clin. North Am. 34, 1015-1030 (2005).
-
(2005)
Endocrinol. Metab. Clin. North Am
, vol.34
, pp. 1015-1030
-
-
Khosla, S.1
Riggs, B.L.2
-
9
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109, S81-S96 (2002).
-
(2002)
Cell
, vol.109
-
-
Ghosh, S.1
Karin, M.2
-
10
-
-
23144449789
-
Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor κB-independent bone morphogenetic protein/Smad signaling
-
Chen, Z.J. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor κB-independent bone morphogenetic protein/Smad signaling. Nat. Cell Biol. 7, 758-765 (2005).
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 758-765
-
-
Chen, Z.J.1
-
11
-
-
0344305376
-
Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress
-
Huang, T.T. et al. Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115, 565-576 (2003).
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
-
12
-
-
0036781052
-
-
Li, Q. & Verma, I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734 (2002).
-
Li, Q. & Verma, I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734 (2002).
-
-
-
-
13
-
-
0035883151
-
-
Silverman, N. & Maniatis, T. NF-kB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342 (2001).
-
Silverman, N. & Maniatis, T. NF-kB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342 (2001).
-
-
-
-
14
-
-
0034730251
-
NF-kappa;B activation induces the loss of MyoD mRNA: Implications for cytokine-induced skeletal muscle dysfunction and cachexia
-
Guttridge, D.C. et al. NF-kappa;B activation induces the loss of MyoD mRNA: implications for cytokine-induced skeletal muscle dysfunction and cachexia. Science 289, 2363-2366 (2000).
-
(2000)
Science
, vol.289
, pp. 2363-2366
-
-
Guttridge, D.C.1
-
15
-
-
2942703810
-
Selective inhibition of NF-kappa;B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
-
Jimi, E. et al. Selective inhibition of NF-kappa;B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat. Med. 10, 617-624 (2004).
-
(2004)
Nat. Med
, vol.10
, pp. 617-624
-
-
Jimi, E.1
-
16
-
-
19344374949
-
Ikappa;B kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
-
Ruocco, M.G. et al. Ikappa;B kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 201, 1677-1687 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 1677-1687
-
-
Ruocco, M.G.1
-
17
-
-
0141621240
-
A role for NF-(B essential modifier/I(B kinase-((NEMO/IKK() ubiquitination in the activation of the I(B kinase complex by tumor necrosis factor-α
-
Tang, E.D. et al. A role for NF-(B essential modifier/I(B kinase-((NEMO/IKK() ubiquitination in the activation of the I(B kinase complex by tumor necrosis factor-α. J. Biol. Chem. 278, 37297-37305 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 37297-37305
-
-
Tang, E.D.1
-
18
-
-
0842321781
-
The zinc finger mutation C417R of I-kappa; B kinase gamma; impairs lipopolysaccharide-and TNF-mediated NF-kappa; B activation through inhibiting phosphorylation of the I-kappa; B kinase β activation loop
-
Yang, F. et al. The zinc finger mutation C417R of I-kappa; B kinase gamma; impairs lipopolysaccharide-and TNF-mediated NF-kappa; B activation through inhibiting phosphorylation of the I-kappa; B kinase β activation loop. J. Immunol. 172, 2446-2452 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 2446-2452
-
-
Yang, F.1
-
19
-
-
0029858387
-
TNF-and cancer therapy - induced apoptosis: Potentiation by inhibition of NF-kappa;B
-
Wang, C.-Y. et al. TNF-and cancer therapy - induced apoptosis: potentiation by inhibition of NF-kappa;B. Science 274, 784-787 (1996).
-
(1996)
Science
, vol.274
, pp. 784-787
-
-
Wang, C.-Y.1
-
20
-
-
33846049299
-
NF-kappa;B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
-
Park, B.K. et al. NF-kappa;B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat. Med. 13, 62-69 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 62-69
-
-
Park, B.K.1
-
21
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy via increased apoptosis through inhibition of NF-kappa;B
-
Wang, C.-Y. et al. Control of inducible chemoresistance: enhanced anti-tumor therapy via increased apoptosis through inhibition of NF-kappa;B. Nat. Med. 5, 412-417 (1999).
-
(1999)
Nat. Med
, vol.5
, pp. 412-417
-
-
Wang, C.-Y.1
-
22
-
-
0033560784
-
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
-
Ducy, P. et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 13, 1025-1036 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 1025-1036
-
-
Ducy, P.1
-
23
-
-
0032515043
-
Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo
-
Frendo, J.L. et al. Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo. J. Biol. Chem. 273, 30509-30516 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 30509-30516
-
-
Frendo, J.L.1
-
24
-
-
27744578616
-
Visualizing levels of osteoblasts differentiation by two-color promoter-GFP strategy:tType I collagen-GFPcyan and osteocalcin-GFPtpz
-
Bilic-Curcic, I. et al. Visualizing levels of osteoblasts differentiation by two-color promoter-GFP strategy:tType I collagen-GFPcyan and osteocalcin-GFPtpz. Genesis 43, 87-98 (2005).
-
(2005)
Genesis
, vol.43
, pp. 87-98
-
-
Bilic-Curcic, I.1
-
25
-
-
33847375078
-
Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development
-
Ge, C. et al. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J. Cell Biol. 176, 709-718 (2007).
-
(2007)
J. Cell Biol
, vol.176
, pp. 709-718
-
-
Ge, C.1
-
26
-
-
0027288498
-
Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene
-
Li, Y.P. & Stashenko, P. Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene. Mol. Cell. Biol. 13, 3714-3721 (1993).
-
(1993)
Mol. Cell. Biol
, vol.13
, pp. 3714-3721
-
-
Li, Y.P.1
Stashenko, P.2
-
27
-
-
0035889252
-
Induction of gadd45β by NF-kappa;B downregulates pro-apoptotic JNK signaling
-
De Smaele, E. et al. Induction of gadd45β by NF-kappa;B downregulates pro-apoptotic JNK signaling. Nature 414, 308-313 (2001).
-
(2001)
Nature
, vol.414
, pp. 308-313
-
-
De Smaele, E.1
-
28
-
-
0035891320
-
Inhibition of JNK activation through NF-kappa;B target genes
-
Tang, G. et al. Inhibition of JNK activation through NF-kappa;B target genes. Nature 414, 313-317 (2001).
-
(2001)
Nature
, vol.414
, pp. 313-317
-
-
Tang, G.1
-
29
-
-
0036888899
-
The p65/RelA subunit of NF-kappa;B suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor
-
Reuther-Madrid, J.Y. et al. The p65/RelA subunit of NF-kappa;B suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol. Cell. Biol. 22, 8175-8183 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 8175-8183
-
-
Reuther-Madrid, J.Y.1
-
30
-
-
17044414102
-
Ubiquitin ligase smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
Yamashita, M. et al. Ubiquitin ligase smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121, 101-113 (2005).
-
(2005)
Cell
, vol.121
, pp. 101-113
-
-
Yamashita, M.1
-
31
-
-
0033835880
-
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
-
Jochum, W. et al. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6, 980-984 (2000).
-
(2000)
Nat. Med
, vol.6
, pp. 980-984
-
-
Jochum, W.1
-
32
-
-
0033624587
-
Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis
-
Sabatakos, G. et al. Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat. Med. 6, 985-990 (2000).
-
(2000)
Nat. Med
, vol.6
, pp. 985-990
-
-
Sabatakos, G.1
-
33
-
-
3543045594
-
The Fos-related antigen Fra-1 is an activator of bone matrix formation
-
Eferl, R. et al. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J. 23, 2789-2799 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 2789-2799
-
-
Eferl, R.1
-
34
-
-
33751032780
-
Estrogen receptor ligands in the control of pathogenic inflammation
-
Harnish, D.C. Estrogen receptor ligands in the control of pathogenic inflammation. Cur. Opin. Investig. Drugs 7, 997-1001 (2006).
-
(2006)
Cur. Opin. Investig. Drugs
, vol.7
, pp. 997-1001
-
-
Harnish, D.C.1
-
35
-
-
33750704287
-
Wnt antagonism in multiple myeloma: A potential cause of uncoupled bone remodeling
-
Pearse, R.N. Wnt antagonism in multiple myeloma: a potential cause of uncoupled bone remodeling. Clin. Cancer Res. 12, 6274s-6278s (2006).
-
(2006)
Clin. Cancer Res
, vol.12
-
-
Pearse, R.N.1
|