Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: Expression levels during development and regulation by oxidative stress

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 3, 2008, Pages 1071-1078

  Kanan, Yogita ^a   Wicker, Lea D ^a   Al Ubaidi, Muayyad R ^a   Mandai, Nawajes A ^a   Kasus Jacobi, Anne ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RETINOL DEHYDROGENASE; RETINOL DEHYDROGENASE 11; RETINOL DEHYDROGENASE 12; UNCLASSIFIED DRUG; OXIDOREDUCTASE; RDH11 PROTEIN, MOUSE; RDH12 PROTEIN, MOUSE; RETINAL DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CELL MATURATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; HOUSEKEEPING GENE; IMMUNOBLOTTING; LEBER CONGENITAL AMAUROSIS; LIGHT EXPOSURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AGING; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; IN SITU HYBRIDIZATION; LIGHT; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT; RADIATION EXPOSURE; RADIATION INJURY; RETINA DEGENERATION;

AGING; ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; LIGHT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; OXIDOREDUCTASES; RADIATION INJURIES, EXPERIMENTAL; RETINA; RETINAL DEGENERATION; RETINAL DEHYDROGENASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 41949121917     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1207     Document Type: Article

References (34)

1. Perrault I, Hanein S, Gerber S, et al. Retinal dehydrogenase 12 (RDH12) mutations in Leber congenital amaurosis. Am J Hum Genet. 2004;75(4):639-646.
2. Janecke AR, Thompson DA, Utermann G, et al. Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. Nat Genet. 2004; 36(8):850-854.
3. Thompson DA, Janecke AR, Lange J, et al. Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle. Hum Mol Genet. 2005;14(24):3865-3875.
4. Schuster A, Janecke AR, Wilke R, et al. The phenotype of earlyonset retinal degeneration in persons with RDH12 mutations. Invest Ophthalmol Vis Sci. 2007;48(4): 1824 -1831.
5. Sun W, Gerth C, Maeda A, et al. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vis Res. 2007;47(15):2055-2066.
6. Haeseleer F, Jang GF, Imanishi Y, et al. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem. 2002;277(47):45537-45546.
7. Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY. Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids. Biochemistry. 2005;44(18):7035-7047.
8. Maeda A, Maeda T, Imanishi Y, et al. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006;281(49):37697-37704.
9. Kurth I, Thompson DA, Rèuther K, et al. Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function. Mol Cell Biol. 2007;27(4):1370-1379.
10. Kasus-Jacobi A, Ou J, Bashmakov YK, et al. Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem. 2003;278(34):32380 -32389.
11. Travis GH, Golczak M, Moise AR, Palczewski K. Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Ann Rev Pharmacol Toxicol. 2007; 47 469-512.
12. Kim TS, Maeda A, Maeda T, et al. Delayed dark adaptation in 11-cis-retinol dehydrogenase deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005;280(10):8694-8704.
13. Kasus-Jacobi A, Ou J, Birch DG, et al. Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J. Biol Chem. 2005;280(21):20413-20420.
14. Hanein S, Perrault I, Gerber S, et al. Leber congenital amaurosis: comprehensive survey of the genetic heterogeneity, refinement of the clinical definition, and genotype-phenotype correlations as a strategy for molecular diagnosis. Hum Mutat. 2004;23(4):306-317.
15. Kedishvili NY, Chumakova OV, Chetyrkin SV, et al. Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDRl) encodes a novel retinal reductase (RalR1). J Biol Chem. 2002;277(32):28909-28915.
16. Porter NA, Caldwell SE, Mills KA. Mechanisms of free radical oxidation of unsaturated lipids. Lipids. 1995;30(4):277-290.
17. Awasthi YC, Sharma R, Cheng JZ, et al. Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol Aspects Med. 2003; 24(4-5):219-230.
18. Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC. Lipid per oxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Bioch Polonica. 2003; 50(2):319-336.
19. Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci 2005;46(10):3859-3868.
20. Tanito M, Anderson RE. Bright cyclic light rearing-mediated retinal protection against damaging light exposure in adrenalectomized mice. Exp Eye Res. 2006;83(3):697-701.
21. Mandai MN, Ayyagari R. Complement factor H: spatial and temporal expression and localization in the eye. Invest Ophthalmol Vis Sci. 2006;47(9):4091-4097.
22. Manda MN, Vasireddy V, Reddy GB, et al. CTRP5 is a membraneassociated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci. 2006;47(12):5505-5513.
23. Wenzel A, Grimm C, Samardzija M, Remâe CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retinal Eye Res. 2005;24(2): 275-306.
24. LaVail MM, Gorrin GM, Repaci MA, Yasumura D. Light-induced retinal degeneration in albino mice and rats: strain and species differences. Prog Clin Biol Res. 1987; 247 439-454.
25. Kaldi I, Martin RE, Huang, Brush RS, Morrison KA, Anderson RE. Bright cyclic rearing protects albino mouse retina against acute light-induced apoptosis. Mol Vis. 2003;9:337-344.
26. Kutty RK, Kutty G, Wiggert B, Chader GJ, Darrow RM, Organisciak DT. Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea. Proc Natl Acad Sci USA. 1995;92(4): 1177-1181.
27. Smith RS, Kao WWY, John SWM. Ocular development. In: Smith RS, John SWM, Nishina PM, Sundberg JP, eds. Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods. New York: CRC Press; 2002; 45-63.
28. Kaufman MH, Bard JBL. The Anatomical Basis of Mouse Development. San Diego: Academic Press; 1999.
29. Dorrell MI, Aguilar E, Weber C, Friedlander M. Global gene expression analysis of the developing postnatal mouse retina. Invest Ophthalmol Vis Sci. 2004;45(3):1009-1019.
30. Blackshaw S, Harpavat S, Trimarchi J, et al. Genomic analysis of mouse retinal development. PLoS Biol. 2004;2(9):E247.
31. Grün G. The development of the vertebrate retina: a comparative survey. Adv Anat Embryo Cell Biol. 1982;78:1-85.
32. Nag TC, Wadhwa S. Morphological and neurochemical development of the human neural retina. Neuroembryol Aging. 2006-07; 4:19-30.
33. Chen L, Wu W, Dentchev T, et al. Light damage induced changes in mouse retinal gene expression. Exp Eye Res. 2004;79(2):239247.
34. Chakravarti B, Chakravarti DN. Oxidative modification of proteins: age-related changes. Gerontology. 2007;53(3):128-139.