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Volumn 91, Issue 2, 2013, Pages 183-193

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

Author keywords

A1; A2A; A2B; A3; Acute lung injury; Adenosine; Adenosine deaminase; Adenosine kinase; AMP; Apyrase; ATP; Cancer; CD39; CD73; Colitis; Ectonucleotidase; ENT1; ENT2; Equilibrative nucleoside transporters; HIF1; HIF2; Hypoxia inducible factor; Inflammatory bowel disease; Ischemia; Sepsis

Indexed keywords

2 NITROIMIDAZOLE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ALLYLGLYCINE; DIMETHYLOXALLYL GLYCINE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NETRIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

EID: 84873986426     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0988-7     Document Type: Review
Times cited : (100)

References (115)
  • 2
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • 8089148 1:CAS:528:DyaK2MXpt1Wnsg%3D%3D
    • Semenza GL, Roth PH, Fang HM, Wang GL (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269:23757-23763
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 3
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • 22304911 1:CAS:528:DC%2BC38XhvFaqsrY%3D 10.1016/j.cell.2012.01.021
    • Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148:399-408
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 4
    • 80051625243 scopus 로고    scopus 로고
    • Oxygen sensing, homeostasis, and disease
    • 21830968 1:CAS:528:DC%2BC3MXhtVars7nP 10.1056/NEJMra1011165
    • Semenza GL (2011) Oxygen sensing, homeostasis, and disease. N Engl J Med 365:537-547
    • (2011) N Engl J Med , vol.365 , pp. 537-547
    • Semenza, G.L.1
  • 5
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • 17916722 1:CAS:528:DC%2BD2sXhtFWitb7N 10.1126/science.1147949
    • Semenza GL (2007) Life with oxygen. Science 318:62-64
    • (2007) Science , vol.318 , pp. 62-64
    • Semenza, G.L.1
  • 7
    • 81255195550 scopus 로고    scopus 로고
    • Ischemia and reperfusion - From mechanism to translation
    • 22064429 1:CAS:528:DC%2BC3MXhsVOisLnJ 10.1038/nm.2507
    • Eltzschig HK, Eckle T (2011) Ischemia and reperfusion - from mechanism to translation. Nat Med 17:1391-1401
    • (2011) Nat Med , vol.17 , pp. 1391-1401
    • Eltzschig, H.K.1    Eckle, T.2
  • 8
    • 79951829343 scopus 로고    scopus 로고
    • Hypoxia and inflammation
    • 21323543 1:CAS:528:DC%2BC3MXitFykt78%3D 10.1056/NEJMra0910283
    • Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364:656-665
    • (2011) N Engl J Med , vol.364 , pp. 656-665
    • Eltzschig, H.K.1    Carmeliet, P.2
  • 9
    • 51749089798 scopus 로고    scopus 로고
    • Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    • 18599532 1:CAS:528:DC%2BD1cXhtFCqsbzP 10.1113/jphysiol.2008.157669
    • Taylor CT (2008) Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation. J Physiol 586:4055-4059
    • (2008) J Physiol , vol.586 , pp. 4055-4059
    • Taylor, C.T.1
  • 10
    • 36849055112 scopus 로고    scopus 로고
    • Hypoxia and gastrointestinal disease
    • 18026919 10.1007/s00109-007-0277-z
    • Taylor CT, Colgan SP (2007) Hypoxia and gastrointestinal disease. J Mol Med 85:1295-1300
    • (2007) J Mol Med , vol.85 , pp. 1295-1300
    • Taylor, C.T.1    Colgan, S.P.2
  • 12
    • 25644446823 scopus 로고    scopus 로고
    • Hypoxia-responsive transcription factors
    • Cummins EP, Taylor CT (2005) Hypoxia-responsive transcription factors. Pflugers Arch 450:363-371
    • (2005) Pflugers Arch , vol.450 , pp. 363-371
    • Cummins, E.P.1    Taylor, C.T.2
  • 13
    • 77951649299 scopus 로고    scopus 로고
    • SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
    • 20207994 1:CAS:528:DC%2BC3cXjs1Wqs78%3D 10.4049/jimmunol.0901851
    • Hart ML, Gorzolla IC, Schittenhelm J, Robson SC, Eltzschig HK (2010) SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol 184:4017-4024
    • (2010) J Immunol , vol.184 , pp. 4017-4024
    • Hart, M.L.1    Gorzolla, I.C.2    Schittenhelm, J.3    Robson, S.C.4    Eltzschig, H.K.5
  • 14
    • 59449096105 scopus 로고    scopus 로고
    • Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    • 18812468 1:CAS:528:DC%2BD1MXmtFSqtg%3D%3D 10.1182/blood-2008-06-165746
    • Eltzschig HK, Kohler D, Eckle T, Kong T, Robson SC, Colgan SP (2009) Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood 113:224-232
    • (2009) Blood , vol.113 , pp. 224-232
    • Eltzschig, H.K.1    Kohler, D.2    Eckle, T.3    Kong, T.4    Robson, S.C.5    Colgan, S.P.6
  • 15
    • 84860663922 scopus 로고    scopus 로고
    • Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    • 22504483 1:CAS:528:DC%2BC38XlsFSqsrY%3D 10.1038/nm.2728
    • Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM et al (2012) Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18:774-782
    • (2012) Nat Med , vol.18 , pp. 774-782
    • Eckle, T.1    Hartmann, K.2    Bonney, S.3    Reithel, S.4    Mittelbronn, M.5    Walker, L.A.6    Lowes, B.D.7    Han, J.8    Borchers, C.H.9    Buttrick, P.M.10
  • 16
    • 47649128513 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning
    • 18591435 1:CAS:528:DC%2BD1cXnvFCgs7o%3D 10.1161/CIRCULATIONAHA.107.758516
    • Eckle T, Kohler D, Lehmann R, El Kasmi KC, Eltzschig HK (2008) Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118:166-175
    • (2008) Circulation , vol.118 , pp. 166-175
    • Eckle, T.1    Kohler, D.2    Lehmann, R.3    El Kasmi, K.C.4    Eltzschig, H.K.5
  • 17
  • 18
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • 21738161 1:CAS:528:DC%2BC3MXos1Srsrw%3D 10.1038/nm.2399
    • Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17:796-808
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 19
    • 11244261365 scopus 로고    scopus 로고
    • Vascular ischaemia and reperfusion injury
    • 15494470 1:CAS:528:DC%2BD2cXhtVSrtbfI 10.1093/bmb/ldh025
    • Eltzschig HK, Collard CD (2004) Vascular ischaemia and reperfusion injury. Br Med Bull 70:71-86
    • (2004) Br Med Bull , vol.70 , pp. 71-86
    • Eltzschig, H.K.1    Collard, C.D.2
  • 20
    • 0028785458 scopus 로고
    • Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • 7547236 1:CAS:528:DyaK2MXptlKjtLc%3D 10.1038/bjc.1995.429
    • Arteel GE, Thurman RG, Yates JM, Raleigh JA (1995) Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br J Cancer 72:889-895
    • (1995) Br J Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 21
    • 0344304679 scopus 로고    scopus 로고
    • No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion
    • 14656914 10.1161/01.CIR.0000101917.80668.E1
    • Reffelmann T, Hale SL, Dow JS, Kloner RA (2003) No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion. Circulation 108:2911-2917
    • (2003) Circulation , vol.108 , pp. 2911-2917
    • Reffelmann, T.1    Hale, S.L.2    Dow, J.S.3    Kloner, R.A.4
  • 22
    • 0016315064 scopus 로고
    • The "no-reflow" phenomenon after temporary coronary occlusion in the dog
    • 4140198 1:STN:280:DyaE2M%2FmtVKrsA%3D%3D 10.1172/JCI107898
    • Kloner RA, Ganote CE, Jennings RB (1974) The "no-reflow" phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54:1496-1508
    • (1974) J Clin Invest , vol.54 , pp. 1496-1508
    • Kloner, R.A.1    Ganote, C.E.2    Jennings, R.B.3
  • 23
    • 69949172891 scopus 로고    scopus 로고
    • Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
    • 19718040 1:CAS:528:DC%2BD1MXhtVKhs7%2FK 10.1038/nm.2022
    • Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T (2009) Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 15:1031-1037
    • (2009) Nat Med , vol.15 , pp. 1031-1037
    • Yemisci, M.1    Gursoy-Ozdemir, Y.2    Vural, A.3    Can, A.4    Topalkara, K.5    Dalkara, T.6
  • 24
    • 84857076647 scopus 로고    scopus 로고
    • Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    • 21942704 1:CAS:528:DC%2BC38XjvFynsbY%3D 10.1146/annurev-physiol-020911- 153230
    • Colgan SP, Eltzschig HK (2012) Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol 74:153-175
    • (2012) Annu Rev Physiol , vol.74 , pp. 153-175
    • Colgan, S.P.1    Eltzschig, H.K.2
  • 25
  • 26
    • 77952092406 scopus 로고    scopus 로고
    • Hypoxia: An alarm signal during intestinal inflammation
    • 20368740 10.1038/nrgastro.2010.39
    • Colgan SP, Taylor CT (2010) Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol 7:281-287
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 281-287
    • Colgan, S.P.1    Taylor, C.T.2
  • 27
    • 27444448072 scopus 로고    scopus 로고
    • Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
    • 16246965 1:CAS:528:DC%2BD2MXhtFajtLvN 10.1161/CIRCULATIONAHA.105.556746
    • Ryan S, Taylor CT, McNicholas WT (2005) Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112:2660-2667
    • (2005) Circulation , vol.112 , pp. 2660-2667
    • Ryan, S.1    Taylor, C.T.2    McNicholas, W.T.3
  • 30
    • 70249099576 scopus 로고    scopus 로고
    • Interdependence of hypoxic and innate immune responses
    • 19704417 1:CAS:528:DC%2BD1MXhtVersbvK 10.1038/nri2607
    • Nizet V, Johnson RS (2009) Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 9:609-617
    • (2009) Nat Rev Immunol , vol.9 , pp. 609-617
    • Nizet, V.1    Johnson, R.S.2
  • 31
    • 20144384861 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: Evidence for a role of hypoxia-inducible factor-1 in bacterial infections
    • 15723970 1:CAS:528:DC%2BD2MXhsFShu7k%3D 10.1161/01.CIR.0000155608.07691. B7
    • Kempf VA, Lebiedziejewski M, Alitalo K, Walzlein JH, Ehehalt U, Fiebig J, Huber S, Schutt B, Sander CA, Muller S et al (2005) Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation 111:1054-1062
    • (2005) Circulation , vol.111 , pp. 1054-1062
    • Kempf, V.A.1    Lebiedziejewski, M.2    Alitalo, K.3    Walzlein, J.H.4    Ehehalt, U.5    Fiebig, J.6    Huber, S.7    Schutt, B.8    Sander, C.A.9    Muller, S.10
  • 32
    • 25444454359 scopus 로고    scopus 로고
    • Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors
    • 16110315 1:CAS:528:DC%2BD2MXpslakurs%3D 10.1038/nri1685
    • Sitkovsky M, Lukashev D (2005) Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat Rev Immunol 5:712-721
    • (2005) Nat Rev Immunol , vol.5 , pp. 712-721
    • Sitkovsky, M.1    Lukashev, D.2
  • 33
    • 2542432162 scopus 로고    scopus 로고
    • Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
    • 15032592 1:CAS:528:DC%2BD2cXktlOgsLY%3D 10.1146/annurev.immunol.22. 012703.104731
    • Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M (2004) Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol 22:657-682
    • (2004) Annu Rev Immunol , vol.22 , pp. 657-682
    • Sitkovsky, M.V.1    Lukashev, D.2    Apasov, S.3    Kojima, H.4    Koshiba, M.5    Caldwell, C.6    Ohta, A.7    Thiel, M.8
  • 34
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • 19946328 10.1038/onc.2009.441 1:CAS:528:DC%2BD1MXhsV2gt77N
    • Semenza GL (2009) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634
    • (2009) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 35
    • 58149500277 scopus 로고    scopus 로고
    • Emerging role of adipose tissue hypoxia in obesity and insulin resistance
    • 1:CAS:528:DC%2BD1MXkslyktw%3D%3D 10.1038/ijo.2008.229
    • Ye J (2009) Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 33:54-66
    • (2009) Int J Obes (Lond) , vol.33 , pp. 54-66
    • Ye, J.1
  • 36
    • 59349098621 scopus 로고    scopus 로고
    • Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
    • 19165233 1:CAS:528:DC%2BD1MXpsVCjtQ%3D%3D 10.1038/nrd2761
    • Fraisl P, Aragones J, Carmeliet P (2009) Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 8:139-152
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 139-152
    • Fraisl, P.1    Aragones, J.2    Carmeliet, P.3
  • 37
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • 11641274 1:CAS:528:DC%2BD3MXnvVWksb4%3D 10.1101/gad.924501
    • Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 38
    • 78651411645 scopus 로고    scopus 로고
    • Adenosine generation and signaling during acute kidney injury
    • 21209250 1:CAS:528:DC%2BC3MXhsVChsr8%3D 10.1681/ASN.2009121217
    • Bauerle JD, Grenz A, Kim JH, Lee HT, Eltzschig HK (2011) Adenosine generation and signaling during acute kidney injury. J Am Soc Nephrol 22:14-20
    • (2011) J Am Soc Nephrol , vol.22 , pp. 14-20
    • Bauerle, J.D.1    Grenz, A.2    Kim, J.H.3    Lee, H.T.4    Eltzschig, H.K.5
  • 39
    • 79953230500 scopus 로고    scopus 로고
    • The resurgence of A2B adenosine receptor signaling
    • 20546702 1:CAS:528:DC%2BC3MXjvFSrsro%3D 10.1016/j.bbamem.2010.05.016
    • Aherne CM, Kewley EM, Eltzschig HK (2011) The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta 1808:1329-1339
    • (2011) Biochim Biophys Acta , vol.1808 , pp. 1329-1339
    • Aherne, C.M.1    Kewley, E.M.2    Eltzschig, H.K.3
  • 40
    • 43049105018 scopus 로고    scopus 로고
    • Neutrophils as sources of extracellular nucleotides: Functional consequences at the vascular interface
    • 18436149 1:CAS:528:DC%2BD1cXlslGju7o%3D 10.1016/j.tcm.2008.01.006
    • Eltzschig HK, Macmanus CF, Colgan SP (2008) Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med 18:103-107
    • (2008) Trends Cardiovasc Med , vol.18 , pp. 103-107
    • Eltzschig, H.K.1    MacManus, C.F.2    Colgan, S.P.3
  • 41
    • 54549113030 scopus 로고    scopus 로고
    • 2 sensing and cancer
    • 18923434 1:CAS:528:DC%2BD1cXht1yjtbnE 10.1038/nrc2502
    • 2 sensing and cancer. Nat Rev Cancer 8:865-873
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin, Jr.W.G.1
  • 42
    • 33947528891 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • 18039096 1:CAS:528:DC%2BD2sXivV2isb8%3D 10.1146/annurev.pathol.2.010506. 092049
    • Kaelin WG (2007) Von Hippel-Lindau disease. Annu Rev Pathol 2:145-173
    • (2007) Annu Rev Pathol , vol.2 , pp. 145-173
    • Kaelin, W.G.1
  • 44
  • 45
    • 57849163103 scopus 로고    scopus 로고
    • Oxygen sensors at the crossroad of metabolism
    • 19117543 1:CAS:528:DC%2BD1MXptFWqtQ%3D%3D 10.1016/j.cmet.2008.10.001
    • Aragones J, Fraisl P, Baes M, Carmeliet P (2009) Oxygen sensors at the crossroad of metabolism. Cell Metab 9:11-22
    • (2009) Cell Metab , vol.9 , pp. 11-22
    • Aragones, J.1    Fraisl, P.2    Baes, M.3    Carmeliet, P.4
  • 46
    • 34147170511 scopus 로고    scopus 로고
    • HIF-1 and HIF-2: Working alone or together in hypoxia?
    • 17404612 1:CAS:528:DC%2BD2sXktVOisLc%3D 10.1172/JCI31750
    • Ratcliffe PJ (2007) HIF-1 and HIF-2: working alone or together in hypoxia? J Clin Invest 117:862-865
    • (2007) J Clin Invest , vol.117 , pp. 862-865
    • Ratcliffe, P.J.1
  • 47
    • 42949154362 scopus 로고    scopus 로고
    • The HIF2A gene in familial erythrocytosis
    • 18450610 1:CAS:528:DC%2BD1cXlt1Gqsbc%3D author reply 1966-1967
    • Eltzschig HK, El Kasmi KC, Eckle T (2008) The HIF2A gene in familial erythrocytosis. N Engl J Med 358:1965-1966, author reply 1966-1967
    • (2008) N Engl J Med , vol.358 , pp. 1965-1966
    • Eltzschig, H.K.1    El Kasmi, K.C.2    Eckle, T.3
  • 48
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • 2005:re12. doi: 10.1126/stke.3062005re12
    • Wenger RH, Stiehl DP, Camenisch G (2005) Integration of oxygen signaling at the consensus HRE. Sci STKE 2005:re12. doi: 10.1126/stke.3062005re12
    • (2005) Sci STKE
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 49
    • 70349658872 scopus 로고    scopus 로고
    • Adenosine: An old drug newly discovered
    • 19741501 1:CAS:528:DC%2BD1MXhtFOjtLnF 10.1097/ALN.0b013e3181b060f2
    • Eltzschig HK (2009) Adenosine: an old drug newly discovered. Anesthesiology 111:904-915
    • (2009) Anesthesiology , vol.111 , pp. 904-915
    • Eltzschig, H.K.1
  • 50
    • 78049442966 scopus 로고    scopus 로고
    • The cellular response to hypoxia: Tuning the system with microRNAs
    • 20972325 1:CAS:528:DC%2BC3cXhsVWgtbrP 10.1172/JCI45105
    • Loscalzo J (2010) The cellular response to hypoxia: tuning the system with microRNAs. J Clin Invest 120:3815-3817
    • (2010) J Clin Invest , vol.120 , pp. 3815-3817
    • Loscalzo, J.1
  • 51
    • 58649112595 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia
    • 19105964 1:CAS:528:DC%2BD1MXislOhtbw%3D 10.1053/j.gastro.2008.10.037
    • Morote-Garcia JC, Rosenberger P, Nivillac NM, Coe IR, Eltzschig HK (2009) Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology 136:607-618
    • (2009) Gastroenterology , vol.136 , pp. 607-618
    • Morote-Garcia, J.C.1    Rosenberger, P.2    Nivillac, N.M.3    Coe, I.R.4    Eltzschig, H.K.5
  • 52
    • 47049088629 scopus 로고    scopus 로고
    • HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
    • 18309031 1:CAS:528:DC%2BD1cXnsVOktLw%3D 10.1182/blood-2007-11-126763
    • Morote-Garcia JC, Rosenberger P, Kuhlicke J, Eltzschig HK (2008) HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood 111:5571-5580
    • (2008) Blood , vol.111 , pp. 5571-5580
    • Morote-Garcia, J.C.1    Rosenberger, P.2    Kuhlicke, J.3    Eltzschig, H.K.4
  • 55
    • 84858797646 scopus 로고    scopus 로고
    • Hypoxia signaling during intestinal ischemia and inflammation
    • doi: 10.1097/MCC.0b013e3283514bd0
    • Grenz A, Clambey E, Eltzschig HK (2012) Hypoxia signaling during intestinal ischemia and inflammation. Curr Opin Crit Care. doi: 10.1097/MCC.0b013e3283514bd0
    • (2012) Curr Opin Crit Care
    • Grenz, A.1    Clambey, E.2    Eltzschig, H.K.3
  • 56
    • 79955948343 scopus 로고    scopus 로고
    • Interplay of hypoxia and A2B adenosine receptors in tissue protection
    • 21586359 1:CAS:528:DC%2BC3MXpsVKms7c%3D 10.1016/B978-0-12-385526-8.00006- 0
    • Koeppen M, Eckle T, Eltzschig HK (2011) Interplay of hypoxia and A2B adenosine receptors in tissue protection. Adv Pharmacol 61:145-186
    • (2011) Adv Pharmacol , vol.61 , pp. 145-186
    • Koeppen, M.1    Eckle, T.2    Eltzschig, H.K.3
  • 57
    • 73349104617 scopus 로고    scopus 로고
    • The double life of ATP
    • Khakh BS, Burnstock G (2009) The double life of ATP. Sci Am 301(84-90):92
    • (2009) Sci Am , vol.301 , Issue.84-90 , pp. 92
    • Khakh, B.S.1    Burnstock, G.2
  • 58
    • 34250770500 scopus 로고    scopus 로고
    • Adenosine, an endogenous distress signal, modulates tissue damage and repair
    • 17396131 1:CAS:528:DC%2BD2sXms1Srurk%3D 10.1038/sj.cdd.4402132
    • Fredholm BB (2007) Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ 14:1315-1323
    • (2007) Cell Death Differ , vol.14 , pp. 1315-1323
    • Fredholm, B.B.1
  • 59
    • 33644842266 scopus 로고    scopus 로고
    • Clinical practice. Supraventricular tachycardia
    • 16525141 1:CAS:528:DC%2BD28XitFWrsL0%3D 10.1056/NEJMcp051145
    • Delacretaz E (2006) Clinical practice. Supraventricular tachycardia. N Engl J Med 354:1039-1051
    • (2006) N Engl J Med , vol.354 , pp. 1039-1051
    • Delacretaz, E.1
  • 61
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • 11780065 1:CAS:528:DC%2BD38XhtlOmtg%3D%3D 10.1038/414916a
    • Ohta A, Sitkovsky M (2001) Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414:916-920
    • (2001) Nature , vol.414 , pp. 916-920
    • Ohta, A.1    Sitkovsky, M.2
  • 63
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • 18758473 1:CAS:528:DC%2BD1cXhtVGgtL7K 10.1038/nrd2638
    • Hasko G, Linden J, Cronstein B, Pacher P (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 7:759-770
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 759-770
    • Hasko, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 64
    • 33751543485 scopus 로고    scopus 로고
    • Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
    • 17088433 1:CAS:528:DC%2BD28Xht12htLfO 10.1084/jem.20061097
    • Lappas CM, Day YJ, Marshall MA, Engelhard VH, Linden J (2006) Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med 203:2639-2648
    • (2006) J Exp Med , vol.203 , pp. 2639-2648
    • Lappas, C.M.1    Day, Y.J.2    Marshall, M.A.3    Engelhard, V.H.4    Linden, J.5
  • 66
    • 33845604971 scopus 로고    scopus 로고
    • HIF-dependent induction of adenosine A2B receptor in hypoxia
    • 17077301 1:CAS:528:DC%2BD28XhtFyktLfJ 10.1096/fj.06-6419com
    • Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP (2006) HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J 20:2242-2250
    • (2006) FASEB J , vol.20 , pp. 2242-2250
    • Kong, T.1    Westerman, K.A.2    Faigle, M.3    Eltzschig, H.K.4    Colgan, S.P.5
  • 67
    • 10244222236 scopus 로고    scopus 로고
    • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: Coordination by extracellular nucleotide metabolism
    • 15319286 1:CAS:528:DC%2BD2cXhtFaju7vK 10.1182/blood-2004-06-2066
    • Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, Colgan SP (2004) Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood 104:3986-3992
    • (2004) Blood , vol.104 , pp. 3986-3992
    • Eltzschig, H.K.1    Thompson, L.F.2    Karhausen, J.3    Cotta, R.J.4    Ibla, J.C.5    Robson, S.C.6    Colgan, S.P.7
  • 68
    • 0042386007 scopus 로고    scopus 로고
    • Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: Role of ectonucleotidases and adenosine A2B receptors
    • 12939345 1:CAS:528:DC%2BD3sXntFeqt7c%3D 10.1084/jem.20030891
    • Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP (2003) Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med 198:783-796
    • (2003) J Exp Med , vol.198 , pp. 783-796
    • Eltzschig, H.K.1    Ibla, J.C.2    Furuta, G.T.3    Leonard, M.O.4    Jacobson, K.A.5    Enjyoji, K.6    Robson, S.C.7    Colgan, S.P.8
  • 72
    • 79954994463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor
    • 21357264 1:CAS:528:DC%2BC3MXjvVKlsrg%3D 10.4049/jimmunol.0903617
    • Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK (2011) Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor. J Immunol 186:4367-4374
    • (2011) J Immunol , vol.186 , pp. 4367-4374
    • Hart, M.L.1    Grenz, A.2    Gorzolla, I.C.3    Schittenhelm, J.4    Dalton, J.H.5    Eltzschig, H.K.6
  • 73
    • 64249107208 scopus 로고    scopus 로고
    • Cutting edge: A2B adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury
    • 19299692 1:CAS:528:DC%2BD1MXjsVSjtrk%3D 10.4049/jimmunol.0802193
    • Hart ML, Jacobi B, Schittenhelm J, Henn M, Eltzschig HK (2009) Cutting edge: A2B adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. J Immunol 182:3965-3968
    • (2009) J Immunol , vol.182 , pp. 3965-3968
    • Hart, M.L.1    Jacobi, B.2    Schittenhelm, J.3    Henn, M.4    Eltzschig, H.K.5
  • 74
    • 65249138361 scopus 로고    scopus 로고
    • Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis
    • 19342675 1:CAS:528:DC%2BD1MXjvFOisrw%3D 10.4049/jimmunol.0801324
    • Frick JS, MacManus CF, Scully M, Glover LE, Eltzschig HK, Colgan SP (2009) Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol 182:4957-4964
    • (2009) J Immunol , vol.182 , pp. 4957-4964
    • Frick, J.S.1    MacManus, C.F.2    Scully, M.3    Glover, L.E.4    Eltzschig, H.K.5    Colgan, S.P.6
  • 76
    • 33748751511 scopus 로고    scopus 로고
    • Nucleotide metabolism and cell-cell interactions
    • 16799190 1:CAS:528:DC%2BD28XlvV2mtL8%3D
    • Eltzschig HK, Weissmuller T, Mager A, Eckle T (2006) Nucleotide metabolism and cell-cell interactions. Methods Mol Biol 341:73-87
    • (2006) Methods Mol Biol , vol.341 , pp. 73-87
    • Eltzschig, H.K.1    Weissmuller, T.2    Mager, A.3    Eckle, T.4
  • 77
    • 50949116679 scopus 로고    scopus 로고
    • ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia
    • 18665255 10.1371/journal.pone.0002801 1:CAS:528:DC%2BD1cXhtVWrs73N
    • Faigle M, Seessle J, Zug S, El Kasmi KC, Eltzschig HK (2008) ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS One 3:e2801
    • (2008) PLoS One , vol.3 , pp. 2801
    • Faigle, M.1    Seessle, J.2    Zug, S.3    El Kasmi, K.C.4    Eltzschig, H.K.5
  • 78
    • 33750929739 scopus 로고    scopus 로고
    • ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function
    • 17038639 1:CAS:528:DC%2BD28XhtFKgurrL 10.1161/01.RES.0000250174.31269.70
    • Eltzschig HK, Eckle T, Mager A, Kuper N, Karcher C, Weissmuller T, Boengler K, Schulz R, Robson SC, Colgan SP (2006) ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res 99:1100-1108
    • (2006) Circ Res , vol.99 , pp. 1100-1108
    • Eltzschig, H.K.1    Eckle, T.2    Mager, A.3    Kuper, N.4    Karcher, C.5    Weissmuller, T.6    Boengler, K.7    Schulz, R.8    Robson, S.C.9    Colgan, S.P.10
  • 79
    • 79954452804 scopus 로고    scopus 로고
    • Adenosine and ATP receptors in the brain
    • 21401499 1:CAS:528:DC%2BC3MXlvFyktLg%3D 10.2174/156802611795347627
    • Burnstock G, Fredholm BB, Verkhratsky A (2011) Adenosine and ATP receptors in the brain. Curr Top Med Chem 11:973-1011
    • (2011) Curr Top Med Chem , vol.11 , pp. 973-1011
    • Burnstock, G.1    Fredholm, B.B.2    Verkhratsky, A.3
  • 80
    • 79952131899 scopus 로고    scopus 로고
    • Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
    • 21173118 1:CAS:528:DC%2BC3MXjsVWntrw%3D 10.1182/blood-2010-10-313957
    • Riegel AK, Faigle M, Zug S, Rosenberger P, Robaye B, Boeynaems JM, Idzko M, Eltzschig HK (2011) Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood 117:2548-2555
    • (2011) Blood , vol.117 , pp. 2548-2555
    • Riegel, A.K.1    Faigle, M.2    Zug, S.3    Rosenberger, P.4    Robaye, B.5    Boeynaems, J.M.6    Idzko, M.7    Eltzschig, H.K.8
  • 81
    • 48749125421 scopus 로고    scopus 로고
    • Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
    • 18353866 1:CAS:528:DC%2BD1cXpsVygsb4%3D 10.1096/fj.07-103911
    • Hart ML, Henn M, Kohler D, Kloor D, Mittelbronn M, Gorzolla IC, Stahl GL, Eltzschig HK (2008) Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J 22:2784-2797
    • (2008) FASEB J , vol.22 , pp. 2784-2797
    • Hart, M.L.1    Henn, M.2    Kohler, D.3    Kloor, D.4    Mittelbronn, M.5    Gorzolla, I.C.6    Stahl, G.L.7    Eltzschig, H.K.8
  • 82
    • 55249105678 scopus 로고    scopus 로고
    • Extracellular adenosine production by ecto-5′-nucleotidase protects during murine hepatic ischemic preconditioning
    • 10.1053/j.gastro.2008.07.064 1:CAS:528:DC%2BD1cXhsVOhtbvE
    • Hart ML, Much C, Gorzolla IC, Schittenhelm J, Kloor D, Stahl GL, Eltzschig HK (2008) Extracellular adenosine production by ecto-5′- nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterology 135:1739.e3-1750.e3
    • (2008) Gastroenterology , vol.135
    • Hart, M.L.1    Much, C.2    Gorzolla, I.C.3    Schittenhelm, J.4    Kloor, D.5    Stahl, G.L.6    Eltzschig, H.K.7
  • 83
    • 52449090560 scopus 로고    scopus 로고
    • Direct treatment of mouse or human blood with soluble 5′-nucleotidase inhibits platelet aggregation
    • 18511695 1:CAS:528:DC%2BD1cXosVeru7g%3D 10.1161/ATVBAHA.108.169219
    • Hart ML, Kohler D, Eckle T, Kloor D, Stahl GL, Eltzschig HK (2008) Direct treatment of mouse or human blood with soluble 5′-nucleotidase inhibits platelet aggregation. Arterioscler Thromb Vasc Biol 28:1477-1483
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1477-1483
    • Hart, M.L.1    Kohler, D.2    Eckle, T.3    Kloor, D.4    Stahl, G.L.5    Eltzschig, H.K.6
  • 86
    • 55849114101 scopus 로고    scopus 로고
    • A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    • 18787641 1:CAS:528:DC%2BD1cXht1Chsr3E
    • Eckle T, Grenz A, Laucher S, Eltzschig HK (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest 118:3301-3315
    • (2008) J Clin Invest , vol.118 , pp. 3301-3315
    • Eckle, T.1    Grenz, A.2    Laucher, S.3    Eltzschig, H.K.4
  • 92
    • 79251584983 scopus 로고    scopus 로고
    • Netrin-1 signaling dampens inflammatory peritonitis
    • 21098235 1:CAS:528:DC%2BC3cXhs1ajtLnN 10.4049/jimmunol.1002671
    • Mirakaj V, Gatidou D, Potzsch C, Konig K, Rosenberger P (2011) Netrin-1 signaling dampens inflammatory peritonitis. J Immunol 186:549-555
    • (2011) J Immunol , vol.186 , pp. 549-555
    • Mirakaj, V.1    Gatidou, D.2    Potzsch, C.3    Konig, K.4    Rosenberger, P.5
  • 95
    • 37349118314 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    • 18166353 1:CAS:528:DC%2BD1cXhtleht74%3D 10.1053/j.gastro.2007.10.012
    • Cummins EP, Seeballuck F, Keely SJ, Mangan NE, Callanan JJ, Fallon PG, Taylor CT (2008) The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134:156-165
    • (2008) Gastroenterology , vol.134 , pp. 156-165
    • Cummins, E.P.1    Seeballuck, F.2    Keely, S.J.3    Mangan, N.E.4    Callanan, J.J.5    Fallon, P.G.6    Taylor, C.T.7
  • 97
    • 37349048502 scopus 로고    scopus 로고
    • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    • 18166352 1:CAS:528:DC%2BD1cXhtlehtrY%3D 10.1053/j.gastro.2007.09.033
    • Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP (2008) Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134:145-155
    • (2008) Gastroenterology , vol.134 , pp. 145-155
    • Robinson, A.1    Keely, S.2    Karhausen, J.3    Gerich, M.E.4    Furuta, G.T.5    Colgan, S.P.6
  • 98
  • 99
    • 70349745514 scopus 로고    scopus 로고
    • From the cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
    • 19805374 1:CAS:528:DC%2BD1MXht1Ogs73I 10.1073/pnas.0902869106
    • Friedman DJ, Kunzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC (2009) From the cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A 106:16788-16793
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16788-16793
    • Friedman, D.J.1    Kunzli, B.M.2    A-Rahim, Y.I.3    Sevigny, J.4    Berberat, P.O.5    Enjyoji, K.6    Csizmadia, E.7    Friess, H.8    Robson, S.C.9
  • 100
    • 73449115750 scopus 로고    scopus 로고
    • Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
    • 19769545 1:CAS:528:DC%2BD1MXhtlSltL7N 10.1517/14728220903241666
    • Eltzschig HK, Rivera-Nieves J, Colgan SP (2009) Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets 13:1267-1277
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 1267-1277
    • Eltzschig, H.K.1    Rivera-Nieves, J.2    Colgan, S.P.3
  • 101
    • 33747785278 scopus 로고    scopus 로고
    • Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis
    • 16920910 1:CAS:528:DC%2BD28Xot1equ7g%3D
    • Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB (2006) Cutting edge: critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J Immunol 177:2765-2769
    • (2006) J Immunol , vol.177 , pp. 2765-2769
    • Naganuma, M.1    Wiznerowicz, E.B.2    Lappas, C.M.3    Linden, J.4    Worthington, M.T.5    Ernst, P.B.6
  • 104
    • 37349104240 scopus 로고    scopus 로고
    • CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
    • 17909107 10.1161/CIRCULATIONAHA.107.690180 1:CAS:528:DC%2BD2sXhtFersLnP
    • Kohler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, Laucher S, Hart ML, Robson SC, Muller CE, Eltzschig HK (2007) CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation 116:1784-1794
    • (2007) Circulation , vol.116 , pp. 1784-1794
    • Kohler, D.1    Eckle, T.2    Faigle, M.3    Grenz, A.4    Mittelbronn, M.5    Laucher, S.6    Hart, M.L.7    Robson, S.C.8    Muller, C.E.9    Eltzschig, H.K.10
  • 105
    • 84867908845 scopus 로고    scopus 로고
    • Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-alpha release
    • doi: 10.4049/jimmunol.1201651
    • Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET (2012) Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-alpha release. J Immunol. doi: 10.4049/jimmunol.1201651
    • (2012) J Immunol
    • Grenz, A.1    Kim, J.H.2    Bauerle, J.D.3    Tak, E.4    Eltzschig, H.K.5    Clambey, E.T.6
  • 109
    • 70349904541 scopus 로고    scopus 로고
    • Role of extracellular adenosine in acute lung injury
    • 1:CAS:528:DC%2BD1MXhtlynsLjL 10.1152/physiol.00022.2009
    • Eckle T, Koeppen M, Eltzschig HK (2009) Role of extracellular adenosine in acute lung injury. Physiology (Bethesda) 24:298-306
    • (2009) Physiology (Bethesda) , vol.24 , pp. 298-306
    • Eckle, T.1    Koeppen, M.2    Eltzschig, H.K.3
  • 110
    • 77954519851 scopus 로고    scopus 로고
    • Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury
    • 20348420 1:CAS:528:DC%2BC3cXltVGht74%3D 10.4049/jimmunol.0903035
    • Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK (2010) Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol 184:5271-5279
    • (2010) J Immunol , vol.184 , pp. 5271-5279
    • Schingnitz, U.1    Hartmann, K.2    MacManus, C.F.3    Eckle, T.4    Zug, S.5    Colgan, S.P.6    Eltzschig, H.K.7
  • 111
    • 59649088866 scopus 로고    scopus 로고
    • Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs
    • 18838482 1:CAS:528:DC%2BD1MXhs1Kmurc%3D 10.1096/fj.08-119701
    • Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri KC, Eltzschig HK (2009) Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J 23:473-482
    • (2009) FASEB J , vol.23 , pp. 473-482
    • Reutershan, J.1    Vollmer, I.2    Stark, S.3    Wagner, R.4    Ngamsri, K.C.5    Eltzschig, H.K.6
  • 113
    • 22744450934 scopus 로고    scopus 로고
    • Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury
    • 15857155 10.1371/journal.pbio.0030174 1:CAS:528:DC%2BD2MXlsFyisbs%3D
    • Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, Lukashev D, Bittmann I, Sitkovsky MV (2005) Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol 3:e174
    • (2005) PLoS Biol , vol.3 , pp. 174
    • Thiel, M.1    Chouker, A.2    Ohta, A.3    Jackson, E.4    Caldwell, C.5    Smith, P.6    Lukashev, D.7    Bittmann, I.8    Sitkovsky, M.V.9
  • 114
    • 33847339352 scopus 로고    scopus 로고
    • Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation
    • 17318263 1:CAS:528:DC%2BD2sXis12htL4%3D 10.1172/JCI30049
    • Khoury J, Ibla JC, Neish AS, Colgan SP (2007) Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest 117:703-711
    • (2007) J Clin Invest , vol.117 , pp. 703-711
    • Khoury, J.1    Ibla, J.C.2    Neish, A.S.3    Colgan, S.P.4
  • 115
    • 41349114840 scopus 로고    scopus 로고
    • A2B adenosine receptor dampens hypoxia-induced vascular leak
    • 18056839 1:CAS:528:DC%2BD1cXisVeisLk%3D 10.1182/blood-2007-10-117044
    • Eckle T, Faigle M, Grenz A, Laucher S, Thompson LF, Eltzschig HK (2008) A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood 111:2024-2035
    • (2008) Blood , vol.111 , pp. 2024-2035
    • Eckle, T.1    Faigle, M.2    Grenz, A.3    Laucher, S.4    Thompson, L.F.5    Eltzschig, H.K.6


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