Gene Therapy for the Nervous System: Challenges and New Strategies

Neurotherapeutics

Volumn 11, Issue 4, 2014, Pages 817-839

  Maguire, Casey A ^a   Ramirez, Servio H ^c   Merkel, Steven F ^c   Sena Esteves, Miguel ^b   Breakefield, Xandra O ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Central nervous system; Gene delivery; Gene therapy; Nonviral gene delivery; Virus vector

Indexed keywords

ABC TRANSPORTER; AROMATIC LEVO AMINO ACID DECARBOXYLASE; CEREBROSIDE SULFATASE; CYTOSINE DEAMINASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; N SULPHOGLUCOSAMINE SULPHOHYDROLASE; NERVE GROWTH FACTOR; SULFATASE; SULFATASE MODIFYING FACTOR 1; THYMIDINE KINASE; TRANSCRIPTOME; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; CELL BASED GENE THERAPY; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENE VECTOR; GENOME; HUMAN; IMMUNE SYSTEM; NEUROLOGIC DISEASE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PROMOTER REGION; REVIEW; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; GENE THERAPY; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES; VIRUS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; HUMANS; VIRUSES;

EID: 84919778470     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-014-0299-5     Document Type: Review

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