-
1
-
-
77749271119
-
Macromolecular drug transport into the brain using targeted therapy
-
Lichota J, Skjorringe T, Thomsen LB, Moos T, (2010) Macromolecular drug transport into the brain using targeted therapy. J Neurochem 113: 1-13.
-
(2010)
J Neurochem
, vol.113
, pp. 1-13
-
-
Lichota, J.1
Skjorringe, T.2
Thomsen, L.B.3
Moos, T.4
-
2
-
-
0037817352
-
Transcytosis: crossing cellular barriers
-
Tuma PL, Hubbard AL, (2003) Transcytosis: crossing cellular barriers. Physiol Rev 83: 871-932.
-
(2003)
Physiol Rev
, vol.83
, pp. 871-932
-
-
Tuma, P.L.1
Hubbard, A.L.2
-
3
-
-
34547645047
-
Modelling of the blood-brain barrier in drug discovery and development
-
Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, et al. (2007) Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 6: 650-661.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 650-661
-
-
Cecchelli, R.1
Berezowski, V.2
Lundquist, S.3
Culot, M.4
Renftel, M.5
-
4
-
-
34547642139
-
Blood-brain barrier transport of therapeutics via receptor-mediation
-
Jones AR, Shusta EV, (2007) Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm Res 24: 1759-1771.
-
(2007)
Pharm Res
, vol.24
, pp. 1759-1771
-
-
Jones, A.R.1
Shusta, E.V.2
-
5
-
-
57149110011
-
CNS delivery via adsorptive transcytosis
-
Herve F, Ghinea N, Scherrmann JM, (2008) CNS delivery via adsorptive transcytosis. Aaps J 10: 455-472.
-
(2008)
Aaps J
, vol.10
, pp. 455-472
-
-
Herve, F.1
Ghinea, N.2
Scherrmann, J.M.3
-
6
-
-
79551648929
-
Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro
-
Georgieva JV, Kalicharan D, Couraud PO, Romero IA, Weksler B, et al. (2010) Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro. Mol Ther 19: 318-325.
-
(2010)
Mol Ther
, vol.19
, pp. 318-325
-
-
Georgieva, J.V.1
Kalicharan, D.2
Couraud, P.O.3
Romero, I.A.4
Weksler, B.5
-
7
-
-
33747259575
-
Transductional targeting of adenovirus vectors for gene therapy
-
Glasgow JN, Everts M, Curiel DT, (2006) Transductional targeting of adenovirus vectors for gene therapy. Cancer Gene Ther 13: 830-844.
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 830-844
-
-
Glasgow, J.N.1
Everts, M.2
Curiel, D.T.3
-
8
-
-
0038745599
-
Progress and problems with the use of viral vectors for gene therapy
-
Thomas CE, Ehrhardt A, Kay MA, (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4: 346-358.
-
(2003)
Nat Rev Genet
, vol.4
, pp. 346-358
-
-
Thomas, C.E.1
Ehrhardt, A.2
Kay, M.A.3
-
9
-
-
77953722282
-
Development of gene therapy for neurological disorders
-
Manfredsson FP, Mandel RJ, (2010) Development of gene therapy for neurological disorders. Discovery Medicine 9: 204-211.
-
(2010)
Discovery Medicine
, vol.9
, pp. 204-211
-
-
Manfredsson, F.P.1
Mandel, R.J.2
-
10
-
-
36348929875
-
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications
-
Barcia C, Jimenez-Dalmaroni M, Kroeger KM, Puntel M, Rapaport AJ, et al. (2007) One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Mol Ther 15: 2154-2163.
-
(2007)
Mol Ther
, vol.15
, pp. 2154-2163
-
-
Barcia, C.1
Jimenez-Dalmaroni, M.2
Kroeger, K.M.3
Puntel, M.4
Rapaport, A.J.5
-
11
-
-
0034567011
-
Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression
-
Smith-Arica JR, Morelli AE, Larregina AT, Smith J, Lowenstein PR, et al. (2000) Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression. Mol Ther 2: 579-587.
-
(2000)
Mol Ther
, vol.2
, pp. 579-587
-
-
Smith-Arica, J.R.1
Morelli, A.E.2
Larregina, A.T.3
Smith, J.4
Lowenstein, P.R.5
-
12
-
-
33749069305
-
Directing neuron-specific transgene expression in the mouse CNS
-
Miyoshi G, Fishell G, (2006) Directing neuron-specific transgene expression in the mouse CNS. Curr Opin Neurobiol 16: 577-584.
-
(2006)
Curr Opin Neurobiol
, vol.16
, pp. 577-584
-
-
Miyoshi, G.1
Fishell, G.2
-
13
-
-
0036118869
-
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types
-
Thomas CE, Edwards P, Wickham TJ, Castro MG, Lowenstein PR, (2002) Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. J Virol 76: 3452-3460.
-
(2002)
J Virol
, vol.76
, pp. 3452-3460
-
-
Thomas, C.E.1
Edwards, P.2
Wickham, T.J.3
Castro, M.G.4
Lowenstein, P.R.5
-
14
-
-
0027408530
-
Transfer of a foreign gene into the brain using adenovirus vectors
-
Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, et al. (1993) Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 3: 224-228.
-
(1993)
Nat Genet
, vol.3
, pp. 224-228
-
-
Akli, S.1
Caillaud, C.2
Vigne, E.3
Stratford-Perricaudet, L.D.4
Poenaru, L.5
-
15
-
-
72949102434
-
Genetic manipulation of endothelial cells by viral vectors
-
Lindemann D, Schnittler H, (2009) Genetic manipulation of endothelial cells by viral vectors. Thromb Haemost 102: 1135-1143.
-
(2009)
Thromb Haemost
, vol.102
, pp. 1135-1143
-
-
Lindemann, D.1
Schnittler, H.2
-
16
-
-
0034467640
-
Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium
-
Xia H, Anderson B, Mao Q, Davidson BL, (2000) Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium. J Virol 74: 11359-11366.
-
(2000)
J Virol
, vol.74
, pp. 11359-11366
-
-
Xia, H.1
Anderson, B.2
Mao, Q.3
Davidson, B.L.4
-
17
-
-
33847791626
-
Directing adenovirus across the blood-brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model
-
Tang Y, Han T, Everts M, Zhu ZB, Gillespie GY, et al. (2007) Directing adenovirus across the blood-brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model. Gene Ther 14: 523-532.
-
(2007)
Gene Ther
, vol.14
, pp. 523-532
-
-
Tang, Y.1
Han, T.2
Everts, M.3
Zhu, Z.B.4
Gillespie, G.Y.5
-
18
-
-
54949092481
-
Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere
-
Corjon S, Wortmann A, Engler T, van Rooijen N, Kochanek S, et al. (2008) Targeting of adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere. Mol Ther 16: 1813-1824.
-
(2008)
Mol Ther
, vol.16
, pp. 1813-1824
-
-
Corjon, S.1
Wortmann, A.2
Engler, T.3
van Rooijen, N.4
Kochanek, S.5
-
19
-
-
20844445679
-
Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors
-
Kreppel F, Gackowski J, Schmidt E, Kochanek S, (2005) Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors. Mol Ther 12: 107-117.
-
(2005)
Mol Ther
, vol.12
, pp. 107-117
-
-
Kreppel, F.1
Gackowski, J.2
Schmidt, E.3
Kochanek, S.4
-
20
-
-
78650881455
-
Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells
-
Prill JM, Espenlaub S, Samen U, Engler T, Schmidt E, et al. (2010) Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells. Mol Ther 19: 83-92.
-
(2010)
Mol Ther
, vol.19
, pp. 83-92
-
-
Prill, J.M.1
Espenlaub, S.2
Samen, U.3
Engler, T.4
Schmidt, E.5
-
21
-
-
55849128943
-
The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies
-
Poller B, Gutmann H, Krahenbuhl S, Weksler B, Romero I, et al. (2008) The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies. J Neurochem 107: 1358-1368.
-
(2008)
J Neurochem
, vol.107
, pp. 1358-1368
-
-
Poller, B.1
Gutmann, H.2
Krahenbuhl, S.3
Weksler, B.4
Romero, I.5
-
22
-
-
0021664128
-
Regulation of the transferrin receptor in K562 erythroleukemia cells
-
Cudkowicz A, Klausner RD, Bridges KR, (1984) Regulation of the transferrin receptor in K562 erythroleukemia cells. Prog Clin Biol Res 165: 509-519.
-
(1984)
Prog Clin Biol Res
, vol.165
, pp. 509-519
-
-
Cudkowicz, A.1
Klausner, R.D.2
Bridges, K.R.3
-
23
-
-
0242610345
-
The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells
-
Goldsmith ME, Kitazono M, Fok P, Aikou T, Bates S, et al. (2003) The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells. Clin Cancer Res 9: 5394-5401.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5394-5401
-
-
Goldsmith, M.E.1
Kitazono, M.2
Fok, P.3
Aikou, T.4
Bates, S.5
-
24
-
-
77957832543
-
Capsomer-specific fluorescent labeling of adenoviral vector particles allows for detailed analysis of intracellular particle trafficking and the performance of bioresponsive bonds for vector capsid modifications
-
Espenlaub S, Corjon S, Engler T, Fella C, Ogris M, et al. (2010) Capsomer-specific fluorescent labeling of adenoviral vector particles allows for detailed analysis of intracellular particle trafficking and the performance of bioresponsive bonds for vector capsid modifications. Hum Gene Ther 21: 1155-1167.
-
(2010)
Hum Gene Ther
, vol.21
, pp. 1155-1167
-
-
Espenlaub, S.1
Corjon, S.2
Engler, T.3
Fella, C.4
Ogris, M.5
-
25
-
-
33646861014
-
Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting
-
Campos SK, Barry MA, (2006) Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting. Virology 349: 453-462.
-
(2006)
Virology
, vol.349
, pp. 453-462
-
-
Campos, S.K.1
Barry, M.A.2
-
26
-
-
27744460321
-
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
-
Weksler BB, Subileau EA, Perriere N, Charneau P, Holloway K, et al. (2005) Blood-brain barrier-specific properties of a human adult brain endothelial cell line. Faseb J 19: 1872-1874.
-
(2005)
Faseb J
, vol.19
, pp. 1872-1874
-
-
Weksler, B.B.1
Subileau, E.A.2
Perriere, N.3
Charneau, P.4
Holloway, K.5
-
27
-
-
0033949264
-
Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro
-
Franke H, Galla H, Beuckmann CT, (2000) Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro. Brain Res Brain Res Protoc 5: 248-256.
-
(2000)
Brain Res Brain Res Protoc
, vol.5
, pp. 248-256
-
-
Franke, H.1
Galla, H.2
Beuckmann, C.T.3
-
28
-
-
0033528231
-
An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol
-
Franke H, Galla HJ, Beuckmann CT, (1999) An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol. Brain Res 818: 65-71.
-
(1999)
Brain Res
, vol.818
, pp. 65-71
-
-
Franke, H.1
Galla, H.J.2
Beuckmann, C.T.3
-
29
-
-
0141463768
-
Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro
-
Nitz T, Eisenblatter T, Psathaki K, Galla HJ, (2003) Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro. Brain Res 981: 30-40.
-
(2003)
Brain Res
, vol.981
, pp. 30-40
-
-
Nitz, T.1
Eisenblatter, T.2
Psathaki, K.3
Galla, H.J.4
-
30
-
-
36248942024
-
Iron trafficking inside the brain
-
Moos T, Rosengren Nielsen T, Skjorringe T, Morgan EH, (2007) Iron trafficking inside the brain. J Neurochem 103: 1730-1740.
-
(2007)
J Neurochem
, vol.103
, pp. 1730-1740
-
-
Moos, T.1
Rosengren Nielsen, T.2
Skjorringe, T.3
Morgan, E.H.4
-
31
-
-
0031959341
-
CNS drug design based on principles of blood-brain barrier transport
-
Pardridge WM, (1998) CNS drug design based on principles of blood-brain barrier transport. Journal Neurochem 70: 1781-1792.
-
(1998)
Journal Neurochem
, vol.70
, pp. 1781-1792
-
-
Pardridge, W.M.1
-
32
-
-
0036463371
-
Drug and gene targeting to the brain with molecular Trojan horses
-
Pardridge WM, (2002) Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov 1: 131-139.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 131-139
-
-
Pardridge, W.M.1
-
33
-
-
60149106907
-
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes
-
Foust KD, Nurre E, Montgomery CL, Hernandez A, Chan CM, et al. (2009) Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat Biotechnol 27: 59-65.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 59-65
-
-
Foust, K.D.1
Nurre, E.2
Montgomery, C.L.3
Hernandez, A.4
Chan, C.M.5
-
34
-
-
75949083145
-
Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease
-
Batista L, Miller F, Clave C, Arfi A, Douillard-Guilloux G, et al. (2010) Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? Neurobiol Dis 37: 656-660.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 656-660
-
-
Batista, L.1
Miller, F.2
Clave, C.3
Arfi, A.4
Douillard-Guilloux, G.5
-
35
-
-
32944463023
-
AAV transcytosis through barrier epithelia and endothelium
-
Di Pasquale G, Chiorini JA, (2006) AAV transcytosis through barrier epithelia and endothelium. Mol Ther 13: 506-516.
-
(2006)
Mol Ther
, vol.13
, pp. 506-516
-
-
Di Pasquale, G.1
Chiorini, J.A.2
-
36
-
-
0035038397
-
Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells
-
Hocini H, Becquart P, Bouhlal H, Chomont N, Ancuta P, et al. (2001) Active and selective transcytosis of cell-free human immunodeficiency virus through a tight polarized monolayer of human endometrial cells. J Virol 75: 5370-5374.
-
(2001)
J Virol
, vol.75
, pp. 5370-5374
-
-
Hocini, H.1
Becquart, P.2
Bouhlal, H.3
Chomont, N.4
Ancuta, P.5
-
38
-
-
0026719204
-
Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models
-
Dehouck MP, Jolliet-Riant P, Bree F, Fruchart JC, Cecchelli R, et al. (1992) Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J Neurochem 58: 1790-1797.
-
(1992)
J Neurochem
, vol.58
, pp. 1790-1797
-
-
Dehouck, M.P.1
Jolliet-Riant, P.2
Bree, F.3
Fruchart, J.C.4
Cecchelli, R.5
-
39
-
-
0034633740
-
Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production
-
Schiedner G, Hertel S, Kochanek S, (2000) Efficient transformation of primary human amniocytes by E1 functions of Ad5: generation of new cell lines for adenoviral vector production. Hum Gene Ther 11: 2105-2116.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2105-2116
-
-
Schiedner, G.1
Hertel, S.2
Kochanek, S.3
|