Lipid nanoparticle delivery of sirna to silence neuronal gene expression in the brain

Molecular Therapy Nucleic Acids

Volumn 2, Issue , 2013, Pages

  Rungta, Ravi L ^a   Choi, Hyun B ^a   Lin, Paulo J C ^b   Ko, Rebecca W Y ^a   Ashby, Donovan ^a   Nair, Jay ^c   Manoharan, Muthiah ^c   Cullis, Pieter R ^b   MacVicar, Brian A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

MiRNAs nanoparticles; ShRNAs; SiRNAs

Indexed keywords

AMPA RECEPTOR; APOLIPOPROTEIN E; GRIN1 PROTEIN; LIPID NANOPARTICLE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; SOLID LIPID NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CYTOTOXICITY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SYNAPSE; ANIMAL MODEL; ANIMAL TISSUE; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; NANOENCAPSULATION; WESTERN BLOTTING;

EID: 84891797936     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.65     Document Type: Article

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