Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

Molecular Therapy

Volumn 10, Issue 2, 2004, Pages 302-317

  Burger, Corinna ^a   Gorbatyuk, Oleg S ^a   Velardo, Margaret J ^a,b   Peden, Carmen S ^a,b   Williams, Philip ^a,b   Zolotukhin, Sergei ^a   Reier, Paul J ^a,b   Mandel, Ronald J ^a,b   Muzyczka, Nicholas ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

AAV; Brain; Capsid; Gene delivery; Nervous system; Retrograde transport; Serotype; Spinal cord; Stereology; Tropism

Indexed keywords

GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DENTATE GYRUS; GENETIC TRANSDUCTION; GLOBUS PALLIDUS; HIPPOCAMPUS; LONG TERMINAL REPEAT; MEDICAL DECISION MAKING; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; RETINA NERVE CELL; SEROTYPE; SPINAL CORD; SPINAL CORD NERVE CELL; SUBSTANTIA NIGRA; TARGET CELL; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS RECOMBINANT;

ANIMALS; CAPSID; CENTRAL NERVOUS SYSTEM; DEPENDOVIRUS; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS 2;

EID: 4344566457     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.05.024     Document Type: Article

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