GFAP promoter elements required for region-specific and astrocyte-specific expression

GLIA

Volumn 56, Issue 5, 2008, Pages 481-493

  Lee, Youngjin ^a   Messing, Albee ^b   Su, Mu ^a   Brenner, Michael ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cell differentiation; Gene expression regulation; Genes; Glial fibrillary acidic protein; Mice; Promoter regions; Regulatory elements; Reporter; Transcriptional; Transgenes; Transgenic; Variation (genetics)

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; BETA GALACTOSIDASE; ENOLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL SPECIFICITY; CEREBELLUM VERMIS; CONTROLLED STUDY; DNA DETERMINATION; EMBRYO; GENE ACTIVATION; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HIPPOCAMPUS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA ANALYSIS; RNA SEQUENCE; TRANSGENE; ANIMAL; BRAIN; CELL CULTURE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; GLIOMA; HISTOLOGY; HUMAN; METABOLISM; METHODOLOGY; MUTATION; NEWBORN; PATHOLOGY; PHYSIOLOGY; PROTEIN MOTIF; TRANSGENIC MOUSE;

AMINO ACID MOTIFS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BETA-GALACTOSIDASE; BRAIN; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; PHOSPHOPYRUVATE HYDRATASE; PROMOTER REGIONS (GENETICS);

EID: 44449173870     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20622     Document Type: Article

References (37)

1. Andrews NC, Faller DV. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499.
2. Bhargava P, Chatterji D. 1992. DNA intervention in transcriptional activation. FEBS Lett 307:245-248.
3. Benavides A, Pastor D, Santos P, Tranque P, Calvo S. 2005. CHOP plays a pivotal role in the astrocyte death induced by oxygen and glucose deprivation. Glia 52:261-275.
4. Besnard F, Brenner M, Nakatani Y, Chao R, Purohit HJ, Freese E. 1991. Multiple interacting sites regulate astrocyte-specific transcription of the human gone for glial fibrillary acidic protein. J Biol Chem 266:18877-18883.
5. Bignami A, Eng LF, Dahl D, Uyeda CT. 1972. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res 43:429-435.
6. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. 1997. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278:477-483.
7. Brenner M. 1994. Structure and transcriptional regulation of the GFAP gene. Brain Pathol 4:245-257.
8. Brenner M, Kisseberth WC, Su Y, Besnard F, Messing A. 1994. GFAP promoter directs astrocyte-specific expression in transgenic mice. J Neurosci 14:1030-1037.
9. Cristiano L, Cimini A, Moreno S, Ragnelli AM, Paola Ceru M. 2005. Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures. Neuroscience 131:577-587.
10. de Leeuw B, Su M, ter Horst M, Iwata S, Rodijk M, Hoeben RC, Messing A, Smitt PS, Brenner M. 2006. Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elements. J Neurosci Res 83:744-753.
11. Dignam JD, Lebovitz RM, Roeder RG. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
12. Duprey P, Chowdhury K, Dressler GR, Balling R, Simon D, Guenet JL, Gruss P. 1998. A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes Dev 2:1647-1654.
13. Eng LF, Ghirnikar RS. 1994. GFAP and agtrogliosis. Brain Pathol 4:229-237.
14. Eng LF, Vanderhaeghen JJ, Bignami A, Gerstl B. 1971. An acidic protein isolated from fibrous astrocytes. Brain Res 28:351-354.
15. Heinemeyer T, Chen X, Karas H, Kel AE, Kel OV, Liebich I, Meinhardt T, Reuter I, Schacherer F, Wingender E. 1999. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res 27:318-322.
16. James R, Kazenwadel J. 1991. Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem 266:3246-3251.
17. Kahn MA, Huang CJ, Caruso A, Barresi V, Nazarian R, Condorelli DF, de Vellis J. 1997. Ciliary neurotrophic factor activates JAK/Stat signal transduction cascade and induces transcriptional expression of glial fibrillary acidic protein in glial cells. J Neurochem 68:1413-1423.
18. Kamnasaran D, Guha A. 2005. Expression of GATA6 in the human and mouse central nervous system. Brain Res Dev Brain Res 160:90-95.
19. Kuzmanovic M, Dudley VJ, Sarthy VP. 2003. GFAP promoter drives Muller cell-specific expression in transgenic mice. Invest Ophthalmol Vis Sci 44:3606-3613.
20. Lee Y, Su M, Messing A, Brenner M. 2006. Astrocyte heterogeneity revealed by expression of a GFAP-LacZ transgene. Glia 53:677-687.
21. Licht JD. 2001. AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:5660-5679.
22. Lo K, Landau NR, Smale ST. 1991. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol Cell Biol 11:5229-5243.
23. Martin A, Hofmann HD, Kirsch M. 2003. Glial reactivity in ciliary neurotrophic factor-deficient mice after optic nerve lesion. J Neurosci 23:5416-5424.
24. Masood K, Besnard F, Su Y, Brenner M. 1993. Analysis of a segment of the human glial fibrillary acidic protein gene that directs astrocyte-specific transcription. 61:160-166.
25. Massa PT, Aleyasin H, Park DS, Mao X, Barger SW. 2006. NF κB in neurons? The uncertainty principle in neurobiology. J Neurochem 97:607-618.
26. Menard C, Hein P, Paquin A, Savelson A, Yang XM, Lederfein D, Barnabe-Heider F, Mir AA, Sterneck E, Peterson AC, Johnson PF, Vinson C, Miller FD. 2002. An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron 36:597-610.
27. Meyer BI, Gruss P. 1993. Mouse Cdx-1 expression during gastrulation. Development 117:191-203.
28. Montoliu L, Chavez S, Vidal M. 2000. Variegation associated with lacZ in transgenic animals: A warning note. Transgenic Res 9:237-239.
29. Nardelli J, Thiesson D, Fujiwara Y, Tsai FY, Orkin SH. 1999. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol 210:305-321.
30. Paquin A, Barnabe-Heider F, Kageyama R, Miller FD. 2005. CCAAT/ enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. J Neurosci 25:10747-10758.
31. Ransom B, Behar T, Nedergaard M. 2003. New roles for astrocytes (stars at last). Trends Neurosci 26:520-522.
32. Schmitt C, Tonnelle C, Dalloul A, Chabannon C, Debre P, Rebollo A. 2002. Aiolos and Ikaros: Regulators of lymphocyte development, homeostasis and lymphoproliferation. Apoptosis 7:277-284.
33. Schmidt-Ullrich R, Memet S, Lilienbaum A, Feuillard J, Raphael M, Israel A. 1996. NF-κB activity in transgenic mice: Developmental regulation and tissue specificity. Development 22:2117-2128.
34. Setoguchi H, Namihira M, Kohyama J, Asano H, Sanosaka T, Nakashima K. 2006. Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons. J Neurosci Res 84:969-979.
35. Su M, Hu H, Lee Y, d'Azzo A, Messing A, Brenner M. 2004. Expression specificity of GFAP transgenes. Neurochem Res 29:2075-2093.
36. Yano S, Fukunaga K, Takiguchi M, Ushio Y, Mori M, Miyamoto E. 1996. Regulation of CCAAT/enhancer-binding protein family members by stimulation of glutamate receptors in cultured rat cortical astrocytes. J Biol Chem 271:23520-23527.
37. Zhou H, Hughes DE, Major ML, Yoo K, Pesold C, Costa RH. 2001. Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3β. Gene Expr 9:217-236.