A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease

Alzheimer's & dementia : the journal of the Alzheimer's Association

Volumn 10, Issue 5, 2014, Pages 571-581

  Rafii, Michael S ^a   Baumann, Tiffany L ^a   Bakay, Roy A E ^b   Ostrove, Jeffrey M ^a   Siffert, Joao ^a   Fleisher, Adam S ^a   Herzog, Christopher D ^a   Barba, David ^a   Pay, Mary ^a   Salmon, David P ^a   Chu, Yaping ^b   Kordower, Jeffrey H ^b   Bishop, Kathie ^a   Keator, David ^a   Potkin, Steven ^a   Bartus, Raymond T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cholinergic neurons; Gene therapy; Nerve growth factor; Neuroprotection; Neurorestoration; Neurotrophic factors; Nucleus basalis of Meynert; Translational R D

Indexed keywords

NERVE GROWTH FACTOR; NGF PROTEIN, HUMAN;

AGED; ALZHEIMER DISEASE; CLINICAL TRIAL; DEPENDOPARVOVIRUS; DIAGNOSTIC IMAGING; FEASIBILITY STUDY; FEMALE; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MEYNERT BASAL NUCLEUS; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHASE 1 CLINICAL TRIAL; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; STEREOTACTIC PROCEDURE; TREATMENT OUTCOME;

AGED; ALZHEIMER DISEASE; BASAL NUCLEUS OF MEYNERT; DEPENDOVIRUS; FEASIBILITY STUDIES; FEMALE; GENETIC THERAPY; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE GROWTH FACTOR; NEUROPSYCHOLOGICAL TESTS; NEUROSURGICAL PROCEDURES; POSITRON-EMISSION TOMOGRAPHY; STEREOTAXIC TECHNIQUES; TREATMENT OUTCOME;

EID: 85027921807     PISSN: None     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2013.09.004     Document Type: Article

References (0)