Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

Gene Therapy

Volumn 10, Issue 26, 2003, Pages 2112-2118

  McCarty, D M ^a,b   Fu, H ^b   Monahan, P E ^b   Toulson, C E ^a,c   Naik, P ^b   Samulski, R J ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

AAV; Double strand; Terminal repeat; Transduction

Indexed keywords

CESIUM CHLORIDE; COMPLEMENTARY DNA; DIMER; DOUBLE STRANDED DNA; ERYTHROPOIETIN; GREEN FLUORESCENT PROTEIN; HELICASE; HEPARIN; IODIXANOL; RNA; SINGLE STRANDED DNA; VIRUS DNA; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASE PAIRING; BRAIN TISSUE; CELL TYPE; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFICACY; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE REPLICATION; GENE TRANSFER; GENETIC TRANSDUCTION; HOST CELL; IN VIVO STUDY; INVERTED TERMINAL REPEAT; LIVER; MOUSE; MUSCLE TISSUE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM; VIRUS CHARACTERIZATION; VIRUS GENOME; VIRUS MUTANT; VIRUS RECOMBINANT; WILD TYPE;

ANIMALS; BRAIN; DEPENDOVIRUS; DNA REPLICATION; DNA, VIRAL; GENE DELETION; GENETIC VECTORS; HEPATOCYTES; MICE; MUSCLE CELLS; TERMINAL REPEAT SEQUENCES; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; ANIMALIA; DNA VIRUSES;

EID: 0346777307     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302134     Document Type: Article

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