Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes

Gene Therapy

Volumn 8, Issue 17, 2001, Pages 1323-1332

  Xu, R ^a,b   Janson, C G ^b,c   Mastakov, M ^a,b   Lawlor, P ^a,b   Young, D ^a,b   Mouravlev, A ^a,b   Fitzsimons, H ^a,b   Choi, K L ^a   Ma, H ^a   Dragunow, M ^a   Leone, P ^b,c   Chen, Q ^a   Dicker, B ^a   During, M J ^a,b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno associated virus; Functional genomics; Gene cassette; Neuron; Post regulatory element; Promoter

Indexed keywords

BETA ACTIN; ENOLASE; EPITOPE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS 2; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN NERVE CELL; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CASSETTE; GENE EXPRESSION; GENE INSERTION; GLIA; IN VIVO STUDY; MAMMAL; NONHUMAN; POLYADENYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RAT; SOUTHERN BLOTTING; TITRIMETRY; TRANSGENE; VIRUS CAPSID; VIRUS INFECTIVITY; VIRUS PURIFICATION; VIRUS RECOMBINANT;

ANIMALS; BLOTTING, SOUTHERN; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; DEPENDOVIRUS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; INJECTIONS; LUCIFERASES; RATS; RATS, WISTAR;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS 2; ANIMALIA; DNA VIRUSES; MAMMALIA; MIRIDAE;

EID: 17944378442     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301529     Document Type: Article

References (58)

1. A system for the propagation of adenoviral vectors with genetically modified receptor specificities
2. Modification of an adenoviral vector with biologically selected peptides: A novel strategy for gene delivery to cells of choice
3. Genetic capsid modifications allow efficent retargeting of AAV-2
4. Recombinant adeno-associated virus type 2, 4 and 5 vectors: Transduction of variant cell types and regions in the mammalian cental nervous system
5. Long-term gene expression and phenotypic correction using AAV vectors in the mammalian brain
6. Efficient transduction of human neurons with an AAV vector
7. Differential and persistent expression patterns of CNS gene transfer by an AAV vector
8. Peroral gene therapy of lactose intolerance using an AAV vector
9. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
10. Recombinant AAV vector: Use for transgene expression and anterograde tract tracing in the CNS
11. Gene transfer into mammalian central nervous system using herpes simplex virus vectors: Extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter
12. Herpesvirus-mediated gene delivery into the brain: Specificity and efficiency of the neuron-specific enolase promoter
13. Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectors
14. Efficient transduction of green fluorescent protein in spinal cord neurons using AAV vectors containing cell type-specific promoter
15. Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant AAV vectors
16. Gene transfer and expression in oligodendrocytes under the control of myelin basic protein transcriptional control region mediated by AAV
17. Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity
18. Diverse stabilities of expression in the rat brain from different cellular promoters in a helper-virus-free herpes simplex virus type 1 vector system
19. Transgene expression of plasmid DNAs directed by viral or neural promoters in the rat brain
20. Efficient gene transfer into non-dividing cells by AAV-based vectors
21. Gene transfer by AAV into the central nervous system
22. AAV vector mediated transgene integration into neurons and other nondividing cell targets
23. AAV-mediated gene transfer to the brain: Duration and modulation of expression
24. AAV-2 binds to a 150kD cell membrane glycoprotein
25. Polarity influences the efficiency of recombinant AAV infection in differentiated airway epithelia
26. Membrane-associated heparan sulfate proteoglycan is a receptor for AAV-2 virions
27. Mutations in the carboxy terminus of AAV capsid proteins affect viral infectivity: Lack of an RGD integrin-binding motif
28. aVb5 integrin: A co-receptor for AAV-2 infection
29. Human fibroblast growth factor receptor is a co-receptor for infection by AAV-2
30. Selective and rapid uptake of AAV-2 in brain
31. AAVant-garde gene therapy
32. Quantitative analysis of the packaging capacity of recombinant AAV
33. The packaging capacity of AAV and the potential for wild-type-plus AAV gene therapy vectors
34. Efficient CFTR expression from AAV vectors packaged with promoters - The 2nd generation
35. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts
36. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element
37. Differential effects of polyadenylation regions on gene expression in mammalian cells
38. Optimization of plasmid vectors for high-level expression in lung epithelial cells
39. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
40. The cell bodies of origin of sympathetic and sensory axons in some skin and muscle nerves of the cat hindlimb
41. Recombinant AAV virus purification using novel methods improves infectious titer and yield
42. AAV-2 co-receptors?
43. Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan
44. Integrin subunit gene expression is regionally differentiated in adult brain
45. Development and FGF-2-mediated regulation of syndecans and glypican in oligodendrocytes
46. FGF-1 expression in the cortex and hippocampus in Alzheimer's Disease
47. Expression and distribution of functional integrins in rat CNS glia
48. Dynamin is required for recombinant AAV-2 infection
49. A 110kDa nuclear shuttle protein, nucleolin, specifically binds to AAV-2 capsid
50. AAV-2-mediated gene transfer: Correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein with transgene expression in human cells in vitro and murine tissues in vivo
51. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an AAV vector
52. Sequences in the proximal 5′ flanking region of the rat neuron-specific enolase (NSE) gene are sufficient for cell type-specific reporter gene expression
53. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control
54. Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease
55. Use of herpes simplex virus type 1 for transgene expression within the nervous system
56. Dopaminergic regulation of a transfected preproenkephalin promoter in primary rat astrocytes in vitro and in vivo
57. Highly purified recombinant AAV vectors are biologically active and free of detectable helper and wild type virus
58. Subcellular compartmentalization of AAV-2 assembly