Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Nature Biotechnology

Volumn 29, Issue 4, 2011, Pages 341-345

  Alvarez Erviti, Lydia ^a   Seow, Yiqi ^a   Yin, Haifang ^a   Betts, Corinne ^a   Lakhal, Samira ^a   Wood, Matthew J A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; DENDRITIC CELLS; ELECTROPORATION; EXOSOMES; GENE KNOCK DOWN; IMMUNOGENICITY; MEMBRANE PROTEINS; MICROGLIA; MOUSE BRAIN; OLIGODENDROCYTES; PRE-EXPOSURE; SIRNA DELIVERY; THERAPEUTIC POTENTIALS; THERAPEUTIC TARGETS; WILD TYPES;

BIOLOGICAL MEMBRANES; CELLS; NUCLEIC ACIDS; PROTEINS; RNA;

GENE THERAPY;

MEMBRANE PROTEIN; PEPTIDE; PROTEIN LAMP 2B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOENGINEERING; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; ELECTROPORATION; EXOSOME; GENE SILENCING; MICROGLIA; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA TRANSPORT;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; CELL LINE; DENDRITIC CELLS; EXOSOMES; GENE KNOCKDOWN TECHNIQUES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; PEPTIDES; PROTEINS; RABIES VIRUS; RNA, MESSENGER; RNA, SMALL INTERFERING;

MUS;

EID: 79953858598     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1807     Document Type: Article

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