Breeding of retroviruses by DNA shuffling for improved stability and processing yields

Nature Biotechnology

Volumn 18, Issue 12, 2000, Pages 1279-1282

  Powell, Sharon K ^a,b   Kaloss, Michele A ^a   Pinkstaff, Anne ^a   McKee, Rebecca ^a   Burimski, Irina ^a   Pensiero, Michael ^a   Otto, Edward ^a   Stemmer, Willem P C ^c   Soong, Nay Wei ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Avigen Inc   (United States)

^c MAXYGEN INC   (United States)

Author keywords

DNA shuffling; Retroviral vectors; Stress resistance; Ultracentrifugation

Indexed keywords

VIRUS ENVELOPE PROTEIN; VIRUS VECTOR;

AMINO ACID SEQUENCE; ARTICLE; CLONE; CONTROLLED STUDY; DNA SEQUENCE; ENVELOPE GENE; GENE THERAPY; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; SEQUENCE ANALYSIS; STRESS; ULTRACENTRIFUGATION; VIRUS CULTURE; VIRUS ENVELOPE; VIRUS ISOLATION;

ANIMALS; CELL LINE; DIRECTED MOLECULAR EVOLUTION; GENE PRODUCTS, ENV; GENETIC VECTORS; MICE; MOLONEY MURINE LEUKEMIA VIRUS; RECOMBINATION, GENETIC; ULTRACENTRIFUGATION; VIRUS REPLICATION;

MURINAE; MURINE LEUKEMIA VIRUS; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0033675531     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/82391     Document Type: Article

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