LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

Neurobiology of Disease

Volumn 62, Issue , 2014, Pages 381-386

  Sanders, Laurie H ^a   Laganière, Josée ^b   Cooper, Oliver ^c   Mak, Sally K ^d   Vu, B Joseph ^b   Huang, Y Anne ^d   Paschon, David E ^b   Vangipuram, Malini ^d   Sundararajan, Ramya ^d   Urnov, Fyodor D ^b   Langston, J William ^d   Gregory, Philip D ^b   Zhang, H Steve ^b   Greenamyre, J Timothy ^a   Isacson, Ole ^c   Schüle, Birgitt ^d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d PARKINSON S INSTITUTE   (United States)

Author keywords

LRRK2; Mitochondrial DNA damage; Parkinson's disease; Stem cells

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; MITOCHONDRIAL DNA; ZINC FINGER NUCLEASE;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE MUTATION; HETEROZYGOSITY; HIGH RISK POPULATION; HOMOZYGOSITY; HUMAN; HUMAN CELL; LRRK2 GENE; NERVE CELL; NEURAL STEM CELL; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL;

LRRK2; MITOCHONDRIAL DNA DAMAGE; PARKINSON'S DISEASE; STEM CELLS;

ADULT; AGED; DNA DAMAGE; DNA REPAIR; DNA, MITOCHONDRIAL; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MIDDLE AGED; MUTATION; NEURAL STEM CELLS; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; TARGETED GENE REPAIR; ZINC FINGERS;

EID: 84887506882     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.10.013     Document Type: Article

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