Gene therapy for deaf mice goes viral

Molecular Therapy

Volumn 20, Issue 10, 2012, Pages 1836-1837

  Holt, Jeffrey R ^a   Vandenberghe, Luk H ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; PARVOVIRUS VECTOR; VESICULAR GLUTAMATE TRANSPORTER 3;

DISEASE MODEL; GENE TARGETING; HAIR CELL; HEARING IMPAIRMENT; HUMAN; INNER EAR; KNOCKOUT MOUSE; NERVE CELL; NONHUMAN; NOTE; PROTEIN EXPRESSION; SENSORY NERVE CELL; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

MUS;

EID: 84866887475     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.196     Document Type: Note

References (8)

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2. Kral, A and O'Donoghue, GM (2010). Profound deafness in childhood. N Engl J Med 363: 1438-1450.
3. National Institute on Deafness and Other Communication Disorders (2010). Quick Statistics 〈http://www.nidcd.nih.gov/health/statistics/Pages/quick. aspx〉 (16 June 2010).
4. Van Camp, G and Smith, RJ (2012). The hereditary hearing loss homepage 〈http://hereditaryhearing-loss.org〉.
5. Izumikawa, M, Minoda, R, Kawamoto, K, Abrashkin, KA, Swiderski, DL, Dolan, DF et al. (2005). Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med 11: 271-276.
6. Gubbels, S P, Woessner, DW, Mitchell, JC, Ricci, AJ and Brigande, JV (2008). Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature 455: 537-541.
7. Ryan, AF (1997). Summary: progress in inner-ear immunology. Ann N Y Acad Sci 830: 326-329.
8. Ruel, J, Emery, S, Nouvian, R, Bersot, T, Amilhon, B, van Rybroek, JM et al. (2008). Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet 83: 278-292.