-
1
-
-
84904733201
-
Integrins and cadherins as therapeutic targets in fibrosis
-
Agarwal SK. Integrins and cadherins as therapeutic targets in fibrosis. Front Pharmacol 5. 131-131, 2014.
-
(2014)
Front Pharmacol
, vol.5
, pp. 131
-
-
Agarwal, S.K.1
-
2
-
-
84868372222
-
Sequential expression of IGF-IB followed by active TGF1 induces synergistic pulmonary fibroproliferation in vivo
-
Andonegui G, Ni A, Leger C, Kelly MM, Wong JF, Jalloul A, Winston BW. Sequential expression of IGF-IB followed by active TGF1 induces synergistic pulmonary fibroproliferation in vivo. Am J Physiol Lung Cell Mol Physiol 303. L788-L798, 2012.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
, pp. L788-L798
-
-
Andonegui, G.1
Ni, A.2
Leger, C.3
Kelly, M.M.4
Wong, J.F.5
Jalloul, A.6
Winston, B.W.7
-
3
-
-
0037461958
-
Transient activation of NFB through a TAK1/IKK kinase pathway by Gerber HP, Ferrara N, Johnson RS. HIF-1 is essential for myeloid TGF1 inhibits AP-1/SMAD signaling and apoptosis. implications in liver tumor formation
-
Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS, Sonenshein GE. Transient activation of NFB through a TAK1/IKK kinase pathway by Gerber HP, Ferrara N, Johnson RS. HIF-1 is essential for myeloid TGF1 inhibits AP-1/SMAD signaling and apoptosis. implications in liver tumor formation. Oncogene 22. 412-425, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 412-425
-
-
Arsura, M.1
Panta, G.R.2
Bilyeu, J.D.3
Cavin, L.G.4
Sovak, M.A.5
Oliver, A.A.6
Factor, V.7
Heuchel, R.8
Mercurio, F.9
Thorgeirsson, S.S.10
Sonenshein, G.E.11
-
4
-
-
39149141572
-
Progressive pulmonary fibrosis is mediated by TGFisoform 1 but not TGF3
-
Ask K, Bonniaud P, Maass K, Eickelberg O, Margetts PJ, Warburton D, Groffen J, Gauldie J, Kolb M. Progressive pulmonary fibrosis is mediated by TGFisoform 1 but not TGF3. Int J Biochem Cell Biol 40. 484-495, 2008.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 484-495
-
-
Ask, K.1
Bonniaud, P.2
Maass, K.3
Eickelberg, O.4
Margetts, P.J.5
Warburton, D.6
Groffen, J.7
Gauldie, J.8
Kolb, M.9
-
5
-
-
22844434968
-
Normal cutaneous wound healing. Clinical correlation with cellular and molecular events
-
Baum CL, Arpey CJ. Normal cutaneous wound healing. Clinical correlation with cellular and molecular events. Dermatol Surg 31. 674-686, 2005.
-
(2005)
Dermatol Surg
, vol.31
, pp. 674-686
-
-
Baum, C.L.1
Arpey, C.J.2
-
6
-
-
80052014052
-
Inflammation meets cancer, with NFB as the matchmaker
-
Ben-Neriah Y, Karin M. Inflammation meets cancer, with NFB as the matchmaker. Nat Immunol 12. 715-723, 2011.
-
(2011)
Nat Immunol
, vol.12
, pp. 715-723
-
-
Ben-Neriah, Y.1
Karin, M.2
-
7
-
-
85027913192
-
Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGF signalling
-
Beyer C, Zenzmaier C, Palumbo-Zerr K, Mancuso R, Distler A, Dees C, Zerr P, Huang J, Friebe A, Sandner P, Distler O, Schett G, Berger P, Distler J. Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGF signalling. Clin Exp Rheumatol 32. S15-S16, 2014.
-
(2014)
Clin Exp Rheumatol
, vol.32
, pp. S15-S16
-
-
Beyer, C.1
Zenzmaier, C.2
Palumbo-Zerr, K.3
Mancuso, R.4
Distler, A.5
Dees, C.6
Zerr, P.7
Huang, J.8
Friebe, A.9
Sandner, P.10
Distler, O.11
Schett, G.12
Berger, P.13
Distler, J.14
-
9
-
-
1642581653
-
Hypoxic gene activation by lipopolysaccharide in macrophages. Implication of hypoxiainducible factor 1
-
Blouin CC, Page EL, Soucy GM, Richard DE. Hypoxic gene activation by lipopolysaccharide in macrophages. Implication of hypoxiainducible factor 1. Blood 103. 1124-1130, 2004.
-
(2004)
Blood
, vol.103
, pp. 1124-1130
-
-
Blouin, C.C.1
Page, E.L.2
Soucy, G.M.3
Richard, D.E.4
-
10
-
-
84906078197
-
fibroblast proliferation in response to hypoxia
-
Bodempudi V, Hergert P, Smith K, Xia H, Herrera J, Peterson M, Khalil M, Kahm J, Bitterman PB, Henke CA. miR-210 Promotes IPF fibroblast proliferation in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 307. L283-L294, 2014.
-
(2014)
Am J Physiol Lung Cell Mol Physiol
, vol.307
, pp. L283-L294
-
-
Bodempudi, V.1
Hergert, P.2
Smith, K.3
Xia, H.4
Herrera, J.5
Peterson, M.6
Khalil, M.7
Kahm, J.8
Bitterman, P.B.9
Henke, C.A.10
Mir-210 Promotes, I.P.F.11
-
11
-
-
80052680456
-
Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis
-
Boergeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O’Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C. Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis. FASEB J 25. 2967-2979, 2011.
-
(2011)
FASEB J
, vol.25
, pp. 2967-2979
-
-
Boergeson, E.1
Docherty, N.G.2
Murphy, M.3
Rodgers, K.4
Ryan, A.5
O’sullivan, T.P.6
Guiry, P.J.7
Goldschmeding, R.8
Higgins, D.F.9
Godson, C.10
-
12
-
-
84875711412
-
Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGF R1
-
Brennan EP, Nolan KA, Boergeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C, Consortium G, Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGF R1. J Am Soc Nephrol 24. 627-637, 2013.
-
(2013)
J Am Soc Nephrol
, vol.24
, pp. 627-637
-
-
Brennan, E.P.1
Nolan, K.A.2
Boergeson, E.3
Gough, O.S.4
McEvoy, C.M.5
Docherty, N.G.6
Higgins, D.F.7
Murphy, M.8
Sadlier, D.M.9
Ali-Shah, S.T.10
Guiry, P.J.11
Savage, D.A.12
Maxwell, A.P.13
Martin, F.14
Godson, C.15
Consortium, G.16
-
13
-
-
84860855375
-
NFB and HIF display synergistic behaviour during hypoxic inflammation
-
Bruning U, Fitzpatrick SF, Frank T, Birtwistle M, Taylor CT, Cheong A. NFB and HIF display synergistic behaviour during hypoxic inflammation. Cell Mol Life Sci 69. 1319-1329, 2012.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 1319-1329
-
-
Bruning, U.1
Fitzpatrick, S.F.2
Frank, T.3
Birtwistle, M.4
Taylor, C.T.5
Cheong, A.6
-
14
-
-
0035983295
-
Hunter CA. NFB family of transcription factors. Central regulators of innate and adaptive immune functions
-
Caamano J, Hunter CA. NFB family of transcription factors. Central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15. 414-429, 2002.
-
(2002)
Clin Microbiol Rev
, vol.15
, pp. 414-429
-
-
Caamano, J.1
-
15
-
-
84892447705
-
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
-
Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L,Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity 40. 66-77, 2014.
-
(2014)
Immunity
, vol.40
, pp. 66-77
-
-
Campbell, E.L.1
Bruyninckx, W.J.2
Kelly, C.J.3
Glover, L.E.4
McNamee, E.N.5
Bowers, B.E.6
Bayless, A.J.7
Scully, M.8
Saeedi, B.J.9
Golden-Mason, L.10
Ehrentraut, S.F.11
Curtis, V.F.12
Burgess, A.13
Garvey, J.F.14
Sorensen, A.15
Nemenoff, R.16
Jedlicka, P.17
Taylor, C.T.18
Kominsky, D.J.19
Colgan, S.P.20
more..
-
16
-
-
84878706261
-
Hypoxia-inducible factor (HIF) network. insights from mathematical models
-
Cavadas MAS, Nguyen LK, Cheong A. Hypoxia-inducible factor (HIF) network. insights from mathematical models. Cell Commun Signal 11. 42, 2013.
-
(2013)
Cell Commun Signal
, vol.11
, pp. 42
-
-
Cavadas, M.A.S.1
Nguyen, L.K.2
Cheong, A.3
-
17
-
-
0344586810
-
Inhibition of CK2 activity by TGF1 promotes I Bprotein stabilization and apoptosis of immortalized hepatocytes
-
Cavin LG, Romieu-Mourez R, Panta GR, Sun JY, Factor VM, Thorgeirsson SS, Sonenshein GE, Arsura M. Inhibition of CK2 activity by TGF1 promotes I Bprotein stabilization and apoptosis of immortalized hepatocytes. Hepatology 38. 1540-1551, 2003.
-
(2003)
Hepatology
, vol.38
, pp. 1540-1551
-
-
Cavin, L.G.1
Romieu-Mourez, R.2
Panta, G.R.3
Sun, J.Y.4
Factor, V.M.5
Thorgeirsson, S.S.6
Sonenshein, G.E.7
Arsura, M.8
-
18
-
-
84902357335
-
Emerging therapeutic interventions for idiopathic pulmonary fibrosis
-
Chakraborty S, Chopra P, Ambi SV, Dastidar SG, Ray A. Emerging therapeutic interventions for idiopathic pulmonary fibrosis. Expert Opin Invest Drugs 23. 893-910, 2014.
-
(2014)
Expert Opin Invest Drugs
, vol.23
, pp. 893-910
-
-
Chakraborty, S.1
Chopra, P.2
Ambi, S.V.3
Dastidar, S.G.4
Ray, A.5
-
19
-
-
0037378954
-
Involve-ment of protein tyrosine kinase in Toll-like receptor 4-mediated NFB activation in human peripheral blood monocytes
-
Chen LY, Zuraw BL, Zhao M, Liu FT, Huang S, Pan ZXK. Involve-ment of protein tyrosine kinase in Toll-like receptor 4-mediated NFB activation in human peripheral blood monocytes. Am J Physiol Lung Cell Mol Physiol 284. L607-L613, 2003.
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.284
, pp. L607-L613
-
-
Chen, L.Y.1
Zuraw, B.L.2
Zhao, M.3
Liu, F.T.4
Huang, S.5
Pan, X.K.6
-
20
-
-
84905460014
-
TGFreceptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling
-
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Faessler R, Zent R, Pozzi A. Integrin-mediated type II TGFreceptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124. 3295-3310, 2014.
-
(2014)
J Clin Invest
, vol.124
, pp. 3295-3310
-
-
Chen, X.1
Wang, H.2
Liao, H.J.3
Hu, W.4
Gewin, L.5
Mernaugh, G.6
Zhang, S.7
Zhang, Z.Y.8
Vega-Montoto, L.9
Vanacore, R.M.10
Faessler, R.11
Zent, R.12
Pozzi, A.13
Integrin-Mediated Type, I.I.14
-
21
-
-
12344291265
-
Impact of the increasing use of immunosuppressants in Crohn’s disease on the need for intestinal surgery
-
Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn’s disease on the need for intestinal surgery. Gut 54. 237-241, 2005.
-
(2005)
Gut
, vol.54
, pp. 237-241
-
-
Cosnes, J.1
Nion-Larmurier, I.2
Beaugerie, L.3
Afchain, P.4
Tiret, E.5
Gendre, J.P.6
-
22
-
-
0037423948
-
Cell-mediated inflammation
-
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, cell-mediated inflammation. Cell 112. 645-657, 2003.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Forster, I.4
Pawlinski, R.5
Mackman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
Firestein, G.S.11
-
23
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates I B kinase-, giving insight into hypoxia-induced NFB activity
-
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, Taylor CT. Prolyl hydroxylase-1 negatively regulates I B kinase-, giving insight into hypoxia-induced NFB activity. Proc Natl Acad Sci USA 103. 18154-18159, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
Ginouves, A.4
Fitzgerald, K.T.5
Seeballuck, F.6
Godson, C.7
Nielsen, J.E.8
Moynagh, P.9
Pouyssegur, J.10
Taylor, C.T.11
-
24
-
-
84875758986
-
Hydroxylases as therapeutic targets in inflammatory bowel disease
-
Cummins EP, Doherty GA, Taylor CT. Hydroxylases as therapeutic targets in inflammatory bowel disease. Lab Invest 93. 378-383, 2013.
-
(2013)
Lab Invest
, vol.93
, pp. 378-383
-
-
Cummins, E.P.1
Doherty, G.A.2
Taylor, C.T.3
-
25
-
-
37349118314
-
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
-
Cummins EP, Seeballuck F, Keely S., Mangan NE, Callanan JJ, Fallon PG, Taylor CT. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134. 156-165, 2008.
-
(2008)
Gastroenterology
, vol.134
, pp. 156-165
-
-
Cummins, E.P.1
Seeballuck, F.2
Keely, S.3
Mangan, N.E.4
Callanan, J.J.5
Fallon, P.G.6
Taylor, C.T.7
-
26
-
-
79952772278
-
Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis
-
Dendooven A, van Oostrom O, van der Giezen DM, Leeuwis JW, Snijckers C, Joles JA, Robertson EJ, Verhaar MC, Nguyen TQ, Goldschmeding R. Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis. Am J Pathol 178. 1069-1079, 2011.
-
(2011)
Am J Pathol
, vol.178
, pp. 1069-1079
-
-
Dendooven, A.1
Van Oostrom, O.2
Van Der Giezen, D.M.3
Leeuwis, J.W.4
Snijckers, C.5
Joles, J.A.6
Robertson, E.J.7
Verhaar, M.C.8
Nguyen, T.Q.9
Goldschmeding, R.10
-
27
-
-
66649106333
-
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures
-
Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NAB, Picariello L, Cazzola P, Monteleone G, Tonelli F, Corazza GR, MacDonald TT, Pender SL. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn’s disease strictures. Gut 58. 777-789, 2009.
-
(2009)
Gut
, vol.58
, pp. 777-789
-
-
Di Sabatino, A.1
Jackson, C.L.2
Pickard, K.M.3
Buckley, M.4
Rovedatti, L.5
Leakey, N.A.B.6
Picariello, L.7
Cazzola, P.8
Monteleone, G.9
Tonelli, F.10
Corazza, G.R.11
Macdonald, T.T.12
Pender, S.L.13
-
28
-
-
77956627158
-
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
-
Dobaczewski M, Bujak M, Li N, Gonzalez-Quesada C, Mendoza LH, Wang XF, Frangogiannis NG. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 107. 418-U176, 2010.
-
(2010)
Circ Res
, vol.107
, pp. 176-418
-
-
Dobaczewski, M.1
Bujak, M.2
Li, N.3
Gonzalez-Quesada, C.4
Mendoza, L.H.5
Wang, X.F.6
Frangogiannis, N.G.7
-
29
-
-
84888998567
-
Slowing progression of chronic kidneydisease
-
Drawz PE, Rosenberg ME. Slowing progression of chronic kidneydisease. Kidney Int Suppl 3. 372-376, 2013.
-
(2013)
Kidney Int Suppl
, vol.3
, pp. 372-376
-
-
Drawz, P.E.1
Rosenberg, M.E.2
-
30
-
-
79952169700
-
Hepatitis B and hepatitis C virus and chronic kidney disease
-
Fabrizi F, Martin P, Messa P. Hepatitis B and hepatitis C virus and chronic kidney disease. Acta Gastroenterol Belg 73. 465-471, 2010.
-
(2010)
Acta Gastroenterol Belg
, vol.73
, pp. 465-471
-
-
Fabrizi, F.1
Martin, P.2
Messa, P.3
-
31
-
-
0034961050
-
Roles of Akt/PKB and IKK complex in constitutive induction of NFB in hepatocellular carcinomas of transforming growth factor /c-myc transgenic mice
-
Factor V, Oliver AL, Panta GR, Thorgeirsson SS, Sonenshein GE, Arsura M. Roles of Akt/PKB and IKK complex in constitutive induction of NFB in hepatocellular carcinomas of transforming growth factor /c-myc transgenic mice. Hepatology 34. 32-41, 2001.
-
(2001)
Hepatology
, vol.34
, pp. 32-41
-
-
Factor, V.1
Oliver, A.L.2
Panta, G.R.3
Thorgeirsson, S.S.4
Sonenshein, G.E.5
Arsura, M.6
-
32
-
-
84878641501
-
Ding X.miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIFactivation
-
Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M, Ding X.miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIFactivation. Am J Physiol Renal Physiol 304. F1274-F1282, 2013.
-
(2013)
Am J Physiol Renal Physiol
, vol.304
, pp. F1274-F1282
-
-
Fang, Y.1
Yu, X.2
Liu, Y.3
Kriegel, A.J.4
Heng, Y.5
Xu, X.6
Liang, M.7
-
33
-
-
2542505844
-
Scar-free healing. from embryonic mechanisms to adult therapeutic intervention
-
Ferguson MWJ, O’Kane S. Scar-free healing. from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc London Ser B-Biol Sci 359. 839-850, 2004.
-
(2004)
Philos Trans R Soc London Ser B-Biol Sci
, vol.359
, pp. 839-850
-
-
Ferguson, M.W.J.1
O’kane, S.2
-
34
-
-
0032762407
-
Antiinflammatory actions of lipoxin A4 stable analogs are demonstrable in human whole blood. Modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions
-
Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN. Antiinflammatory actions of lipoxin A4 stable analogs are demonstrable in human whole blood. Modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood 94. 4132-4142, 1999.
-
(1999)
Blood
, vol.94
, pp. 4132-4142
-
-
Filep, J.G.1
Zouki, C.2
Petasis, N.A.3
Hachicha, M.4
Serhan, C.N.5
-
36
-
-
79251549807
-
Pathway is required for inflammatory gene expression in response to hypoxia
-
Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O’Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT. An intact canonical NFB pathway is required for inflammatory gene expression in response to hypoxia. J Immunol 186. 1091-1096, 2011.
-
(2011)
J Immunol
, vol.186
, pp. 1091-1096
-
-
Fitzpatrick, S.F.1
Tambuwala, M.M.2
Bruning, U.3
Schaible, B.4
Scholz, C.C.5
Byrne, A.6
O’connor, A.7
Gallagher, W.M.8
Lenihan, C.R.9
Garvey, J.F.10
Howell, K.11
Fallon, P.G.12
Cummins, E.P.13
Taylor, C.T.14
An Intact Canonical, N.F.B.15
-
37
-
-
0036124599
-
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
-
Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Deng CX, Russo A, Mitchell JB, Roberts AB. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 160. 1057-1068, 2002.
-
(2002)
Am J Pathol
, vol.160
, pp. 1057-1068
-
-
Flanders, K.C.1
Sullivan, C.D.2
Fujii, M.3
Sowers, A.4
Anzano, M.A.5
Arabshahi, A.6
Major, C.7
Deng, C.X.8
Russo, A.9
Mitchell, J.B.10
Roberts, A.B.11
-
38
-
-
59649112848
-
Regulation of angiogenesis by oxygen and metabolism
-
Fraisl P, Mazzone M, Schmidt T, Carmeliet P. Regulation of angiogenesis by oxygen and metabolism. Dev Cell 16. 167-179, 2009.
-
(2009)
Dev Cell
, vol.16
, pp. 167-179
-
-
Fraisl, P.1
Mazzone, M.2
Schmidt, T.3
Carmeliet, P.4
-
39
-
-
33745003285
-
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NFB
-
Frede S, Stockmann C, Freitag P, Fandrey J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NFB. Biochem J 396. 517-527, 2006.
-
(2006)
Biochem J
, vol.396
, pp. 517-527
-
-
Frede, S.1
Stockmann, C.2
Freitag, P.3
Fandrey, J.4
-
40
-
-
84884211557
-
Signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers
-
Freudlsperger C, Bian Y, Wise SC, Burnett J, Coupar J, Yang X, Chen Z, Van Waes C. TGFand NFB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene 32. 1549-1559, 2013.
-
(2013)
Oncogene
, vol.32
, pp. 1549-1559
-
-
Freudlsperger, C.1
Bian, Y.2
Wise, S.C.3
Burnett, J.4
Coupar, J.5
Yang, X.6
Chen, Z.7
Van Waes, C.8
Tgfand, N.F.B.9
-
41
-
-
50049098006
-
TGFcoordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
-
Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, Oursler MJ. TGFcoordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Exp Cell Res 314. 2725-2738, 2008.
-
(2008)
Exp Cell Res
, vol.314
, pp. 2725-2738
-
-
Gingery, A.1
Bradley, E.W.2
Pederson, L.3
Ruan, M.4
Horwood, N.J.5
Oursler, M.J.6
-
42
-
-
84885976399
-
Hypoxia and integrin-mediated epithelial restitution during mucosal inflammation
-
Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S. Hypoxia and integrin-mediated epithelial restitution during mucosal inflammation. Front Immunol 4. 272-272, 2013.
-
(2013)
Front Immunol
, vol.4
, pp. 272
-
-
Goggins, B.J.1
Chaney, C.2
Radford-Smith, G.L.3
Horvat, J.C.4
Keely, S.5
-
43
-
-
67650973314
-
Increased shortand long-term risk of inflammatory bowel disease after Salmonella or Campylobacter gastroenteritis
-
Gradel KO, Nielsen H., Schonheyder HC, Ejlertsen T, Kristensen B, Nielsen H. Increased shortand long-term risk of inflammatory bowel disease after Salmonella or Campylobacter gastroenteritis. Gastroenterology 137. 495-501, 2009.
-
(2009)
Gastroenterology
, vol.137
, pp. 495-501
-
-
Gradel, K.O.1
Nielsen, H.2
Schonheyder, H.C.3
Ejlertsen, T.4
Kristensen, B.5
Nielsen, H.6
-
44
-
-
0031791075
-
The role of apoptosis in wound healing
-
Greenhalgh DG. The role of apoptosis in wound healing. Int J Biochem Cell Biol 30. 1019-1030, 1998.
-
(1998)
Int J Biochem Cell Biol
, vol.30
, pp. 1019-1030
-
-
Greenhalgh, D.G.1
-
45
-
-
33847210725
-
Effect ofTGF/Smad signaling pathway on lung myofibroblast differentiation
-
Gu L, Zhu YJ Yang X, Guo ZJ, Xu WB, Tian XL. Effect ofTGF/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin 28. 382-391, 2007.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 382-391
-
-
Gu, L.1
Zhu Yj Yang, X.2
Guo, Z.J.3
Xu, W.B.4
Tian, X.L.5
-
46
-
-
77749260633
-
Factors affecting wound healing
-
Guo S, DiPietro LA. Factors affecting wound healing. J Dental Res 89. 219-229, 2010.
-
(2010)
J Dental Res
, vol.89
, pp. 219-229
-
-
Guo, S.1
Dipietro, L.A.2
-
47
-
-
43749088730
-
Wound repair and regeneration
-
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 453. 314-321, 2008.
-
(2008)
Nature
, vol.453
, pp. 314-321
-
-
Gurtner, G.C.1
Werner, S.2
Barrandon, Y.3
Longaker, M.T.4
-
48
-
-
80051988912
-
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
-
Hams E, Saunders SP, Cummins EP, O’Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock 36. 295-302, 2011.
-
(2011)
Shock
, vol.36
, pp. 295-302
-
-
Hams, E.1
Saunders, S.P.2
Cummins, E.P.3
O’connor, A.4
Tambuwala, M.T.5
Gallagher, W.M.6
Byrne, A.7
Campos-Torres, A.8
Moynagh, P.M.9
Jobin, C.10
Taylor, C.T.11
Fallon, P.G.12
-
49
-
-
0033104679
-
Elevation of expression of Smads 2, 3, and 4, decorin and TGFin the chronic phase of myocardial infarct scar healing
-
Hao JM, Ju HS, Zhao SF, Junaid A, Fleur TSL, Dixon IMC. Elevation of expression of Smads 2, 3, and 4, decorin and TGFin the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol 31. 667-678, 1999.
-
(1999)
J Mol Cell Cardiol
, vol.31
, pp. 667-678
-
-
Hao, J.M.1
Ju, H.S.2
Zhao, S.F.3
Junaid, A.4
Fleur, T.S.L.5
Dixon, M.C.6
-
50
-
-
36849021771
-
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
-
Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117. 3810-3820, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 3810-3820
-
-
Higgins, D.F.1
Kimura, K.2
Bernhardt, W.M.3
Shrimanker, N.4
Akai, Y.5
Hohenstein, B.6
Saito, Y.7
Johnson, R.S.8
Kretzler, M.9
Cohen, C.D.10
Eckardt, K.U.11
Iwano, M.12
Haase, V.H.13
-
51
-
-
84890961378
-
New therapies for diabetic kidney disease
-
Himmelfarb J, Tuttle KR. New therapies for diabetic kidney disease. N Engl J Med 369. 2549-2550, 2013.
-
(2013)
N Engl J Med
, vol.369
, pp. 2549-2550
-
-
Himmelfarb, J.1
Tuttle, K.R.2
-
52
-
-
78650654512
-
Hydroxylase inhibition abrogates TNF-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
-
Hindryckx P, De Vos M, Jacques P, Ferdinande L, Peeters H, Olievier K, Bogaert S, Brinkman B, Vandenabeele P, Elewaut D, Laukens D. Hydroxylase inhibition abrogates TNF-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J Immunol 185. 6306-6316, 2010.
-
(2010)
J Immunol
, vol.185
, pp. 6306-6316
-
-
Hindryckx, P.1
De Vos, M.2
Jacques, P.3
Ferdinande, L.4
Peeters, H.5
Olievier, K.6
Bogaert, S.7
Brinkman, B.8
Vandenabeele, P.9
Elewaut, D.10
Laukens, D.11
-
53
-
-
84880869807
-
The complexity of NFB signaling in inflammation and cancer
-
Hoesel B, Schmid JA. The complexity of NFB signaling in inflammation and cancer. Mol Cancer 12. 86, 2013.
-
(2013)
Mol Cancer
, vol.12
, pp. 86
-
-
Hoesel, B.1
Schmid, J.A.2
-
54
-
-
0023025366
-
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
-
Ignotz RA, Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261. 4337-4345, 1986.
-
(1986)
J Biol Chem
, vol.261
, pp. 4337-4345
-
-
Ignotz, R.A.1
Massague, J.2
-
55
-
-
81455128726
-
Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model
-
Inoue K, Naito Y, Takagi T, Hayashi N, Hirai Y, Mizushima K, Horie R, Fukumoto K, Yamada S, Harusato A, Hirata I, Omatsu T, Yoshida N, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Ichikawa H, Kokura S, Yoshikawa T. Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model. Biol Pharm Bull 34. 1659-1665, 2011.
-
(2011)
Biol Pharm Bull
, vol.34
, pp. 1659-1665
-
-
Inoue, K.1
Naito, Y.2
Takagi, T.3
Hayashi, N.4
Hirai, Y.5
Mizushima, K.6
Horie, R.7
Fukumoto, K.8
Yamada, S.9
Harusato, A.10
Hirata, I.11
Omatsu, T.12
Yoshida, N.13
Uchiyama, K.14
Ishikawa, T.15
Handa, O.16
Konishi, H.17
Wakabayashi, N.18
Yagi, N.19
Ichikawa, H.20
Kokura, S.21
Yoshikawa, T.22
more..
-
56
-
-
84902172100
-
Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury
-
Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest 124. 2396-2409, 2014.
-
(2014)
J Clin Invest
, vol.124
, pp. 2396-2409
-
-
Kapitsinou, P.P.1
Sano, H.2
Michael, M.3
Kobayashi, H.4
Davidoff, O.5
Bian, A.6
Yao, B.7
Zhang, M.Z.8
Harris, R.C.9
Duffy, K.J.10
Erickson-Miller, C.L.11
Sutton, T.A.12
Haase, V.H.13
-
57
-
-
84901759236
-
ASCEND Study Group. A Phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
-
King TE Jr, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L, Lederer DJ, Nathan SD, Pereira CA, Sahn SA, Sussman R, Swigris JJ, Noble PW, ASCEND Study Group. A Phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med 370. 2083-2092, 2014.
-
(2014)
N Engl J Med
, vol.370
, pp. 2083-2092
-
-
King, T.E.1
Bradford, W.Z.2
Castro-Bernardini, S.3
Fagan, E.A.4
Glaspole, I.5
Glassberg, M.K.6
Gorina, E.7
Hopkins, P.M.8
Kardatzke, D.9
Lancaster, L.10
Lederer, D.J.11
Nathan, S.D.12
Pereira, C.A.13
Sahn, S.A.14
Sussman, R.15
Swigris, J.J.16
Noble, P.W.17
-
58
-
-
0031911356
-
SMADs. mediators and regulators of TGFsignaling
-
Kretzschmar M, Massague J. SMADs. mediators and regulators of TGFsignaling. Curr Opin Genet Dev 8. 103-111, 1998.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 103-111
-
-
Kretzschmar, M.1
Massague, J.2
-
59
-
-
80052754775
-
Diverse roles of TGF/Smads in renal fibrosis and inflamma-tion
-
Lan HY. Diverse roles of TGF/Smads in renal fibrosis and inflamma-tion. Int J Biol Sci 7. 1056-1067, 2011.
-
(2011)
Int J Biol Sci
, vol.7
, pp. 1056-1067
-
-
Lan, H.Y.1
-
60
-
-
0036779617
-
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
-
Lawrence T, Willoughby DA, Gilroy DW. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol 2. 787-795, 2002.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 787-795
-
-
Lawrence, T.1
Willoughby, D.A.2
Gilroy, D.W.3
-
61
-
-
40949132841
-
Turn me on. regulating HIF transcriptional activity
-
Lisy K, Peet DJ. Turn me on. regulating HIF transcriptional activity. Cell Death Differ 15. 642-649, 2008.
-
(2008)
Cell Death Differ
, vol.15
, pp. 642-649
-
-
Lisy, K.1
Peet, D.J.2
-
62
-
-
84895537045
-
The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis
-
Liu T, Yu H, Ullenbruch M, Jin H, Ito T, Wu Z, Liu J, Phan SH. The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis. Plos One 9. e88362, 2014.
-
(2014)
Plos One
, pp. 9
-
-
Liu, T.1
Yu, H.2
Ullenbruch, M.3
Jin, H.4
Ito, T.5
Wu, Z.6
Liu, J.7
Phan, S.H.8
-
63
-
-
84871595397
-
The evolving pharmacotherapy of pulmonary fibrosis
-
Lota HK, Wells AU. The evolving pharmacotherapy of pulmonary fibrosis. Expert Opin Pharmacother 14. 79-89, 2013.
-
(2013)
Expert Opin Pharmacother
, vol.14
, pp. 79-89
-
-
Lota, H.K.1
Wells, A.U.2
-
64
-
-
70350127334
-
Lipoxins. resolutionary road
-
Maderna P, Godson C. Lipoxins. resolutionary road. Br J Pharmacol 158. 947-959, 2009.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 947-959
-
-
Maderna, P.1
Godson, C.2
-
65
-
-
33746103683
-
The transforming growth factor (TGF) family and pulmonary fibrosis
-
Martin GEM, Ask K, Gilpin SE, Kolb M, Gauldie J. The transforming growth factor (TGF) family and pulmonary fibrosis. Drug Discov Today 3. 99-103, 2006.
-
(2006)
Drug Discov Today
, vol.3
, pp. 99-103
-
-
Martin, G.E.M.1
Ask, K.2
Gilpin, S.E.3
Kolb, M.4
Gauldie, J.5
-
66
-
-
66949129763
-
ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis
-
Martins V, Valença SS, Farias-Filho FA, Molinaro R, Simões RL, Ferreira TP, e Silva PM, Hogaboam CM, Kunkel SL, Fierro IM, Canetti C, Benjamim CF. ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis. J Immunol 182. 5374-5381, 2009.
-
(2009)
J Immunol
, vol.182
, pp. 5374-5381
-
-
Martins, V.1
Valença, S.S.2
Farias-Filho, F.A.3
Molinaro, R.4
Simões, R.L.5
Ferreira, T.P.6
E Silva, P.M.7
Hogaboam, C.M.8
Kunkel, S.L.9
Fierro, I.M.10
Canetti, C.11
Benjamim, C.F.12
-
69
-
-
0029794356
-
Mesenchymal cell activation is the ratelimiting step of granulation tissue induction
-
McClain SA, Simon M, Jones E, Nandi A, Gailit JO, Tonnesen MG, Newman D, Clark RAF. Mesenchymal cell activation is the ratelimiting step of granulation tissue induction. Am J Pathol 149. 1257-1270, 1996.
-
(1996)
Am J Pathol
, vol.149
, pp. 1257-1270
-
-
McClain, S.A.1
Simon, M.2
Jones, E.3
Nandi, A.4
Gailit, J.O.5
Tonnesen, M.G.6
Newman, D.7
Clark, A.F.8
-
70
-
-
0345237913
-
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
-
McKaig BC, McWilliams D, Watson SA, Mahida YR. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 162. 1355-1360, 2003.
-
(2003)
Am J Pathol
, vol.162
, pp. 1355-1360
-
-
McKaig, B.C.1
McWilliams, D.2
Watson, S.A.3
Mahida, Y.R.4
-
71
-
-
79959993387
-
Transforming growth factortype 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis
-
Medina C, Santos-Martinez MJ, Santana A, Cristina Paz-Cabrera M, Johnston MJ, Mourelle M, Salas A, andGuarner F. Transforming growth factortype 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis. J Pathol 224. 461-472, 2011.
-
(2011)
J Pathol
, vol.224
, pp. 461-472
-
-
Medina, C.1
Santos-Martinez, M.J.2
Santana, A.3
Cristina Paz-Cabrera, M.4
Johnston, M.J.5
Mourelle, M.6
Salas, A.7
Andguarner, F.8
-
73
-
-
2542450917
-
HIF hydroxylation and cellular oxygen sensing
-
Metzen E, Ratcliffe PJ. HIF hydroxylation and cellular oxygen sensing. Biol Chem 385. 223-230, 2004.
-
(2004)
Biol Chem
, vol.385
, pp. 223-230
-
-
Metzen, E.1
Ratcliffe, P.J.2
-
74
-
-
84885318238
-
Van Ypersele de Strihou C. Diabetic nephropathy. are there new and potentially promising therapies targeting oxygen biology
-
Miyata T, Suzuki N, van Ypersele de Strihou C. Diabetic nephropathy. are there new and potentially promising therapies targeting oxygen biology? Kidney Int 84. 693-702, 2013.
-
(2013)
Kidney Int
, vol.84
, pp. 693-702
-
-
Miyata, T.1
Suzuki, N.2
-
75
-
-
84883341999
-
The role of infection in the pathogenesis of idiopathic pulmonary fibrosis
-
Molyneaux PL, Maher TM. The role of infection in the pathogenesis of idiopathic pulmonary fibrosis. Eur Respir Rev 22. 376-381, 2013.
-
(2013)
Eur Respir Rev
, vol.22
, pp. 376-381
-
-
Molyneaux, P.L.1
Maher, T.M.2
-
76
-
-
65349175992
-
Reduced liver fibrosis in hypoxia-inducible factor-1-deficient mice
-
Moon JO, Welch TP, Gonzalez FJ, Copple BL. Reduced liver fibrosis in hypoxia-inducible factor-1-deficient mice. Am J Physiol Gastrointest Liver Physiol 296. G582-G592, 2009.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
, pp. G582-G592
-
-
Moon, J.O.1
Welch, T.P.2
Gonzalez, F.J.3
Copple, B.L.4
-
77
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8. 958-969, 2008.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
-
79
-
-
27744603002
-
Hypoxia regulates macrophage functions in inflammation
-
Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 175. 6257-6263, 2005.
-
(2005)
J Immunol
, vol.175
, pp. 6257-6263
-
-
Murdoch, C.1
Muthana, M.2
Lewis, C.E.3
-
80
-
-
0034123135
-
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes. Selective expression of TLR3 in dendritic cells
-
Muzio M, Bosisio D, Polentarutti N, D’Amico G, Stoppacciaro A, Mancinelli R, van’t Veer C, Penton-Rol G, Ruco LP, Allavena P, Mantovani A. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes. Selective expression of TLR3 in dendritic cells. J Immunol 164. 5998-6004, 2000.
-
(2000)
J Immunol
, vol.164
, pp. 5998-6004
-
-
Muzio, M.1
Bosisio, D.2
Polentarutti, N.3
D’amico, G.4
Stoppacciaro, A.5
Mancinelli, R.6
Van’T Veer, C.7
Penton-Rol, G.8
Ruco, L.P.9
Allavena, P.10
Mantovani, A.11
-
81
-
-
50649120554
-
Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets
-
Myllyharju J. Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med 40. 402-417, 2008.
-
(2008)
Ann Med
, vol.40
, pp. 402-417
-
-
Myllyharju, J.1
-
82
-
-
0037452081
-
Immunology— oxygen and the inflammatory cell
-
Nathan C. Immunology— oxygen and the inflammatory cell. Nature 422. 675-676, 2003.
-
(2003)
Nature
, vol.422
, pp. 675-676
-
-
Nathan, C.1
-
83
-
-
84877917354
-
A dynamic model of the hypoxia-inducible factor 1 (HIF-1) network
-
Nguyen LK, Cavadas MAS, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A. A dynamic model of the hypoxia-inducible factor 1 (HIF-1) network. J Cell Sci 126. 1454-1463, 2013.
-
(2013)
J Cell Sci
, vol.126
, pp. 1454-1463
-
-
Nguyen, L.K.1
Cavadas, M.A.S.2
Scholz, C.C.3
Fitzpatrick, S.F.4
Bruning, U.5
Cummins, E.P.6
Tambuwala, M.M.7
Manresa, M.C.8
Kholodenko, B.N.9
Taylor, C.T.10
Cheong, A.11
-
84
-
-
84903411670
-
Inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90 cardiac myofibroblast activation
-
Nural-Guvener HF, Zakharova L, Nimlos J, Popovic S, Mastroeni D, Gaballa MA. HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90 cardiac myofibroblast activation. Fibrogenesis Tissue Rep 7. 10-10, 2014.
-
(2014)
Fibrogenesis Tissue Rep
, vol.7
, pp. 10
-
-
Nural-Guvener, H.F.1
Zakharova, L.2
Nimlos, J.3
Popovic, S.4
Mastroeni, D.5
Gaballa, M.A.6
Class, I.7
-
85
-
-
79961016308
-
Platelets inflammation and tissue regeneration
-
Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 105. S13-S33, 2011.
-
(2011)
Thromb Haemost
, vol.105
, pp. S13-S33
-
-
Nurden, A.T.1
-
86
-
-
42649128355
-
Platelets and wound healing
-
Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci 13, 2008.
-
(2008)
Front Biosci
, pp. 13
-
-
Nurden, A.T.1
Nurden, P.2
Sanchez, M.3
Andia, I.4
Anitua, E.5
-
87
-
-
34347252262
-
Inflammation and wound healing
-
Oberyszyn TM. Inflammation and wound healing. Front Biosci 12. 2993-2999, 2007.
-
(2007)
Front Biosci
, vol.12
, pp. 2993-2999
-
-
Oberyszyn, T.M.1
-
88
-
-
69249220253
-
Hypoxia regulation of NFB signalling during inflammation. the role of hydroxylases
-
Oliver KM, Taylor CT, Cummins EP. Hypoxia regulation of NFB signalling during inflammation. the role of hydroxylases. Arthritis Res Ther 11. 215, 2009.
-
(2009)
Arthritis Res Ther
, vol.11
, pp. 215
-
-
Oliver, K.M.1
Taylor, C.T.2
Cummins, E.P.3
-
89
-
-
84899660163
-
Critical role of transforming growth factor beta in different phases of wound healing
-
Pakyari M, Farrokhi A, Maharlooei M, Ghahary A. Critical role of transforming growth factor beta in different phases of wound healing. Adv Wound Care 2. 215-224, 2013.
-
(2013)
Adv Wound Care
, vol.2
, pp. 215-224
-
-
Pakyari, M.1
Farrokhi, A.2
Maharlooei, M.3
Ghahary, A.4
-
90
-
-
34249845879
-
Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
-
Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M. Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem 282. 10405–10413, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 10405-10413
-
-
Pannu, J.1
Nakerakanti, S.2
Smith, E.3
Ten Dijke, P.4
Trojanowska, M.5
-
91
-
-
3543098600
-
Liver fibrosis. from the bench to clinical targets
-
Pinzani M, Rombouts K. Liver fibrosis. from the bench to clinical targets. Dig Liver Dis 36. 231–242, 2004.
-
(2004)
Dig Liver Dis
, vol.36
, pp. 231-242
-
-
Pinzani, M.1
Rombouts, K.2
-
92
-
-
80051480268
-
Treatment of inflammatory bowel disease (IBD)
-
Pithadia AB, Jain S. Treatment of inflammatory bowel disease (IBD). Pharmacol Rep 63. 629–642, 2011.
-
(2011)
Pharmacol Rep
, vol.63
, pp. 629-642
-
-
Pithadia, A.B.1
Jain, S.2
-
93
-
-
0027939832
-
The role of extracellular matrix in postinflammatory wound healing and fibrosis
-
Raghow R. The role of extracellular matrix in postinflammatory wound healing and fibrosis. FASEB J 8. 823–831, 1994.
-
(1994)
FASEB J
, vol.8
, pp. 823-831
-
-
Raghow, R.1
-
94
-
-
84901810710
-
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
-
Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR, Investigators IT. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 370. 2071–2082, 2014.
-
(2014)
N Engl J Med
, vol.370
, pp. 2071-2082
-
-
Richeldi, L.1
Du Bois, R.M.2
Raghu, G.3
Azuma, A.4
Brown, K.K.5
Costabel, U.6
Cottin, V.7
Flaherty, K.R.8
Hansell, D.M.9
Inoue, Y.10
Kim, D.S.11
Kolb, M.12
Nicholson, A.G.13
Noble, P.W.14
Selman, M.15
Taniguchi, H.16
Brun, M.17
Le Maulf, F.18
Girard, M.19
Stowasser, S.20
Schlenker-Herceg, R.21
Disse, B.22
Collard, H.R.23
Investigators, I.T.24
more..
-
95
-
-
33846001022
-
Healing and fibrosis in intestinal disease
-
Rieder F, Brenmoehl J, Leeb S, Schoelmerich J, Rogler G. Healing and fibrosis in intestinal disease. Gut 56. 130–139, 2007.
-
(2007)
Gut
, vol.56
, pp. 130-139
-
-
Rieder, F.1
Brenmoehl, J.2
Leeb, S.3
Schoelmerich, J.4
Rogler, G.5
-
96
-
-
37349048502
-
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
-
Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134. 145–155, 2008.
-
(2008)
Gastroenterology
, vol.134
, pp. 145-155
-
-
Robinson, A.1
Keely, S.2
Karhausen, J.3
Gerich, M.E.4
Furuta, G.T.5
Colgan, S.P.6
-
98
-
-
84919457239
-
Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1
-
Ruthenborg RJ, Ban JJ, Wazir A, Takeda1 N, Kim JW. Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1. Mol Cells 37. 637–643, 2014.
-
(2014)
Mol Cells
, vol.37
, pp. 637-643
-
-
Ruthenborg, R.J.1
Ban, J.J.2
Wazir, A.3
Takeda1, N.4
Kim, J.W.5
-
99
-
-
84868305344
-
Signaling in tissue fibrosis. Redox controls, target genes and therapeutic opportunities
-
Samarakoon R, Overstreet JM, Higgins PJ. TGF- signaling in tissue fibrosis. Redox controls, target genes and therapeutic opportunities. Cell Signal 25. 264–268, 2013.
-
(2013)
Cell Signal
, vol.25
, pp. 264-268
-
-
Samarakoon, R.1
Overstreet, J.M.2
Higgins, P.J.3
-
100
-
-
55249091834
-
Current directions in IBD therapy. what goals are feasible with biological modifiers?
-
Sandborn WJ. Current directions in IBD therapy. what goals are feasible with biological modifiers? Gastroenterology 135. 1442–1447, 2008.
-
(2008)
Gastroenterology
, vol.135
, pp. 1442-1447
-
-
Sandborn, W.J.1
-
101
-
-
84887501809
-
Regulation of IL-1β-induced NF-kappa B by hydroxylases links key hypoxic and inflammatory signaling pathways
-
Scholz CC, Cavadas MAS, Tambuwala MM, Hams E, Rodriguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT. Regulation of IL-1β-induced NF-kappa B by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci USA 110. 18, 490-18, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.18
, pp. 490-518
-
-
Scholz, C.C.1
Cavadas, M.A.S.2
Tambuwala, M.M.3
Hams, E.4
Rodriguez, J.5
Von Kriegsheim, A.6
Cotter, P.7
Bruning, U.8
Fallon, P.G.9
Cheong, A.10
Cummins, E.P.11
Taylor, C.T.12
-
102
-
-
84885950065
-
Targeting the HIF pathway in inflammation and immunity
-
Scholz CC, Taylor CT. Targeting the HIF pathway in inflammation and immunity. Curr Opin Pharmacol 13. 646–653, 2013.
-
(2013)
Curr Opin Pharmacol
, vol.13
, pp. 646-653
-
-
Scholz, C.C.1
Taylor, C.T.2
-
103
-
-
77954881513
-
Oxygen in acute and chronic wound healing
-
Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. Br J Dermatol 163. 257–268, 2010.
-
(2010)
Br J Dermatol
, vol.163
, pp. 257-268
-
-
Schreml, S.1
Szeimies, R.M.2
Prantl, L.3
Karrer, S.4
Landthaler, M.5
Babilas, P.6
-
104
-
-
0035895243
-
Idiopathic pulmonary fibrosis. Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
-
Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis. Prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134. 136–151, 2001.
-
(2001)
Ann Intern Med
, vol.134
, pp. 136-151
-
-
Selman, M.1
King, T.E.2
Pardo, A.3
-
105
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12. 5447-5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
107
-
-
79957670746
-
Pirfenidone for diabetic nephropathy
-
Sharma K, Ix JH, Mathew AV, Cho M, Pflueger A, Dunn SR, Francos B, Sharma S, Falkner B, McGowan TA, Donohue M, RamachandraRao S, Xu R, Fervenza FC, Kopp JB. Pirfenidone for diabetic nephropathy. J Am Soc Nephrol 22. 1144–1151, 2011.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1144-1151
-
-
Sharma, K.1
Ix, J.H.2
Mathew, A.V.3
Cho, M.4
Pflueger, A.5
Dunn, S.R.6
Francos, B.7
Sharma, S.8
Falkner, B.9
McGowan, T.A.10
Donohue, M.11
Ramachandrarao, S.12
Xu, R.13
Fervenza, F.C.14
Kopp, J.B.15
-
108
-
-
58249109358
-
Requirement of transforming growth factor β-activated kinase 1 for transforming growth factor β-induced α-smooth muscle actin expression and extracellular matrix contraction in fibroblasts
-
Shi-wen X, Parapuram SK, Pala D, Chen Y, Carter DE, Eastwood M, Denton CP, Abraham DJ, Leask A. Requirement of transforming growth factor β-activated kinase 1 for transforming growth factor β-induced α-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum 60. 234–241, 2009.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 234-241
-
-
Shi-Wen, X.1
Parapuram, S.K.2
Pala, D.3
Chen, Y.4
Carter, D.E.5
Eastwood, M.6
Denton, C.P.7
Abraham, D.J.8
Leask, A.9
-
109
-
-
56349108016
-
Inhibition of the renin-angiotensin system and chronic kidney disease
-
Siamopoulos KC, Kalaitzidis RG. Inhibition of the renin-angiotensin system and chronic kidney disease. Int Urol Nephrol 40. 1015–1025, 2008.
-
(2008)
Int Urol Nephrol
, vol.40
, pp. 1015-1025
-
-
Siamopoulos, K.C.1
Kalaitzidis, R.G.2
-
110
-
-
0036721057
-
IGF-I and TGFβ1 have distinct effects on phenotype and proliferation of intestinal fibroblasts
-
Simmons JG, Pucilowska JB, Keku TO, Lund PK. IGF-I and TGFβ1 have distinct effects on phenotype and proliferation of intestinal fibroblasts. Am J Physiol Gastrointest Liver Physiol 283. G809–G818, 2002.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.283
, pp. G809-G818
-
-
Simmons, J.G.1
Pucilowska, J.B.2
Keku, T.O.3
Lund, P.K.4
-
111
-
-
72949106456
-
Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney
-
Song YR, You SJ, Lee YM, Chin HJ, Chae DW, Oh YK, Joo KW, Han JS, Na KY. Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney. Nephrol Dial Transpl 25. 77–85, 2010.
-
(2010)
Nephrol Dial Transpl
, vol.25
, pp. 77-85
-
-
Song, Y.R.1
You, S.J.2
Lee, Y.M.3
Chin, H.J.4
Chae, D.W.5
Oh, Y.K.6
Joo, K.W.7
Han, J.S.8
Na, K.Y.9
-
112
-
-
84880305212
-
Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Reply
-
Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Reply. Nat Med 19. 810–811, 2013.
-
(2013)
Nat Med
, vol.19
, pp. 810-811
-
-
Sugimoto, H.1
Lebleu, V.S.2
Bosukonda, D.3
Keck, P.4
Taduri, G.5
Bechtel, W.6
Okada, H.7
Carlson, W.8
Bey, P.9
Rusckowski, M.10
Tampe, B.11
Tampe, D.12
Kanasaki, K.13
Zeisberg, M.14
Kalluri, R.15
-
113
-
-
84858008133
-
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
-
Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, CarlsonWJr, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 18. 396-U264, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 264-396
-
-
Sugimoto, H.1
Lebleu, V.S.2
Bosukonda, D.3
Keck, P.4
Taduri, G.5
Bechtel, W.6
Okada, H.7
Carlsonwjr, B.P.8
Rusckowski, M.9
Tampe, B.10
Tampe, D.11
Kanasaki, K.12
Zeisberg, M.13
Kalluri, R.14
-
114
-
-
79952780231
-
Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium
-
Suzuki K, Sun X, Nagata M, Kawase T, Yamaguchi H, Sukumaran V, Kawauchi Y, Kawachi H, Nishino T, Watanabe K, Yoneyama H, Asakura H. Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium. Pathol Int 61. 228–238, 2011.
-
(2011)
Pathol Int
, vol.61
, pp. 228-238
-
-
Suzuki, K.1
Sun, X.2
Nagata, M.3
Kawase, T.4
Yamaguchi, H.5
Sukumaran, V.6
Kawauchi, Y.7
Kawachi, H.8
Nishino, T.9
Watanabe, K.10
Yoneyama, H.11
Asakura, H.12
-
115
-
-
78649705245
-
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
-
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology 139:2093–2101, 2010.
-
(2010)
Gastroenterology
, vol.139
, pp. 2093-2101
-
-
Tambuwala, M.M.1
Cummins, E.P.2
Lenihan, C.R.3
Kiss, J.4
Stauch, M.5
Scholz, C.C.6
Fraisl, P.7
Lasitschka, F.8
Mollenhauer, M.9
Saunders, S.P.10
Maxwell, P.H.11
Carmeliet, P.12
Fallon, P.G.13
Schneider, M.14
Taylor, C.T.15
-
116
-
-
1642269211
-
Oxygen in wound healing—more than a nutrient
-
Tandara AA, Mustoe TA. Oxygen in wound healing—more than a nutrient. World J Surg 28. 294–300, 2004.
-
(2004)
World J Surg
, vol.28
, pp. 294-300
-
-
Tandara, A.A.1
Mustoe, T.A.2
-
117
-
-
38149059911
-
Mitochondria and cellular oxygen sensing in the HIF pathway
-
Taylor CT. Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem J 409. 19–26, 2008.
-
(2008)
Biochem J
, vol.409
, pp. 19-26
-
-
Taylor, C.T.1
-
118
-
-
36849055112
-
Hypoxia and gastrointestinal disease
-
Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med 85. 1295–1300, 2007.
-
(2007)
J Mol Med
, vol.85
, pp. 1295-1300
-
-
Taylor, C.T.1
Colgan, S.P.2
-
119
-
-
70350373671
-
The role of NF- [1] B in hypoxia-induced gene expression. Hypoxia and consequences from molecule to malady
-
Taylor CT, Cummins EP. The role of NF-[1]B in hypoxia-induced gene expression. Hypoxia and consequences from molecule to malady. Ann NY Acad Sci 1177. 178–184, 2009.
-
(2009)
Ann NY Acad Sci
, vol.1177
, pp. 178-184
-
-
Taylor, C.T.1
Cummins, E.P.2
-
120
-
-
27744461703
-
Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2
-
Theiss AL, Simmons JG, Jobin C, Lund PK. Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 280. 36,36-96, 2005.
-
(2005)
J Biol Chem
, vol.280
, Issue.36
, pp. 36-96
-
-
Theiss, A.L.1
Simmons, J.G.2
Jobin, C.3
Lund, P.K.4
-
121
-
-
18744413253
-
Aetiology of inflammatory bowel disease (IBD). Role of intestinal microbiota and gut-associated lymphoid tissue immune response
-
Thompson-Chagoyan OC, Maldonado J, Gil A. Aetiology of inflammatory bowel disease (IBD). Role of intestinal microbiota and gut-associated lymphoid tissue immune response. Clin Nutr 24. 339–352, 2005.
-
(2005)
Clin Nutr
, vol.24
, pp. 339-352
-
-
Thompson-Chagoyan, O.C.1
Maldonado, J.2
Gil, A.3
-
122
-
-
70349808182
-
Noncanonical transforming growth factor beta signaling in scleroderma fibrosis
-
Trojanowska M. Noncanonical transforming growth factor beta signaling in scleroderma fibrosis. Curr Opin Rheumatol 21. 623–629, 2009.
-
(2009)
Curr Opin Rheumatol
, vol.21
, pp. 623-629
-
-
Trojanowska, M.1
-
123
-
-
24344500807
-
Smad2 and smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
-
Uemura M, Swenson ES, Gaca MDA, Giordano FJ, Reiss M, Wells RG. Smad2 and smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell 16. 4214–4224, 2005.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4214-4224
-
-
Uemura, M.1
Swenson, E.S.2
Gaca, M.D.A.3
Giordano, F.J.4
Reiss, M.5
Wells, R.G.6
-
124
-
-
79955784909
-
Hypoxia-inducible factor-1 alpha mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis
-
Ueno M, Maeno T, Nomura M, Aoyagi-Ikeda K, Matsui H, Hara K, Tanaka T, Iso T, Suga T, Kurabayashi M. Hypoxia-inducible factor-1 alpha mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 300. L740–L752, 2011.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.300
, pp. L740-L752
-
-
Ueno, M.1
Maeno, T.2
Nomura, M.3
Aoyagi-Ikeda, K.4
Matsui, H.5
Hara, K.6
Tanaka, T.7
Iso, T.8
Suga, T.9
Kurabayashi, M.10
-
125
-
-
70449659580
-
The wound-healing process. an overview of the cellular and molecular mechanisms
-
Velnar T, Bailey T, Smrkoli V. The wound-healing process. an overview of the cellular and molecular mechanisms. J Int Med Res 37. 1528–1542, 2009.
-
(2009)
J Int Med Res
, vol.37
, pp. 1528-1542
-
-
Velnar, T.1
Bailey, T.2
Smrkoli, V.3
-
126
-
-
77952548279
-
Extracellular BMPantagonist regulation in development and disease. tied up in knots
-
Walsh DW, Godson C, Brazil DP, Martin F. Extracellular BMPantagonist regulation in development and disease. tied up in knots. Trends Cell Biol 20. 244–256, 2010.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 244-256
-
-
Walsh, D.W.1
Godson, C.2
Brazil, D.P.3
Martin, F.4
-
127
-
-
33748062324
-
Renal bone morphogenetic protein-7 protects against diabetic nephropathy
-
Wang S, de Caestecker M, Kopp J, Mitu G, LaPage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17. 2504–2512, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2504-2512
-
-
Wang, S.1
De Caestecker, M.2
Kopp, J.3
Mitu, G.4
Lapage, J.5
Hirschberg, R.6
-
128
-
-
84880300183
-
Regarding the mechanism of action of a proposed peptide agonistof the bone morphogenetic protein receptor activin-like kinase 3
-
Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T. Regarding the mechanism of action of a proposed peptide agonistof the bone morphogenetic protein receptor activin-like kinase 3. Nat Med 19. 809–810, 2013.
-
(2013)
Nat Med
, vol.19
, pp. 809-810
-
-
Whitman, M.1
Rosen, V.2
Brivanlou, A.H.3
Groppe, J.C.4
Sebald, W.5
Mueller, T.6
-
129
-
-
33646691720
-
Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells
-
Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, Thorikay M, ten Dijke P, Mertens PR, Breitkopf K, Dooley S. Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells. Hepatology 43. 1032–1041, 2006.
-
(2006)
Hepatology
, vol.43
, pp. 1032-1041
-
-
Wiercinska, E.1
Wickert, L.2
Denecke, B.3
Said, H.M.4
Hamzavi, J.5
Gressner, A.M.6
Thorikay, M.7
Ten Dijke, P.8
Mertens, P.R.9
Breitkopf, K.10
Dooley, S.11
-
130
-
-
84897499528
-
The treatment of idiopathic pulmonary fibrosis
-
Woodcock HV, Maher TM. The treatment of idiopathic pulmonary fibrosis. F1000Prime Rep 6. 16, 2014.
-
(2014)
F1000Prime Rep
, vol.6
, pp. 16
-
-
Woodcock, H.V.1
Maher, T.M.2
-
131
-
-
84879286188
-
Reducing lung function decline in patients with idiopathic pulmonary fibrosis. potential of nintedanib
-
Woodcock HV, Molyneaux PL, Maher TM. Reducing lung function decline in patients with idiopathic pulmonary fibrosis. potential of nintedanib. Drug Design Dev Ther 7. 503–510, 2013.
-
(2013)
Drug Design Dev Ther
, vol.7
, pp. 503-510
-
-
Woodcock, H.V.1
Molyneaux, P.L.2
Maher, T.M.3
-
132
-
-
77954961992
-
Macrophages. master regulators of inflammation and fibrosis
-
Wynn TA, Barron L. Macrophages. master regulators of inflammation and fibrosis. Semin Liver Dis 30. 245–257, 2010.
-
(2010)
Semin Liver Dis
, vol.30
, pp. 245-257
-
-
Wynn, T.A.1
Barron, L.2
-
133
-
-
84863702343
-
Mechanisms of fibrosis. therapeutic translation for fibrotic disease
-
Wynn TA, Ramalingam TR. Mechanisms of fibrosis. therapeutic translation for fibrotic disease. Nat Med 18. 1028–1040, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 1028-1040
-
-
Wynn, T.A.1
Ramalingam, T.R.2
-
134
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448. 427–434, 2007.
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
135
-
-
31044453402
-
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury
-
Yanagita M, Okuda T, Endo S, Tanaka M, Takahashi K, Sugiyama F, Kunita S, Takahashi S, Fukatsu A, Yanagisawa M, Kita T, Sakurai T. Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. J Clin Invest 116. 70–79, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 70-79
-
-
Yanagita, M.1
Okuda, T.2
Endo, S.3
Tanaka, M.4
Takahashi, K.5
Sugiyama, F.6
Kunita, S.7
Takahashi, S.8
Fukatsu, A.9
Yanagisawa, M.10
Kita, T.11
Sakurai, T.12
-
137
-
-
15444372825
-
Type I transforming growth factor-β receptor binds to and activates phosphatidylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL. Type I transforming growth factor-β receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280. 10,870-10,876, 2005.
-
(2005)
J Biol Chem 280. 10,870-10
, pp. 876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
138
-
-
77953695161
-
Cellular and molecular basis for the regulation of inflammation by TGF-β
-
Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF-β. J Biochem 147. 781–792, 2010.
-
(2010)
J Biochem
, vol.147
, pp. 781-792
-
-
Yoshimura, A.1
Wakabayashi, Y.2
Mori, T.3
-
139
-
-
84855182504
-
Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine
-
Yu X, Fang Y, Ding X, Liu H, Zhu J, Zou J, Xu X, Zhong Y. Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine. Nephrology 17. 58–67, 2012.
-
(2012)
Nephrology
, vol.17
, pp. 58-67
-
-
Yu, X.1
Fang, Y.2
Ding, X.3
Liu, H.4
Zhu, J.5
Zou, J.6
Xu, X.7
Zhong, Y.8
-
140
-
-
84880329491
-
Cellular and molecular mechanisms in the hypoxic tissue. role of HIF-1 and ROS
-
Zepeda AB, Pessoa A Jr, Castillo RL, Figueroa CA, Pulgar VM, Farias JG. Cellular and molecular mechanisms in the hypoxic tissue. role of HIF-1 and ROS. Cell Biochem Funct 31. 451–459, 2013.
-
(2013)
Cell Biochem Funct
, vol.31
, pp. 451-459
-
-
Zepeda, A.B.1
Pessoa, A.2
Castillo, R.L.3
Figueroa, C.A.4
Pulgar, V.M.5
Farias, J.G.6
-
141
-
-
84862279514
-
Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells
-
Zhang P, Cai Y, Soofi A, Dressler GR. Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells. J Biol Chem 287. 21290–21302, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 21290-21302
-
-
Zhang, P.1
Cai, Y.2
Soofi, A.3
Dressler, G.R.4
-
142
-
-
77955411901
-
In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7
-
Zhang Q, Shi Y, Wada J, Malakauskas SM, Liu M, Ren Y, Du C, Duan H, Li Y, Li Y, Zhang Y. In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7. Plos One 5, 2010.
-
(2010)
Plos One
, vol.5
-
-
Zhang, Q.1
Shi, Y.2
Wada, J.3
Malakauskas, S.M.4
Liu, M.5
Ren, Y.6
Du, C.7
Duan, H.8
Li, Y.9
Li, Y.10
Zhang, Y.11
-
143
-
-
84898638029
-
Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases
-
Zhao H, Dong Y, Tian X, Tan TK, Liu Z, Zhao Y, Zhang Y, Harris DC, Zheng G. Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World J Nephrol 2. 84–89, 2013.
-
(2013)
World J Nephrol
, vol.2
, pp. 84-89
-
-
Zhao, H.1
Dong, Y.2
Tian, X.3
Tan, T.K.4
Liu, Z.5
Zhao, Y.6
Zhang, Y.7
Harris, D.C.8
Zheng, G.9
-
144
-
-
0036086293
-
Smad3 deficiency attenuates bleomycininduced pulmonary fibrosis in mice
-
Zhao JS, Shi W, Wang YL, Chen H, Bringas P, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycininduced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 282. L585–L593, 2002.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
, pp. L585-L593
-
-
Zhao, J.S.1
Shi, W.2
Wang, Y.L.3
Chen, H.4
Bringas, P.5
Datto, M.B.6
Frederick, J.P.7
Wang, X.F.8
Warburton, D.9
-
145
-
-
84903769379
-
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
-
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev 28. 1429–1444, 2014.
-
(2014)
Genes Dev
, vol.28
, pp. 1429-1444
-
-
Zheng, X.1
Zhai, B.2
Koivunen, P.3
Shin, S.J.4
Lu, G.5
Liu, J.6
Geisen, C.7
Chakraborty, A.A.8
Moslehi, J.J.9
Smalley, D.M.10
Wei, X.11
Chen, X.12
Chen, Z.13
Beres, J.M.14
Zhang, J.15
Tsao, J.L.16
Brenner, M.C.17
Zhang, Y.18
Fan, C.19
Depinho, R.A.20
Paik, J.21
Gygi, S.P.22
Kaelin, W.G.23
Zhang, Q.24
more..
-
146
-
-
80052669057
-
Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis
-
Zhou Q, Pardo A, Koenigshoff M, Eickelberg O, Budinger GRS, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J 25. 3032–3044, 2011.
-
(2011)
FASEB J
, vol.25
, pp. 3032-3044
-
-
Zhou, Q.1
Pardo, A.2
Koenigshoff, M.3
Eickelberg, O.4
Budinger, G.R.S.5
Thavarajah, K.6
Gottardi, C.J.7
Jones, J.8
Varga, J.9
Selman, M.10
Sznajder, J.I.11
Raj, J.U.12
Zhou, G.13
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