The transforming growth factor-beta (TGF-β) family and pulmonary fibrosis

Drug Discovery Today: Disease Mechanisms

Volumn 3, Issue 1, 2006, Pages 99-103

  Martin, Gail E M ^a   Ask, Kjetil ^a   Gilpin, Sarah E ^a   Kolb, Martin ^a   Gauldie, Jack ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CONNECTIVE TISSUE GROWTH FACTOR; DECORIN; ENDOGLIN; FIBRONECTIN; GELATINASE A; GELATINASE B; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; LAMININ; MACROPHAGE ELASTASE; PHOSPHOTRANSFERASE INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; SD 208; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TENASCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BINDING AFFINITY; DRUG EFFICACY; DRUG TARGETING; FIBROGENESIS; HUMAN; INFLAMMATION; LUNG FIBROSIS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SCAR FORMATION; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 33746103683     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2006.03.006     Document Type: Review

References (40)

1. Selman M., et al. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Am. J. Respir. Crit. Care Med. 165 (2001) 1205-1206
2. Bonniaud P., et al. Progressive transforming growth factor {beta}1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor. Am. J. Respir. Crit. Care Med. 171 (2005) 889-898
3. Jones A.W., and Reeve N.L. Ultrastructural study of bleomycin-induced pulmonary changes in mice. J. Pathol. 124 (1978) 227-233
4. Kolb M., et al. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J. Clin. Invest. 107 (2001) 1529-1536
5. Massagué J., and Kelly B. Internalization of transforming growth factor-beta and its receptor in BALB/c 3T3 fibroblasts. J. Cell. Physiol. 128 (1986) 216-222
6. Wahl S.M., et al. Transforming growth factor beta (TGF-β) induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. U S A 84 (1987) 5788-5792
7. Postlethwaite A.E., et al. Stimulation of the chemotactic migration of the human fibroblasts by transforming growth factor-β. J. Exp. Med. 165 (1987) 251-256
8. Ashcroft G.A. Bidirectional regulation of macrophage function by TGF-β. Microb. Infect. 1 (1999) 1275-1282
9. Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16 (1998) 137-161
10. Bauvois B., et al. IFN-γ and transforming growth factor-beta1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells. J. Immunol. 148 (1992) 3912-3919
11. Wahl S.M., et al. TGF-β enhances integrin expression and type IV collagenase secretion in human monocytes. Proc. Natl. Acad. Sci. U S A 90 (1993) 4577-4581
12. 6 binds and activates latent TGF-β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96 (1999) 319-328
13. Welch G.R., et al. Selective induction of Fc gamma RIII on human monocytes by transforming growth factor-beta. J. Immunol. 144 (1990) 3444-3448
14. Blakytny R., et al. Latent TGF-beta1 activation by platelets. J. Cell Physiol. 199 (2004) 67-76
15. Piguet P.F., and Vesin C. Pulmonary platelet trapping induced by bleomycin: correlation with fibrosis and involvement of the beta 2 integrins. Int. J. Exp. Pathol. 75 (1994) 321-328
16. Allen J.B., et al. Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J. Exp. Med. 171 (1990) 231-247
17. Wahl S.M., et al. Macrophage production of TGF-β and regulation by TGF-β. Ann. N.Y. Acad. Sci. 593 (1990) 188-196
18. Assoian R.K., et al. Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc. Natl. Acad. Sci. U S A 84 (1987) 6020-6024
19. McCartney-Francis N., et al. TGF-β regulates production of growth factors and TGF-β by human peripheral blood monocytes. Growth Factors 4 (1990) 27-35
20. Sheppard D. Roles of alphav integrins in vascular biology and pulmonary pathology. Curr. Opin. Cell Biol. 16 (2004) 552-557
21. Massagué J. Receptors for the TGF-β family. Cell 69 (1992) 1067-1070
22. Franzen P., et al. Cloning of TGF-β type I receptor that forms a heterodimeric complex with the type II TGF-β receptor. Cell 75 (1993) 681-692
23. Boyd F.T., and Massagué J. Transforming growth factor-beta inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J. Biol. Chem. 264 (1989) 2272-2278
24. Boyd F.T., et al. Transforming growth factor-beta receptors and binding proteoglycans. J. Cell Sci. Suppl. 13 (1990) 131-138
25. Blobe G.C., et al. Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling. J. Biol. Chem. 276 (2001) 24627-24637
26. Cheifetz S., et al. Endoglin is a component of the transforming growth factor-β receptor system in human endothelial cells. J. Biol. Chem. 267 (1992) 19027-19030
27. Yamashita H., et al. Endoglin forms a heteromeric complex with the signalling receptors for TGF-β. J. Biol. Chem. 269 (1994) 1995-2001
28. Cheifetz S., and Massagué J. Isoform specific transforming growth factor-β binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C. J. Biol. Chem. 266 (1991) 20767-20772
29. Bonniaud P., et al. Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J. Immunol. 173 (2004) 2099-2108
30. Bonniaud P., et al. TGF-β and Smad3 signaling link inflammation to chronic fibrogenesis. J. Immunol. 175 (2005) 5390-5395
31. Sime P.J., et al. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100 (1997) 768-776
32. Lee C.G., et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J. Exp. Med. 200 (2004) 377-389
33. Eikelberg O., et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3. Am. J. Physiol. 276 (1999) L814-L824
34. Shah M., et al. Control of scarring in adult wounds by neutralising antibodies to transforming growth factor beta. Lancet 339 (1992) 213-214
35. Shah M., et al. Neutralising antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents. J. Cell Sci. 107 (1994) 1137-1157
36. Shah M., et al. Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J. Cell Sci. 108 (1995) 985-1002
37. Bonniaud P., et al. Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis. Am. J. Respir. Crit. Care Med. 168 (2003) 770-778
38. Margetts P.J., et al. Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J. Am. Soc. Nephrol. 12 (2001) 2029-2039
39. Margetts P.J., et al. Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum. J. Am. Soc. Nephrol. 16 (2005) 425-436
40. Breen E., et al. Bleomycin regulation of transforming growth factor-beta mRNA in rat lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 6 (1992) 146-152