Roles of Akt/PKB and IKK complex in constitutive induction of NF-κB in hepatocellular carcinomas of transforming growth factor α/c-myc transgenic mice

Hepatology

Volumn 34, Issue 1, 2001, Pages 32-41

  Factor, Valentina ^a   Oliver, Aundrea L ^b   Panta, Ganesh R ^c   Thorgeirsson, Snorri S ^a   Sonenshein, Gail E ^b   Arsura, Marcello ^b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; RAS PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; ONCOGENE C MYC; ONCOGENE RAS; PRIORITY JOURNAL; TRANSGENIC MOUSE; TUMOR GROWTH;

EID: 0034961050     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.25270     Document Type: Article

References (74)

1. Multiple nuclear factors interact with the immuno-globulin enhancer sequences
2. Function and activation of NF-kappaB in the immune system
3. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
4. NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit
5. The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression
6. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
7. The NF-kappa B and I kappa B proteins: New discoveries and insights
8. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
9. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
10. IKK-1 and IKK-2: Cytokine-activated IkappaB kinases essential for NF-kappaB activation
11. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
12. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
13. Identification and characterization of an IkappaB kinase
14. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
15. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
16. The beginning of the end:IkappaB kinase (1KK) and NF-kappaB activation
17. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
18. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
19. Site-specific phosphorylation of Ikappa-Balpha by a novel ubiquitination-dependent protein kinase activity
20. Rel/NF-kappaB/IkappaB proteins and cancer
21. N-terminal determinants of I kappa B alpha necessary for the cytoplasmic regulation of c-Rel
22. TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: Transcriptional activation of I kappa B alpha
23. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells
24. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
25. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
26. Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T-cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates
27. MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells
28. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
29. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
30. Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells
31. Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites
32. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
33. Suppression of TNF-alpha-induced apoptosis by NF-kappaB
34. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
35. TNF- and cancer therapy-induced apoptosis Potentiation by inhibition of NF-kappaB
36. Control of inducible chemoresistance enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
37. Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
38. Role of the IkappaB kinase complex in oncogenic ras- and raf-mediated transformation of rat liver epithelial cells
39. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: Interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
40. Disruption of the pRb/ E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha
41. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
42. Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis
43. Report of a complex karyotype in recurrent metastatic fibrolamellar hepatocellular carcinoma and a review of hepatocellular carcinoma cytogenetics
44. Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines
45. Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization
46. Interspecies comparison of liver carcinogenesis: Implications for cancer risk assessment
47. Nuclear factor-kappaB/Rel blocks transforming growth factor betal-induced apoptosis of murine hepatocyte cell lines
48. Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability
49. Interaction of an NF-kappa B-like factor with a site upstream of the c- myc promoter
50. The transcription factor NF-kappaB: Control of oncogenesis and cancer therapy resistance
51. Constitutive phosphorylation of I kappa B alpha by casein kinase II
52. Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation
53. Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: Requirement for degradation of free IkappaBalpha
54. Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha
55. Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes
56. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
57. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
58. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
59. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice
60. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration
61. Roles of protein kinase CK2 and IKK kinases in activation of NF-kappaB in breast cancer
62. Activation of nuclear factor kappaB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis
63. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors
64. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha
65. The core protein of hepatitis C virus induces hepato-cellular carcinoma in transgenic mice
66. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
67. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C
68. Epidermal growth factor-related peptides and their receptors in human malignancies
69. The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4
70. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
71. IkappaB kinases: Kinsmen with different crafts [comment]
72. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha
73. Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha
74. Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model