Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3

Nature Medicine

Volumn 19, Issue 7, 2013, Pages 809-810

  Whitman, Malcolm ^a,b   Rosen, Vicki ^a   Brivanlou, Ali H ^c   Groppe, Jay C ^d   Sebald, Walter ^e   Mueller, Thomas ^e  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF DENTISTRY   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; BONE MORPHOGENETIC PROTEIN RECEPTOR ACTIVIN LIKE KINASE 3; CYTOKINE RECEPTOR AGONIST; OSTEOGENIC PROTEIN 1; PHOSPHOTRANSFERASE; THR 123; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; KIDNEY FIBROSIS; LETTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; KIDNEY; PEPTIDES; REGENERATION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84880300183     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3080     Document Type: Letter

References (28)

1. Sugimoto, H. et al. Nat. Med. 18, 396-404 (2012).
2. Attisano, L., Wrana, J.L., Lopez-Casillas, F. & Massague, J. Biochim. Biophys. Acta 1222, 71-80 (1994).
3. Wrana, J.L. Miner. Electrolyte Metab. 24, 120-130 (1998).
4. Ehrlich, M., Horbelt, D., Marom, B., Knaus, P. & Henis, Y.I. Cell. Signal. 23, 1424-1432 (2011).
5. Nickel, J., Sebald, W., Groppe, J.C. & Mueller, T.D. Cytokine Growth Factor Rev. 20, 367-377 (2009).
6. Harrison, C.A. et al. Mol. Cell. Endocrinol. 225, 19-24 (2004).
7. Knaus, P. & Sebald, W. Biol. Chem. 382, 1189-1195 (2001).
8. Greenwald, J. et al. Mol. Cell 11, 605-617 (2003).
9. ten Dijke, P. et al. J. Biol. Chem. 269, 16985-16988 (1994).
10. Bernkop-Schnürch, A. & Schmitz, T. Curr. Drug Metab. 8, 509-517 (2007).
11. Burton, P.S., Conradi, R.A., Ho, N.F., Hilgers, A.R. & Borchardt, R.T. J. Pharm. Sci. 85, 1336-1340 (1996).
12. Bellmann-Sickert, K. & Beck-Sickinger, A.G. Trends Pharmacol. Sci. 31, 434-441 (2010).
13. Dewulf, N. et al. Endocrinology 136, 2652-2663 (1995).
14. Whitman, M.L. Nat. Med. 19, 809-810 (2013).
15. Sugimoto, H. et al. Nat. Med. 18, 396-404 (2012).
16. Kirsch, T., Sebald, W. & Dreyer, M.K. Nat. Struct. Biol. 7, 492-496 (2000).
17. Allendorph, G.P., Vale, W.W. & Choe, S. Proc. Natl. Acad. Sci. USA 103, 7643-7648 (2006).
18. Daopin, S., Piez, K.A., Ogawa, Y. & Davies, D.R. Science 257, 369-373 (1992).
19. Schlunegger, M.P. & Grutter, M.G. Nature 358, 430-434 (1992).
20. Griffith, D.L., Keck, P.C., Sampath, T.K., Rueger, D.C. & Carlson, W.D. Proc. Natl. Acad. Sci. USA 93, 878-883 (1996).
21. Bosukonda, D. Screening method for bone marrow morphogenic mimetics. Patent application number: PCT/US00/42657. WIPO publication WO 2002/039118. (2002).
22. Duan, Z. et al. J. Huazhong Univ. Sci. Technolog. Med. Sci. 28, 426-430 (2008).
23. Lock, J. & Liu, H. Int. J. Nanomedicine 6, 2769-2777 (2011).
24. Saito, A., Suzuki, Y., Ogata, S., Ohtsuki, C. & Tanihara, M. J. Biomed. Mater. Res. A 72, 77-82 (2005).
25. Chen, Y. & Webster, T.J. J. Biomed. Mater. Res. A 91, 296-304 (2009).
26. Weiner, H.L. J. Clin. Invest. 106, 935-937 (2000).
27. Amidon, G.L. & Lee, H.J. Annu. Rev. Pharmacol. Toxicol. 34, 321-341 (1994).
28. Bosukonda, D., Shih, M.S., Sampath, K.T. & Vukicevic, S. Kidney Int. 58, 1902-1911 (2000).