Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

FASEB Journal

Volumn 25, Issue 9, 2011, Pages 3032-3044

  Zhou, Qiyuan ^a   Pardo, Annie ^b   Königshoff, Melanie ^c   Eickelberg, Oliver ^c   Budinger, G R Scott ^d   Thavarajah, Krishna ^d   Gottardi, Cara J ^d   Jones, Jonathan ^d   Varga, John ^e   Selman, Moises ^f   Sznajder, Jacob I ^d   Raj, J Usha ^a   Zhou, Guofei ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSITY OF MUNICH   (Germany)

^d NORTHWESTERN UNIVERSITY   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

Extracellular matrix; Focal adhesion kinase; Idiopathic pulmonary fibrosis; Integrin 5 1

Indexed keywords

ALPHA4 INTEGRIN; ALPHA5 INTEGRIN; BETA1 INTEGRIN; BLEOMYCIN; COLLAGEN TYPE 1; FIBRONECTIN; FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR; LUCIFERASE; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; FIBROSING ALVEOLITIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LUNG FIBROBLAST; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL LINE; CELL PROLIFERATION; FIBROBLASTS; FIBRONECTINS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INTEGRIN ALPHA5; INTEGRIN ALPHA5BETA1; MICE; MICE, INBRED C57BL; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 80052669057     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-177824     Document Type: Article

References (40)

1. Selman, M., King, T. E., Pardo, A., American Thoracic Society, European Respiratory Society, and American College of Chest Physicians. (2001) Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann. Intern. Med. 134, 136-151 (Pubitemid 32096342)
2. Du Bois, R. M. (2010) Strategies for treating idiopathic pulmonary fibrosis. Nat. Rev. Drug Disc. 9, 129-140
3. Geiger, B., Bershadsky, A., Pankov, R., and Yamada, K. M. (2001) Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev. Mol. Cell. Biol. 2, 793-805
4. Berrier, A. L., and Yamada, K. M. (2007) Cell-matrix adhesion. J. Cell. Physiol. 213, 565-573 (Pubitemid 350058247)
5. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687
6. Fontana, L., Chen, Y., Prijatelj, P., Sakai, T., Fassler, R., Sakai, L. Y., and Rifkin, D. B. (2005) Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J. 19, 1798 -1808
7. Dallas, S. L., Sivakumar, P., Jones, C. J., Chen, Q., Peters, D. M., Mosher, D. F., Humphries, M. J., and Kielty, C. M. (2005) Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J. Biol. Chem. 280, 18871-18880 (Pubitemid 41379589)
8. Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J., Dalton, S. L., Wu, J., Pittet, J. F., Kaminski, N., Garat, C., Matthay, M. A., Rifkin, D. B., and Sheppard, D. (1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319-328 (Pubitemid 29077586)
9. Annes, J. P., Chen, Y., Munger, J. S., and Rifkin, D. B. (2004) Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J. Cell Biol. 165, 723-734 (Pubitemid 38765773)
10. Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., Goyal, J., Feghali-Bostwick, C. A., Matteson, E. L., O'Hara, C., Lafyatis, R., Davis, G. S., Huang, X., Sheppard, D., and Violette, S. M. (2008) Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am. J. Respir. Crit. Care Med. 177, 56-65
11. Puthawala, K., Hadjiangelis, N., Jacoby, S. C., Bayongan, E., Zhao, Z., Yang, Z., Devitt, M. L., Horan, G. S., Weinreb, P. H., Lukashev, M. E., Violette, S. M., Grant, K. S., Colarossi, C., Formenti, S. C., and Munger, J. S. (2008) Inhibition of integrin alpha(v) beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am. J. Respir. Crit. Care Med. 177, 82-90
12. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G., Jr. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. [see comment] Science 292, 464-468 (Pubitemid 32335941)
13. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. [see comment] Science 292, 468-472 (Pubitemid 32335942)
14. Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206 (Pubitemid 32910914)
15. Ohh, M., Yauch, R. L., Lonergan, K. M., Whaley, J. M., Stemmer-Rachamimov, A. O., Louis, D. N., Gavin, B. J., Kley, N., Kaelin, W. G., Jr., and Iliopoulos, O. (1998) The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 1, 959 -968
16. Grosfeld, A., Stolze, I. P., Cockman, M. E., Pugh, C. W., Edelmann, M., Kessler, B., Bullock, A. N., Ratcliffe, P. J., and Masson, N. (2007) Interaction of hydroxylated collagen IV with the von Hippel-Lindau tumor suppressor. J. Biol. Chem. 282, 13264-13269 (Pubitemid 47100504)
17. Kurban, G., Hudon, V., Duplan, E., Ohh, M., and Pause, A. (2006) Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 66, 1313-1319 (Pubitemid 43259909)
18. Tang, N., Mack, F., Haase, V. H., Simon, M. C., and Johnson, R. S. (2006) pVHL function is essential for endothelial extracellular matrix deposition. Mol. Cell. Biol. 26, 2519 -2530
19. Mack, F. A., Patel, J. H., Biju, M. P., Haase, V. H., and Simon, M. C. (2005) Decreased growth of Vhl-/-fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol. Cell. Biol. 25, 4565-4578 (Pubitemid 40705761)
20. Goda, N., Ryan, H. E., Khadivi, B., McNulty, W., Rickert, R. C., and Johnson, R. S. (2003) Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23, 359-369 (Pubitemid 36008526)
21. Frew, I. J., and Krek, W. (2007) Multitasking by pVHL in tumour suppression. Curr. Opin. Cell Biol. 19, 685-690 (Pubitemid 350216423)
22. Budinger, G. R., Mutlu, G. M., Eisenbart, J., Fuller, A. C., Bellmeyer, A. A., Baker, C. M., Wilson, M., Ridge, K., Barrett, T. A., Lee, V. Y., and Chandel, N. S. (2006) Proapoptotic Bid is required for pulmonary fibrosis. Proc. Natl. Acad. Sci. U. S. A. 103, 4604-4609
23. Eickelberg, O., Kohler, E., Reichenberger, F., Bertschin, S., Woodtli, T., Erne, P., Perruchoud, A. P., and Roth, M. (1999) Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3. Am. J. Physiol. 276, L814-L824 (Pubitemid 29249635)
24. Konigshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O. V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., Gunther, A., and Eickelberg, O. (2009) WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J. Clin. Invest. 119, 772-787
25. Abe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., and Rifkin, D. B. (1994) An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal. Biochem. 216, 276-284 (Pubitemid 24076008)
26. Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., and Chapman, H. A. (2006) Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl. Acad. Sci. U. S. A. 103, 13180-13185 (Pubitemid 44338936)
27. Pardo, A., Gibson, K., Cisneros, J., Richards, T. J., Yang, Y., Becerril, C., Yousem, S., Herrera, I., Ruiz, V., Selman, M., and Kaminski, N. (2005) Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Med. 2, e251
28. Meighan, C. M., and Schwarzbauer, J. E. (2008) Temporal and spatial regulation of integrins during development. Curr. Opin. Cell Biol. 20, 520-524
29. Esteban-Barragan, M. A., Avila, P., Alvarez-Tejado, M., Gutierrez, M. D., Garcia-Pardo, A., Sanchez-Madrid, F., and Landazuri, M. O. (2002) Role of the von Hippel-Lindau tumor suppressor gene in the formation of beta1-integrin fibrillar adhesions. Cancer Res. 62, 2929-2936 (Pubitemid 34525781)
30. Sastry, S. K., Lakonishok, M., Thomas, D. A., Muschler, J., and Horwitz, A. F. (1996) Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation. J. Cell Biol. 133, 169-184
31. Liu, J., DeYoung, S. M., Zhang, M., Cheng, A., and Saltiel, A. R. (2005) Changes in integrin expression during adipocyte differentiation. Cell Metab. 2, 165-177
32. Mitra, S. K., and Schlaepfer, D. D. (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18, 516-523 (Pubitemid 44332916)
33. Horowitz, J. C., Rogers, D. S., Sharma, V., Vittal, R., White, E. S., Cui, Z., and Thannickal, V. J. (2007) Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell. Signal. 19, 761-771 (Pubitemid 46290691)
34. Weston, B. S., Wahab, N. A., and Mason, R. M. (2003) CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J. Am. Soc. Nephrol. 14, 601-610 (Pubitemid 36246003)
35. White, E. S., Thannickal, V. J., Carskadon, S. L., Dickie, E. G., Livant, D. L., Markwart, S., Toews, G. B., and Arenberg, D. A. (2003) Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. Am. J. Resp. Crit. Care Med. 168, 436-442 (Pubitemid 37046872)
36. Jatta, K., Eliason, G., Portela-Gomes, G. M., Grimelius, L., Caro, O., Nilholm, L., Sirjso, A., Piehl-Aulin, K., and Abdel-Halim, S. M. (2009) Overexpression of von Hippel-Lindau protein in skeletal muscles of patients with chronic obstructive pulmonary disease. J. Clin. Pathol. 62, 70-76
37. Hickey, M. M., Richardson, T., Wang, T., Mosqueira, M., Arguiri, E., Yu, H., Yu, Q. C., Solomides, C. C., Morrisey, E. E., Khurana, T. S., Christofidou-Solomidou, M., and Simon, M. C. (2010) The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J. Clin. Invest. 120, 827-839
38. Lei, L., Mason, S., Liu, D., Huang, Y., Marks, C., Hickey, R., Jovin, I. S., Pypaert, M., Johnson, R. S., and Giordano, F. J. (2008) Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol. Cell. Biol. 28, 3790 -3803
39. Higgins, D. F., Kimura, K., Bernhardt, W. M., Shrimanker, N., Akai, Y., Hohenstein, B., Saito, Y., Johnson, R. S., Kretzler, M., Cohen, C. D., Eckardt, K. U., Iwano, M., and Haase, V. H. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 117, 3810-3820 (Pubitemid 350224091)
40. Zhou, G., Dada, L. A., Wu, M., Kelly, A., Trejo, H., Zhou, Q., Varga, J., and Sznajder, J. I. (2009) Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L1120-L1130