HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

Fibrogenesis and Tissue Repair

Volumn 7, Issue 1, 2014, Pages

  Nural Guvener, Hikmet F ^a   Zakharova, Luidmila ^a   Nimlos, James ^a   Popovic, Snjezana ^a   Mastroeni, Diego ^a   Gaballa, Mohamed A ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

Congestive heart failure; Fibrosis; HDAC; Mocetinostat; Myocardial Infarction; Myofibroblast; Rat

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; CASPASE 3; COLLAGEN TYPE 3; GELATINASE A; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; MOCETINOSTAT; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; THY 1 ANTIGEN; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE CELL; CARDIAC MYOFIBROBLAST; CELLULAR DISTRIBUTION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; HEART FIBROBLAST; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

EID: 84903411670     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-7-10     Document Type: Article

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