-
1
-
-
84906416572
-
Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia
-
Ashton N, Ward B, Serpell G (1954) Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol 38:397-432
-
(1954)
Br J Ophthalmol
, vol.38
, pp. 397-432
-
-
Ashton, N.1
Ward, B.2
Serpell, G.3
-
2
-
-
0020557197
-
Oxygen tension regulates the expression of angiogenesis factor by macrophages
-
Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ (1983) Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 221:1283-1285
-
(1983)
Science
, vol.221
, pp. 1283-1285
-
-
Knighton, D.R.1
Hunt, T.K.2
Scheuenstuhl, H.3
Halliday, B.J.4
Werb, Z.5
Banda, M.J.6
-
3
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
4
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn HF, Poyton RO (1996) Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839-885
-
(1996)
Physiol Rev
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
5
-
-
0034940761
-
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia
-
Jiang H, Guo R, Powell-Coffman JA (2001) The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc Natl Acad Sci USA 98:7916-7921
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7916-7921
-
-
Jiang, H.1
Guo, R.2
Powell-Coffman, J.A.3
-
6
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein ACR et al. (2001) C. elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-45
-
(2001)
Cell
, vol.107
, pp. 43-45
-
-
Epstein, A.C.R.1
-
7
-
-
0034901463
-
Hypoxia-inducible factor 1: Oxygen homeostasis and diseases pathophysiology
-
Semenza GL (2001) Hypoxia-inducible factor 1: Oxygen homeostasis and diseases pathophysiology. Trends Mol Med 7:345-350
-
(2001)
Trends Mol Med
, vol.7
, pp. 345-350
-
-
Semenza, G.L.1
-
8
-
-
0027367661
-
Identification of the renal erythropoietin-producing cells using transgenic mice
-
Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJP, Johnson MH, Ratcliffe PJ (1993) Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 44:1149-1162
-
(1993)
Kidney Int
, vol.44
, pp. 1149-1162
-
-
Maxwell, P.H.1
Osmond, M.K.2
Pugh, C.W.3
Heryet, A.4
Nicholls, L.G.5
Tan, C.C.6
Doe, B.G.7
Ferguson, D.J.P.8
Johnson, M.H.9
Ratcliffe, P.J.10
-
10
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its a subunit
-
Huang LE, Arany Z, Livingston DM, Bunn HF (1996) Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its a subunit. J Biol Chem 271:32253-32259
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
11
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1a is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF (1998) Regulation of hypoxia-inducible factor 1a is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95:7987-7992
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
12
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
-
Salceda S, Caro J (1997) Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J Biol Chem 272:22642-22647
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
13
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1a
-
Wiesener MS et al. (1998) Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1a. Blood 92:2260-2268
-
(1998)
Blood
, vol.92
, pp. 2260-2268
-
-
Wiesener, M.S.1
-
14
-
-
0035347260
-
Induction of HIF-1 alpha in response to hypoxia is instantaneous
-
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH, Gassmann M (2001) Induction of HIF-1 alpha in response to hypoxia is instantaneous. FASEB J 15:1312-1314
-
(2001)
FASEB J
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
Gassmann, M.6
-
15
-
-
0030937718
-
Activation of hypoxia inducible factor-1; definition of regulatory domains within the a subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ (1997) Activation of hypoxia inducible factor-1; definition of regulatory domains within the a subunit. J Biol Chem 272:11205-11214
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
16
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1a. Modulation of transcriptional activity by oxygen tension
-
Jiang B-H, Zheng JZ, Leung SW, Roe R, Semenza GL (1997) Transactivation and inhibitory domains of hypoxia-inducible factor 1a. Modulation of transcriptional activity by oxygen tension. J Biol Chem 272:19253-19260
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
17
-
-
0033593219
-
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia inducible factor-1α
-
O'Rourke JF, Tian Y-M, Ratcliffe PJ, Pugh CW (1999) Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia inducible factor-1α. J Biol Chem 274:2060-2071
-
(1999)
J Biol Chem
, vol.274
, pp. 2060-2071
-
-
O'Rourke, J.F.1
Tian, Y.-M.2
Ratcliffe, P.J.3
Pugh, C.W.4
-
18
-
-
0029803552
-
An essential role for p300/CBP in the cellular response to hypoxia
-
Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM (1996) An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93:12969-12973
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
Bunn, H.F.7
Livingston, D.M.8
-
19
-
-
0033986948
-
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
-
Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L (2000) Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol 20:402-415
-
(2000)
Mol Cell Biol
, vol.20
, pp. 402-415
-
-
Carrero, P.1
Okamoto, K.2
Coumailleau, P.3
O'Brien, S.4
Tanaka, H.5
Poellinger, L.6
-
20
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1a
-
Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L (1998) Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1a. EMBO J 17:6573-6586
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
21
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang G-W, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
22
-
-
0034682783
-
Hypoxia inducible factor-a binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH (2000) Hypoxia inducible factor-a binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 275:25733-25741
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
23
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2:423-427
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
24
-
-
0034641615
-
Activation of HIF1a ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000) Activation of HIF1a ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97:10430-10435
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
25
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1a by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, Poellinger L (2000) Mechanism of regulation of the hypoxia-inducible factor-1a by the von Hippel-Lindau tumor suppressor protein. EMBO J 19:4298-4309
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
26
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a. Genes Dev 14:34-44
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
27
-
-
0035852668
-
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
-
Haase VH, Glickman JN, Socolovsky M, Jaenisch R (2001) Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci USA 98:1583-1588
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1583-1588
-
-
Haase, V.H.1
Glickman, J.N.2
Socolovsky, M.3
Jaenisch, R.4
-
28
-
-
0035941195
-
Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor
-
Vaux EC, Wood SM, Cockman ME, Nicholls LG, Yeates KM, Pugh CW, Maxwell PH, Ratcliffe PJ (2001) Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. J Biol Chem 276:44323-44330
-
(2001)
J Biol Chem
, vol.276
, pp. 44323-44330
-
-
Vaux, E.C.1
Wood, S.M.2
Cockman, M.E.3
Nicholls, L.G.4
Yeates, K.M.5
Pugh, C.W.6
Maxwell, P.H.7
Ratcliffe, P.J.8
-
29
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL (2001) FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
30
-
-
0345164318
-
The VHL tumour-suppressor gene paradigm
-
Kaelin WG, Maher ER (1998) The VHL tumour-suppressor gene paradigm. Trends Genet 14:423-426
-
(1998)
Trends Genet
, vol.14
, pp. 423-426
-
-
Kaelin, W.G.1
Maher, E.R.2
-
31
-
-
0035336706
-
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
-
Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WGJ (2001) von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet 10:1019-1027
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1019-1027
-
-
Hoffman, M.A.1
Ohh, M.2
Yang, H.3
Klco, J.M.4
Ivan, M.5
Kaelin, W.G.J.6
-
32
-
-
0035339044
-
Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
-
Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER (2001) Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum Mol Genet 10:1029-1038
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1029-1038
-
-
Clifford, S.C.1
Cockman, M.E.2
Smallwood, A.C.3
Mole, D.R.4
Woodward, E.R.5
Maxwell, P.H.6
Ratcliffe, P.J.7
Maher, E.R.8
-
33
-
-
0031870653
-
Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α
-
Flamme I, Krieg M, Plate KH (1998) Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α. Am J Pathol 153:25-29
-
(1998)
Am J Pathol
, vol.153
, pp. 25-29
-
-
Flamme, I.1
Krieg, M.2
Plate, K.H.3
-
34
-
-
0032916281
-
VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma
-
Chang C-C, Vortmeyer AO, Chew EY, Green WR, Matteson DM, Linehan WM, Lubensky IA, Zhuang Z (1999) VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma. Arch Ophthalmol 117:625-630
-
(1999)
Arch Ophthalmol
, vol.117
, pp. 625-630
-
-
Chang, C.-C.1
Vortmeyer, A.O.2
Chew, E.Y.3
Green, W.R.4
Matteson, D.M.5
Linehan, W.M.6
Lubensky, I.A.7
Zhuang, Z.8
-
35
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR et al. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet 7:85-90
-
(1994)
Nature Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
-
36
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG Jr, Iliopoulos O (1998) The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1:959-968
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
Whaley, J.M.4
Stemmer-Rachamimov, A.O.5
Louis, D.N.6
Gavin, B.J.7
Kley, N.8
Kaelin W.G., Jr.9
Iliopoulos, O.10
-
37
-
-
0032477788
-
The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit on serum withdrawal
-
Pause A, Lee S, Lonergan KM, Klausner RD (1998) The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit on serum withdrawal. Proc Natl Acad Sci USA 95:993-998
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 993-998
-
-
Pause, A.1
Lee, S.2
Lonergan, K.M.3
Klausner, R.D.4
-
38
-
-
0034735902
-
The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis
-
Schoenfeld AR, Parris T, Eisenberger A, Davidowitz EJ, Leon MD, Talasazan F, Devarajan P, Burk RD (2000) The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis. Oncogene 19:5851-5857
-
(2000)
Oncogene
, vol.19
, pp. 5851-5857
-
-
Schoenfeld, A.R.1
Parris, T.2
Eisenberger, A.3
Davidowitz, E.J.4
Leon, M.D.5
Talasazan, F.6
Devarajan, P.7
Burk, R.D.8
-
39
-
-
0024273450
-
Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
-
Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242:1412-1415
-
(1988)
Science
, vol.242
, pp. 1412-1415
-
-
Goldberg, M.A.1
Dunning, S.P.2
Bunn, H.F.3
-
40
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
Wang GL, Semenza GL (1993) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction. Blood 82:3610-3615
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
41
-
-
0027970536
-
Role of hydrogen peroxide in hypoxia-induced erythropoietin production
-
Fandrey J, Frede S, Jelkmann W (1994) Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 303:507-510
-
(1994)
Biochem J
, vol.303
, pp. 507-510
-
-
Fandrey, J.1
Frede, S.2
Jelkmann, W.3
-
42
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 alpha during hypoxia: A mechanism of oxygen sensing
-
Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 alpha during hypoxia: A mechanism of oxygen sensing. J Biol Chem 75:1013-1021
-
(2000)
J Biol Chem
, vol.75
, pp. 1013-1021
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
Wood, T.M.4
Melendez, J.A.5
Rodriguez, A.M.6
Schumacker, P.T.7
-
43
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JDR (2000) The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10:429-439
-
(2000)
Trends Cell Biol
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
Eldridge, A.G.2
Freed, E.3
Furstenthal, L.4
Hsu, J.Y.5
Kaiser, B.K.6
Reimann, J.D.R.7
-
44
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292:468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
45
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292:464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
W K., Jr.10
-
46
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
-
Masson N, William C, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 20:5197-5206
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
William, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
47
-
-
0032760945
-
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
-
Schofield CJ, Zhang Z (1999) Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol 9:722-731
-
(1999)
Curr Opin Struct Biol
, vol.9
, pp. 722-731
-
-
Schofield, C.J.1
Zhang, Z.2
-
48
-
-
0020808726
-
Egg-laying defective mutants of the nematode Caenorhabditis elegans
-
Trent C, Tsung N, Horvitz HR (1983) Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104:619-647
-
(1983)
Genetics
, vol.104
, pp. 619-647
-
-
Trent, C.1
Tsung, N.2
Horvitz, H.R.3
-
49
-
-
0035685108
-
Pseudomonas aeruginosa POA1 kills Caenorhabditis elegans by cyanide poisoning
-
Gallagher LA, Manoil C (2001) Pseudomonas aeruginosa POA1 kills Caenorhabditis elegans by cyanide poisoning. J Bacteriol 183:6207-6214
-
(2001)
J Bacteriol
, vol.183
, pp. 6207-6214
-
-
Gallagher, L.A.1
Manoil, C.2
-
50
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
2 homeostasis by hypoxia-inducible factor 1α. Genes Dev 12:149-162
-
(1997)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
-
51
-
-
0032213236
-
The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL (1998) The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12:3320-3324
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
52
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
-
Peng J, Zhang L, Drysdale L, Fong GH (2000) The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97:8386-8391
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.H.4
-
53
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC (1997) Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386:403-407
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
54
-
-
0030847165
-
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
-
Gnarra JR, Ward JM, Porter FD, Wagner JR, Devor DE, Grinberg A, Emmert-Buck MR, Westphal H, Klausner RD, Linehan WM (1997) Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci USA 94:9102-9107
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9102-9107
-
-
Gnarra, J.R.1
Ward, J.M.2
Porter, F.D.3
Wagner, J.R.4
Devor, D.E.5
Grinberg, A.6
Emmert-Buck, M.R.7
Westphal, H.8
Klausner, R.D.9
Linehan, W.M.10
-
55
-
-
0029082384
-
Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
-
Stein I, Neeman M, Shweiki D, Itin A, Keshet E (1995) Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15:5363-5368
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5363-5368
-
-
Stein, I.1
Neeman, M.2
Shweiki, D.3
Itin, A.4
Keshet, E.5
-
56
-
-
0034946944
-
Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport
-
Ozawa K, Kondo T, Hori O, Kitao Y, Stern DM, Eisenmenger W, Ogawa S, Ohshima T (2001) Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. J Clin Invest 108:41-50
-
(2001)
J Clin Invest
, vol.108
, pp. 41-50
-
-
Ozawa, K.1
Kondo, T.2
Hori, O.3
Kitao, Y.4
Stern, D.M.5
Eisenmenger, W.6
Ogawa, S.7
Ohshima, T.8
-
57
-
-
0035955745
-
The von Hippel-Lindau protein interacts with hnRNP A2 and regulates its expression
-
Pioli PA, Rigby WFC (2001) The von Hippel-Lindau protein interacts with hnRNP A2 and regulates its expression. J Biol Chem 276:40346-40352
-
(2001)
J Biol Chem
, vol.276
, pp. 40346-40352
-
-
Pioli, P.A.1
Rigby, W.F.C.2
-
58
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
-
Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA (1998) Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 7:205-213
-
(1998)
Gene Expr
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
Wartman, L.4
Bradfield, C.A.5
-
59
-
-
0035812789
-
Expression and characterization of hypoxia-inducible factor (hif)-3alpha in human kidney: Suppression of hif-mediated gene expression by hif-3alpha
-
Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (2001) Expression and characterization of hypoxia-inducible factor (hif)-3alpha in human kidney: Suppression of hif-mediated gene expression by hif-3alpha. Biochem Biophys Res Commun 287:808-813
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 808-813
-
-
Hara, S.1
Hamada, J.2
Kobayashi, C.3
Kondo, Y.4
Imura, N.5
-
61
-
-
0034739533
-
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
-
Vincent KA, Shyu KG, Luo Y, Magner M, Tio RA, Jiang C, Goldberg MA, Akita GY, Gregory RJ, Isner JM (2000) Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 102:2255-2261
-
(2000)
Circulation
, vol.102
, pp. 2255-2261
-
-
Vincent, K.A.1
Shyu, K.G.2
Luo, Y.3
Magner, M.4
Tio, R.A.5
Jiang, C.6
Goldberg, M.A.7
Akita, G.Y.8
Gregory, R.J.9
Isner, J.M.10
-
62
-
-
0035476509
-
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
-
Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM (2001) Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev 15:2520-2532
-
(2001)
Genes Dev
, vol.15
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
Ginzinger, D.G.4
McDonald, D.M.5
Johnson, R.S.6
Arbeit, J.M.7
-
63
-
-
0033970878
-
PR39, a peptide regulator of angiogenesis
-
Li J et al. (2000) PR39, a peptide regulator of angiogenesis. Nature Med 6:49-55
-
(2000)
Nature Med
, vol.6
, pp. 49-55
-
-
Li, J.1
-
64
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM (2000) Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Med 6:1335-1340
-
(2000)
Nature Med
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
65
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse B et al. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genet 28:131-138
-
(2001)
Nature Genet
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
|