Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis

Journal of Pathology

Volumn 224, Issue 4, 2011, Pages 461-472

  Medina, Carlos ^a   Santos Martinez, Maria Jose ^a   Santana, Alfredo ^b   Paz Cabrera, Maria Cristina ^b   Johnston, Michael J ^a   Mourelle, Marisabel ^c   Salas, Antonio ^d   Guarner, Francisco ^c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^d HOSPITAL MÚTUA DE TERRASSA   (Spain)

Author keywords

bacteria; experimental colitis; intestinal fibrosis; matrix metalloproteinases; smad 2; smad 3; tissue inhibitor of metalloproteinase 1; transforming growth factor beta 1; transforming growth factor beta receptor 1

Indexed keywords

COLLAGEN TYPE 1; RECOMBINANT PROTEIN; SD 208; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; SULFONIC ACID DERIVATIVE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRINITROBENZENSULPHONIC ACID; UNCLASSIFIED DRUG;

ANAEROBIC BACTERIUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; COLITIS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; INTESTINAL FIBROSIS; INTESTINE WALL; MALE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ANIMALS; BACTERIA, ANAEROBIC; BACTERIAL INFECTIONS; CELLS, CULTURED; COLITIS; COLLAGEN; COLON; DISEASE MODELS, ANIMAL; FIBROSIS; INTESTINAL MUCOSA; MALE; MYOFIBROBLASTS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRINITROBENZENES;

EID: 79959993387     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2870     Document Type: Article

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