Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase

Journal of Biological Chemistry

Volumn 280, Issue 11, 2005, Pages 10870-10876

  Jae, Youn Yi ^a   Shin, Incheol ^a   Arteaga, Carlos L ^a,b  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; ENZYME INHIBITION; ENZYMES; IMMUNOLOGY;

EPITHELIAL CELLS; OVEREXPRESSION; RECEPTORS; TRANSFORMING GROWTH FACTOR (TGF);

GROWTH KINETICS;

HYBRID PROTEIN; LY 580276; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN P58; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL STRAIN COS7; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME RECONSTITUTION; EPITHELIUM CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RABBIT; RECEPTOR BINDING; RETICULOCYTE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELL LINE; COS CELLS; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENES, DOMINANT; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; LIGANDS; MICE; MUTATION; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RETICULOCYTES; SMAD7 PROTEIN; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 15444372825     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413223200     Document Type: Article

References (37)

1. Massague, J. (1998) Annu. Rev. Biochem. 67, 753-791
2. Liu, X., Sun, Y., Constantinescu, S. N., Karam, E., Weinberg, R. A., and Lodish, H. F. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10669-10674
3. Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) EMBO J. 16, 5353-5362
4. Wakefield, L. M., and Roberts, A. B. (2002) Curr. Opin. Genet. Dev. 12, 22-29
5. Derynck, R., and Zhang, Y. E. (2003) Nature 425, 577-584
6. Vanhaesebroeck, B., and Waterfield, M. D. (1999) Exp. Cell Res. 253, 239-254
7. Vivanco, I., and Sawyers, C. L. (2002) Nat. Rev. Cancer 2, 489-501
8. Higaki, M., and Shimokado, K. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 2127-2132
9. Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., and Arteaga, C. L. (2000) J. Biol. Chem. 275, 36803-36810
10. Shin, I., Bakin, A. V., Rodeck, U., Brunet, A., and Arteaga, C. L. (2001) Mol. Biol. Cell 12, 3328-3339
11. Horowitz, J. C., Lee, D. Y., Waghray, M., Keshamouni, V. G., Thomas, P. E., Zhang, H., Cui, Z., and Thannickal, V. J. (2004) J. Biol. Chem. 279, 1359-1367
12. Muraoka, R. S., Kurokawa, H., Koh, Y., Forbes, J. T., Roebuck, L. R., Barcellos-Hoff, M. H., Moody, S. E., Chodosh, L. A., and Arteaga, C. L. (2004) Cancer Res. 64, 9002-9011
13. Gotzmann, J., Huber, H., Thallinger, C., Wolschek, M., Jansen, B., Schulte-Hermann, R., Beug, H., and Mikulits, W. (2002) J. Cell Sci. 115, 1189-1202
14. Oft, M., Heider, K. H., and Beug, H. (1998) Curr. Biol. 8, 1243-1252
15. Grignani, F., Kinsella, T., Mencarelli, A., Valtieri, M., Riganelli, D., Lanfrancone, L., Peschle, C., Nolan, G. P., and Pelicci, P. G. (1998) Cancer Res. 58, 14-19
16. Yee, J. K., Miyanohara, A., LaPorte, P., Bouic, K., Burns, J. C., and Friedmann, T. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9564-9568
17. Dumont, N., Bakin, A. V., and Arteaga, C. L. (2003) J. Biol. Chem. 278, 3275-3285
18. Carpenter, C. L., Tolias, K. F., Couvillon, A. C., and Hartwig, J. H. (1997) Adv. Enzyme Regul. 37, 377-390
19. Zhu, H. J., and Sizeland, A. M. (1999) J. Biol. Chem. 274, 11773-11781
20. Wieser, R., Wrana, J. L., and Massague, J. (1995) EMBO J. 14, 2199-2208
21. Sawyer, J. S., Beight, D. W., Britt, K. S., Anderson, B. D., Campbell, R. M., Goodson, T., Herron, D. K., Li, H. Y., McMillen, W. T., Mort, N., Parsons, S., Smith, E. C., Wagner, J.R., Yan, L., Zhang, F., and Yingling, J. M. (2004) Bioorg. Med. Chem. Lett. 14, 3581-3584
22. Singh, J., Ling, L. E., Sawyer, J. S., Lee, W. C., Zhang, F., and Yingling, J. M. (2004) Curr. Opin. Drug Discovery Dev. 7, 437-445
23. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y. Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Jr., Wrana, J. L., and Falb, D. (1997) Cell 89, 1165-1173
24. Itoh, S., Landstrom, M., Hermansson, A., Itoh, F., Heldin, C. H., Heldin, N. E., and ten Dijke, P. (1998) J. Biol. Chem. 273, 29195-29201
25. Domin, J., Dhand, R., and Waterfield, M. D. (1996) J. Biol. Chem. 271, 21614-21621
26. Downing, J. R., and Reynolds, A. B. (1991) Oncogene 6, 607-613
27. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., and White, M. F. (1991) Nature 352, 73-77
28. Peles, E., Lamprecht, R., Ben-Levy, R., Tzahar, E., and Yarden, Y. (1992) J. Biol. Chem. 267, 12266-12274
29. Krymskaya, V. P., Hoffman, R., Eszterhas, A., Ciocca, V., and Panettieri, R. A., Jr. (1997) Am. J. Physiol. 273, L1220-L1227
30. Giorgetti, S., Ballotti, R., Kowalski-Chauvel, A., Cormont, M., and Van Obberghen, E. (1992) Eur. J. Biochem. 207, 599-606
31. Carter, A. N., and Downes, C. P. (1992) J. Biol. Chem. 267, 14563-14567
32. Kim, H. H., Sierke, S. L., and Koland, J. G. (1994) J. Biol. Chem. 269, 24747-24755
33. Hellyer, N. J., Kim, H. H., Greaves, C. H., Sierke, S. L., and Koland, J. G. (1995) Gene (Amst.) 165, 279-284
34. Yarden, Y., and Sliwkowski, M. X. (2001) Nat. Rev. Mol. Cell. Biol. 2, 127-137
35. Kaplan, D. R., Whitman, M., Schaffhausen, B., Pallas, D. C., White, M., Cantley, L., and Roberts, T. M. (1987) Cell 50, 1021-1029
36. Tanti, J. F., Gremeaux, T., Van Obberghen, E., and Le Marchand-Brustel, Y. (1994) Biochem. J. 304, 17-21
37. Yamada, M., Ohnishi, H., Sano, S., Nakatani, A., Ikeuchi, T., and Hatanaka, H. (1997) J. Biol. Chem. 272, 30334-30339