Themes in fibrosis and gastrointestinal inflammation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 5, 2011, Pages

  Fiocchi, Claudio ^a   Kay Lund, P ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular and molecular mediators; Extracellular matrix; Stem cells

Indexed keywords

ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER;

CELL ACTIVATION; CELL CULTURE; CELL INTERACTION; DIGESTIVE SYSTEM INFLAMMATION; DIGESTIVE SYSTEM INJURY; DISEASE SEVERITY; EDITORIAL; EXTRACELLULAR MATRIX; HUMAN; INTESTINAL FIBROSIS; MOLECULAR IMAGING; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PREDICTIVE VALIDITY; PRIORITY JOURNAL; STEM CELL; SURGICAL APPROACH;

ANIMALS; ENVIRONMENT; EXTRACELLULAR MATRIX; FIBROSIS; GASTROINTESTINAL DISEASES; HUMANS; INFLAMMATION; INTESTINES; LIVER CIRRHOSIS;

EID: 79955559415     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00104.2011     Document Type: Editorial

References (65)

1. Aceves SS, Newbury RO, Dohil R, Bastian JF, Broide DH. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 119: 206-212, 2007.
2. Adler J, Swanson SD, Schmiedlin-Ren P, Higgins PD, Golembeski CP, Polydorides AD, McKenna BJ, Hussain HK, Verrot TM, Zimmermann EM. Magnetization transfer helps detect intestinal fibrosis in an animal model of Crohn disease. Radiology 2011. [EPub ahead of print].
3. Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129: 969-984, 2005.
4. Atherton JC. The pathogenesis of Helicobacter pylori-induced gastroduodenal diseases. Annu Rev Pathol 1: 63-96, 2006.
5. Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9: 839-845, 2008.
6. Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre JP. Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 8: 244-250, 2002.
7. De La Motte CA, Hascall VC, Calabro A, Yen-Lieberman B, Strong SA. Mononuclear leukocytes preferentially bind via CD44 to hyaluronan on human intestinal mucosal smooth muscle cells after virus infection or treatment with poly(I. C). J Biol Chem 274: 30747-30755, 1999.
8. Dessein A, Chevillard C, Arnaud V, Hou X, Hamdoun AA, Dessein H, He H, Abdelmaboud SA, Luo X, Li J, Varoquaux A, Mergani A, Abdelwahed M, Zhou J, Monis A, Pitta MG, Gasmelseed N, Cabantous S, Zhao Y, Prata A, Brandt C, Elwali NE, Argiro L, Li Y. Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes. J Exp Med 206: 2321-2328, 2009.
9. Diehl AM. Hepatic complications of obesity. Gastroenterol Clin North Am 34: 45-61, 2005.
10. Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One 5: e12191, 2010.
11. Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol 6: 1105-1111, 2008.
12. Eberl G. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol 3: 450-460, 2010.
13. Economou M, Trikalinos TA, Loizou KT, Tsianos EV, Ioannidis JP. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol 99: 2393-2404, 2004.
14. Embrace the complexity. Nat Immunol 10: 325, 2009.
15. Froslie KF, Jahnsen J, Moum BA, Vatn MH. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 133: 412-422, 2007.
16. Grassl GA, Valdez Y, Bergstrom KS, Vallance BA, Finlay BB. Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology 134: 768-780, 2008.
17. Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, Okuno T, Fujiyama Y, Bamba T. IL-17 stimulates inflammatory responses via NF-κB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 282: G1035-G1044, 2002.
18. Henckaerts L, Van Steen K, Verstreken I, Cleynen I, Franke A, Schreiber S, Rutgeerts P, Vermeire S. Genetic risk profiling and prediction of disease course in Crohn's disease patients. Clin Gastroenterol Hepatol 7: 972-980. e2, 2009.
19. Jiang X, Tsitsiou E, Herrick SE, Lindsay MA. MicroRNAs and the regulation of fibrosis. FEBS J 277: 2015-2021, 2010.
20. Johnson LA, Luke A, Blanco LP, Sauder KL, Higgins PD. Late removal of inflammatory stimulus does not abrogate fibrosis development in vivo in a mouse model of inflammation and fibrosis. Gastroenterology 138, Suppl 1: S-758, 2010.
21. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003.
22. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
23. Kawaguchi Y, McCarthy SA, Watkins SC, Wright TM. Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts. J Rheumatol 31: 1946-1954, 2004.
24. Lawrance IC, Maxwell L, Doe W. Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine. Inflamm Bowel Dis 7: 16-26, 2001.
25. Lawrance IC, Wu F, Leite AZ, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology 125: 1750-1761, 2003.
26. Lee CH, Shah B, Moioli EK, Mao JJ. CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model. J Clin Invest 120: 3340-3349, 2010.
27. Leite AZ, de la Motte C, Strong SA, Fiocchi C. Isolation and functional characterization of human intestinal mucosal stellate cells (Abstract). Gastroenterology 122: A-111, 2002.
28. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102: 11070-11075, 2005.
29. Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 65: S140-S146, 2007.
30. Lichtenstein GR, Rutgeerts P. Importance of mucosal healing in ulcerative colitis. Inflamm Bowel Dis 16: 338-346, 2010.
31. Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nat Med 15: 846-847, 2009.
32. Lund PK, Zuniga CC. Intestinal fibrosis in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 17: 318-323, 2001.
33. Medzhitov R. Origin and physiological roles of inflammation. Nature 454: 428-435, 2008.
34. Mourelle M, Salas A, Guarner F, Crespo E, Garcia-Lafuente A, Malagelada JR. Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis. Gastroenterology 114: 519-526, 1998.
35. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10: 111-122, 2010.
36. Paz Z, Shoenfeld Y. Antifibrosis: to reverse the irreversible. Clin Rev Allergy Immunol 38: 276-286, 2010.
37. Pennisi E. Body's hardworking microbes get some overdue respect. Science 330: 1619, 2010.
38. Rappaport SM, Smith MT. Epidemiology. Environment and disease risks. Science 330: 460-461, 2010.
39. Rieder F, Fiocchi C. Intestinal fibrosis in IBD-a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol 6: 228-235, 2009.
40. Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol 24: 462-468, 2008.
41. Rieder F, Schleder S, Wolf A, Dirmeier A, Strauch U, Obermeier F, Lopez R, Spector L, Fire E, Yarden J, Rogler G, Dotan N, Klebl F. Serum anti-glycan antibodies predict complicated Crohn's disease behavior: a cohort study. Inflamm Bowel Dis 16: 1367-1375, 2010.
42. Rigby RJ, Hunt MR, Scull BP, Simmons JG, Speck KE, Helmrath MA, Lund PK. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora. Gut 58: 1104-1112, 2009.
43. Rivera RM, Bennett LB. Epigenetics in humans: an overview. Curr Opin Endocrinol Diabetes Obes 17: 493-499, 2010.
44. Rock KL, Kono H. The inflammatory response to cell death. Annu Rev Pathol 3: 99-126, 2008.
45. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 28: 321-342, 2010.
46. Rosenbloom J, Castro SV, Jimenez SA. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med 152: 159-166, 2010.
47. Rubartelli A, Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 28: 429-436, 2007.
48. Ruiz-Perez B, Chung DR, Sharpe AH, Yagita H, Kalka-Moll WM, Sayegh MH, Kasper DL, Tzianabos AO. Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proc Natl Acad Sci USA 102: 16753-16758, 2005.
49. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 461: 218-223, 2009.
50. Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel therapies. Gastroenterology 137: 1912-1933, 2009.
51. Sivakumar P, Das AM. Fibrosis, chronic inflammation and new pathways for drug discovery. Inflamm Res 57: 410-418, 2008.
52. Stevens EA, Bradfield CA. Immunology: T cells hang in the balance. Nature 453: 46-47, 2008.
53. Strohacker K, McFarlin BK. Influence of obesity, physical inactivity, and weight cycling on chronic inflammation. Front Biosci (Elite Ed) 2: 98-104, 2010.
54. Sun G, Reddy MA, Yuan H, Lanting L, Kato M, Natarajan R. Epigenetic histone methylation modulates fibrotic gene expression. J Am Soc Nephrol 21: 2069-2080, 2010.
55. Swaminathan S, Shah SV. New insights into nephrogenic systemic fibrosis. J Am Soc Nephrol 18: 2636-2643, 2007.
56. Szabo H, Fiorino G, Spinelli A, Rovida S, Repici A, Malesci AC, Danese S. Review article: anti-fibrotic agents for the treatment of Crohn's disease-lessons learnt from other diseases. Aliment Pharmacol Ther 31: 189-201, 2010.
57. Taskar V, Coultas D. Exposures and idiopathic lung disease. Semin Respir Crit Care Med 29: 670-679, 2008.
58. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027-1031, 2006.
59. Van Tol EA, Holt L, Li FL, Kong FM, Rippe R, Yamauchi M, Pucilowska J, Lund PK, Sartor RB. Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts. Am J Physiol Gastrointest Liver Physiol 277: G245-G255, 1999.
60. Weersma RK, Stokkers PC, van Bodegraven AA, van Hogezand RA, Verspaget HW, de Jong DJ, van der Woude CJ, Oldenburg B, Linskens RK, Festen EA, van der Steege G, Hommes DW, Crusius JB, Wijmenga C, Nolte IM, Dijkstra G. Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut 58: 388-395, 2009.
61. Wick G, Backovic A, Rabensteiner E, Plank N, Schwentner C, Sgonc R. The immunology of fibrosis: innate and adaptive responses. Trends Immunol 31: 110-119, 2010.
62. Wood MJ, Powell LW, Ramm GA. Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis. Blood 111: 4456-4462, 2008.
63. Wu F, Chakravarti S. Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. J Immunol 179: 6988-7000, 2007.
64. Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 117: 524-529, 2007.
65. Yan X, Huang Y, Wang H, Du M, Hess BW, Ford SP, Nathanielsz PW, Zhu MJ. Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep*. Inflamm Bowel Dis 2010. [EPub ahead of print].