Hydroxylase inhibition abrogates TNF-α-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD

Journal of Immunology

Volumn 185, Issue 10, 2010, Pages 6306-6316

  Hindryckx, Pieter ^a   De Vos, Martine ^a   Jacques, Peggy ^b   Ferdinande, Liesbeth ^b   Peeters, Harald ^a   Olievier, Kim ^a   Bogaert, Sara ^a   Brinkman, Brigitta ^b,c   Vandenabeele, Peter ^b,c   Elewaut, Dirk ^b   Laukens, Debby ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DIMETHYLOXALYLGLYCIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGENASE INHIBITOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENTERITIS; ILEITIS; ILEUM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ILEITIS; IMMUNITY, MUCOSAL; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MIXED FUNCTION OXYGENASES; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650654512     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002541     Document Type: Article

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