메뉴 건너뛰기




Volumn 37, Issue 9, 2014, Pages 637-643

Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1

Author keywords

Fibrosis; Hypoxia; Hypoxia inducible factor 1; Oxygen; Wound healing

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1;

EID: 84919457239     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2014.0150     Document Type: Review
Times cited : (150)

References (60)
  • 1
    • 84857535891 scopus 로고    scopus 로고
    • Critical role of hypoxia sensor--HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing
    • Ahluwalia, A., and Tarnawski, A.S. (2012). Critical role of hypoxia sensor--HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr. Med. Chem. 19, 90-97.
    • (2012) Curr. Med. Chem. , vol.19 , pp. 90-97
    • Ahluwalia, A.1    Tarnawski, A.S.2
  • 4
    • 84878544545 scopus 로고    scopus 로고
    • The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition
    • Barriga, E.H., Maxwell, P.H., Reyes, A.E., and Mayor, R. (2013). The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition. J. Cell Biol. 201, 759-776.
    • (2013) J. Cell Biol. , vol.201 , pp. 759-776
    • Barriga, E.H.1    Maxwell, P.H.2    Reyes, A.E.3    Mayor, R.4
  • 5
    • 79954463134 scopus 로고    scopus 로고
    • Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression
    • Basu, R.K., Hubchak, S., Hayashida, T., Runyan, C.E., Schumacker, P.T., and Schnaper, H.W. (2011). Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am. J. Physiol. Renal Physiol. 300, F898-905.
    • (2011) Am. J. Physiol. Renal Physiol. , vol.300 , pp. 898-905
    • Basu, R.K.1    Hubchak, S.2    Hayashida, T.3    Runyan, C.E.4    Schumacker, P.T.5    Schnaper, H.W.6
  • 6
    • 0034904751 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm
    • Berra, E., Roux, D., Richard, D.E., and Pouyssegur, J. (2001). Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm. EMBO Rep. 2, 615-620.
    • (2001) EMBO Rep. , vol.2 , pp. 615-620
    • Berra, E.1    Roux, D.2    Richard, D.E.3    Pouyssegur, J.4
  • 7
    • 84870248829 scopus 로고    scopus 로고
    • Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesisstimulating agents in current and preventive doping analysis
    • Beuck, S., Schanzer, W., and Thevis, M. (2012). Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesisstimulating agents in current and preventive doping analysis. Drug Test. Anal. 4, 830-845.
    • (2012) Drug Test. Anal. , vol.4 , pp. 830-845
    • Beuck, S.1    Schanzer, W.2    Thevis, M.3
  • 9
    • 9444296528 scopus 로고    scopus 로고
    • Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    • Catrina, S.B., Okamoto, K., Pereira, T., Brismar, K., and Poellinger, L. (2004). Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 53, 3226-3232.
    • (2004) Diabetes , vol.53 , pp. 3226-3232
    • Catrina, S.B.1    Okamoto, K.2    Pereira, T.3    Brismar, K.4    Poellinger, L.5
  • 10
    • 18844406447 scopus 로고    scopus 로고
    • Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue
    • Ceradini, D.J., and Gurtner, G.C. (2005). Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med. 15, 57-63.
    • (2005) Trends Cardiovasc. Med. , vol.15 , pp. 57-63
    • Ceradini, D.J.1    Gurtner, G.C.2
  • 13
    • 0027948327 scopus 로고
    • Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies
    • De Luca, M., Pellegrini, G., Zambruno, G., and Marchisio, P.C. (1994). Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies. J. Dermatol. 21, 821-828.
    • (1994) J. Dermatol. , vol.21 , pp. 821-828
    • De Luca, M.1    Pellegrini, G.2    Zambruno, G.3    Marchisio, P.C.4
  • 14
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson, D.A., Ryan, H.E., Snow, J.W., Johnson, R., and Arbeit, J.M. (2000). Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 60, 6189-6195.
    • (2000) Cancer Res. , vol.60 , pp. 6189-6195
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3    Johnson, R.4    Arbeit, J.M.5
  • 15
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J.A., Jiang, B.H., Iyer, N.V., Agani, F., Leung, S.W., Koos, R.D., and Semenza, G.L. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 16
    • 33847385903 scopus 로고    scopus 로고
    • High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway
    • Gao, W., Ferguson, G., Connell, P., Walshe, T., Murphy, R., Birney, Y.A., O’Brien, C., and Cahill, P.A. (2007). High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway. J. Mol. Cell. Cardiol. 42, 609-619.
    • (2007) J. Mol. Cell. Cardiol. , vol.42 , pp. 609-619
    • Gao, W.1    Ferguson, G.2    Connell, P.3    Walshe, T.4    Murphy, R.5    Birney, Y.A.6    O’Brien, C.7    Cahill, P.A.8
  • 20
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
    • Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S., and Kaelin, W.G., Jr. (2001). HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-468.
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3    Kim, W.4    Valiando, J.5    Ohh, M.6    Salic, A.7    Asara, J.M.8    Lane, W.S.9    Kaelin, W.G.10
  • 23
    • 33744960738 scopus 로고    scopus 로고
    • Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: Can we identify the right target genes? Proc
    • Kaminski, N., and Rosas, I.O. (2006). Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc. Am. Thorac. Soc. 3, 339-344.
    • (2006) Am. Thorac. Soc. , vol.3 , pp. 339-344
    • Kaminski, N.1    Rosas, I.O.2
  • 24
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J.W., Tchernyshyov, I., Semenza, G.L., and Dang, C.V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metabol. 3, 177-185.
    • (2006) Cell Metabol. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 26
    • 37749010070 scopus 로고    scopus 로고
    • Aerobic metabolism underlies complexity and capacity
    • Koch, L.G., and Britton, S.L. (2008). Aerobic metabolism underlies complexity and capacity. J. Physiol. 586, 83-95.
    • (2008) J. Physiol. , vol.586 , pp. 83-95
    • Koch, L.G.1    Britton, S.L.2
  • 28
    • 84881364698 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor nuclear translocator (ARNT) family of proteins: Transcriptional modifiers with multi-functional protein interfaces
    • Labrecque, M.P., Prefontaine, G.G., and Beischlag, T.V. (2013). The aryl hydrocarbon receptor nuclear translocator (ARNT) family of proteins: transcriptional modifiers with multi-functional protein interfaces. Curr. Mol. Med. 13, 1047-1065.
    • (2013) Curr. Mol. Med. , vol.13 , pp. 1047-1065
    • Labrecque, M.P.1    Prefontaine, G.G.2    Beischlag, T.V.3
  • 29
    • 84863183146 scopus 로고    scopus 로고
    • New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis
    • Lee, K., and Nelson, C.M. (2012). New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int. Rev. Cell Mol. Biol. 294, 171-221.
    • (2012) Int. Rev. Cell Mol. Biol. , vol.294 , pp. 171-221
    • Lee, K.1    Nelson, C.M.2
  • 30
    • 33846627240 scopus 로고    scopus 로고
    • Pathophysiology of acute wound healing
    • Li, J., Chen, J., and Kirsner, R. (2007). Pathophysiology of acute wound healing. Clin. Dermatol. 25, 9-18.
    • (2007) Clin. Dermatol. , vol.25 , pp. 9-18
    • Li, J.1    Chen, J.2    Kirsner, R.3
  • 32
    • 84879117465 scopus 로고    scopus 로고
    • Pathogenesis, current treatments and future directions for idiopathic pulmonary fibrosis
    • Loomis-King, H., Flaherty, K.R., and Moore, B.B. (2013). Pathogenesis, current treatments and future directions for idiopathic pulmonary fibrosis. Curr. Opin. Pharmacol. 13, 377-385.
    • (2013) Curr. Opin. Pharmacol. , vol.13 , pp. 377-385
    • Loomis-King, H.1    Flaherty, K.R.2    Moore, B.B.3
  • 33
    • 84857433362 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Pathobiology of novel approaches to treatment
    • Maher, T.M. (2012). Idiopathic pulmonary fibrosis: pathobiology of novel approaches to treatment. Clin. Chest Med. 33, 69-83.
    • (2012) Clin. Chest Med. , vol.33 , pp. 69-83
    • Maher, T.M.1
  • 35
    • 0041308236 scopus 로고    scopus 로고
    • Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology
    • Moulik, P.K., Mtonga, R., and Gill, G.V. (2003). Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care 26, 491-494.
    • (2003) Diabetes Care , vol.26 , pp. 491-494
    • Moulik, P.K.1    Mtonga, R.2    Gill, G.V.3
  • 36
    • 27744603002 scopus 로고    scopus 로고
    • Hypoxia regulates macrophage functions in inflammation
    • Murdoch, C., Muthana, M., and Lewis, C.E. (2005). Hypoxia regulates macrophage functions in inflammation. J. Immunol. 175, 6257-6263.
    • (2005) J. Immunol. , vol.175 , pp. 6257-6263
    • Murdoch, C.1    Muthana, M.2    Lewis, C.E.3
  • 37
    • 70649085074 scopus 로고    scopus 로고
    • HIF prolyl 4-hydroxylases and their potential as drug targets
    • Myllyharju, J. (2009). HIF prolyl 4-hydroxylases and their potential as drug targets. Curr. Pharm. Des. 15, 3878-3885.
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 3878-3885
    • Myllyharju, J.1
  • 38
    • 84877704490 scopus 로고    scopus 로고
    • Prolyl 4-hydroxylases, master regulators of the hypoxia response
    • Myllyharju, J. (2013). Prolyl 4-hydroxylases, master regulators of the hypoxia response. Acta Physiol. 208, 148-165.
    • (2013) Acta Physiol. , vol.208 , pp. 148-165
    • Myllyharju, J.1
  • 39
    • 84864740280 scopus 로고    scopus 로고
    • Pulmonary fibrosis: Patterns and Perpetrators
    • Noble, P.W., Barkauskas, C.E., and Jiang, D.H. (2012). Pulmonary fibrosis: patterns and Perpetrators. J. Clin. Invest. 122, 2756-2762.
    • (2012) J. Clin. Invest. , vol.122 , pp. 2756-2762
    • Noble, P.W.1    Barkauskas, C.E.2    Jiang, D.H.3
  • 40
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh, M., Park, C.W., Ivan, M., Hoffman, M.A., Kim, T.Y., Huang, L.E., Pavletich, N., Chau, V., and Kaelin, W.G. (2000). Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2, 423-427.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3    Hoffman, M.A.4    Kim, T.Y.5    Huang, L.E.6    Pavletich, N.7    Chau, V.8    Kaelin, W.G.9
  • 41
    • 80053936422 scopus 로고    scopus 로고
    • Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice
    • Pan, X., Suzuki, N., Hirano, I., Yamazaki, S., Minegishi, N., and Yamamoto, M. (2011). Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice. PLoS One 6, e25839.
    • (2011) PLoS One , vol.6 , pp. 25839
    • Pan, X.1    Suzuki, N.2    Hirano, I.3    Yamazaki, S.4    Minegishi, N.5    Yamamoto, M.6
  • 42
    • 1842478183 scopus 로고    scopus 로고
    • Hypoxic regulation of angiopoietin-2 expression in endothelial cells
    • Pichiule, P., Chavez, J.C., and LaManna, J.C. (2004). Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J. Biol. Chem. 279, 12171-12180.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12171-12180
    • Pichiule, P.1    Chavez, J.C.2    LaManna, J.C.3
  • 43
    • 0014248318 scopus 로고
    • Oxygen gradients in healing wounds
    • Remensnyder, J.P., and Majno, G. (1968). Oxygen gradients in healing wounds. Am. J. Pathol. 52, 301-323.
    • (1968) Am. J. Pathol. , vol.52 , pp. 301-323
    • Remensnyder, J.P.1    Majno, G.2
  • 44
    • 53249117183 scopus 로고    scopus 로고
    • Oxidative stress in normal and impaired wound repair
    • Schafer, M., and Werner, S. (2008). Oxidative stress in normal and impaired wound repair. Pharmacol. Res. 58, 165-171.
    • (2008) Pharmacol. Res. , vol.58 , pp. 165-171
    • Schafer, M.1    Werner, S.2
  • 45
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza, G.L. (2012). Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 46
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G.L., and Wang, G.L. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12, 5447-5454.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 48
    • 77958042201 scopus 로고    scopus 로고
    • Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans
    • Taylor, C.T., and McElwain, J.C. (2010). Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans. Physiology 25, 272-279.
    • (2010) Physiology , vol.25 , pp. 272-279
    • Taylor, C.T.1    McElwain, J.C.2
  • 49
    • 12844252393 scopus 로고    scopus 로고
    • Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells
    • Tepper, O.M., Capla, J.M., Galiano, R.D., Ceradini, D.J., Callaghan, M.J., Kleinman, M.E., and Gurtner, G.C. (2005). Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow-derived cells. Blood 105, 1068-1077.
    • (2005) Blood , vol.105 , pp. 1068-1077
    • Tepper, O.M.1    Capla, J.M.2    Galiano, R.D.3    Ceradini, D.J.4    Callaghan, M.J.5    Kleinman, M.E.6    Gurtner, G.C.7
  • 51
    • 84867607862 scopus 로고    scopus 로고
    • Lactate, a novel trigger of transforming growth factor-beta activation in idiopathic pulmonary fibrosis
    • Tuder, R.M., Lara, A.R., and Thannickal, V.J. (2012). Lactate, a novel trigger of transforming growth factor-beta activation in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 186, 701-703.
    • (2012) Am. J. Respir. Crit. Care Med. , vol.186 , pp. 701-703
    • Tuder, R.M.1    Lara, A.R.2    Thannickal, V.J.3
  • 53
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang, G.L., and Semenza, G.L. (1993). Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513-21518.
    • (1993) J. Biol. Chem. , vol.268 , pp. 21513-21518
    • Wang, G.L.1    Semenza, G.L.2
  • 54
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G.L., Jiang, B.H., Rue, E.A., and Semenza, G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92, 5510-5514.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 55
    • 84897879302 scopus 로고    scopus 로고
    • Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype
    • Watson, C.J., Collier, P., Tea, I., Neary, R., Watson, J.A., Robinson, C., Phelan, D., Ledwidge, M.T., McDonald, K.M., McCann, A., et al. (2014). Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Hum. Mol. Genet. 23, 2176-2188.
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 2176-2188
    • Watson, C.J.1    Collier, P.2    Tea, I.3    Neary, R.4    Watson, J.A.5    Robinson, C.6    Phelan, D.7    Ledwidge, M.T.8    McDonald, K.M.9    McCann, A.10
  • 58
    • 84873344021 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
    • Zeisberg, M., and Kalluri, R. (2013). Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am. J. Physiol. Cell Physiol. 304, C216-C225.
    • (2013) Am. J. Physiol. Cell Physiol. , vol.304 , pp. C216-C225
    • Zeisberg, M.1    Kalluri, R.2
  • 60
    • 84893185949 scopus 로고    scopus 로고
    • Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice
    • Zhang, X., Yan, X., Cheng, L., Dai, J., Wang, C., Han, P., and Chai, Y. (2013). Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice. PLoS One 8, e84548.
    • (2013) PLoS One , vol.8 , pp. 84548
    • Zhang, X.1    Yan, X.2    Cheng, L.3    Dai, J.4    Wang, C.5    Han, P.6    Chai, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.