Elevation of expression of Smads 2, 3, and 4, decorin and TGF-β in the chronic phase of myocardial infarct scar healing

Journal of Molecular and Cellular Cardiology

Volumn 31, Issue 3, 1999, Pages 667-678

  Hao, Jianming ^a   Ju, Haisong ^a   Zhao, Shufang ^a   Junaid, Asad ^b   Scammell La Fleur, Tracy ^a   Dixon, Ian M C ^a,b  

^a Institute of Cardiovascular Sciences   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cardiac remodeling; Collagen; Decorin; Infarct scar; Myocardial infarction; Smad proteins; Transforming growth factor 1

Indexed keywords

COLLAGEN; DECORIN; MATRIX PROTEIN; STRUCTURAL PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; HEALING; HEART FAILURE; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCAR; SIGNAL TRANSDUCTION;

EID: 0033104679     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1998.0902     Document Type: Article

References (62)

1. Border WA, Noble NA, 1994. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292.
2. Brand T, Schneider MD, 1995. The TGF beta superfamily in myocardium: Ligands, receptors, transduction, and function. J Mol Cell Cardiol 27: 5-18.
3. Brilla CG, Zhou G, Matsubara L, Weber KT, 1994. Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone. J Mol Cell Cardiol 26: 809-820.
4. Centrella M, Ji C, Casinghino S, McCarthy TL, 1996. Rapid flux in transforming growth factor-beta receptors on bone cells. J Biol Chem 271: 18616-18622.
5. Chareonthaitawee P, Christian TF, Hirose K, Gibbons RJ, Rumberger JA, 1995. Relation of initial infarct size to extent of left ventricular remodeling in the year after acute myocardial infarction. J Am Coll Cardiol 25: 567-573.
6. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M, 1997. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389: 85-89.
7. Chiariello M, Ambrosio G, Cappelli Bigazzi M, Perrone Filardi P, Brigante F, Sifola C, 1986. A biochemical method for the quantitation of myocardial scarring after experimental coronary artery occlusion. J Mol Cell Cardiol 18: 283-290.
8. Chomczynski P, Sacchi N, 1987. Single-step method of RNA isolation by acid guanidium thiocyanatephenol-chloroform extraction. Anal Biochem 162: 156-159.
9. Chua CC, Chua BH, Zhao ZY, Krebs C, Diglio C, Perrin E, 1991. Effect of growth factors on collagen metabolism in cultured heart fibroblasts. Connect Tissue Res 26: 271-281.
10. Cleutjens JP, Verluyten MJ, Smits JF, Daemen MJ, 1995. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol 147: 325-338.
11. Crabos M, Roth M, Hahn AW, Erne P, 1994. Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression. J Clin Invest 93: 2372-2378.
12. Dixon IMC, Lee SL, Dhalla NS, 1990. Nitrendipine binding in congestive heart failure due to myocardial infarction. Circ Res 66: 782-788.
13. Dixon IMC, Hata T, Dhalla NS, 1992. Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats. Am J Physiol 262: H1387-H1394.
14. Eghbali M, 1989. Cellular origin and distribution of transforming growth factor-beta in the normal rat myocardium. Cell Tissue Res 256: 553-558.
15. Eghbali M, Sigel A, 1995. Role of transforming growth factor beta-1 in the remodeling of collagen matrix in the heart. In Heart Hypertrophy and Failure, N.S. Dhalla, G.N. Pierce, V. Panagia and R.E. Beamish, pp. 287-297. Boston: Kluwer Academic Publishers.
16. Eghbali M, Tomek R, Sukhatme VP, Woods C, Bhambi B, 1991. Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors. Circ Res 69: 483-490.
17. Engelmann GL, Grutkoski PS, 1994. Coordinate TGF-beta receptor gene expression during rat heart development. Cell Mol Biol Res 40: 93-104.
18. Engelmann GL, Boehm KD, Birchenall Roberts MC, Ruscetti FW, 1992. Transforming growth factor-beta 1 in heart development. Mech Dev 38: 85-97.
19. Fishbein MC, MacLean D, Maroko PE, 1978. Experimental myocardial infarction in the rat: Qualitative and quantitative changes during pathologic evolution. Am J Pathol 90: 57-70.
20. Flanders KC, Winokur TS, Holder MG, Sporn MB, 1993. Hyperthermia induces expression of transforming growth factor-betas in rat cardiac cells in vitro and in vivo. J Clin Invest 92: 404-410.
21. Hall FL, Benya PD, Padilla SR, Carbonaro Hall D, Williams R, Buckley S, Warburton D, 1996. Transforming growth factor-beta type-II receptor signalling: Intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies. Biochem J 316: 303-310.
22. Heimer R, Bashey RI, Kyle J, Jiminez SA, 1995. TGF-beta modulates the synthesis of proteoglycans by myocardial fibroblasts in culture. J Mol Cell Cardiol 27: 2191-2198.
23. Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E, 1994. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 302: 527-534.
24. Holmes JW, Nunez JA, Covell JW, 1997. Functional implications of myocardial scar structure. Am J Physiol 272: H2123-H2130.
25. Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA, 1996. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 2: 418-423.
26. Ju H, Scammel LaFleur T, Dixon IMC, 1996. Altered mRNA abundance of calcium transported genes in cardiac myocytes induced by angiotensin II. J Mol Cell Cardiol 28: 1119-1128.
27. Ju H, Zhao S, Davinder SJ, Dixon IM, 1997. Effect of AT1 receptor blockade on cardiac collagen remodeling after myocardial infarction. Cardiovasc Res 35: 223-232.
28. Ju H, Zhao S, Tappia P, Panagia V, Dixon IMC, 1998. Expression of Gqalpha and PLC-beta in scar and border tissue in heart failure due to myocardial infraction. Circulation 97: 892-899.
29. Junaid A, Rosenberg ME, Hostetter TH, 1997. Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney [published erratum appears in J Am Soc Nephrol (1998) 9(1):154]. J Am Soc Nephrol 8: 1732-1738.
30. Lagna G, Hata A, Hemmati Brivanlou A, Massague J, 1996. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 383: 832-836.
31. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ, 1995. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac flbroblasts. J Mol Cell Cardiol 27: 2347-2357.
32. Lefroy DC, Wharton J, Crake T, Knock GA, Rutherford RA, Suzuki T, Morgan K, Polak JM, Poole-Wilson PA, 1996. Regional changes in angiotensin II receptor density after experimental myocardial infarction. J Mol Cell Cardiol 28: 429-440.
33. Li JM, Brooks G, 1997. Differential protein expression and subcellular distribution of TGF beta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy. J Mol Cell Cardiol 29: 2213-2224.
34. Liu F, Pouponnot C, Massague J, 1997. Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev 11: 3157-3167.
35. Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF, 1997. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci USA 94: 10669-10674.
36. Macias Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL, 1996. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
37. Massague J, 1990. The transforming growth factor-beta family. Annu Rev Cell Biol 6: 597-641.
38. Massague J, 1998. TGF-beta signal transduction. Annu Rev Biochem 67: 753-791.
39. Massague J, Hata A, Liu F, 1997. TGF-beta signalling through the Smad pathway. Trends Cell Biol 7: 187-192.
40. McCaffrey TA, Consiglis S, Du B, Falcone DJ, Sanborn TA, Spokojny AM, Bush HLJ, 1995. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1. J Clin Invest 96: 2667-2675.
41. Miyazono K, 1997. TGF-beta receptors and signal transduction. Int J Hematol 65: 97-104.
42. Mucsi I, Goldberg HJ, 1997. Dominant-negative SMAD-3 interferes with transcriptional activation by multiple agonists. Biochem Biophys Res Commun 232: 517-521.
43. Pelouch V, Dixon IM, Sethi R, Dhalla NS, 1993. Alteration of collagenous protein profile in congestive heart failure secondary to myocardial infarction. Mol Cell Biochem 129: 121-131.
44. Peterson D, Ju H, Panagia M, Chapman D, Dixon IMC, 1998. Expression of Gia2 and Gsa in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction. Cardiovasc Res in press.
45. Pfeffer JM, Fischer TA, Pfeffer MA, 1995. Angiotensin-converting enzyme inhibition and ventricular remodeling after myocardial infarction. Annu Rev Physiol 57: 805-826.
46. Pfeffer MA, Braunwald E, 1990. Ventricular remodeling after myocardial infraction. Experimental observations and clinical implications. Circulation 81: 1161-1172.
47. Roberts AB, Sporn MB, 1990. The transforming growth factor-betas. In Peptide Growth Factors and their Receptors I, M.B. Sporn and A.B. Roberts, pp. 420-472. Handbook of Experimental Pharmacology. New York: Springer-Verlag.
48. Sadoshima J, Izumo S, 1993. Molecular characterization and angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73: 413-423.
49. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC, 1985. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85.
50. Sun Y, Weber KT, 1996. Cells expressing angiotensin II receptors in fibrous tissue of rat heart. Cardiovasc Res 31: 518-525.
51. Takahashi N, Calderone A, Izzo NJ, Jr., Maki TM, Marsh JD, Colucci WS, 1994. Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes. J Clin Invest 94: 1470-1476.
52. Thompson NL, Bazoberry F, Speir EH, Casscells W, Ferrans VJ, Flanders KC, Kondaiah P, Geiser AG, Sporn MB, 1988. Transforming growth factor beta-1 in acute myocardial infarction in rats. Growth Factors 1: 91-99.
53. Villarreal FJ, Lee AA, Dillmann WH, Giordano FJ, 1996. Adenovirus-mediated overexpression of human transforming growth factor-beta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells. J Mol Cell Cardiol 28: 735-742.
54. Vracko R, Thorning D, 1991. Contractile cells in rat myocardial scar tissue. Lab Invest 65: 214-227.
55. Ward MR, Agrotis A, Jennings G, Bobik A, 1998. Vascular types I and II transforming growth factor-beta receptor expression: Differential dependency on tyrosine kinases during induction by TGF-beta. FEBS Lett 422: 197-200.
56. Weber KT, 1989. Cardiac interstitium in health and disease: The fibrillar collagen network. J Am Coll Cardiol 13: 1637-1652.
57. Weber KT, Sun Y, Katwa LC, 1996. Wound healing following myocardial infarction. Clin Cardiol 19: 447-455.
58. Willems IE, Havenith MG, De Mey JG, Daemen MJ, 1994. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am J Pathol 145: 868-875.
59. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J, 1994. Mechanism of activation of the TGF-beta receptor. Nature 370: 341-347.
60. Yamagishi H, Kim S, Nishikimi T, Takeuchi K, Takeda T, 1993. Contribution of cardiac renin-angiotensin system to ventricular remodelling in myocardial-infarcted rats. J Mol Cell Cardiol 25: 1369-1380.
61. Yamaguchi Y, Mann DM, Ruoslahti E, 1990. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346: 281-284.
62. Zhang Y, Feng X, We R, Derynck R, 1996. Receptor-associated mad homologues synergize as effectors of the TGF-beta response. Nature 383: 168-172.