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Volumn 276, Issue 6, 2014, Pages 579-617

Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications

Author keywords

Critical nanoscale design parameters; Dendrimers; Drug delivery; Nanomedicine; Nanoperiodic concept

Indexed keywords

COMPLEMENTARY DNA; DENDRIMER; FUNCTIONAL GROUP; GEMCITABINE; NANOCARRIER; NANOMATERIAL; NANOPARTICLE; PACLITAXEL; POLYAMIDOAMINE; POLYMER; PROTEIN DERIVATIVE; SMALL INTERFERING RNA;

EID: 84911990896     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/joim.12280     Document Type: Review
Times cited : (445)

References (228)
  • 1
    • 84870680872 scopus 로고    scopus 로고
    • The nanomedicine revolution, part 3: regulatory and safety challenges
    • Ventola CL. The nanomedicine revolution, part 3: regulatory and safety challenges. Pharm Ther 2012; 37: 632-9.
    • (2012) Pharm Ther , vol.37 , pp. 632-639
    • Ventola, C.L.1
  • 3
    • 33746985456 scopus 로고    scopus 로고
    • Polymer therapeutics-polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities
    • Duncan R, Ringsdorf H, Satchi-Fainaro R. Polymer therapeutics-polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities. J Drug Target 2006; 14: 337-41.
    • (2006) J Drug Target , vol.14 , pp. 337-341
    • Duncan, R.1    Ringsdorf, H.2    Satchi-Fainaro, R.3
  • 4
    • 0016622773 scopus 로고
    • Structure and properties of pharmacologically active polymers
    • Ringsdorf H. Structure and properties of pharmacologically active polymers. J Appl Polym Sci Symp 1975; 51: 135-53.
    • (1975) J Appl Polym Sci Symp , vol.51 , pp. 135-153
    • Ringsdorf, H.1
  • 5
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan R. The dawning era of polymer therapeutics. Nature Rev 2003; 2: 347-60.
    • (2003) Nature Rev , vol.2 , pp. 347-360
    • Duncan, R.1
  • 6
    • 33745461665 scopus 로고    scopus 로고
    • Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties
    • Nijhara R, Balakrishnan K. Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties. Nanomedicine 2006; 2: 127-36.
    • (2006) Nanomedicine , vol.2 , pp. 127-136
    • Nijhara, R.1    Balakrishnan, K.2
  • 7
    • 79955812915 scopus 로고    scopus 로고
    • Considerations when submitting nanotherapeutics to FDA/CDER for regulatory review
    • Tyner K, Sadrieh N. Considerations when submitting nanotherapeutics to FDA/CDER for regulatory review. Methods Mol Biol 2011; 697: 17-31.
    • (2011) Methods Mol Biol , vol.697 , pp. 17-31
    • Tyner, K.1    Sadrieh, N.2
  • 9
    • 84875167951 scopus 로고    scopus 로고
    • Dendrimer and cancer: a patent review (2006-present)
    • Cai X, Hu J, Xiao J, Cheng Y. Dendrimer and cancer: a patent review (2006-present). Expert Opin Ther Pat 2013; 23: 515-29.
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 515-529
    • Cai, X.1    Hu, J.2    Xiao, J.3    Cheng, Y.4
  • 10
    • 79953774517 scopus 로고    scopus 로고
    • Regulating nanomedicine - can the FDA handle it?
    • Bawa R. Regulating nanomedicine - can the FDA handle it? Curr Drug Deliv 2011; 8: 227-34.
    • (2011) Curr Drug Deliv , vol.8 , pp. 227-234
    • Bawa, R.1
  • 11
    • 79957745191 scopus 로고    scopus 로고
    • Nanotechnology and nanomedicine for healthcare: challenges in translating innovations from bench to bedside
    • Bellare JR. Nanotechnology and nanomedicine for healthcare: challenges in translating innovations from bench to bedside. J Biomed Nanotechnol 2011; 7: 36-7.
    • (2011) J Biomed Nanotechnol , vol.7 , pp. 36-37
    • Bellare, J.R.1
  • 14
    • 79959872019 scopus 로고    scopus 로고
    • Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles
    • Valencia PM, Hanewich-Hollatz MH, Gao W et al. Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles. Biomaterials 2011; 32: 6226-33.
    • (2011) Biomaterials , vol.32 , pp. 6226-6233
    • Valencia, P.M.1    Hanewich-Hollatz, M.H.2    Gao, W.3
  • 15
    • 0035937592 scopus 로고    scopus 로고
    • Block copolymer micelles for drug delivery: design, characterization and biological significance
    • Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001; 47: 113-31.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 113-131
    • Kataoka, K.1    Harada, A.2    Nagasaki, Y.3
  • 16
    • 84911989810 scopus 로고    scopus 로고
    • 6224898 (2001); 6475994 (2002); 6471968 (2002); 7005124 (2006).
    • Tomalia DA et al. U.S. Patents: 5714166 (1998); 6224898 (2001); 6475994 (2002); 6471968 (2002); 7005124 (2006).
    • (1998)
    • Tomalia, D.A.1
  • 18
    • 84911985377 scopus 로고    scopus 로고
    • A proposed taxonomy and classification strategy for well-defined, soft-matter nanoscale building blocks
    • Tomas T, Bottari G, eds. Hoboken, NJ: John Wiley & Sons
    • Christensen JB, Tomalia DA. A proposed taxonomy and classification strategy for well-defined, soft-matter nanoscale building blocks. In: Tomas T, Bottari G, eds. Organic Nanomaterials: Synthesis, Characterization, and Device Applications. Hoboken, NJ: John Wiley & Sons, 2013; 1-32.
    • (2013) Organic Nanomaterials: Synthesis, Characterization, and Device Applications , pp. 1-32
    • Christensen, J.B.1    Tomalia, D.A.2
  • 19
    • 0025373701 scopus 로고
    • Starburst dendrimers: molecular level control of size, shape, surface chemistry, topology and flexibility from atoms to macroscopic matter
    • Tomalia DA, Naylor AM, Goddard WA III. Starburst dendrimers: molecular level control of size, shape, surface chemistry, topology and flexibility from atoms to macroscopic matter. Angew Chem Int Ed Engl 1990; 29: 138-75.
    • (1990) Angew Chem Int Ed Engl , vol.29 , pp. 138-175
    • Tomalia, D.A.1    Naylor, A.M.2    Goddard, W.A.3
  • 20
    • 68149173128 scopus 로고    scopus 로고
    • In quest of a systematic framework for unifying and defining nanoscience
    • Tomalia DA. In quest of a systematic framework for unifying and defining nanoscience. J Nanopart Res 2009; 11: 1251-310.
    • (2009) J Nanopart Res , vol.11 , pp. 1251-1310
    • Tomalia, D.A.1
  • 21
    • 75949118217 scopus 로고    scopus 로고
    • Dendrons/Dendrimer: quantized, nano-element like building blocks for soft-soft and soft-hard nano-compound synthesis
    • Tomalia DA. Dendrons/Dendrimer: quantized, nano-element like building blocks for soft-soft and soft-hard nano-compound synthesis. Soft Matter 2010; 6: 456-74.
    • (2010) Soft Matter , vol.6 , pp. 456-474
    • Tomalia, D.A.1
  • 23
    • 84893685184 scopus 로고    scopus 로고
    • In quest of a systematic framework for unifying and defining nanoscience
    • 1430002-1-47
    • Tomalia DA, Khanna SN. In quest of a systematic framework for unifying and defining nanoscience. Mod Phys Lett B 2014; 28: 1430002-1-47.
    • (2014) Mod Phys Lett B , vol.28
    • Tomalia, D.A.1    Khanna, S.N.2
  • 25
    • 0026470988 scopus 로고
    • Directed molecular evolution
    • Joyce GF. Directed molecular evolution. Sci Am 1992; 267: 90-7.
    • (1992) Sci Am , vol.267 , pp. 90-97
    • Joyce, G.F.1
  • 26
    • 0037062978 scopus 로고    scopus 로고
    • The antiquity of RNA-based evolution
    • Joyce GF. The antiquity of RNA-based evolution. Nature 2002; 418: 214-21.
    • (2002) Nature , vol.418 , pp. 214-221
    • Joyce, G.F.1
  • 28
    • 84907515191 scopus 로고    scopus 로고
    • Dendrimers as quantized nano-modules in the nanotechnology field
    • Hoboken, NJ: John Wiley & Sons
    • Christensen JB, Tomalia DA. Dendrimers as quantized nano-modules in the nanotechnology field. In: Designing Dendrimers. Hoboken, NJ: John Wiley & Sons, 2012; 1-33.
    • (2012) Designing Dendrimers , pp. 1-33
    • Christensen, J.B.1    Tomalia, D.A.2
  • 29
    • 84898919503 scopus 로고    scopus 로고
    • Precision synthesis of subnanoparticles using dendrimers as a superatom synthesizer
    • Yamamoto K, Imaoka T. Precision synthesis of subnanoparticles using dendrimers as a superatom synthesizer. Acc Chem Res 2014; 47: 1127-36.
    • (2014) Acc Chem Res , vol.47 , pp. 1127-1136
    • Yamamoto, K.1    Imaoka, T.2
  • 30
    • 85050577752 scopus 로고    scopus 로고
    • Developing superatom science
    • Kemsley J. Developing superatom science. Chem Eng News 2013; 2013: 24-5.
    • (2013) Chem Eng News , vol.2013 , pp. 24-25
    • Kemsley, J.1
  • 31
    • 0033614097 scopus 로고    scopus 로고
    • Tobacco mosiac virus particle structure and the initiation of disassembly
    • Klug A. Tobacco mosiac virus particle structure and the initiation of disassembly. Phil Trans R Soc Lond B 1999; 354: 531-5.
    • (1999) Phil Trans R Soc Lond B , vol.354 , pp. 531-535
    • Klug, A.1
  • 32
    • 84985631191 scopus 로고
    • From macromolecules to biological assemblies (Nobel lecture)
    • Klug A. From macromolecules to biological assemblies (Nobel lecture). Angew Chem Int Ed 1983; 22: 565-82.
    • (1983) Angew Chem Int Ed , vol.22 , pp. 565-582
    • Klug, A.1
  • 33
    • 77951877325 scopus 로고    scopus 로고
    • Conscripts of the infinite armada: systemic cancer therapy using nanomaterials
    • Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR. Conscripts of the infinite armada: systemic cancer therapy using nanomaterials. Nat Rev 2010; 7: 266-76.
    • (2010) Nat Rev , vol.7 , pp. 266-276
    • Scheinberg, D.A.1    Villa, C.H.2    Escorcia, F.E.3    McDevitt, M.R.4
  • 34
    • 79959874185 scopus 로고    scopus 로고
    • Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations
    • Wijagkanalan W, Kawakami S, Hashida M. Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations. Pharm Res 2011; 28: 1500-19.
    • (2011) Pharm Res , vol.28 , pp. 1500-1519
    • Wijagkanalan, W.1    Kawakami, S.2    Hashida, M.3
  • 35
    • 0036844787 scopus 로고    scopus 로고
    • Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis
    • Iyer M, Mishra R, Han Y, Hopfinger AJ. Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis. Pharm Res 2002; 19: 1611-21.
    • (2002) Pharm Res , vol.19 , pp. 1611-1621
    • Iyer, M.1    Mishra, R.2    Han, Y.3    Hopfinger, A.J.4
  • 36
    • 79960733045 scopus 로고    scopus 로고
    • Interactions of poly(amidoamine) dendrimers with human serum albumin: Binding constants and mechanisms
    • Giri J, Diallo MS, Simpson AJ, Goddard WA III, Kumar R, Woods GC. Interactions of poly(amidoamine) dendrimers with human serum albumin: Binding constants and mechanisms. ACS Nano 2011; 5: 3456-68.
    • (2011) ACS Nano , vol.5 , pp. 3456-3468
    • Giri, J.1    Diallo, M.S.2    Simpson, A.J.3    Goddard, W.A.4    Kumar, R.5    Woods, G.C.6
  • 37
    • 77958599623 scopus 로고    scopus 로고
    • The influence of dendron's architecture on the "rigid" and "flexible" behaviour in binding DNA-a modelling study
    • Pavan GM, Danini A. The influence of dendron's architecture on the "rigid" and "flexible" behaviour in binding DNA-a modelling study. Phys Chem Chem Phys 2010; 1: 13914-7.
    • (2010) Phys Chem Chem Phys , vol.1 , pp. 13914-13917
    • Pavan, G.M.1    Danini, A.2
  • 38
    • 84871952514 scopus 로고    scopus 로고
    • Theoretical and computational studies of dendrimers as delivery vectors
    • Tian W, Ma Y. Theoretical and computational studies of dendrimers as delivery vectors. Chem Soc Rev 2013; 42: 705-27.
    • (2013) Chem Soc Rev , vol.42 , pp. 705-727
    • Tian, W.1    Ma, Y.2
  • 39
    • 84873718392 scopus 로고    scopus 로고
    • Physicochemical properties determine nanomaterial cellular uptake, transport, and fate
    • Zhu M, Nie G, Meng H, Xia T, Nel A, Zhao Y. Physicochemical properties determine nanomaterial cellular uptake, transport, and fate. Acc Chem Res 2013; 46: 622-31.
    • (2013) Acc Chem Res , vol.46 , pp. 622-631
    • Zhu, M.1    Nie, G.2    Meng, H.3    Xia, T.4    Nel, A.5    Zhao, Y.6
  • 40
    • 79959811662 scopus 로고    scopus 로고
    • Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism
    • Meng H, Yang S, Li Z et al. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano 2011; 5: 4434-47.
    • (2011) ACS Nano , vol.5 , pp. 4434-4447
    • Meng, H.1    Yang, S.2    Li, Z.3
  • 41
    • 36749045172 scopus 로고    scopus 로고
    • The molecular architecture of the nuclear pore complex
    • Alber F, Dokudovskaya S, Veenhoff LM et al. The molecular architecture of the nuclear pore complex. Nature 2007; 450: 695-701.
    • (2007) Nature , vol.450 , pp. 695-701
    • Alber, F.1    Dokudovskaya, S.2    Veenhoff, L.M.3
  • 42
    • 78049323834 scopus 로고    scopus 로고
    • Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future
    • Gil PR, Oberdorster G, Elder A, Puntes V, Parak WJ. Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future. ACS Nano 2010; 4: 5527-31.
    • (2010) ACS Nano , vol.4 , pp. 5527-5531
    • Gil, P.R.1    Oberdorster, G.2    Elder, A.3    Puntes, V.4    Parak, W.J.5
  • 43
    • 81855198887 scopus 로고    scopus 로고
    • Factors controlling nanoparticles pharmacokinetics: an integrated analysis and perspective
    • Moghimi SM, Hunter AC, Andresen TL. Factors controlling nanoparticles pharmacokinetics: an integrated analysis and perspective. Annu Rev Pharmacol Toxicol 2012; 52: 481-503.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 481-503
    • Moghimi, S.M.1    Hunter, A.C.2    Andresen, T.L.3
  • 44
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000; 65: 271-84.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 45
    • 33847017288 scopus 로고    scopus 로고
    • Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging
    • Tomalia DA, Reyna LA, Svenson S. Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochem Soc Trans 2007; 35: 61-7.
    • (2007) Biochem Soc Trans , vol.35 , pp. 61-67
    • Tomalia, D.A.1    Reyna, L.A.2    Svenson, S.3
  • 46
    • 35148864458 scopus 로고    scopus 로고
    • Renal clearance of quantum dots
    • Choi HS, Liu W, Misra P et al. Renal clearance of quantum dots. Nat Biotechnol 2007; 25: 1165-70.
    • (2007) Nat Biotechnol , vol.25 , pp. 1165-1170
    • Choi, H.S.1    Liu, W.2    Misra, P.3
  • 47
    • 61649102498 scopus 로고    scopus 로고
    • Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine
    • Burns AA, Vider J, Ow H et al. Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett 2009; 9: 442-8.
    • (2009) Nano Lett , vol.9 , pp. 442-448
    • Burns, A.A.1    Vider, J.2    Ow, H.3
  • 49
    • 78649538085 scopus 로고    scopus 로고
    • Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering
    • Hamad I, Al-Hanbali O, Hunger AC, Rutt KJ, Andresen TL, Moghimi SM. Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. ACS Nano 2010; 4: 6629-38.
    • (2010) ACS Nano , vol.4 , pp. 6629-6638
    • Hamad, I.1    Al-Hanbali, O.2    Hunger, A.C.3    Rutt, K.J.4    Andresen, T.L.5    Moghimi, S.M.6
  • 51
    • 68649116329 scopus 로고    scopus 로고
    • Stoichiometry and structure of poly(amidoamine) dendrimer-lipid complexes
    • Kelly CV, Liroff MG, Triplett LD et al. Stoichiometry and structure of poly(amidoamine) dendrimer-lipid complexes. ACS Nano 2009; 3: 1886-96.
    • (2009) ACS Nano , vol.3 , pp. 1886-1896
    • Kelly, C.V.1    Liroff, M.G.2    Triplett, L.D.3
  • 52
    • 36049015878 scopus 로고    scopus 로고
    • Size-dependent cytoxocity of gold nanoparticles
    • Pan Y, Neuss S, Leifert A et al. Size-dependent cytoxocity of gold nanoparticles. Small 2007; 3: 1941-9.
    • (2007) Small , vol.3 , pp. 1941-1949
    • Pan, Y.1    Neuss, S.2    Leifert, A.3
  • 53
    • 83555166219 scopus 로고    scopus 로고
    • Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
    • Cabral H, Matsumoto Y, Mizuno K et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011; 6: 815-23.
    • (2011) Nat Nanotechnol , vol.6 , pp. 815-823
    • Cabral, H.1    Matsumoto, Y.2    Mizuno, K.3
  • 54
    • 0024470863 scopus 로고
    • Influence of vesicle size, lipid composition and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
    • Mayer LD, Tai LCL, Ko DSC et al. Influence of vesicle size, lipid composition and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res 1989; 49: 5922-30.
    • (1989) Cancer Res , vol.49 , pp. 5922-5930
    • Mayer, L.D.1    Tai, L.C.L.2    Ko, D.S.C.3
  • 55
    • 84874636369 scopus 로고    scopus 로고
    • Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates
    • Tang L, Gabrielson NP, Uckun FM, Fan TM, Cheng J. Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates. Mol Pharm 2013; 10: 883-92.
    • (2013) Mol Pharm , vol.10 , pp. 883-892
    • Tang, L.1    Gabrielson, N.P.2    Uckun, F.M.3    Fan, T.M.4    Cheng, J.5
  • 56
    • 84881442222 scopus 로고    scopus 로고
    • Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems
    • Yue J, Liu S, Xie Z, Xing Y, Jing X. Size-dependent biodistribution and antitumor efficacy of polymer micelle drug delivery systems. J Mater Chem B 2013; 1: 4273-80.
    • (2013) J Mater Chem B , vol.1 , pp. 4273-4280
    • Yue, J.1    Liu, S.2    Xie, Z.3    Xing, Y.4    Jing, X.5
  • 57
    • 0029006392 scopus 로고
    • Effect of the non-cross-resistant anthracycline annamycin incorporated in liposomes
    • Zou YY, Ling YH, Reddy ST, Priebe W, Perezsoler R. Effect of the non-cross-resistant anthracycline annamycin incorporated in liposomes. Int J Cancer 1995; 61: 666-71.
    • (1995) Int J Cancer , vol.61 , pp. 666-671
    • Zou, Y.Y.1    Ling, Y.H.2    Reddy, S.T.3    Priebe, W.4    Perezsoler, R.5
  • 58
    • 77955251549 scopus 로고    scopus 로고
    • The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles
    • Lee H, Fonge H, Hoang B, Reilly RM, Allen C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol Pharm 2010; 7: 1195-208.
    • (2010) Mol Pharm , vol.7 , pp. 1195-1208
    • Lee, H.1    Fonge, H.2    Hoang, B.3    Reilly, R.M.4    Allen, C.5
  • 59
    • 84864722016 scopus 로고    scopus 로고
    • Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates
    • Tang L, Fan TM, Borst LB, Cheng JJ. Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates. ACS Nano 2012; 6: 3954-66.
    • (2012) ACS Nano , vol.6 , pp. 3954-3966
    • Tang, L.1    Fan, T.M.2    Borst, L.B.3    Cheng, J.J.4
  • 60
    • 84896696928 scopus 로고    scopus 로고
    • Heterogeneity in nanoparticles influences biodistribution and targeting
    • Adjei IM, Peetla C, Labhasetwar V. Heterogeneity in nanoparticles influences biodistribution and targeting. Nanomedicine 2014; 9: 267-78.
    • (2014) Nanomedicine , vol.9 , pp. 267-278
    • Adjei, I.M.1    Peetla, C.2    Labhasetwar, V.3
  • 61
    • 84886310583 scopus 로고    scopus 로고
    • Strategies for advancing cancer nanomedicine
    • Chauhan VP, Jain RK. Strategies for advancing cancer nanomedicine. Nat Mater 2013; 12: 958-62.
    • (2013) Nat Mater , vol.12 , pp. 958-962
    • Chauhan, V.P.1    Jain, R.K.2
  • 63
    • 46949106134 scopus 로고    scopus 로고
    • The long and short of carbon nanotube toxicity
    • Kostarelos K. The long and short of carbon nanotube toxicity. Nat Biotechnol 2008; 7: 774-5.
    • (2008) Nat Biotechnol , vol.7 , pp. 774-775
    • Kostarelos, K.1
  • 64
    • 38849152834 scopus 로고    scopus 로고
    • Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion
    • Lacerda L, Soundararajan A, Singh R et al. Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv Mater 2008; 20: 225-30.
    • (2008) Adv Mater , vol.20 , pp. 225-230
    • Lacerda, L.1    Soundararajan, A.2    Singh, R.3
  • 65
    • 80054048527 scopus 로고    scopus 로고
    • Gold nanoparticles: a revival in precious metal administration to patients
    • Thakor AS, Jokerst J, Zavaleta C, Massoud TF, Gambhir SS. Gold nanoparticles: a revival in precious metal administration to patients. Nano Lett 2011; 11: 4029-36.
    • (2011) Nano Lett , vol.11 , pp. 4029-4036
    • Thakor, A.S.1    Jokerst, J.2    Zavaleta, C.3    Massoud, T.F.4    Gambhir, S.S.5
  • 66
    • 81755187274 scopus 로고    scopus 로고
    • Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration
    • Chauhan VP, Popović Z, Chen O et al. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angew Chem Int Ed 2011; 50: 11417-20.
    • (2011) Angew Chem Int Ed , vol.50 , pp. 11417-11420
    • Chauhan, V.P.1    Popović, Z.2    Chen, O.3
  • 67
    • 84879459400 scopus 로고    scopus 로고
    • Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft
    • Chu KS, Hasan W, Rawal S et al. Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft. Nanomed Nanotechnol Biol Med 2013; 9: 686-93.
    • (2013) Nanomed Nanotechnol Biol Med , vol.9 , pp. 686-693
    • Chu, K.S.1    Hasan, W.2    Rawal, S.3
  • 68
    • 34248402413 scopus 로고    scopus 로고
    • Shape effects of filaments versus spherical particles in flow and drug delivery
    • Geng Y, Dalhaimer P, Cai S et al. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2007; 2: 249-55.
    • (2007) Nat Nanotechnol , vol.2 , pp. 249-255
    • Geng, Y.1    Dalhaimer, P.2    Cai, S.3
  • 69
    • 84877625601 scopus 로고    scopus 로고
    • Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery
    • Zhou Z, Ma X, Jin E et al. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. Biomaterials 2013; 34: 5722-35.
    • (2013) Biomaterials , vol.34 , pp. 5722-5735
    • Zhou, Z.1    Ma, X.2    Jin, E.3
  • 71
    • 84858042094 scopus 로고    scopus 로고
    • Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro
    • Dobrovolskaia MA, Patri AK, Simak J et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol Pharm 2012; 9: 382-93.
    • (2012) Mol Pharm , vol.9 , pp. 382-393
    • Dobrovolskaia, M.A.1    Patri, A.K.2    Simak, J.3
  • 72
    • 84896535996 scopus 로고    scopus 로고
    • How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo
    • Shcharbin D, Janaszewska A, Klajnert-Maculewicz B et al. How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo. J Control Release 2014; 181: 40-52.
    • (2014) J Control Release , vol.181 , pp. 40-52
    • Shcharbin, D.1    Janaszewska, A.2    Klajnert-Maculewicz, B.3
  • 73
    • 84894608275 scopus 로고    scopus 로고
    • Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration
    • Wu W, Driessen W, Jiang X. Oligo(ethylene glycol)-based thermosensitive dendrimers and their tumor accumulation and penetration. J Am Chem Soc 2014; 136: 3145-55.
    • (2014) J Am Chem Soc , vol.136 , pp. 3145-3155
    • Wu, W.1    Driessen, W.2    Jiang, X.3
  • 74
    • 84897025238 scopus 로고    scopus 로고
    • Large-scale dendrimer-based uneven nanopatterns for the study of local arginine-glycine-aspartic acid (RGD) density effects on cell adhesion
    • Lagunas A, Castaño AG, Artés JM et al. Large-scale dendrimer-based uneven nanopatterns for the study of local arginine-glycine-aspartic acid (RGD) density effects on cell adhesion. Nano Res 2014; 7: 399-409.
    • (2014) Nano Res , vol.7 , pp. 399-409
    • Lagunas, A.1    Castaño, A.G.2    Artés, J.M.3
  • 75
    • 84859761719 scopus 로고    scopus 로고
    • Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery
    • Sadekar S, Ghandehari H. Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery. Adv Drug Deliv Rev 2012; 64: 571-88.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 571-588
    • Sadekar, S.1    Ghandehari, H.2
  • 76
    • 46549084447 scopus 로고    scopus 로고
    • The effect of surface functionality on cellular trafficking of dendrimers
    • Perumal OP, Inapagolla R, Kannan S, Kannan RM. The effect of surface functionality on cellular trafficking of dendrimers. Biomaterals 2008; 29: 3469-76.
    • (2008) Biomaterals , vol.29 , pp. 3469-3476
    • Perumal, O.P.1    Inapagolla, R.2    Kannan, S.3    Kannan, R.M.4
  • 77
    • 33645464504 scopus 로고    scopus 로고
    • Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines
    • Gurdag S, Khandare J, Stapels S, Matherly LH, Kannan RM. Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines. Bioconjug Chem 2006; 17: 275-83.
    • (2006) Bioconjug Chem , vol.17 , pp. 275-283
    • Gurdag, S.1    Khandare, J.2    Stapels, S.3    Matherly, L.H.4    Kannan, R.M.5
  • 78
    • 0030293017 scopus 로고    scopus 로고
    • In vitro gene delivery by degraded polyamidoamine dendrimers
    • Tang MX, Redemann CT, Szoka FC. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703-14.
    • (1996) Bioconjug Chem , vol.7 , pp. 703-714
    • Tang, M.X.1    Redemann, C.T.2    Szoka, F.C.3
  • 79
    • 84555186724 scopus 로고    scopus 로고
    • Structurally flexible triethanolamine core PAMAM dendrimers are effective nanovectors for DNA transfection in vitro and in vivo to the mouse thymus
    • Liu X, Wu J, Yamine M et al. Structurally flexible triethanolamine core PAMAM dendrimers are effective nanovectors for DNA transfection in vitro and in vivo to the mouse thymus. Bioconjug Chem 2011; 22: 2461-73.
    • (2011) Bioconjug Chem , vol.22 , pp. 2461-2473
    • Liu, X.1    Wu, J.2    Yamine, M.3
  • 80
    • 84894288569 scopus 로고    scopus 로고
    • Nanodynamics of dendritic core-multishell nanocarriers
    • Boreham A, Pfaff M, Fleige E, Haag R, Alexiev U. Nanodynamics of dendritic core-multishell nanocarriers. Langmuir 2014; 30: 1686-95.
    • (2014) Langmuir , vol.30 , pp. 1686-1695
    • Boreham, A.1    Pfaff, M.2    Fleige, E.3    Haag, R.4    Alexiev, U.5
  • 82
    • 84894856234 scopus 로고    scopus 로고
    • A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis invivo
    • Reebye V, Sætrom PI, Mintz PJ et al. A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis invivo. Hepatology 2014; 59: 216-27.
    • (2014) Hepatology , vol.59 , pp. 216-227
    • Reebye, V.1    Sætrom, P.I.2    Mintz, P.J.3
  • 83
    • 84885386826 scopus 로고    scopus 로고
    • Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview
    • Mignami S, El Kazzouli S, Bousmina M, Majoral J-P. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Adv Drug Deliv Rev 2013; 65: 1316-30.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1316-1330
    • Mignami, S.1    El Kazzouli, S.2    Bousmina, M.3    Majoral, J.-P.4
  • 84
    • 84856540364 scopus 로고    scopus 로고
    • Dendritic effects: dependency of dendritic nano-periodic property patterns on critical nanoscale design parameters (CNDPs)
    • Tomalia DA. Dendritic effects: dependency of dendritic nano-periodic property patterns on critical nanoscale design parameters (CNDPs). New J Chem 2012; 36: 264-81.
    • (2012) New J Chem , vol.36 , pp. 264-281
    • Tomalia, D.A.1
  • 85
    • 0021586266 scopus 로고
    • A new class of polymers: starburst dendritic macromolecules
    • Tomalia DA, Baker H, Dewald J et al. A new class of polymers: starburst dendritic macromolecules. Polym J (Tokyo) 1985; 17: 117-32.
    • (1985) Polym J (Tokyo) , vol.17 , pp. 117-132
    • Tomalia, D.A.1    Baker, H.2    Dewald, J.3
  • 86
    • 0037103007 scopus 로고    scopus 로고
    • Discovery of dendrimers and dendritic polymers: a brief historical perspective
    • Tomalia DA, Fréchet JMJ. Discovery of dendrimers and dendritic polymers: a brief historical perspective. J Polym Sci A Polym Chem 2002; 40: 2719-28.
    • (2002) J Polym Sci A Polym Chem , vol.40 , pp. 2719-2728
    • Tomalia, D.A.1    Fréchet, J.M.J.2
  • 87
    • 73249139071 scopus 로고    scopus 로고
    • Dendron-mediated self-assembly, disassembly, and self-organization of complex systems
    • Rosen BM, Wilson CJ, Wilson DA, Peterca M, Imam MR, Percec V. Dendron-mediated self-assembly, disassembly, and self-organization of complex systems. Chem Rev 2009; 109: 6275-540.
    • (2009) Chem Rev , vol.109 , pp. 6275-6540
    • Rosen, B.M.1    Wilson, C.J.2    Wilson, D.A.3    Peterca, M.4    Imam, M.R.5    Percec, V.6
  • 88
    • 84861226527 scopus 로고    scopus 로고
    • Triazine dendrimers as drug delivery systems: from synthesis to therapy
    • Lim J, Simanek EE. Triazine dendrimers as drug delivery systems: from synthesis to therapy. Adv Drug Deliv Rev 2012; 64: 826-35.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 826-835
    • Lim, J.1    Simanek, E.E.2
  • 89
    • 77957827161 scopus 로고    scopus 로고
    • Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery
    • Jain S, Kaur A, Puri R et al. Poly propyl ether imine (PETIM) dendrimer: a novel non-toxic dendrimer for sustained drug delivery. Eur J Med Chem 2010; 45: 4997-5005.
    • (2010) Eur J Med Chem , vol.45 , pp. 4997-5005
    • Jain, S.1    Kaur, A.2    Puri, R.3
  • 90
    • 0035342007 scopus 로고    scopus 로고
    • Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications
    • Esfand R, Tomalia DA. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001; 6: 427-36.
    • (2001) Drug Discovery Today , vol.6 , pp. 427-436
    • Esfand, R.1    Tomalia, D.A.2
  • 91
    • 0037493690 scopus 로고    scopus 로고
    • Interaction of dendrimers (artificial proteins) with hydroxyapatite crystals
    • Chen H, Banaszak Holl M, Orr B, Majoros I, Clarkson BH. Interaction of dendrimers (artificial proteins) with hydroxyapatite crystals. J Dent Res 2003; 82: 443-8.
    • (2003) J Dent Res , vol.82 , pp. 443-448
    • Chen, H.1    Banaszak Holl, M.2    Orr, B.3    Majoros, I.4    Clarkson, B.H.5
  • 92
    • 84873292926 scopus 로고    scopus 로고
    • Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry
    • Wong C-H, Zimmerman SC. Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry. Chem Commun 2013; 49: 1679-95.
    • (2013) Chem Commun , vol.49 , pp. 1679-1695
    • Wong, C.-H.1    Zimmerman, S.C.2
  • 93
    • 0030682417 scopus 로고    scopus 로고
    • A contemporary survey of covalent connectivity and complexity. The divergent synthesis of poly(thioether) dendrimers. Amplified, genealogical directed synthesis leading to the de gennes dense packed state
    • Lothian-Tomalia MK, Hedstrand DM, Tomalia DA. A contemporary survey of covalent connectivity and complexity. The divergent synthesis of poly(thioether) dendrimers. Amplified, genealogical directed synthesis leading to the de gennes dense packed state. Tetrahedron 1997; 53: 15495-513.
    • (1997) Tetrahedron , vol.53 , pp. 15495-15513
    • Lothian-Tomalia, M.K.1    Hedstrand, D.M.2    Tomalia, D.A.3
  • 95
    • 73249130570 scopus 로고    scopus 로고
    • Applications of orthogonal "click" chemistries in the synthesis of functional soft materials
    • Iha RK, Wooley KL, Nystrom AM, Burke DJ, Kade MJ, Hawker CJ. Applications of orthogonal "click" chemistries in the synthesis of functional soft materials. Chem Rev 2009; 109: 5620-86.
    • (2009) Chem Rev , vol.109 , pp. 5620-5686
    • Iha, R.K.1    Wooley, K.L.2    Nystrom, A.M.3    Burke, D.J.4    Kade, M.J.5    Hawker, C.J.6
  • 96
    • 77954314881 scopus 로고    scopus 로고
    • Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide click chemistry
    • Hourani R, Sharma A, Kakkar A. Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide click chemistry. Tetrahedron Lett 2010; 51: 3792-5.
    • (2010) Tetrahedron Lett , vol.51 , pp. 3792-3795
    • Hourani, R.1    Sharma, A.2    Kakkar, A.3
  • 97
    • 0037959570 scopus 로고    scopus 로고
    • Structure control within poly(amidoamine) dendrimers: size, shape and regio-chemical mimicry of globular proteins
    • Tomalia DA, Huang B, Swanson DR, Brothers HM II, Klimash JW. Structure control within poly(amidoamine) dendrimers: size, shape and regio-chemical mimicry of globular proteins. Tetrahedron 2003; 59: 3799-813.
    • (2003) Tetrahedron , vol.59 , pp. 3799-3813
    • Tomalia, D.A.1    Huang, B.2    Swanson, D.R.3    Brothers, H.M.4    Klimash, J.W.5
  • 98
    • 84862557067 scopus 로고    scopus 로고
    • Simplifying the synthesis of dendrimers: accelerated approaches
    • Walter MV, Malkoch M. Simplifying the synthesis of dendrimers: accelerated approaches. Chem Soc Rev 2012; 41: 4593-609.
    • (2012) Chem Soc Rev , vol.41 , pp. 4593-4609
    • Walter, M.V.1    Malkoch, M.2
  • 99
    • 18444392735 scopus 로고    scopus 로고
    • Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry
    • Tomalia DA. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci 2005; 30: 294-324.
    • (2005) Prog Polym Sci , vol.30 , pp. 294-324
    • Tomalia, D.A.1
  • 100
    • 79953716272 scopus 로고    scopus 로고
    • Clinically relevant anticancer polymer paclitaxel therapeutics
    • Yang D, Yu L, Van S. Clinically relevant anticancer polymer paclitaxel therapeutics. Cancers 2011; 3: 17-42.
    • (2011) Cancers , vol.3 , pp. 17-42
    • Yang, D.1    Yu, L.2    Van, S.3
  • 101
    • 84874075020 scopus 로고    scopus 로고
    • A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs
    • Rios-Doria J, Carie A, Costich T et al. A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs. J Drug Deliv 2012; 2012: 1-8.
    • (2012) J Drug Deliv , vol.2012 , pp. 1-8
    • Rios-Doria, J.1    Carie, A.2    Costich, T.3
  • 103
    • 84898872381 scopus 로고    scopus 로고
    • Isolation and characterization of precise dye/dendrimer ratios
    • Dougherty CA, Furgal JC, Van Dongen MA et al. Isolation and characterization of precise dye/dendrimer ratios. Chem Eur J 2014; 20: 1-9.
    • (2014) Chem Eur J , vol.20 , pp. 1-9
    • Dougherty, C.A.1    Furgal, J.C.2    Van Dongen, M.A.3
  • 104
    • 84856716430 scopus 로고    scopus 로고
    • Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component
    • Karton-Lifshin N, Shabat D. Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component. New J Chem 2012; 36: 386-93.
    • (2012) New J Chem , vol.36 , pp. 386-393
    • Karton-Lifshin, N.1    Shabat, D.2
  • 105
    • 33750423606 scopus 로고    scopus 로고
    • Cationic poly-l-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats
    • Boyd BJ, Kaminskas LM, Karellas P, Krippner G, Lessene R, Porter CJH. Cationic poly-l-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Mol Pharm 2006; 3: 614-27.
    • (2006) Mol Pharm , vol.3 , pp. 614-627
    • Boyd, B.J.1    Kaminskas, L.M.2    Karellas, P.3    Krippner, G.4    Lessene, R.5    Porter, C.J.H.6
  • 106
    • 84868283684 scopus 로고    scopus 로고
    • Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration
    • Yang Y, Sunoqrot S, Stowell C et al. Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration. Biomacromolecules 2012; 13: 2154-62.
    • (2012) Biomacromolecules , vol.13 , pp. 2154-2162
    • Yang, Y.1    Sunoqrot, S.2    Stowell, C.3
  • 108
    • 77749297971 scopus 로고    scopus 로고
    • Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases
    • Olson ES, Jiang T, Aguilera TA et al. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc of the National Acad of Sci 2010; 107: 4311-6.
    • (2010) Proc of the National Acad of Sci , vol.107 , pp. 4311-4316
    • Olson, E.S.1    Jiang, T.2    Aguilera, T.A.3
  • 109
    • 80054769453 scopus 로고    scopus 로고
    • Theranostic nanoparticles engineered for clinic and pharmaceutics
    • Ma X, Zhao Y, Liang XJ. Theranostic nanoparticles engineered for clinic and pharmaceutics. Acc Chem Res 2011; 44: 1114-22.
    • (2011) Acc Chem Res , vol.44 , pp. 1114-1122
    • Ma, X.1    Zhao, Y.2    Liang, X.J.3
  • 110
    • 84874637808 scopus 로고    scopus 로고
    • Theranostics: are we there yet?
    • Svenson S. Theranostics: are we there yet? Mol Pharm 2012; 10: 848-56.
    • (2012) Mol Pharm , vol.10 , pp. 848-856
    • Svenson, S.1
  • 111
    • 84874619226 scopus 로고    scopus 로고
    • Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry
    • Lo S-T, Kumar A, Hsieh J-T, Sun X. Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry. Mol Pharm 2013; 10: 793-812.
    • (2013) Mol Pharm , vol.10 , pp. 793-812
    • Lo, S.-T.1    Kumar, A.2    Hsieh, J.-T.3    Sun, X.4
  • 112
    • 84893320082 scopus 로고    scopus 로고
    • Nanoparticles for multimodal in vivo imaging in nanomedicine
    • Key J, Leary JF. Nanoparticles for multimodal in vivo imaging in nanomedicine. Int J Nanomed 2014; 9: 711-26.
    • (2014) Int J Nanomed , vol.9 , pp. 711-726
    • Key, J.1    Leary, J.F.2
  • 113
    • 84888373686 scopus 로고    scopus 로고
    • A multifunctional theranostic platform based on phthalocyanine-loaded dendrimer for image-guided drug delivery and photodynamic therapy
    • Taratula O, Schumann C, Naleway MA, Pang AJ, Chon KJ. A multifunctional theranostic platform based on phthalocyanine-loaded dendrimer for image-guided drug delivery and photodynamic therapy. Mol Pharm 2013; 10: 3946-58.
    • (2013) Mol Pharm , vol.10 , pp. 3946-3958
    • Taratula, O.1    Schumann, C.2    Naleway, M.A.3    Pang, A.J.4    Chon, K.J.5
  • 114
    • 80054821668 scopus 로고    scopus 로고
    • Theranostics: combining imaging and therapy
    • Kelkar SS, Reineke TM. Theranostics: combining imaging and therapy. Bioconjug Chem 2011; 22: 1879-903.
    • (2011) Bioconjug Chem , vol.22 , pp. 1879-1903
    • Kelkar, S.S.1    Reineke, T.M.2
  • 115
    • 80054766761 scopus 로고    scopus 로고
    • Cell-specific, activatable, and theranostic prodrug for dual-targeted cancer imaging and therapy
    • Santra S, Kaittanis C, Santiesteban OJ, Perez JM. Cell-specific, activatable, and theranostic prodrug for dual-targeted cancer imaging and therapy. J Am Chem Soc 2011; 133: 16680-8.
    • (2011) J Am Chem Soc , vol.133 , pp. 16680-16688
    • Santra, S.1    Kaittanis, C.2    Santiesteban, O.J.3    Perez, J.M.4
  • 116
    • 84874643120 scopus 로고    scopus 로고
    • Special issue: theranostic nanomedicine with functional nanoarchitecture
    • Pan D. Special issue: theranostic nanomedicine with functional nanoarchitecture. Mol Pharm 2013; 10: 781-1150.
    • (2013) Mol Pharm , vol.10 , pp. 781-1150
    • Pan, D.1
  • 118
    • 77749254873 scopus 로고    scopus 로고
    • Surgery with molecular fluorescence imaging using activable cell-penetrating peptides decreases residual cancer and improves survival
    • Nguyen QT, Olson ES, Aguilera TA et al. Surgery with molecular fluorescence imaging using activable cell-penetrating peptides decreases residual cancer and improves survival. Proc of the National Acad of Sci 2010; 107: 4317-22.
    • (2010) Proc of the National Acad of Sci , vol.107 , pp. 4317-4322
    • Nguyen, Q.T.1    Olson, E.S.2    Aguilera, T.A.3
  • 119
    • 84874417298 scopus 로고    scopus 로고
    • In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity
    • Olson ES, Whitney MA, Friedman B et al. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol 2012; 4: 595-605.
    • (2012) Integr Biol , vol.4 , pp. 595-605
    • Olson, E.S.1    Whitney, M.A.2    Friedman, B.3
  • 120
    • 28744445460 scopus 로고    scopus 로고
    • Dendrimer biocompatibility and toxicity
    • Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 2005; 57: 2215-37.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2215-2237
    • Duncan, R.1    Izzo, L.2
  • 121
    • 84870414034 scopus 로고    scopus 로고
    • Dendrimers and the development of new complex nanomaterials for biomedical applications
    • Gardikis K, Micha-Screttas M, Demetzos C, Steele BR. Dendrimers and the development of new complex nanomaterials for biomedical applications. Curr Med Chem 2012; 19: 4913-28.
    • (2012) Curr Med Chem , vol.19 , pp. 4913-4928
    • Gardikis, K.1    Micha-Screttas, M.2    Demetzos, C.3    Steele, B.R.4
  • 122
    • 84858679264 scopus 로고    scopus 로고
    • Multifunctional dendritic polymers in nanomedicine: opportunities and challenges
    • Khandare J, Calderon M, Dagia MN, Haag R. Multifunctional dendritic polymers in nanomedicine: opportunities and challenges. Chem Soc Rev 2012; 41: 2824-48.
    • (2012) Chem Soc Rev , vol.41 , pp. 2824-2848
    • Khandare, J.1    Calderon, M.2    Dagia, M.N.3    Haag, R.4
  • 124
    • 80052323457 scopus 로고    scopus 로고
    • Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis
    • Thomas TP, Goonewardena SN, Majoros IJ et al. Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arthritis Rheum 2011; 63: 2671-80.
    • (2011) Arthritis Rheum , vol.63 , pp. 2671-2680
    • Thomas, T.P.1    Goonewardena, S.N.2    Majoros, I.J.3
  • 125
    • 84884289033 scopus 로고    scopus 로고
    • Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae
    • Gerard HC, Mishra MJ, Mao G et al. Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae. Nanomed Nanotechnol Biol Med 2013; 9: 996-1008.
    • (2013) Nanomed Nanotechnol Biol Med , vol.9 , pp. 996-1008
    • Gerard, H.C.1    Mishra, M.J.2    Mao, G.3
  • 126
    • 84885068319 scopus 로고    scopus 로고
    • Dendrimer-enabled transformation of Chlamydia trachomatis
    • Kannan RM, Gerard HC, Mishra MK et al. Dendrimer-enabled transformation of Chlamydia trachomatis. Microb Pathog 2013; 65: 29-35.
    • (2013) Microb Pathog , vol.65 , pp. 29-35
    • Kannan, R.M.1    Gerard, H.C.2    Mishra, M.K.3
  • 127
    • 79955703641 scopus 로고    scopus 로고
    • A phosphorus-based dendrimer targets inflammation and dosteoclastogenesis in experimental arthritis
    • 81ra35
    • Hayder M, Poupot M, Baron M et al. A phosphorus-based dendrimer targets inflammation and dosteoclastogenesis in experimental arthritis. Sci Transl Med 2011; 2011: 81ra35.
    • (2011) Sci Transl Med , vol.2011
    • Hayder, M.1    Poupot, M.2    Baron, M.3
  • 128
    • 11944272030 scopus 로고    scopus 로고
    • Solubility enhancement of indomethacin using dendrimer complex and bio-disposition profile of these complexes in arthiritic rats
    • Chauhan AS, Jain NK, Diwan PV, Khopade AJ. Solubility enhancement of indomethacin using dendrimer complex and bio-disposition profile of these complexes in arthiritic rats. J Drug Target 2004; 12: 575-83.
    • (2004) J Drug Target , vol.12 , pp. 575-583
    • Chauhan, A.S.1    Jain, N.K.2    Diwan, P.V.3    Khopade, A.J.4
  • 129
    • 66149083636 scopus 로고    scopus 로고
    • Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers
    • Chauhan AS, Diwan PV, Jain NK, Tomalia DA. Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers. Biomacromolecules 2009; 10: 1195-202.
    • (2009) Biomacromolecules , vol.10 , pp. 1195-1202
    • Chauhan, A.S.1    Diwan, P.V.2    Jain, N.K.3    Tomalia, D.A.4
  • 130
    • 77956885441 scopus 로고    scopus 로고
    • In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation
    • Inapagolla R, Guru BR, Kurtoglu KE et al. In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation. Int J Pharm 2010; 399: 140-7.
    • (2010) Int J Pharm , vol.399 , pp. 140-147
    • Inapagolla, R.1    Guru, B.R.2    Kurtoglu, K.E.3
  • 131
    • 84878464740 scopus 로고    scopus 로고
    • Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment
    • Blattes E, Vercellone A, Eutamène H et al. Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment. Proc Natl Acad Sci USA 2013; 110: 8795-800.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 8795-8800
    • Blattes, E.1    Vercellone, A.2    Eutamène, H.3
  • 132
    • 81155152766 scopus 로고    scopus 로고
    • Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
    • Iezzi R, Guru BR, Glybina IV, Mishra MJ, Kennedy A, Kannan RM. Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012; 33: 979-88.
    • (2012) Biomaterials , vol.33 , pp. 979-988
    • Iezzi, R.1    Guru, B.R.2    Glybina, I.V.3    Mishra, M.J.4    Kennedy, A.5    Kannan, R.M.6
  • 133
    • 84860129964 scopus 로고    scopus 로고
    • Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model
    • 130ra46
    • Kannan S, Dai H, Navath RS et al. Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Sci Transl Med 2012; 4: 130ra46.
    • (2012) Sci Transl Med , vol.4
    • Kannan, S.1    Dai, H.2    Navath, R.S.3
  • 134
    • 0033376651 scopus 로고    scopus 로고
    • Dendrimer-platinate: a novel approach to cancer chemotherapy
    • Malik N, Evagorou EG, Duncan R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs 1999; 10: 767-76.
    • (1999) Anticancer Drugs , vol.10 , pp. 767-776
    • Malik, N.1    Evagorou, E.G.2    Duncan, R.3
  • 135
    • 84858060982 scopus 로고    scopus 로고
    • Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models
    • Kaminskas LM, McLeod VM, Kelly BD et al. Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models. Mol Pharm 2012; 9: 422-32.
    • (2012) Mol Pharm , vol.9 , pp. 422-432
    • Kaminskas, L.M.1    McLeod, V.M.2    Kelly, B.D.3
  • 136
    • 77952226982 scopus 로고    scopus 로고
    • PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex
    • Jiang YY, Tang G-T, Zhang L-H, Kong S-Y, Zhu S-J, Pei Y-Y. PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex. J Drug Target 2010; 18: 389-403.
    • (2010) J Drug Target , vol.18 , pp. 389-403
    • Jiang, Y.Y.1    Tang, G.-T.2    Zhang, L.-H.3    Kong, S.-Y.4    Zhu, S.-J.5    Pei, Y.-Y.6
  • 137
    • 80054981542 scopus 로고    scopus 로고
    • RGD-modified PEG-PAMAM-DOX conjugates: in vitro and in vivo studies for glioma
    • Zhang L, Zhu S, Qian L, Pei Y, Qiu Y, Jiang Y. RGD-modified PEG-PAMAM-DOX conjugates: in vitro and in vivo studies for glioma. Eur J Pharm Biopharm 2011; 79: 232-40.
    • (2011) Eur J Pharm Biopharm , vol.79 , pp. 232-240
    • Zhang, L.1    Zhu, S.2    Qian, L.3    Pei, Y.4    Qiu, Y.5    Jiang, Y.6
  • 138
    • 79959861668 scopus 로고    scopus 로고
    • The treatment of Glioblastoma Xenografts by surfactant conjugated dendritic nanoconjugates
    • Gajbhiye V, Jain NK. The treatment of Glioblastoma Xenografts by surfactant conjugated dendritic nanoconjugates. Biomaterials 2011; 32: 6213-25.
    • (2011) Biomaterials , vol.32 , pp. 6213-6225
    • Gajbhiye, V.1    Jain, N.K.2
  • 139
    • 84876512877 scopus 로고    scopus 로고
    • Pegylated dendrimer and its effect in fluorouracil loading and release for enhancing antitumor activity
    • Ly TU, Tran NQ, Hoang TKD, Phan KN, Truong HN, Nguyen CK. Pegylated dendrimer and its effect in fluorouracil loading and release for enhancing antitumor activity. J Biomed Nanotechnol 2013; 9: 213-20.
    • (2013) J Biomed Nanotechnol , vol.9 , pp. 213-220
    • Ly, T.U.1    Tran, N.Q.2    Hoang, T.K.D.3    Phan, K.N.4    Truong, H.N.5    Nguyen, C.K.6
  • 140
    • 56749185962 scopus 로고    scopus 로고
    • Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug deliery potential in tumor bearing mice
    • Singh P, Gupta U, Asthana A, Jain NK. Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug deliery potential in tumor bearing mice. Bioconjug Chem 2008; 19: 2239-52.
    • (2008) Bioconjug Chem , vol.19 , pp. 2239-2252
    • Singh, P.1    Gupta, U.2    Asthana, A.3    Jain, N.K.4
  • 141
    • 70350055331 scopus 로고    scopus 로고
    • Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates
    • Fox ME, Guillaudeu S, Fréchet JMJ, Jerger K, Macaraeg N, Szoka FC. Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates. Mol Pharm 2009; 6: 1562-672.
    • (2009) Mol Pharm , vol.6 , pp. 1562-1672
    • Fox, M.E.1    Guillaudeu, S.2    Fréchet, J.M.J.3    Jerger, K.4    Macaraeg, N.5    Szoka, F.C.6
  • 142
    • 0035181482 scopus 로고    scopus 로고
    • Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice1
    • Sato N, Kobayashi H, Saga T et al. Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice1. Clin Cancer Res 2001; 7: 3606-12.
    • (2001) Clin Cancer Res , vol.7 , pp. 3606-3612
    • Sato, N.1    Kobayashi, H.2    Saga, T.3
  • 143
    • 0037544228 scopus 로고    scopus 로고
    • Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: in vitro and in vivo studies
    • Vincent L, Varet J, Pille J-Y et al. Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: in vitro and in vivo studies. Int J Cancer 2003; 105: 419-29.
    • (2003) Int J Cancer , vol.105 , pp. 419-429
    • Vincent, L.1    Varet, J.2    Pille, J.-Y.3
  • 144
    • 77950341675 scopus 로고    scopus 로고
    • Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA
    • Koppu S, Oh YJ, Edrada-Ebel RA et al. Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. J Control Release 2010; 143: 215-21.
    • (2010) J Control Release , vol.143 , pp. 215-221
    • Koppu, S.1    Oh, Y.J.2    Edrada-Ebel, R.A.3
  • 145
    • 3542993234 scopus 로고    scopus 로고
    • Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
    • Shaunak S, Thomas S, Gianasi E et al. Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nat Biotechnol 2004; 22: 977-84.
    • (2004) Nat Biotechnol , vol.22 , pp. 977-984
    • Shaunak, S.1    Thomas, S.2    Gianasi, E.3
  • 146
    • 77954315628 scopus 로고    scopus 로고
    • Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    • Wang B, Navath RS, Menjoge AR et al. Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers. Int J Pharm 2010; 395: 298-308.
    • (2010) Int J Pharm , vol.395 , pp. 298-308
    • Wang, B.1    Navath, R.S.2    Menjoge, A.R.3
  • 147
    • 0036838275 scopus 로고    scopus 로고
    • Prevention of influenza pneumonitis by sialic acid conjugated dendritic polymers
    • Landers JJ, Cao Z, Lee I et al. Prevention of influenza pneumonitis by sialic acid conjugated dendritic polymers. J Infect Dis 2002; 186: 1222-30.
    • (2002) J Infect Dis , vol.186 , pp. 1222-1230
    • Landers, J.J.1    Cao, Z.2    Lee, I.3
  • 148
    • 33846115676 scopus 로고    scopus 로고
    • PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug
    • Kumar PV, Agashe H, Dutta T, Jain NK. PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug. Curr Drug Deliv 2007; 4: 11-9.
    • (2007) Curr Drug Deliv , vol.4 , pp. 11-19
    • Kumar, P.V.1    Agashe, H.2    Dutta, T.3    Jain, N.K.4
  • 149
    • 80052844387 scopus 로고    scopus 로고
    • ®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans
    • ®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans. PLoS One 2011; 6: e24095.
    • (2011) PLoS One , vol.6 , pp. e24095
    • Price, C.F.1    Tyssen, D.2    Sonza, S.3
  • 150
    • 82955237641 scopus 로고    scopus 로고
    • Systemic administration of combinatorial dsiRNAs via nanoparticles efficiciently suppresses HIV-1 infection in humanized mice
    • Zhou J, Neff CP, Liu X et al. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiciently suppresses HIV-1 infection in humanized mice. Mol Ther 2011; 19: 2228-38.
    • (2011) Mol Ther , vol.19 , pp. 2228-2238
    • Zhou, J.1    Neff, C.P.2    Liu, X.3
  • 151
    • 0035105015 scopus 로고    scopus 로고
    • 3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmokinetic properties
    • Kobayashi H, Sato N, Hiraga A et al. 3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmokinetic properties. Magn Reson Med 2001; 45: 454-60.
    • (2001) Magn Reson Med , vol.45 , pp. 454-460
    • Kobayashi, H.1    Sato, N.2    Hiraga, A.3
  • 152
    • 0035145270 scopus 로고    scopus 로고
    • Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer
    • Kobayashi H, Sato N, Kawamoto S et al. Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer. Bioconjug Chem 2001; 12: 100-7.
    • (2001) Bioconjug Chem , vol.12 , pp. 100-107
    • Kobayashi, H.1    Sato, N.2    Kawamoto, S.3
  • 153
    • 0035190689 scopus 로고    scopus 로고
    • Pharmacokinetics and enhancement of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores
    • Sato N, Kobayashi H, Hiraga A et al. Pharmacokinetics and enhancement of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores. Magn Reson Med 2001; 46: 1169-73.
    • (2001) Magn Reson Med , vol.46 , pp. 1169-1173
    • Sato, N.1    Kobayashi, H.2    Hiraga, A.3
  • 155
    • 84894468671 scopus 로고    scopus 로고
    • 64Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic placque
    • 64Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic placque. Bioconjug Chem 2014; 25: 231-9.
    • (2014) Bioconjug Chem , vol.25 , pp. 231-239
    • Seo, J.W.1    Baek, H.2    Mahakian, L.M.3
  • 156
    • 84879540484 scopus 로고    scopus 로고
    • Nanoparticle-based chemical exchange saturation transfer (CEST) agents
    • Castelli DD, Terreno E, Longo D, Aime S. Nanoparticle-based chemical exchange saturation transfer (CEST) agents. NMR Biomed 2013; 26: 839-49.
    • (2013) NMR Biomed , vol.26 , pp. 839-849
    • Castelli, D.D.1    Terreno, E.2    Longo, D.3    Aime, S.4
  • 157
    • 38649103503 scopus 로고    scopus 로고
    • Dendritic PARACEST contrast agents for magnetic resonance imaging
    • Pikkemaat JA, Wegh RT, Lamerichs R et al. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol Imaging 2007; 2: 229-39.
    • (2007) Contrast Media Mol Imaging , vol.2 , pp. 229-239
    • Pikkemaat, J.A.1    Wegh, R.T.2    Lamerichs, R.3
  • 158
    • 67651089633 scopus 로고    scopus 로고
    • Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies
    • Ali MM, Liu G, Shah T, Flask CA, Pagel MD. Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies. Acc Chem Res 2009; 42: 915-24.
    • (2009) Acc Chem Res , vol.42 , pp. 915-924
    • Ali, M.M.1    Liu, G.2    Shah, T.3    Flask, C.A.4    Pagel, M.D.5
  • 159
    • 84878531449 scopus 로고    scopus 로고
    • Solubility enhancement of non-steroidal anti-inflammatory drugs (NSAIDs) using polypolypropylene oxide core PAMAM dendrimers
    • Koc FE, Senel M. Solubility enhancement of non-steroidal anti-inflammatory drugs (NSAIDs) using polypolypropylene oxide core PAMAM dendrimers. Int J Pharm 2013; 451: 18-22.
    • (2013) Int J Pharm , vol.451 , pp. 18-22
    • Koc, F.E.1    Senel, M.2
  • 160
    • 84878664140 scopus 로고    scopus 로고
    • Click dendrimers as anti-inflammatory agents: with insights into their binding from molecular modeling studies
    • Neibert K, Gosein V, Sharma A et al. Click dendrimers as anti-inflammatory agents: with insights into their binding from molecular modeling studies. Mol Pharm 2013; 10: 2502-8.
    • (2013) Mol Pharm , vol.10 , pp. 2502-2508
    • Neibert, K.1    Gosein, V.2    Sharma, A.3
  • 161
    • 84896934276 scopus 로고    scopus 로고
    • Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest
    • Mishra MK, Beaty CA, Lesniak WG et al. Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest. ACS Nano 2014; 8: 2134-47.
    • (2014) ACS Nano , vol.8 , pp. 2134-2147
    • Mishra, M.K.1    Beaty, C.A.2    Lesniak, W.G.3
  • 162
    • 78650070100 scopus 로고    scopus 로고
    • Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration
    • Dai H, Navath RS, Balakrishnan B et al. Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration. Nanomedicine (Lond) 2010; 5: 1317-29.
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 1317-1329
    • Dai, H.1    Navath, R.S.2    Balakrishnan, B.3
  • 163
    • 84872165093 scopus 로고    scopus 로고
    • In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry
    • Albertazzi L, Gherardini L, Brondi M et al. In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry. Mol Pharm 2013; 10: 249-60.
    • (2013) Mol Pharm , vol.10 , pp. 249-260
    • Albertazzi, L.1    Gherardini, L.2    Brondi, M.3
  • 164
    • 41649102800 scopus 로고    scopus 로고
    • Whither antibacterial drug discovery?
    • Projan SJ. Whither antibacterial drug discovery? Drug Discovery Today 2008; 13: 279-80.
    • (2008) Drug Discovery Today , vol.13 , pp. 279-280
    • Projan, S.J.1
  • 166
    • 0035989698 scopus 로고    scopus 로고
    • Interactions between dendrimer biocides and bacterial membranes
    • Chen CZ, Cooper SL. Interactions between dendrimer biocides and bacterial membranes. Biomaterials 2002; 23: 3359-68.
    • (2002) Biomaterials , vol.23 , pp. 3359-3368
    • Chen, C.Z.1    Cooper, S.L.2
  • 167
    • 78650316044 scopus 로고    scopus 로고
    • Biomedical applications of dendrimers: a tutorial
    • Mintzer MA, Grinstaff MW. Biomedical applications of dendrimers: a tutorial. Chem Soc Rev 2011; 40: 173-90.
    • (2011) Chem Soc Rev , vol.40 , pp. 173-190
    • Mintzer, M.A.1    Grinstaff, M.W.2
  • 169
    • 84858013352 scopus 로고    scopus 로고
    • Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases
    • Mintzer MA, Dane EL, O'Toole GA, Grinstaff MW. Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases. Mol Pharm 2012; 9: 342-54.
    • (2012) Mol Pharm , vol.9 , pp. 342-354
    • Mintzer, M.A.1    Dane, E.L.2    O'Toole, G.A.3    Grinstaff, M.W.4
  • 171
    • 84872865923 scopus 로고    scopus 로고
    • Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface
    • Choi SK, Myc A, Silpe JE et al. Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface. ACS Nano 2013; 7: 214-28.
    • (2013) ACS Nano , vol.7 , pp. 214-228
    • Choi, S.K.1    Myc, A.2    Silpe, J.E.3
  • 172
    • 84865764962 scopus 로고    scopus 로고
    • Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers
    • Teo I, Toms SM, Marteyn B et al. Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers. EMBO Mol Med 2012; 4: 866-81.
    • (2012) EMBO Mol Med , vol.4 , pp. 866-881
    • Teo, I.1    Toms, S.M.2    Marteyn, B.3
  • 173
    • 33644889388 scopus 로고    scopus 로고
    • PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate
    • Bhadra D, Bhadra S, Jain NK. PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate. Pharm Res 2006; 23: 623-33.
    • (2006) Pharm Res , vol.23 , pp. 623-633
    • Bhadra, D.1    Bhadra, S.2    Jain, N.K.3
  • 174
    • 10744228936 scopus 로고    scopus 로고
    • Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes
    • Bernstein DI, Stanberry LR, Sacks S et al. Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes. Antimicrob Agents Chemother 2003; 47: 3784-8.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3784-3788
    • Bernstein, D.I.1    Stanberry, L.R.2    Sacks, S.3
  • 175
    • 16444385352 scopus 로고    scopus 로고
    • SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques
    • Jiang YH, Emau P, Cairns JS et al. SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. AIDS Res Hum Retroviruses 2005; 21: 207-13.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 207-213
    • Jiang, Y.H.1    Emau, P.2    Cairns, J.S.3
  • 177
    • 84872529442 scopus 로고    scopus 로고
    • Influence of surface groups on poly(propylene imine) dendrimers antiprion activity
    • McCarthy JM, Moreno BR, Filippini D et al. Influence of surface groups on poly(propylene imine) dendrimers antiprion activity. Biomacromolecules 2013; 14: 27-37.
    • (2013) Biomacromolecules , vol.14 , pp. 27-37
    • McCarthy, J.M.1    Moreno, B.R.2    Filippini, D.3
  • 179
    • 84879813285 scopus 로고    scopus 로고
    • Nanomedicine for prion disease treatment: new insights into the role of dendrimers
    • McCarthy JM, Appelhans D, Tatzelt J, Rogers MS. Nanomedicine for prion disease treatment: new insights into the role of dendrimers. Prion 2013; 7: 198-202.
    • (2013) Prion , vol.7 , pp. 198-202
    • McCarthy, J.M.1    Appelhans, D.2    Tatzelt, J.3    Rogers, M.S.4
  • 180
    • 72149092999 scopus 로고    scopus 로고
    • Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers
    • Klajnert B, Cangiotti M, Calici S et al. Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers. New J Chem 2009; 33: 1087-93.
    • (2009) New J Chem , vol.33 , pp. 1087-1093
    • Klajnert, B.1    Cangiotti, M.2    Calici, S.3
  • 181
    • 84856735496 scopus 로고    scopus 로고
    • Glycodendrimers as functional antigens and antitumor vaccines
    • Shiao TC, Roy R. Glycodendrimers as functional antigens and antitumor vaccines. New J Chem 2012; 36: 324-39.
    • (2012) New J Chem , vol.36 , pp. 324-339
    • Shiao, T.C.1    Roy, R.2
  • 182
    • 84897504262 scopus 로고    scopus 로고
    • Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy
    • Kaminskas LM, McLeod VM, Ryan GM et al. Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. J Control Release 2014; 183: 18-26.
    • (2014) J Control Release , vol.183 , pp. 18-26
    • Kaminskas, L.M.1    McLeod, V.M.2    Ryan, G.M.3
  • 183
    • 59649120675 scopus 로고    scopus 로고
    • Dendrimers in oncology: an expanding horizon
    • Tekade RK, Kumar PV, Jain NK. Dendrimers in oncology: an expanding horizon. Chem Rev 2009; 109: 49-87.
    • (2009) Chem Rev , vol.109 , pp. 49-87
    • Tekade, R.K.1    Kumar, P.V.2    Jain, N.K.3
  • 186
    • 77955272031 scopus 로고    scopus 로고
    • Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery
    • Navarro G, Maiwald G, Haase R et al. Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery. J Control Release 2010; 146: 99-105.
    • (2010) J Control Release , vol.146 , pp. 99-105
    • Navarro, G.1    Maiwald, G.2    Haase, R.3
  • 187
    • 84891926803 scopus 로고    scopus 로고
    • RNA-mediated gene activation
    • Jiao AL, Slack FJ. RNA-mediated gene activation. Epigenetics 2014; 9: 1-10.
    • (2014) Epigenetics , vol.9 , pp. 1-10
    • Jiao, A.L.1    Slack, F.J.2
  • 189
    • 34948840023 scopus 로고    scopus 로고
    • Designing hydrogel adhesives for corneal wound repair
    • Grinstaff MW. Designing hydrogel adhesives for corneal wound repair. Biomaterials 2007; 28: 5205-14.
    • (2007) Biomaterials , vol.28 , pp. 5205-5214
    • Grinstaff, M.W.1
  • 190
    • 65249106054 scopus 로고    scopus 로고
    • Compression of sutures and dendritic polymer adhesitves for cornial laceration repair in an in vivo chicken model
    • Berdahl JP, Johnson CS, Proia AD, Grinstaff MW, Kim T. Compression of sutures and dendritic polymer adhesitves for cornial laceration repair in an in vivo chicken model. Arch Ophthalmol 2009; 127: 442-7.
    • (2009) Arch Ophthalmol , vol.127 , pp. 442-447
    • Berdahl, J.P.1    Johnson, C.S.2    Proia, A.D.3    Grinstaff, M.W.4    Kim, T.5
  • 191
    • 65249114842 scopus 로고    scopus 로고
    • In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive
    • Johnson CS, Wathier M, Grinstaff MW, Kim T. In vitro sealing of clear corneal cataract incisions with a novel biodendrimer adhesive. Arch Ophthalmol 2009; 127: 430-4.
    • (2009) Arch Ophthalmol , vol.127 , pp. 430-434
    • Johnson, C.S.1    Wathier, M.2    Grinstaff, M.W.3    Kim, T.4
  • 194
    • 84899085765 scopus 로고    scopus 로고
    • Dendrimers for gene delivery - a potential approach for ocular therapy?
    • Chaplot SP, Rupenthal ID. Dendrimers for gene delivery - a potential approach for ocular therapy? J Pharm Pharmacol 2013; 66: 542-56.
    • (2013) J Pharm Pharmacol , vol.66 , pp. 542-556
    • Chaplot, S.P.1    Rupenthal, I.D.2
  • 195
    • 77956183767 scopus 로고    scopus 로고
    • Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies - a review
    • Oliveira JM, Salgado AJ, Sousa N, Mano JF. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies - a review. Prog Polym Sci 2010; 35: 1163-94.
    • (2010) Prog Polym Sci , vol.35 , pp. 1163-1194
    • Oliveira, J.M.1    Salgado, A.J.2    Sousa, N.3    Mano, J.F.4
  • 196
    • 84866656642 scopus 로고    scopus 로고
    • Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration
    • Yang H, Tyagi P, Kadam RS, Holden CA, Kompella UB. Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration. ACS Nano 2012; 6: 7595-606.
    • (2012) ACS Nano , vol.6 , pp. 7595-7606
    • Yang, H.1    Tyagi, P.2    Kadam, R.S.3    Holden, C.A.4    Kompella, U.B.5
  • 197
    • 84875021801 scopus 로고    scopus 로고
    • Dendrimer nanoparticles for ocular drug delivery
    • Kambhampati SP, Kannan RM. Dendrimer nanoparticles for ocular drug delivery. J Ocul Pharmacol Ther 2013; 29: 151-65.
    • (2013) J Ocul Pharmacol Ther , vol.29 , pp. 151-165
    • Kambhampati, S.P.1    Kannan, R.M.2
  • 198
    • 84893828474 scopus 로고    scopus 로고
    • Dendrimeric systems and their applications in ocular drug delivery
    • Yavuz B, Pehlivan SB, Unlu N. Dendrimeric systems and their applications in ocular drug delivery. Scientific World Journal 2013; 2013: 1-13.
    • (2013) Scientific World Journal , vol.2013 , pp. 1-13
    • Yavuz, B.1    Pehlivan, S.B.2    Unlu, N.3
  • 201
    • 34247953814 scopus 로고
    • More is different
    • Anderson PW. More is different. Science 1972; 177: 393-6.
    • (1972) Science , vol.177 , pp. 393-396
    • Anderson, P.W.1
  • 202
  • 203
    • 80052280058 scopus 로고    scopus 로고
    • Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties
    • Kaminskas LM, Boyd BJ, Porter CJH. Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties. Nanomedicine (Lond) 2011; 6: 1063-84.
    • (2011) Nanomedicine (Lond) , vol.6 , pp. 1063-1084
    • Kaminskas, L.M.1    Boyd, B.J.2    Porter, C.J.H.3
  • 204
    • 84875357552 scopus 로고    scopus 로고
    • Nanomateral toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening
    • Nel A, Xia T, Meng H et al. Nanomateral toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 2013; 46: 607-21.
    • (2013) Acc Chem Res , vol.46 , pp. 607-621
    • Nel, A.1    Xia, T.2    Meng, H.3
  • 206
    • 0035191513 scopus 로고    scopus 로고
    • Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generatioin of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents
    • Kobayashi H, Kawamoto S, Saga T et al. Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generatioin of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents. J Magn Reson Imaging 2001; 14: 705-13.
    • (2001) J Magn Reson Imaging , vol.14 , pp. 705-713
    • Kobayashi, H.1    Kawamoto, S.2    Saga, T.3
  • 208
  • 209
    • 55949126429 scopus 로고    scopus 로고
    • Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats
    • Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine 2008; 3: 703-17.
    • (2008) Nanomedicine , vol.3 , pp. 703-717
    • Longmire, M.1    Choyke, P.L.2    Kobayashi, H.3
  • 210
    • 0034005436 scopus 로고    scopus 로고
    • Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125 l-labelled polyamidoamine dendrimers in vivo
    • Malik N, Wiwattanapatapee R, Klopsch R et al. Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125 l-labelled polyamidoamine dendrimers in vivo. J Control Release 2000; 65: 133-48.
    • (2000) J Control Release , vol.65 , pp. 133-148
    • Malik, N.1    Wiwattanapatapee, R.2    Klopsch, R.3
  • 213
    • 84862001474 scopus 로고    scopus 로고
    • Cationic PAMAM dendrimers disrupt key platelet functions
    • Jones CF, Campbell RA, Franks Z et al. Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm 2012; 9: 1599-611.
    • (2012) Mol Pharm , vol.9 , pp. 1599-1611
    • Jones, C.F.1    Campbell, R.A.2    Franks, Z.3
  • 214
    • 84867528048 scopus 로고    scopus 로고
    • Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles
    • Greish K, Thiagarajan G, Herd H et al. Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles. Nanotoxicology 2010; 6: 713-23.
    • (2010) Nanotoxicology , vol.6 , pp. 713-723
    • Greish, K.1    Thiagarajan, G.2    Herd, H.3
  • 215
    • 68049107455 scopus 로고    scopus 로고
    • Synthesis, radiolabeling, and bio-imaging of high-generation polyester dendrimers
    • Parrott MC, Benhabbour SR, Saab C et al. Synthesis, radiolabeling, and bio-imaging of high-generation polyester dendrimers. J Am Chem Soc 2009; 131: 2906-16.
    • (2009) J Am Chem Soc , vol.131 , pp. 2906-2916
    • Parrott, M.C.1    Benhabbour, S.R.2    Saab, C.3
  • 216
    • 70449526181 scopus 로고    scopus 로고
    • Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers
    • Kojima C, Regino CAS, Umeda Y, Kobayashi H, Kono K. Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers. Int J Pharm 2010; 383: 293-6.
    • (2010) Int J Pharm , vol.383 , pp. 293-296
    • Kojima, C.1    Regino, C.A.S.2    Umeda, Y.3    Kobayashi, H.4    Kono, K.5
  • 217
    • 80955130278 scopus 로고    scopus 로고
    • Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics
    • Kojima C, Turkbey B, Ogawa M et al. Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics. Nanomed Nanotechnol Biol Med 2011; 7: 1001-8.
    • (2011) Nanomed Nanotechnol Biol Med , vol.7 , pp. 1001-1008
    • Kojima, C.1    Turkbey, B.2    Ogawa, M.3
  • 218
    • 84887407466 scopus 로고    scopus 로고
    • Implementation of alternative test strategies for the safety assessment of engineered nanomaterials
    • Nel AE. Implementation of alternative test strategies for the safety assessment of engineered nanomaterials. J Int Med 2013; 274: 561-77.
    • (2013) J Int Med , vol.274 , pp. 561-577
    • Nel, A.E.1
  • 219
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006; 311: 622-7.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 220
    • 39349118236 scopus 로고    scopus 로고
    • Toxicology. Transforming environmental health protection
    • Collins FS, Gray GM, Butcher JR. Toxicology. Transforming environmental health protection. Science 2008; 319: 906-7.
    • (2008) Science , vol.319 , pp. 906-907
    • Collins, F.S.1    Gray, G.M.2    Butcher, J.R.3
  • 221
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung T. Toxicology for the twenty-first century. Nature 2009; 460: 208-12.
    • (2009) Nature , vol.460 , pp. 208-212
    • Hartung, T.1
  • 222
    • 71949117632 scopus 로고    scopus 로고
    • Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    • Oberdorster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med 2010; 267: 89-105.
    • (2010) J Intern Med , vol.267 , pp. 89-105
    • Oberdorster, G.1
  • 223
    • 70349144397 scopus 로고    scopus 로고
    • Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs)
    • Jacobson KA. Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs). Bioconjug Chem 2009; 20: 1816-35.
    • (2009) Bioconjug Chem , vol.20 , pp. 1816-1835
    • Jacobson, K.A.1
  • 224
    • 84881222126 scopus 로고    scopus 로고
    • Dendrimers terminated with dichlorotrizine groups provide a route to compositional diversity
    • Patra S, Kozura B, Huang AY-T et al. Dendrimers terminated with dichlorotrizine groups provide a route to compositional diversity. Org Lett 2013; 15: 3808-11.
    • (2013) Org Lett , vol.15 , pp. 3808-3811
    • Patra, S.1    Kozura, B.2    Huang, A.-T.3
  • 225
    • 84887407783 scopus 로고    scopus 로고
    • Nanosafety: towards safer design of nanomedicines
    • Fadeel B. Nanosafety: towards safer design of nanomedicines. J Intern Med 2013; 274: 578-80.
    • (2013) J Intern Med , vol.274 , pp. 578-580
    • Fadeel, B.1
  • 227
    • 81855218204 scopus 로고    scopus 로고
    • Reshaping the future of nanopharmaceuticals: ad Iudicium
    • Moghimi SM, Peer D, Langer R. Reshaping the future of nanopharmaceuticals: ad Iudicium. ACS Nano 2011; 5: 8454-8.
    • (2011) ACS Nano , vol.5 , pp. 8454-8458
    • Moghimi, S.M.1    Peer, D.2    Langer, R.3


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