Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy

Journal of Controlled Release

Volumn 183, Issue 1, 2014, Pages 18-26

  Kaminskas, Lisa M ^a   McLeod, Victoria M ^a   Ryan, Gemma M ^a   Kelly, Brian D ^b   Haynes, John M ^a   Williamson, Mark ^c   Thienthong, Neeranat ^b   Owen, David J ^b   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b Starpharma Holdings Limited   (Australia)

^c Gribbles Veterinary Pathology   (Australia)

Author keywords

Dendrimer; Inhalation; Lung metastases; Pharmacokinetics; Pulmonary

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; CHEMOTHERAPY; DENDRIMERS; DISEASES; DRUG DELIVERY; PATHOLOGY; PHARMACOKINETICS; SCAFFOLDS; TOXICITY; TUMORS;

ANTICANCER ACTIVITIES; CHEMOTHERAPEUTIC DRUGS; INHALATION; INTRATRACHEAL INSTILLATION; INTRAVENOUS ADMINISTRATION; LUNG METASTASIS; PULMONARY; PULMONARY ADMINISTRATIONS;

BIOLOGICAL ORGANS;

DENDRIMER; DOXORUBICIN; DRUG CARRIER; PEGYLATED POLYLYSINE DENDRIMER; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG EXPOSURE; DRUG FATALITY; DRUG HALF LIFE; FEMALE; IN VITRO STUDY; LONG TERM EXPOSURE; LUNG BURDEN; LUNG METASTASIS; LUNG TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MUCOCILIARY CLEARANCE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; RAT MODEL; REDUCTION; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; FISCHER 344 RAT; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; PATHOLOGY; SECONDARY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ADMINISTRATION, INHALATION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DELAYED-ACTION PREPARATIONS; DENDRIMERS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; FEMALE; INJECTIONS, INTRAVENOUS; LUNG; LUNG NEOPLASMS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MOLECULAR STRUCTURE; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84897504262     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.012     Document Type: Article

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