Dendrimer-enabled transformation of Chlamydia trachomatis

Microbial Pathogenesis

Volumn 65, Issue , 2013, Pages 29-35

  Kannan, Rangaramanujam M ^a   Gérard, Hérve C ^b   Mishra, Manoj K ^a   Mao, Guangzhao ^c   Wang, Sunxi ^c   Hali, Mirabela ^b   Whittum Hudson, Judith A ^b   Hudson, Alan P ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Wayne State University   (United States)

Author keywords

Chlamydia; Genetics; Pathogenesis; Plasmids; Transcription; Transformation

Indexed keywords

DENDRIMER; GLYCOGEN SYNTHASE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM TRANSFORMATION; CHLAMYDIA TRACHOMATIS; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLYCOGEN SYNTHASE GENE; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

CHLAMYDIA; GENETICS; PATHOGENESIS; PLASMIDS; TRANSCRIPTION; TRANSFORMATION;

CHLAMYDIA TRACHOMATIS; DENDRIMERS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC VECTORS; GLYCOGEN SYNTHASE; GREEN FLUORESCENT PROTEINS; PLASMIDS; TRANSFORMATION, BACTERIAL; VIRULENCE;

EID: 84885068319     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2013.08.003     Document Type: Article

References (46)

1. Whittum-Hudson J.A., Hudson A.P. Human chlamydial infections: persistence, prevalence, and prospects for the future. Nat Sci Soc 2005, 13:371-382.
2. http://www.cdc.gov/std/Chlamydia/STDFact-Chlamydia.htm.
3. Gérard H.C., Whittum-Hudson J.A., Carter J.D., Hudson A.P. Molecular biology of infectious agents in chronic arthritis. Rheum Dis Clin North Am 2009, 35:1-19.
4. Schumacher H.R., Gérard H.C., Arayssi T.K., Pando J.A., Branigan P.J., Saaibi D.L., et al. Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients. Arthritis Rheum 1999, 42:1889-1893.
5. Whittum-Hudson J.A., Gérard H.C., Schumacher H.R., Hudson A.P. Pathogenesis of Chlamydia-associated arthritis. Chlamydia-genomics and pathogenesis 2007, 475-504. Horizon Bioscience Press, London UK. P. Bavoil, P. Wyrick (Eds.).
6. Nicholson T.L., Olinger L., Chong K., Schoolnik G., Stephens R.S. Global stage-specific gene regulation during the developmental cycle of Chlamydia trachomatis. JBacteriol 2003, 185:3179-3189.
7. Hackstadt T. Cell biology. Chlamydia-intracellular biology, pathogenesis, and immunity 1999, 101-138. ASM Press, Washington DC. R.S. Stephens (Ed.).
8. Abdelrahman Y.M., Belland R.J. The chlamydial developmental cycle. FEMS Microbiol Rev 2005, 29:949-959.
9. Beatty W.L., Morrison R.P., Byrne G.I. Reactivation of persistent C.trachomatis infection in cell culture. Infect Immun 1995, 63:199-205.
10. Köhler L., Nettelnbreker E., Hudson A.P., Ott N., Gérard H.C., Branigan P.J., et al. Ultrastructural and molecular analysis of the persistence of Chlamydia trachomatis (serovar K) in human monocytes. Microb Pathogen 1997, 22:133-142.
11. Gérard H.C., Krausse-Opatz B., Wang Z., Rudy D., Rao J.P., Zeidler H., et al. Expression of Chlamydia trachomatis genes required for DNA synthesis and cell division in active vs. persistent infection. Mol Microbiol 2001, 41:731-741.
12. Gérard H.C., Köhler L., Branigan P.J., Zeidler H., Schumacher H.R., Hudson A.P. Viability and gene expression in Chlamydia trachomatis during persistent infection of cultured human monocytes. Med Microbiol Immunol 1997, 187:115-120.
13. Gérard H.C., Whittum-Hudson J.A., Schumacher H.R., Hudson A.P. Differential expression of the three Chlamydia trachomatis hsp60-encoding genes in active vs persistent infection. Microb Pathogen 2004, 36:35-39.
14. Gérard H.C., Freise J., Wang Z., Roberts G., Rudy D., Krauss-Opatz B., et al. Chlamydia trachomatis genes whose products are related to energy metabolism are expressed differentially in active vs. persistent infection. Microb Infect 2002, 4:13-22.
15. Schoborg R.V. Chlamydia persistence - a tool to dissect Chlamydia-host interactions. Microbe Infect 2011, 13:649-662.
16. Cheema M.A., Rahman M.U., Whittum-Hudson J.A., Hudson A.P. Cervical Chlamydia trachomatis in women at low risk for infection. Am J Med Sci 2000, 319:123-125.
17. Stephens R.S., Kalman S., Lammel C., Fan J., Marathe R., Aravind L., et al. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 1998, 282:754-759.
18. Gérard H.C., Whittum-Hudson J.A., Schumacher H.R., Hudson A.P. Synovial Chlamydia trachomatis up-regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection. Ann Rheum Dis 2006, 65:321-327.
19. Palmer L., Falkow S. Acommon plasmid of Chlamydia trachomatis. Plasmid 1986, 16:52-62.
20. Sriprakash K.S., Macavoy E.S. Characterization and sequence of a plasmid from the trachoma biovar of C.trachomatis. Plasmid 1987, 18:205-214.
21. Thomas N.S., Jusher M., Storey C.C., Clarke I.N. Plasmid diversity in Chlamydia. Microbiology 1997, 143:1847-1854.
22. Farencena A., Comanducci M., Donati M., Ratti G., Cevenini R. Characterization of a new isolate of Chlamydia trachomatis which lacks the common plasmid and has properties of biovar trachoma. Infect Immun 1997, 65:2965-2969.
23. Peterson E.M., Markoff B.A., Schachter J., de la Maza L.M. The 7.5 kbp plasmid present in Chlamydia trachomatis is not essential for the growth of this microorganism. Plasmid 1990, 23:144-145.
24. Carlson J.H., Whitmire W.M., Crane D.D., Wicke L., Virtaneva K., Sturdevant D.E., et al. The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor. Infect Immun 2008, 76:2273-2283.
25. O'Connell C.M., Nicks K.M. Aplasmid-cured Chlamydia muridarum strain displays altered plaque morphology and reduced infectivity in cell culture. Microbiology 2006, 152:1601-1607.
26. Russell M., Darville T., Chandra-Kintal K., Smith B., Andrews C.W., O'Connell C.M. Infectivity acts as invivo selection for maintenance of the chlamydial cryptic plasmid. Infect Immun 2011, 79:98-107.
27. Rockey D.D. Unraveling the basic biology and clinical significance of the chlamydial plasmid. JExp Med 2011, 208:2159-2162.
28. Iliffe-Lee E.R., McClarty G. Regulation of carbon metabolism in Chlamydia trachomatis. Mol Microbiol 2000, 38:20-30.
29. O'Connell C.M., AbdelRahman Y.M., Green E., Darville H.K., Saira K., Smith B., et al. Toll-like receptor activation by Chlamydia trachomatis is plasmid-dependent and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C.trachomatis but not by C.muridarum. Infect Immun 2011, 79:1044-1056.
30. Tam J.E., Davis C.H., Wyrick P.B. Expression of recombinant DNA introduced into Chlamydia trachomatis by electroporation. Can J Microbiol 1994, 40:5835-5891.
31. Binet R., Maurelli A.T. Transformation and isolation of allelic exchange mutants of C psittaci using recombinant DNA introduced by electroporation. Proc Natl Acad Sci U S A 2009, 106:292-297.
32. Wang Y., Kahane S., Cutcliffe L.T., Skilton R.J., Lambden P.R., Clarke I.N. Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathogens 2011, 7:e1002258.
33. Luo D., Saltzman W.M. Synthetic DNA delivery systems. Nat Biotechnol 2000, 18:33-37.
34. Mishra M.K., Kotta K., Hali M., Wykes S., Gérard H.C., Hudson A.P., et al. PAMAM dendrimer-azithromycin conjugates for the treatment of Chlamydia trachomatis Infections. Nanomed: Nanotechnol, Biol Med 2011, 33:979-988.
35. Mishra M.K., Gérard H.C., Whittum-Hudson J.A., Hudson A.P., Kannan R.M. Dendrimer-enabled modulation of gene expression in Chlamydia trachomatis. Mol Pharmaceut 2012, 9:413-421.
36. Gérard H.C., Mishra M.K., Mao G., Wang S., Hali M., Whittum-Hudson J.A., et al. Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae. Nanomed: Nanotechnol, Biol Med 2013, in press (e-pub ahead of print).
37. Schachter J., Osoba A.O. Lymphogranulosum venererum. Br Med Bull 1983, 39:151-154.
38. Hatt C., Ward M.E., Clarke I.N. Analysis of the entire nucleotide sequence of the cryptic plasmid of C.trachomatis serovar L1. Evidence for involvement in DNA replication. Nucleic Acids Res 1998, 16:4053-4067.
39. Sambrook J., Russell D.W. Molecular cloning: a laboratory manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY.
40. Bumann D., Valdivia R. Identification of host-induced pathogen genes by differential fluorescence induction reporter systems. Nat Protoc 2007, 2:770-777.
41. Dreses-Werringloer U., Bhuiyan M., Zhao Y., Gérard H.C., Whittum-Hudson J.A., Hudson A.P. Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer's brain. Int J Med Microbiol 2009, 299:187-201.
42. Byrne G.I. Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severity. JInfect Dis 2010, 201(Suppl.2):S126-S133.
43. van Bueren A.L., Higgins M., Wang D., Burke R.D., Boraston A.B. Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors. Nat Struct Mol Biol 2007, 14:76-84.
44. Mäurer A.P., Mehlitz A., Mollenkopf H.J., Meyer T.F. Gene expression profiles of Chlamydia pneumoniae during the developmental cycle and iron-depletion mediated persistence. PLoS Pathog 2007, 3:e83.
45. Song L., Carlson J.H., Whitmire W.M., Kari L., Virtaneva K., Sturdevant D.E., et al. Chlamydia trachomatis plasmid-encoded pgp4 is a transcriptional regulator of virulence-associated genes. Infect Immun 2013, 81:636-644.
46. Kari L., Goheen M.M., Randall L.B., Taylor L.D., Carlson J.H., Whitmire W.M., et al. Generation of targeted Chlamydia trachomatis null mutants. Proc Natl Acad Sci U S A 2011, 108:7189-7193.