Designing dendrimers for drug delivery and imaging: Pharmacokinetic considerations

Pharmaceutical Research

Volumn 28, Issue 7, 2011, Pages 1500-1519

  Wijagkanalan, Wassana ^a,b,c   Kawakami, Shigeru ^a   Hashida, Mitsuru ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

biodistribution; dendrimer; drug delivery; imaging; pharmacokinetics

Indexed keywords

ARYLSULFONIC ACID DERIVATIVE; CAMPTOTHECIN; CARBOMER; DENDRIMER; DOXORUBICIN; GADOLINIUM PENTETATE; IMMUNOGLOBULIN G; METHOTREXATE; NANOMATERIAL; POLYAMIDOAMINE; POLYMER; SUPEROXIDE DISMUTASE; TRASTUZUMAB; VIVAGEL;

BIOCOMPATIBILITY; BODY SURFACE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; GENE OVEREXPRESSION; HEMOLYSIS; HYDROGEN BOND; HYDROPHILICITY; IMAGING; KIDNEY CLEARANCE; LIVER BLOOD FLOW; LIVER CLEARANCE; MICHAELIS MENTEN KINETICS; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPSONIZATION; PARTICLE SIZE; PHARMACOKINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RETICULOENDOTHELIAL SYSTEM; REVIEW; SIGNAL TRANSDUCTION;

CHEMISTRY, PHARMACEUTICAL; DENDRIMERS; DIAGNOSTIC IMAGING; DRUG CARRIERS;

EID: 79959874185     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0339-8     Document Type: Review

References (166)

1. R Duncan 2003 The dawning era of polymer therapeutics Nat Rev Drug Discov 2 347 360 12750738 1:CAS:528:DC%2BD3sXjslamtb0%3D (Pubitemid 37361705)
2. Y Matsumura K Kataoka 2009 Preclinical and clinical studies of anticancer agent-incorporating polymer micelles Cancer Sci 100 572 579 19462526 1:CAS:528:DC%2BD1MXlsFSrs7g%3D
3. Y Matsumura H Maeda 1986 A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 46 6387 6392 2946403 1:CAS:528: DyaL2sXnvVensA%3D%3D (Pubitemid 17221789)
4. Buhleier E, Wehner W, Vogtle F. "Cascade"-and "Nonskid-Chain-like" syntheses of molecular cavity topologies. Synthesis. 1978;155.
5. Denkewalter RG, Kolc J, Lukasavage WJ. Macromolecular highly branched homogeneous compound based on lysine units. 1981.
6. DA Tomalia H Baker J Dewald M Hall G Kallos S Martin, et al. 1985 A new class of polymer: starburst-dendritic macromolecules Polym J 17 117 132 1:CAS:528:DyaL2MXhsV2ru70%3D
7. GR Newkome Z Yao GR Baker VK Gupta 1985 Micelles. Part 1. Cascade molecules: a new approach to micelles. A[27]-arbosol J Org Chem 50 2003 2004 1:CAS:528:DyaL2MXit1Snsrc%3D
8. S Svenson D Tomalia 2005 Dendrimers in biomedical applications- reflections on the field Adv Drug Deliv Rev 57 2106 2129 16305813 1:CAS:528:DC%2BD2MXht12ksbzL
9. J Wolinsky M Grinstaff 2008 Therapeutic and diagnostic applications of dendrimers for cancer treatment Adv Drug Deliv Rev 60 1037 1055 18448187 1:CAS:528:DC%2BD1cXmtVWrsr4%3D
10. H Kobayashi M Brechbiel 2005 Nano-sized MRI contrast agents with dendrimer cores Adv Drug Deliv Rev 57 2271 2286 16290152 1:CAS:528: DC%2BD2MXht12ksbrF (Pubitemid 41759396)
11. Y Sugao K Watanabe Y Higuchi R Kurihara S Kawakami M Hashida, et al. 2009 NFkappaB decoy delivery using dendritic poly(l-lysine) for treatment of endotoxin-induced hepatitis in mice Bioorg Med Chem 17 4990 4995 19539484 1:CAS:528:DC%2BD1MXosVyrtro%3D
12. C Dufès I Uchegbu A Schätzlein 2005 Dendrimers in gene delivery Adv Drug Deliv Rev 57 2177 2202 16310284 (Pubitemid 41759392)
13. C Hawker J Fréchet 1990 Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules J Am Chem Soc 112 7638 7647 1:CAS:528:DyaK3cXmtFaktLY%3D
14. J Fréchet C Hawker I Gitsov JW Leon 1996 Dendrimers and hyperbranched polymers: two families of three-dimensional macromolecules with similar but clearly distinct properties J Macromol Sci Pure Appl Chem 33 1399 1425 (Pubitemid 126579267)
15. C Lee J MacKay J Fréchet F Szoka 2005 Designing dendrimers for biological applications Nat Biotechnol 23 1517 1526 16333296 1:CAS:528:DC%2BD2MXht1yisrnE (Pubitemid 41752929)
16. R Duncan L Izzo 2005 Dendrimer biocompatibility and toxicity Adv Drug Deliv Rev 57 2215 2237 16297497 1:CAS:528:DC%2BD2MXht12ksbrP (Pubitemid 41759394)
17. Y Cheng T Xu 2008 The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs Eur J Med Chem 43 2291 2297 18276038 1:CAS:528:DC%2BD1cXht12ku7rO
18. A Menjoge R Kannan D Tomalia 2010 Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications Drug Discov Today 15 171 185 20116448 1:CAS:528:DC%2BC3cXjtFynsrY%3D
19. E de Brabander-van den Berg E Meijer 1993 Poly(propylene imine) dendrimers: large-scale synthesis by heterogeneously catalyzed hydrogenations Angew Chem Int Ed Engl 32 1308 1311
20. J Spetzler J Tam 1995 Unprotected peptides as building blocks for branched peptides and peptide dendrimers Int J Pept Protein Res 45 78 85 7775011 1:CAS:528:DyaK2MXjslWhuro%3D
21. J Fréchet 1994 Functional polymers and dendrimers: reactivity, molecular architecture, and interfacial energy Science 263 1710 1715 8134834 (Pubitemid 24133373)
22. W Zhang E Simanek 2000 Dendrimers based on melamine. Divergent and orthogonal, convergent syntheses of a G3 dendrimer Org Lett 2 843 845 10814438 1:CAS:528:DC%2BD3cXht1ahsLk%3D
23. P Wu A Feldman A Nugent C Hawker A Scheel B Voit, et al. 2004 Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes Angew Chem Int Ed Engl 43 3928 3932 15274216 1:CAS:528:DC%2BD2cXmsFSrsLs%3D (Pubitemid 39257472)
24. D McGrath 2005 Dendrimer disassembly as a new paradigm for the application of dendritic structures Mol Pharm 2 253 263 16053328 1:CAS:528:DC%2BD2MXmtVWisbg%3D (Pubitemid 41186401)
25. B Boyd L Kaminskas P Karellas G Krippner R Lessene C Porter 2006 Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats Mol Pharm 3 614 627 17009860 1:CAS:528:DC%2BD28Xnsl2rtbw%3D (Pubitemid 44639138)
26. K Vega-Villa J Takemoto J Yáñez C Remsberg M Forrest N Davies 2008 Clinical toxicities of nanocarrier systems Adv Drug Deliv Rev 60 929 938 18313790 1:CAS:528:DC%2BD1cXlslagu7c%3D
27. J Roberts M Bhalgat R Zera 1996 Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers J Biomed Mater Res 30 53 65 8788106 1:CAS:528:DyaK28XisVyqsQ%3D%3D
28. N Malik R Wiwattanapatapee R Klopsch K Lorenz H Frey J Weener, et al. 2000 Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo J Control Release 65 133 148 10699277 1:CAS:528: DC%2BD3cXhtl2qs7o%3D (Pubitemid 30122922)
29. M Ohsaki T Okuda A Wada T Hirayama T Niidome H Aoyagi 2002 In vitro gene transfection using dendritic poly(L-lysine) Bioconjug Chem 13 510 517 12009940 1:CAS:528:DC%2BD38Xis12gtr0%3D (Pubitemid 34527512)
30. S Hong A Bielinska A Mecke B Keszler J Beals X Shi, et al. 2004 Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport Bioconjug Chem 15 774 782 15264864 1:CAS:528:DC%2BD2cXlsF2isbg%3D (Pubitemid 38981951)
31. R Jevprasesphant J Penny R Jalal D Attwood N McKeown A D'Emanuele 2003 The influence of surface modification on the cytotoxicity of PAMAM dendrimers Int J Pharm 252 263 266 12550802 1:CAS:528:DC%2BD3sXmtVCqtg%3D%3D (Pubitemid 36126635)
32. H Yang S Lopina L DiPersio S Schmidt 2008 Stealth dendrimers for drug delivery: correlation between PEGylation, cytocompatibility, and drug payload J Mater Sci Mater Med 19 1991 1997 17952565 1:CAS:528:DC%2BD1cXjsVCrsrw%3D (Pubitemid 351422699)
33. D Bhadra S Bhadra S Jain N Jain 2003 A PEGylated dendritic nanoparticulate carrier of fluorouracil Int J Pharm 257 111 124 12711167 1:CAS:528:DC%2BD3sXjtVemsrs%3D (Pubitemid 36507038)
34. R Kolhatkar K Kitchens P Swaan H Ghandehari 2007 Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability Bioconjug Chem 18 2054 2060 17960872 1:CAS:528: DC%2BD2sXht1aitrnK (Pubitemid 350220008)
35. A Asthana A Chauhan P Diwan N Jain 2005 Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient AAPS PharmSciTech 6 E536 E542 16354015
36. J Kukowska-Latallo K Candido Z Cao S Nigavekar I Majoros T Thomas, et al. 2005 Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer Cancer Res 65 5317 5324 15958579 1:CAS:528:DC%2BD2MXltFelsrw%3D (Pubitemid 40827344)
37. C Lee M Yoshida J Fréchet E Dy F Szoka 2005 In vitro and in vivo evaluation of hydrophilic dendronized linear polymers Bioconjug Chem 16 535 541 15898719 1:CAS:528:DC%2BD2MXjs1Kit7k%3D (Pubitemid 40696044)
38. E Gillies E Dy J Fréchet F Szoka 2005 Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture Mol Pharm 2 129 138 15804187 1:CAS:528:DC%2BD2MXhtFentbg%3D (Pubitemid 41295360)
39. T Miyano W Wijagkanalan S Kawakami F Yamashita M Hashida 2010 Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells Mol Pharm 7 1318 1327 20527783 1:CAS:528: DC%2BC3cXns1Cmtb0%3D
40. M Neerman W Zhang A Parrish E Simanek 2004 In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery Int J Pharm 281 129 132 15288350 1:CAS:528:DC%2BD2cXmtFCmu7Y%3D (Pubitemid 39024270)
41. T Okuda S Kawakami T Maeie T Niidome F Yamashita M Hashida 2006 Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration J Control Release 114 69 77 16814896 1:CAS:528:DC%2BD28XnsFCrtrk%3D (Pubitemid 44128625)
42. H Chen M Neerman A Parrish E Simanek 2004 Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery J Am Chem Soc 126 10044 10048 15303879 1:CAS:528: DC%2BD2cXlvVartL0%3D (Pubitemid 39079425)
43. O Padilla De Jesús H Ihre L Gagne J Fréchet FJ Szoka 2002 Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation Bioconjug Chem 13 453 461 12009933 (Pubitemid 34535938)
44. DA Tomalia AM Naylor WA Goddard III 1990 Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter Angew Chem Int Ed Engl 29 138 175 (Pubitemid 20142204)
45. C Kojima K Kono K Maruyama T Takagishi 2000 Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs Bioconjug Chem 11 910 917 11087341 1:CAS:528: DC%2BD3cXns1amsrY%3D
46. T Okuda S Kawakami N Akimoto T Niidome F Yamashita M Hashida 2006 PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice J Control Release 116 330 336 17118476 1:CAS:528:DC%2BD28Xht1KitL%2FK (Pubitemid 44827409)
47. V Gajbhiye PV Kumar RK Tekade NK Jain 2007 Pharmaceutical and biomedical potential of PEGylated dendrimers Curr Pharm Des 13 415 429 1:CAS:528: DC%2BD2sXjvVyltrY%3D (Pubitemid 46477762)
48. S Shukla G Wu M Chatterjee W Yang M Sekido L Diop, et al. 2003 Synthesis and biological evaluation of folate receptor-targeted boronated PAMAM dendrimers as potential agents for neutron capture therapy Bioconjug Chem 14 158 167 12526705 1:CAS:528:DC%2BD38Xos1Kjs7c%3D (Pubitemid 36169029)
49. D Chandrasekar R Sistla F Ahmad R Khar P Diwan 2007 The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats Biomaterials 28 504 512 16996126 1:CAS:528:DC%2BD28XhtFeiu7vL (Pubitemid 44602223)
50. W Yang R Barth D Adams A Soloway 1997 Intratumoral delivery of boronated epidermal growth factor for neutron capture therapy of brain tumors Cancer Res 57 4333 4339 9331095 1:CAS:528:DyaK2sXmsFCgsr8%3D (Pubitemid 27413443)
51. R Shukla T Thomas J Peters A Desai J Kukowska-Latallo A Patri, et al. 2006 HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb Bioconjug Chem 17 1109 1115 16984117 1:CAS:528:DC%2BD28XotV2ltb0%3D (Pubitemid 44455317)
52. H Agashe A Babbar S Jain R Sharma A Mishra A Asthana, et al. 2007 Investigations on biodistribution of technetium-99m-labeled carbohydrate-coated poly(propylene imine) dendrimers Nanomedicine 3 120 127 17572354 1:CAS:528:DC%2BD2sXnsVOrtLc%3D (Pubitemid 46899616)
53. S Gurdag J Khandare S Stapels L Matherly R Kannan 2006 Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines Bioconjug Chem 17 275 283 16536456 1:CAS:528:DC%2BD28Xhsl2nu7s%3D
54. Shukla R, Thomas TP, Desai AM, A. K, Park SJ, Baker JR Jr. HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb. Nanotechnology. 2008;19:art. no. 295102.
55. L Kaminskas B Kelly V McLeod B Boyd G Krippner E Williams, et al. 2009 Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers Mol Pharm 6 1190 1204 19453158 1:CAS:528: DC%2BD1MXntVSku7w%3D
56. C Lee E Gillies M Fox S Guillaudeu J Fréchet E Dy, et al. 2006 A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas Proc Natl Acad Sci USA 103 16649 16654 17075050 1:CAS:528:DC%2BD28Xht1egtbnJ (Pubitemid 44737307)
57. S Guillaudeu M Fox Y Haidar E Dy F Szoka J Fréchet 2008 PEGylated dendrimers with core functionality for biological applications Bioconjug Chem 19 461 469 18173227 1:CAS:528:DC%2BD1cXitFegsw%3D%3D (Pubitemid 351294917)
58. D van der Poll H Kieler-Ferguson W Floyd S Guillaudeu K Jerger F Szoka, et al. 2010 Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer Bioconjug Chem 21 764 773 20353169
59. S Zhu M Hong L Zhang G Tang Y Jiang Y Pei 2010 PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation Pharm Res 27 1 161 174 19862607 1:CAS:528:DC%2BD1MXhtlanu7fE
60. M Fox S Guillaudeu J Fréchet K Jerger N Macaraeg F Szoka 2009 Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates Mol Pharm 6 1562 1572 19588994 1:CAS:528:DC%2BD1MXpt1Kjtrk%3D
61. E Wiener M Brechbiel H Brothers R Magin O Gansow D Tomalia, et al. 1994 Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents Magn Reson Med 31 1 8 8121264 1:CAS:528:DyaK2cXivFeju7g%3D (Pubitemid 24016935)
62. S Konda M Aref M Brechbiel E Wiener 2000 Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress Invest Radiol 35 50 57 10639036 1:CAS:528:DC%2BD3cXmsVGgtg%3D%3D (Pubitemid 30033607)
63. G Wu R Barth W Yang S Kawabata L Zhang K Green-Church 2006 Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates Mol Cancer Ther 5 52 59 16432162 1:CAS:528:DC%2BD28XmsFKqsA%3D%3D
64. W Yang G Wu R Barth M Swindall A Bandyopadhyaya W Tjarks, et al. 2008 Molecular targeting and treatment of composite EGFR and EGFRvIII-positive gliomas using boronated monoclonal antibodies Clin Cancer Res 14 883 891 18245552 1:CAS:528:DC%2BD1cXhsFyktLs%3D (Pubitemid 351231173)
65. O Perumal R Inapagolla S Kannan R Kannan 2008 The effect of surface functionality on cellular trafficking of dendrimers Biomaterials 29 3469 3476 18501424 1:CAS:528:DC%2BD1cXntFGmsbs%3D
66. M Najlah S Freeman D Attwood A D'Emanuele 2006 Synthesis, characterization and stability of dendrimer prodrugs Int J Pharm 308 175 182 16384673 1:CAS:528:DC%2BD28Xls1Sruw%3D%3D (Pubitemid 43097250)
67. Y Kurtoglu R Navath B Wang S Kannan R Romero R Kannan 2009 Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery Biomaterials 30 2112 2121 19171376 1:CAS:528:DC%2BD1MXhvFaqtr8%3D
68. J Jansen E de Brabander-van den Berg E Meijer 1994 Encapsulation of guest molecules into a dendritic box Science 266 1226 1229 17810265 1:CAS:528:DyaK2MXit1GrtLg%3D (Pubitemid 24371278)
69. U Gupta H Agashe A Asthana N Jain 2006 Dendrimers: novel polymeric nanoarchitectures for solubility enhancement Biomacromolecules 7 649 658 16529394 1:CAS:528:DC%2BD28XhtlOqsr4%3D
70. Y Cheng Y Li Q Wu J Zhang T Xu 2009 Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: evidence from 2D-NOESY investigations Eur J Med Chem 44 2219 2223 18635290 1:CAS:528:DC%2BD1MXjsl2gsL8%3D
71. T Ooya J Lee K Park 2003 Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel J Control Release 93 121 127 14636718 1:CAS:528:DC%2BD3sXovFGjurk%3D (Pubitemid 37421354)
72. R Dhanikula P Hildgen 2007 Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate Biomaterials 28 3140 3152 17428531 1:CAS:528:DC%2BD2sXksVers7w%3D (Pubitemid 46656188)
73. H Yang J Morris S Lopina 2004 Polyethylene glycol-polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water J Colloid Interface Sci 273 148 154 15051444 1:CAS:528:DC%2BD2cXisFCnsrc%3D (Pubitemid 38407379)
74. T Dutta N Jain 2007 Targeting potential and anti-HIV activity of lamivudine loaded mannosylated poly (propyleneimine) dendrimer Biochim Biophys Acta 1770 681 686 17276009 1:CAS:528:DC%2BD2sXit1Ggsbs%3D (Pubitemid 46281473)
75. M Morgan Y Nakanishi D Kroll A Griset M Carnahan M Wathier, et al. 2006 Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro Cancer Res 66 11913 11921 17178889 1:CAS:528:DC%2BD28Xhtlagu7vJ (Pubitemid 46094204)
76. N Malik E Evagorou R Duncan 1999 Dendrimer-platinate: a novel approach to cancer chemotherapy Anticancer Drugs 10 767 776 10573209 1:CAS:528: DyaK1MXntlGhtrk%3D (Pubitemid 30015678)
77. A Chauhan S Sridevi K Chalasani A Jain S Jain N Jain, et al. 2003 Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin J Control Release 90 335 343 12880700 1:CAS:528: DC%2BD3sXls1Srt7c%3D (Pubitemid 36869009)
78. A Patri J Kukowska-Latallo JJ Baker 2005 Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex Adv Drug Deliv Rev 57 2203 2214 16290254 1:CAS:528:DC%2BD2MXht12ksbrM (Pubitemid 41759393)
79. J Kukowska-Latallo A Bielinska J Johnson R Spindler D Tomalia JJ Baker 1996 Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers Proc Natl Acad Sci USA 93 4897 4902 8643500 1:CAS:528:DyaK28XjtVKltrg%3D (Pubitemid 26163501)
80. T Okuda A Sugiyama T Niidome H Aoyagi 2004 Characters of dendritic poly(L-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro Biomaterials 25 537 544 14585703 1:CAS:528:DC%2BD3sXotlynt7g%3D (Pubitemid 37329706)
81. D Radu C Lai K Jeftinija E Rowe S Jeftinija V Lin 2004 A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent J Am Chem Soc 126 13216 13217 15479063 1:CAS:528:DC%2BD2cXnvVektr0%3D (Pubitemid 39382736)
82. J Haensler FJ Szoka 1993 Polyamidoamine cascade polymers mediate efficient transfection of cells in culture Bioconjug Chem 4 372 379 8274523 1:CAS:528:DyaK3sXlslCqt7w%3D
83. M Nishikawa Y Takakura M Hashida 1996 Pharmacokinetic evaluation of polymeric carriers Adv Drug Deliv Rev 21 135 155 1:CAS:528:DyaK28XmvFams78%3D (Pubitemid 26401715)
84. Y Takakura M Hashida 1996 Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution Pharm Res 13 820 831 8792417 1:CAS:528:DyaK28Xjs1yrtr0%3D (Pubitemid 26227738)
85. B Brenner T Hostetter H Humes 1978 Glomerular permselectivity: barrier function based on discrimination of molecular size and charge Am J Physiol 234 F455 F460 665772 1:CAS:528:DyaE1cXkvVOmu78%3D
86. L Gerlowski R Jain 1983 Physiologically based pharmacokinetic modeling: principles and applications J Pharm Sci 72 1103 1127 6358460 1:CAS:528:DyaL3sXlvVKrtrc%3D (Pubitemid 13013622)
87. H Rennke Y Patel M Venkatachalam 1978 Glomerular filtration of proteins: clearance of anionic, neutral, and cationic horseradish peroxidase in the rat Kidney Int 13 278 288 651127 1:CAS:528:DyaE1cXktF2kt74%3D (Pubitemid 8325477)
88. K Nishida K Mihara T Takino S Nakane Y Takakura M Hashida, et al. 1991 Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver Pharm Res 8 437 444 1714579 1:CAS:528:DyaK3MXit1SksL8%3D
89. Y Takakura T Fujita H Furitsu M Nishikawa H Sekaki M Hashida 1994 Pharmacokinetics of succinylated proteins and dextran sulfate in mice: implications for hepatic targeting of protein drugs by direct succinylation via scavenger receptors Int J Pharm 105 19 29 1:CAS:528:DyaK2cXjtVOgsb0%3D (Pubitemid 24087669)
90. O Dr PN Opsonization 2006 biodistribution, and pharmacokinetics of polymeric nanoparticles Int J Pharm 307 93 102
91. AJ D'Souza EM Topp 2004 Release from polymeric prodrugs: linkages and their degradation J Pharm Sci 93 1962 1979 15236447 (Pubitemid 39045479)
92. CA Hunt RD MacGregor RA Siegel 1986 Engineering targeted in vivo drug delivery. I. the physiological and physicochemical principles governing opportunities and limitations Pharm Res 3 333 344 1:CAS:528:DyaL2sXnt1yisA%3D%3D (Pubitemid 17234030)
93. J Khandare P Kolhe O Pillai S Kannan M Lieh-Lai R Kannan 2005 Synthesis, cellular transport, and activity of polyamidoamine dendrimer-methylprednisolone conjugates Bioconjug Chem 16 330 337 15769086 1:CAS:528:DC%2BD2MXhslajtb0%3D (Pubitemid 40388208)
94. M Khan S Nigavekar L Minc M Kariapper B Nair W Lesniak, et al. 2005 In vivo biodistribution of dendrimers and dendrimer nanocomposites - implications for cancer imaging and therapy Technol Cancer Res Treat 4 603 613 16292880 1:CAS:528:DC%2BD28Xps1ansQ%3D%3D (Pubitemid 43083344)
95. L Kaminskas B Boyd P Karellas S Henderson M Giannis G Krippner, et al. 2007 Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition Mol Pharm 4 949 961 17953445 1:CAS:528:DC%2BD2sXht1SgtbfP
96. S Wang M Brechbiel E Wiener 2003 Characteristics of a new MRI contrast agent prepared from polypropyleneimine dendrimers, generation 2 Invest Radiol 38 662 668 14501494 1:CAS:528:DC%2BD3sXntlyqt7k%3D (Pubitemid 37140289)
97. EC Weiner MW Brechbiel H Brothers RL Magin OA Gansow DA Tomalia, et al. 1994 Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents Magn Reson Med 31 1 8 (Pubitemid 24016935)
98. H Kobayashi N Sato A Hiraga T Saga Y Nakamoto H Ueda, et al. 2001 3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties Magn Reson Med 45 454 460 11241704 1:CAS:528:DC%2BD3MXhvFKgu7o%3D (Pubitemid 32173273)
99. H Kobayashi S Kawamoto T Saga N Sato A Hiraga J Konishi, et al. 2001 Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents J Magn Reson Imaging 14 705 713 11747027 1:STN:280: DC%2BD3MjgtFCitA%3D%3D (Pubitemid 33101529)
100. LJ Bryant E Jordan J Bulte V Herynek J Frank 2002 Pharmacokinetics of a high-generation dendrimer-Gd-DOTA Acad Radiol 9 S29 S33 12019888
101. M Bohrer W Deen C Robertson J Troy B Brenner 1979 Influence of molecular configuration on the passage of macromolecules across the glomerular capillary wall J Gen Physiol 74 583 593 512632 1:CAS:528:DyaL3cXhvFGhsg%3D%3D (Pubitemid 10192795)
102. H Sarin A Kanevsky H Wu A Sousa C Wilson M Aronova, et al. 2009 Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors J Transl Med 7 51 19549317
103. H Kobayashi S Kawamoto P Choyke N Sato M Knopp R Star, et al. 2003 Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography Magn Reson Med 50 758 766 14523962 1:CAS:528:DC%2BD3sXosFClu70%3D (Pubitemid 37187841)
104. H Kobayashi S Kawamoto M Bernardo M Brechbiel M Knopp P Choyke 2006 Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging J Control Release 111 343 351 16490277 1:CAS:528:DC%2BD28Xisl2lu7o%3D
105. H Kobayashi S Kawamoto S Jo HJ Bryant M Brechbiel R Star 2003 Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores Bioconjug Chem 14 388 394 12643749 1:CAS:528:DC%2BD3sXht1OiurY%3D (Pubitemid 36348662)
106. LD Margerum BK Campion M Koo N Shargill J-J Lai A Marumoto, et al. 1997 Gadolinium(III)DO3A macrocycles and polyethylene glycol coupled to dendrimers: Effect of molecular weight on physical and biological properties of macromolecular magnetic resonance imaging contrast agents J Alloys Compd 249 185 190 1:CAS:528:DyaK2sXjs1Smsb8%3D (Pubitemid 127415072)
107. D Sakharov A Jie M Bekkers J Emeis D Rijken 2001 Polylysine as a vehicle for extracellular matrix-targeted local drug delivery, providing high accumulation and long-term retention within the vascular wall Arterioscler Thromb Vasc Biol 21 943 948 11397701 1:CAS:528:DC%2BD3MXksVakt7w%3D (Pubitemid 34168650)
108. R Wiwattanapatapee B Carreño-Gómez N Malik R Duncan 2000 Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system? Pharm Res 17 991 998 11028947 1:CAS:528: DC%2BD3cXntVSltbc%3D
109. K Kitchens R Kolhatkar P Swaan H Ghandehari 2008 Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells Mol Pharm 5 364 369 18173246 1:CAS:528:DC%2BD1cXitFejtQ%3D%3D (Pubitemid 351579139)
110. 3H dendrimer nanoparticle organ/tumor distribution Pharm Res 21 476 483 15070099 1:CAS:528:DC%2BD2cXhvF2ls7Y%3D (Pubitemid 38344114)
111. T Uehara D Ishii T Uemura H Suzuki T Kanei K Takagi, et al. 2010 Gamma-Glutamyl PAMAM dendrimer as versatile precursor for dendrimer-based targeting devices Bioconjug Chem 21 175 181 20000792 1:CAS:528: DC%2BD1MXhsFGnt7bK
112. K Kitchens R Kolhatkar P Swaan N Eddington H Ghandehari 2006 Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: Influence of size, charge and fluorescent labeling Pharm Res 23 2818 2826 17094034 1:CAS:528:DC%2BD28Xht1Kmt7zE (Pubitemid 44885368)
113. M Parrott S Benhabbour C Saab J Lemon S Parker J Valliant, et al. 2009 Synthesis, radiolabeling, and bio-imaging of high-generation polyester dendrimers J Am Chem Soc 131 2906 2916 19239268 1:CAS:528:DC%2BD1MXhs1SlsL8%3D
114. H Kobayashi S Kawamoto T Saga N Sato A Hiraga T Ishimori, et al. 2001 Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents Magn Reson Med 46 781 788 11590655 1:CAS:528:DC%2BD3MXnslKgsLc%3D (Pubitemid 32906148)
115. S Zhu M Hong G Tang L Qian J Lin Y Jiang, et al. 2010 Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style Biomaterials 31 1360 1371 19883938 1:CAS:528:DC%2BD1MXhs1SltLjM
116. L Kaminskas B Boyd P Karellas G Krippner R Lessene B Kelly, et al. 2008 The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly l-lysine dendrimers Mol Pharm 5 449 463 18393438 1:CAS:528:DC%2BD1cXksVSgurw%3D (Pubitemid 351929829)
117. L Kaminskas Z Wu N Barlow G Krippner B Boyd C Porter 2009 Partly-PEGylated Poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers J Pharm Sci 98 3871 3875 19283758 1:CAS:528:DC%2BD1MXhtVKhsr3N
118. E Gillies J Fréchet 2002 Designing macromolecules for therapeutic applications: polyester dendrimer-poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture J Am Chem Soc 124 14137 14146 12440912 1:CAS:528:DC%2BD38XotlGjsb4%3D (Pubitemid 35386865)
119. D Venturoli B Rippe 2005 Ficoll and dextran vs.. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability Am J Physiol Renal Physiol 288 F605 F613 15753324 1:CAS:528:DC%2BD2MXjtlOqtr0%3D
120. J Lim Y Guo C Rostollan J Stanfield J Hsieh X Sun, et al. 2008 The role of the size and number of polyethylene glycol chains in the biodistribution and tumor localization of triazine dendrimers Mol Pharm 5 540 547 18672950 1:CAS:528:DC%2BD1cXpsVGlur0%3D
121. C Hoppe Y Lee 1983 The binding and processing of mannose-bovine serum albumin derivatives by rabbit alveolar macrophages. Effect of the sugar density J Biol Chem 258 14193 14199 6643476 1:CAS:528:DyaL3sXlvFejs74%3D (Pubitemid 14217940)
122. W Yeeprae S Kawakami F Yamashita M Hashida 2006 Effect of mannose density on mannose receptor-mediated cellular uptake of mannosylated O/W emulsions by macrophages J Control Release 114 193 201 16876282 1:CAS:528: DC%2BD28XovF2ksbw%3D (Pubitemid 44291840)
123. W Wijagkanalan S Kawakami M Takenaga R Igarashi F Yamashita M Hashida 2008 Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats J Control Release 125 121 130 18037185 1:CAS:528:DC%2BD1cXhtFWrsw%3D%3D (Pubitemid 350299608)
124. R Barth D Adams A Soloway F Alam M Darby 1994 Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy Bioconjug Chem 5 58 66 8199235 1:CAS:528:DyaK2cXos1eqsw%3D%3D (Pubitemid 2043885)
125. R Barth W Yang D Adams J Rotaru S Shukla M Sekido, et al. 2002 Molecular targeting of the epidermal growth factor receptor for neutron capture therapy of gliomas Cancer Res 62 3159 3166 12036929 1:CAS:528:DC%2BD38XksVyqs7o%3D (Pubitemid 34602409)
126. W Yang R Barth G Wu S Kawabata T Sferra A Bandyopadhyaya, et al. 2006 Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4 Clin Cancer Res 12 3792 3802 16778107 1:CAS:528:DC%2BD28XlvVSltrc%3D (Pubitemid 44000261)
127. S Konda S Wang M Brechbiel E Wiener 2002 Biodistribution of a 153 Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts Invest Radiol 37 199 204 11923642 1:CAS:528:DC%2BD38XjtFSgsb8%3D (Pubitemid 34259729)
128. Z Yao M Zhang H Sakahara T Saga Y Arano J Konishi 1998 Avidin targeting of intraperitoneal tumor xenografts J Natl Cancer Inst 90 25 29 9428779 1:CAS:528:DyaK1cXktlOktQ%3D%3D (Pubitemid 28078077)
129. D Wilbur P Pathare D Hamlin K Buhler R Vessella 1998 Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrimers Bioconjug Chem 9 813 825 9815176 1:CAS:528:DyaK1cXmsleit7Y%3D (Pubitemid 28542250)
130. H Kobayashi S Kawamoto T Saga N Sato T Ishimori J Konishi, et al. 2001 Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI Bioconjug Chem 12 587 593 11459464 1:CAS:528: DC%2BD3MXktVyksL4%3D (Pubitemid 32696233)
131. H Kobayashi S Kawamoto R Star T Waldmann M Brechbiel P Choyke 2003 Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase Bioconjug Chem 14 1044 1047 13129410 1:CAS:528:DC%2BD3sXmtFOht7w%3D (Pubitemid 37152966)
132. I Dijkgraaf A Rijnders A Soede A Dechesne G van Esse A Brouwer, et al. 2007 Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1, 3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes Org Biomol Chem 5 935 944 17340009 1:CAS:528:DC%2BD2sXisV2gt7Y%3D (Pubitemid 46375649)
133. A Almutairi R Rossin M Shokeen A Hagooly A Ananth B Capoccia, et al. 2009 Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis Proc Natl Acad Sci USA 106 685 690 19129498 1:CAS:528:DC%2BD1MXht12jtbc%3D
134. R Huang Y Qu W Ke J Zhu Y Pei C Jiang 2007 Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer FASEB J 21 1117 1125 17218540 1:CAS:528: DC%2BD2sXksVSqtb8%3D (Pubitemid 46495701)
135. M Mamede T Saga T Ishimori T Higashi N Sato H Kobayashi, et al. 2004 Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex J Control Release 95 133 141 15013240 1:CAS:528:DC%2BD2cXotlWnsA%3D%3D (Pubitemid 38167687)
136. J Kukowska-Latallo E Raczka A Quintana C Chen M Rymaszewski JJ Baker 2000 Intravascular and endobronchial DNA delivery to murine lung tissue using a novel, nonviral vector Hum Gene Ther 11 1385 1395 10910136 1:CAS:528: DC%2BD3cXks1yktbs%3D (Pubitemid 30451019)
137. N Sato H Kobayashi T Saga Y Nakamoto T Ishimori K Togashi, et al. 2001 Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice Clin Cancer Res 7 3606 3612 11705883 1:CAS:528:DC%2BD3MXptFaisb4%3D (Pubitemid 33070001)
138. L Vinter-Jensen J Frøkiaer P Jørgensen J Marqversen M Rehling E Dajani, et al. 1995 Tissue distribution of 131I-labelled epidermal growth factor in the pig visualized by dynamic scintigraphy J Endocrinol 144 5 12 7891025 1:CAS:528:DyaK2MXjtlCkt7s%3D
139. W Yang R Barth D Adams M Ciesielski R Fenstermaker S Shukla, et al. 2002 Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas Cancer Res 62 6552 6558 12438250 1:CAS:528:DC%2BD38XovFOksrc%3D (Pubitemid 35364121)
140. S Bai C Thomas F Ahsan 2007 Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin J Pharm Sci 96 2090 2106 17286291 1:CAS:528:DC%2BD2sXoslSgs7k%3D (Pubitemid 47280103)
141. A Menjoge R Navath A Asad S Kannan C Kim R Romero, et al. 2010 Transport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates Biomaterials 31 5007 5021 20346497 1:CAS:528:DC%2BC3cXkvVejsrk%3D
142. W Wijagkanalan Y Higuchi S Kawakami M Teshima H Sasaki M Hashida 2008 Enhanced anti-inflammation of inhaled dexamethasone palmitate using mannosylated liposomes in an endotoxin-induced lung inflammation model Mol Pharmacol 74 1183 1192 18669445 1:CAS:528:DC%2BD1cXhtlCntrbI
143. Wijagkanalan W, Kawakami S, Higuchi Y, Yamashita F, Hashida M. Intratracheally instilled mannosylated cationic liposome/NFkappaB decoy complexes for effective prevention of LPS-induced lung inflammation. J Control Release. 2010 in press.
144. DN McLennan CJH Porter SA Charman 2005 Subcutaneous drug delivery and the role of the lymphatics Drug Discov Today Tech 2 89 96 1:CAS:528: DC%2BD2MXpvFOmtL8%3D (Pubitemid 40946313)
145. L Kaminskas J Kota V McLeod B Kelly P Karellas C Porter 2009 PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats J Control Release 140 108 116 19686787 1:CAS:528:DC%2BD1MXhtlOks7zK
146. A Florence N Hussain 2001 Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas Adv Drug Deliv Rev 50 S69 S89 11576696 1:CAS:528:DC%2BD3MXntVWku78%3D
147. A Florence T Sakthivel I Toth 2000 Oral uptake and translocation of a polylysine dendrimer with a lipid surface J Control Release 65 253 259 10699285 1:CAS:528:DC%2BD3cXhtl2qsLw%3D (Pubitemid 30122930)
148. W Ke Y Zhao R Huang C Jiang Y Pei 2008 Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system J Pharm Sci 97 2208 2216 17879294 1:CAS:528:DC%2BD1cXntFWru7Y%3D
149. B Zolnik N Sadrieh 2009 Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs Adv Drug Deliv Rev 61 422 427 19389437 1:CAS:528:DC%2BD1MXmsF2js78%3D
150. C Herborn J Barkhausen I Paetsch P Hunold M Mahler K Shamsi, et al. 2003 Coronary arteries: contrast-enhanced MR imaging with SH L 643A-experience in 12 volunteers Radiology 229 217 223 12944598 (Pubitemid 37152127)
151. T McCarthy P Karellas S Henderson M Giannis D O'Keefe G Heery, et al. 2005 Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention Mol Pharm 2 312 318 16053334 1:CAS:528:DC%2BD2MXltlGhu7w%3D (Pubitemid 41186407)
152. D Patton Y Cosgrove Sweeney T McCarthy S Hillier 2006 Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model Antimicrob Agents Chemother 50 1696 1700 16641437 1:CAS:528:DC%2BD28XksVKkt7w%3D
153. R Rupp S Rosenthal L Stanberry 2007 VivaGel (SPL7013 Gel): a candidate dendrimer-microbicide for the prevention of HIV and HSV infection Int J Nanomedicine 2 561 566 18203424 1:CAS:528:DC%2BD1cXhtFKrtr0%3D
154. Yao H, Veine D, Fay K, Staszewski E, Zeng Z, Livant D. The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation. Breast Cancer Res Treat. 2010 in press.
155. H Kobayashi N Sato T Saga Y Nakamoto T Ishimori S Toyama, et al. 2000 Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity Eur J Nucl Med 27 1334 1339 11007515 1:CAS:528:DC%2BD3cXnsFCjs78%3D
156. P Carney P Rogers D Johnson 1989 Dual isotope study of iodine-125 and indium-111-labeled antibody in athymic mice J Nucl Med 30 374 384 2738666 1:CAS:528:DyaK3cXmt1OhtL8%3D (Pubitemid 19077328)
157. A Casas S Battah G Di Venosa P Dobbin L Rodriguez H Fukuda, et al. 2009 Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy J Control Release 135 136 143 19168101 1:CAS:528:DC%2BD1MXjslWqsrw%3D
158. A Chauhan N Jain P Diwan A Khopade 2004 Solubility enhancement of indomethacin with poly(amidoamine) dendrimers and targeting to inflammatory regions of arthritic rats J Drug Target 12 575 583 15621683 1:CAS:528: DC%2BD2cXhtFCqurfM (Pubitemid 40100705)
159. A Chauhan P Diwan N Jain D Tomalia 2009 Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers Biomacromolecules 10 1195 1202 19348417 1:CAS:528:DC%2BD1MXktVOks70%3D
160. Y Cheng N Man T Xu R Fu X Wang L Wen 2007 Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers J Pharm Sci 96 595 602 17094130 1:CAS:528:DC%2BD2sXis1ejsrg%3D
161. T Vandamme L Brobeck 2005 Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide J Control Release 102 23 38 15653131 1:CAS:528:DC%2BD2MXktVGjsQ%3D%3D (Pubitemid 40093773)
162. D Bhadra S Bhadra N Jain 2006 PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate Pharm Res 23 623 633 16374532 1:CAS:528:DC%2BD28Xitlemtrk%3D
163. Y Koyama V Talanov M Bernardo Y Hama C Regino M Brechbiel, et al. 2007 A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice J Magn Reson Imaging 25 866 871 17345640 (Pubitemid 46516742)
164. M Subbarayan SJ Shetty TS Srivastava OP Noronha AM Samuel H Mukhtar 2001 Water-soluble 99mTc-labeled dendritic novel porphyrins tumor imaging and diagnosis Biochem Biophys Res Commun 281 32 36 11178956 1:CAS:528: DC%2BD3MXhtFems7g%3D (Pubitemid 32924395)
165. Y Zhang Y Sun X Xu X Zhang H Zhu L Huang, et al. 2010 Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates J Med Chem 53 3262 3272 20350006 1:CAS:528:DC%2BC3cXjvFKjurs%3D
166. H Sarin A Kanevsky H Wu K Brimacombe S Fung A Sousa, et al. 2008 Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells J Transl Med 6 80 19094226