In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation

International Journal of Pharmaceutics

Volumn 399, Issue 1-2, 2010, Pages 140-147

  Inapagolla, R ^a   Guru, B Raja ^a   Kurtoglu, Y E ^a   Gao, X ^b   Lieh Lai, M ^c   Bassett, D J P ^b   Kannan, R M ^a  

^a Wayne State University   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Dendrimers; Drug delivery; Methylprednisolone; Murine lung inflammation model; PAMAM

Indexed keywords

COLLAGENASE; DENDRIMER; LYSINE; METHYLPREDNISOLONE SODIUM SUCCINATE; OVALBUMIN; POLYAMIDOAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE MODEL; DISPERSION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG FORMULATION; EOSINOPHIL; FEMALE; IN VIVO STUDY; LUNG LAVAGE; MOUSE; NONHUMAN; PHAGOCYTE; PNEUMONIA; PRIORITY JOURNAL; SINGLE DRUG DOSE; SOLUBILIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; CHEMISTRY, PHARMACEUTICAL; DENDRIMERS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; FEMALE; GLUTARATES; METHYLPREDNISOLONE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NYLONS; OVALBUMIN; PNEUMONIA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77956885441     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.07.030     Document Type: Article

References (26)

1. Barrington K.J., Bull D., Finer N.N. Randomized trial of nasal synchronized intermittent mandatory ventilation compared with continuous positive airway pressure after extubation of very low birth weight infants. Pediatrics 2001, 107:638-641.
2. Birrell M.A., Battram C.H., Woodman P., McCluskie K., Belvisi M.G. Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways. Respir. Res. 2003, 4:3-8.
3. Chand N., Hess F.G., Nolan K., Diamantis W., McGee J., Sofia R.D. Aeroallergen-induced immediate asthmatic responses and late-phase associated pulmonary eosinophilia in the guinea pig: Effect of methylprednisolone and mepyramine. Int. Arch. Allergy Appl. Immunol. 1990, 91:311-314.
4. DeLorme M.P., Yang H., Elbon-Copp C., Gao X., Barraclough-Mitchell H., Bassett D.J.P. Hyperresponsive airways correlate with lung tissue inflammatory cell changes in ozone-exposed rats. J. Toxicol. Environ. Health A 2002, 65:1453-1470.
5. Esfand R., Tomalia D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. DDT 2001, 6:427-436.
6. 2 muscarnic receptors in antigen-challenged guinea pigs. J. Clin. Invest. 1997, 100:2254-2262.
7. Eventov-Friedman S., Shinwell E.S. Current controversies in perinatal steroid therapy. Acta Paediatr. 2008, 97:1492-1501.
8. Elenkov I.J. Glucocorticoids and the Th1/Th2 balance. Ann. N.Y. Acad. Sci. 2004, 1024:138-146.
9. Franchimont D. Overview of the actions of glucocorticoids on the immune response-a good model to characterize new pathways of immunosuppression for new treatment strategies. Ann. N.Y. Acad. Sci. 2004, 1024:124-137.
10. +γ δT cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J. Immunol. 2003, 171:3170-3178.
11. Halliday H.L., Ehrenkranz R.A. Early postnatal (<96hours) corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst. Rev. 2001, 1:1146.
12. Holgate S.T., Holloway J., Wilson S., Howarth P.H., Haitchi H.M., Babu S., Davies D.E. Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities. J. Allergy Clin. Immunol. 2006, 117:496-506.
13. Kannisto S., Laatikainen A., Taivainen A., Savolainen K., Tukiainen H., Voutilainen R. Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical suppression during inhaled steroid therapy in adult asthmatic patients. Eur. J. Endocrinol. 2004, 50:687-690.
14. Khandare J., Kolhe P., Pillai O., Kannan S., Lieh-Lai M., Kannan R.M. Synthesis, cellular transport, and activity of polamidoamine dendrimer-methylprednisolone conjugate. Bioconjugate Chem. 2005, 60:330-337.
15. Kolhe P., Khandare J., Pillai O., Kannan S., Lieh-Lai M., Kannan R.M. Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload. Biomaterials 2006, 27:660-669.
16. Kolhe P., Kannan R.M., Lieh-lai M., Glibatec M. Effect of dendrimer end functionality on the cytotoxicity and the cellular drug delivery in lung epithelial cells. J. Biomater. Sci. Polym. Ed. 2004, 15:311-330.
17. Kurtoglu Y.E., Navath R.S., Wang B., Kannan S., Romero R., Kannan R.M. Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery. Biomaterials 2009, 30:2112-2121.
18. Li C.Y., Lam K.W., Yam L.T. Esterases in human leukocytes. J. Histochem. Cytochem. 1973, 21:1-12.
19. Navath R., Kurtoglu Y.E., Wang B., Kannan S., Romero R., Kannan R.M. Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels. Bioconjugate Chem. 2008, 19:2446-2455.
20. Rao R., Gregson R.K., Jones A.C., Miles E.A., Campbell M.J., Warner J.O. Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone with beclomethasone. Eur. Respir. J. 1999, 13:87-94.
21. Roberts K., Jaffar Z.H., Semper A.E., Holgate S.T. Asthma: clinical aspects and mucosal immunity. Mucosal Immunology 1999, 1197-1211. Academic Press, San Diego. P.L. Ogra, M.E. Lamm, J. Bienenstock, J. Mestecky, W. Strober, J.R. McGhee (Eds.).
22. Schultheis A.H., Bassett D.J. Guinea pig lung inflammatory cell changes following acute ozone exposure. Lung 1994, 172:169-181.
23. Shinwell E.S., Karplus M., Reich D., Weintraub Z., Blazer S., Bader D., Yurman S., Dolfin T., Kogan A., Dollberg S., Arbel E., Goldberg M., Gur I., Naor N., Sirota L., Mogilner S., Zaritsky A., Barak M., Gottfried E. Early postnatal dexamethasone treatment and increased incidence of cerebral palsy. Arch. Dis. Childhood: Fetal Neonatal Ed. 2000, 83:F177-181.
24. Wang B., Navath R.S., Romero R., Kannan S., Kannan R. Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells. Int. J. Pharm. 2009, 377:159-168.
25. Wilson-Costello D., Walsh M.C., Langer J.C., Guillet R., Laptook A.R., Stoll B.J., Shankaran S., Finer N.N., Van Meurs K.P., Engle W.A., Das A. Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. Pediatrics 2009, 123:430-437.
26. Wiwattanapatapee R., Lomlim L., Saramunee K. Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid. J. Control. Release 2003, 88:1-9.