Dendrimeric systems and their applications in ocular drug delivery

The Scientific World Journal

Volumn 2013, Issue , 2013, Pages

  Yavuz, Burçin ^a   Bozdaǧ Pehlivan, Sibel ^a   Ünlü, Nurşen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRIMER; DRUG CARRIER; EYE DROPS;

ANIMAL; CHEMISTRY; DIFFUSION; HUMAN; INTRAOCULAR DRUG ADMINISTRATION; REVIEW; SYNTHESIS;

ADMINISTRATION, OPHTHALMIC; ANIMALS; DENDRIMERS; DIFFUSION; DRUG CARRIERS; HUMANS; OPHTHALMIC SOLUTIONS;

EID: 84893828474     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1155/2013/732340     Document Type: Article

References (99)

1. Nagarwal R. C., Kant S., Singh P. N., Maiti P., Pandit J. K., Polymeric nanoparticulate system: a potential approach for ocular drug delivery. Journal of Controlled Release 2009 136 1 2 13 2-s2.0-67349084376 10.1016/j.jconrel.2008. 12.018
2. Gaudana R., Jwala J., Boddu S. H. S., Mitra A. K., Recent perspectives in ocular drug delivery. Pharmaceutical Research 2009 26 5 1197 1216 2-s2.0-63949084823 10.1007/s11095-008-9694-0
3. Lang J. C., Ocular drug delivery conventional ocular formulations. Advanced Drug Delivery Reviews 1995 16 1 39 43 2-s2.0-0029347541 10.1016/0169-409X(95)00012-V
4. Ranta V. P., Mannermaa E., Lummepuro K., Subrizi A., Laukkanen A., Antopolsky M., Murtomaki L., Hornof M., Urtti A., Barrier analysis of periocular drug delivery to the posterior segment. Journal of Controlled Release 2010 148 1 42 48 2-s2.0-78649529307 10.1016/j.jconrel.2010.08.028
5. Eljarrat-Binstock E., Pe'er J., Domb A. J., New techniques for drug delivery to the posterior eye segment. Pharmaceutical Research 2010 27 4 530 543 2-s2.0-77953173751 10.1007/s11095-009-0042-9
6. Del Amo E. M., Urtti A., Current and future ophthalmic drug delivery systems: a shift to the posterior segment. Drug Discovery Today 2008 13 3-4 135 143 2-s2.0-39149121847 10.1016/j.drudis.2007.11.002
7. Ranta V. P., Urtti A., Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling. Advanced Drug Delivery Reviews 2006 58 11 1164 1181 2-s2.0-33751192060 10.1016/j.addr.2006.07.025
8. Quintana A., Raczka E., Piehler L., Lee I., Myc A., Majoros I., Patri A. K., Thomas T., Mule J., Baker J. R., Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharmaceutical Research 2002 19 9 1310 1316 2-s2.0-0036744856 10.1023/A:1020398624602
9. Diebold Y., Calonge M., Applications of nanoparticles in ophthalmology. Progress in Retinal and Eye Research 2010 29 6 596 609 2-s2.0-78650582969 10.1016/j.preteyeres.2010.08.002
10. Yasukawa T., Ogura Y., Tabata Y., Kimura H., Wiedemann P., Honda Y., Drug delivery systems fo (Pubitemid 38737129)
11. Campbell M., Nguyen A. T. H., Kiang A. S., Tam L., Kenna P. F., Dhubhghaill S. N., Humphries M., Farrar G. J., Humphries P., Reversible and size-selective opening of the inner blood-retina barrier: a novel therapeutic strategy. Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations 2010 664 New York, NY, USA Springer 301 308 10.1007/978-1-4419- 1399-9-34
12. Pahuja P., Arora S., Pawar P., Ocular drug delivery system: a reference to natural polymers. Expert Opinion on Drug Delivery 2012 9 7 837 861
13. Wadhwa S., Paliwal R., Paliwal S. R., Vyas S. P., Nanocarriers in ocular drug delivery: an update review. Current Pharmaceutical Design 2009 15 23 2724 2750 2-s2.0-70350148188 10.2174/138161209788923886
14. Raghava S., Hammond M., Kompella U. B., Periocular routes for retinal drug delivery. Expert Opinion on Drug Delivery 2004 1 1 99 114 2-s2.0-14544282902 10.1517/17425247.1.1.99 (Pubitemid 40297959)
15. Patel P. B., Shastri D. H., Shelat P. K., Shukla A. K., Ophthalmic drug delivery system: challenges and approaches. Systematic Reviews in Pharmacy 2010 1 2 113 120
16. Perry H. D., Solomon R., Donnenfeld E. D., Perry A. R., Wittpenn J. R., Greenman H. E., Savage H. E., Evaluation of topical cyclosporine for the treatment of dry eye disease. Archives of Ophthalmology 2008 126 8 1046 1050 2-s2.0-49449090225 10.1001/archopht.126.8.1046
17. Yavuz B., Bozdaǧ Pehlvan S., Ünlü N., An overview on dry eye treartment: approaches for cyclosporin a delivery. The Scientific World Journal 2012 2012 1 12
18. Venkata Ratnam G., Madhavi S., Rajesh P., Ocular drug delivery: an update review. International Journal of Pharma and Bio Sciences 2011 1 4 437 446
19. Hamidi M., Azadi A., Rafiei P., Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews 2008 60 15 1638 1649 2-s2.0-55749083044 10.1016/j.addr.2008.08.002
20. Jiang J., Moore J. S., Edelhauser H. F., Prausnitz M. R., Intrascleral drug delivery to the eye using hollow microneedles. Pharmaceutical Research 2009 26 2 395 403 2-s2.0-58549106105 10.1007/s11095-008-9756-3
21. Urtti A., Challenges and obstacles of ocular pharmacokinetics and drug delivery. Advanced Drug Delivery Reviews 2006 58 11 1131 1135 2-s2.0-33751187547 10.1016/j.addr.2006.07.027
22. Sahoo S. K., Diinawaz F., Krishnakumar S., Nanotechnology in ocular drug delivery. Drug Discovery Today 2008 13 3-4 144 151 2-s2.0-39149109626 10.1016/j.drudis.2007.10.021
23. Gillies E. R., Frechet J. M., Dendrimers and dendritic polymers in drug delivery. Drug Discovery Today 2005 10 1 35 43 2-s2.0-12844258906 10.1016/S1359-6446(04)03276-3 (Pubitemid 40164817)
24. Cheng Y. Y., Xu Z. H., Ma M. L., Xu T. W., Dendrimers as drug carriers: applications in different routes of drug administration. Journal of Pharmaceutical Sciences 2008 97 1 123 143 2-s2.0-38349134916 10.1002/jps.21079
25. Esfand R., Tomalia D. A., Poly(amidoamine) (pamam) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discovery Today 2001 6 8 427 436 2-s2.0-0035342007 10.1016/S1359-6446(01)01757-3 (Pubitemid 32328297)
26. Hecht S., Frechet J. M. J., Dendritic encapsulation of function: applying nature's site isolation principle from biomimetics to materials science. Angewandte Chemie International Edition 2001 40 1 74 91
27. Trivedi V., Patel U., Bhimani B., Daslania D., Patel G., Vyas B., Dendrimer: a polymer of 21st century. IJPRBS Journal 2012 1 2 1 21
28. Hodge P., Organic-chemistry: polymer science branches out. Nature 1993 362 6415 18 19 2-s2.0-0040246081
29. Klajnert B., Bryszewska M., Dendrimers: properties and applications. Acta Biochimica Polonica 2001 48 1 199 208 2-s2.0-0035229874 (Pubitemid 33632622)
30. Nanjwade B. K., Bechra H. M., Derkar G. K., Manvi F. V., Nanjwade V. K., Dendrimers: emerging polymers for drug-delivery systems. European Journal of Pharmaceutical Sciences 2009 38 3 185 196 2-s2.0-70349129495 10.1016/j.ejps.2009.07.008
31. Tomalia D. A., Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Progress in Polymer Science 2005 30 3-4 294 324 2-s2.0-18444392735 10.1016/j.progpolymsci. 2005.01.007 (Pubitemid 40642933)
32. Bharti J. P., Prajapati S. K., Jaiswal M. K., Yadav R. D., Dendrimer multifunctional nano-device: a review. International Journal of Pharmaceutical Sciences and Research 2011 2 8 1947 1960
33. Garg T., Singh O., Arora S., Murthy R., Dendrimer: a novel scaffold for drug delivery. International Journal of Pharmaceutical Sciences Review and Research 2011 7 2 211 220 2-s2.0-79955550509
34. Kaminskas L. M., Boyd B. J., Porter C. J. H., Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on adme properties. Nanomedicine 2011 6 6 1063 1084 2-s2.0-80052280058 10.2217/nnm.11.67
35. Jevprasesphant R., Penny J., Attwood D., McKeown N. B., D'Emanuele A., Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharmaceutical Research 2003 20 10 1543 1550 2-s2.0-0142042448 10.1023/A:1026166729873 (Pubitemid 37268266)
36. Chen H. T., Neerman M. F., Parrish A. R., Simanek E. E., Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery. Journal of the American Chemical Society 2004 126 32 10044 10048 2-s2.0-4043103282 10.1021/ja048548j (Pubitemid 39079425)
37. Jain K., Kesharwani P., Gupta U., Jain N. K., Dendrimer toxicity: let's meet the challenge. International Journal of Pharmaceutics 2010 394 1-2 122 142 2-s2.0-77953702051 10.1016/j.ijpharm.2010.04.027
38. Shaunak S., Thomas S., Gianasi E., Godwin A., Jones E., Teo I., Mireskandari K., Luthert P., Duncan R., Patterson S., Khaw P., Brocchini S., Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nature Biotechnology 2004 22 8 977 984 2-s2.0-3542993234 10.1038/nbt995 (Pubitemid 39014474)
39. Kang S. J., Durairaj C., Kompella U. B., O'Brien J. M., Grossniklaus H. E., Subconjunctival nanoparticle carboplatin in the treatment of murine retinoblastoma. Archives of Ophthalmology 2009 127 8 1043 1047 2-s2.0-68549123611 10.1001/archophthalmol.2009.185
40. Eichman J. D., Bielinska A. U., Kukowska-Latallo J. F., Baker J. R. Jr., The use of pamam dendrimers in the efficient transfer of genetic material into cells. Pharmaceutical Science and Technology Today 2000 3 7 232 245 2-s2.0-0034234877 10.1016/S1461-5347(00)00273-X (Pubitemid 30462197)
41. Silva N. P., Menacho F. P., Chorilli M., Dendrimers as potential platform in nanotechnology-based drug delivery systems. IOSR Journal of Pharmacy 2012 2 5 23 30
42. Tomalia D. A., Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angewandte Chemie International Edition 1990 29 2 138 175 (Pubitemid 20142204)
43. Duncan R., Izzo L., Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews 2005 57 15 2215 2237 2-s2.0-28744445460 10.1016/j.addr.2005.09.019 (Pubitemid 41759394)
44. Malik A., Chaudhary S., Garg G., Tomar A., Dendrimers: a tool for drug delivery. Advances in Biological Research 2012 6 4 165 169
45. Malik N., Wiwattanapatapee R., Klopsch R., Lorenz K., Frey H., Weener J. W., Meijer E. W., Paulus W., Duncan R., Dendrimers: relationship between structure and biocompatibility in vitro and preliminary studies on the biodistribution of i-125-labelled polyamidoamine dendrimers in vivo. Journal of Controlled Release 2000 65 1-2 133 148 2-s2.0-0034005436 10.1016/S0168-3659(99) 00246-1 (Pubitemid 30122922)
46. Liu M., Kono K., Frechet J. M., Water-soluble dendritic unimolecular micelles: their potential as drug delivery agents. Journal of Controlled Release 2000 65 1-2 121 131 2-s2.0-0033997598 10.1016/S0168-3659(99)00245-X (Pubitemid 30122921)
47. Oliveira J. M., Salgado A. J., Sousa N., Mano J. F., Reis R. L., Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies: a review. Progress in Polymer Science 2010 35 9 1163 1194 2-s2.0-77956183767 10.1016/j.progpolymsci.2010.04.006
48. Medina S. H., El-Sayed M. E., Dendrimers as carriers for delivery of chemotherapeutic agents. Chemical Reviews 2009 109 7 3141 3157 2-s2.0-67650690627 10.1021/cr900174j
49. Gajbhiye V., Vijayaraj Kumar P., Tekade R. K., Jain N. K., Pegylated ppi dendritic architectures for sustained delivery of h2 receptor antagonist. European Journal of Medicinal Chemistry 2009 44 3 1155 1166 2-s2.0-60549108884 10.1016/j.ejmech.2008.06.012
50. Stasko N. A., Johnson C. B., Schoenfisch M. H., Johnson T. A., Holmuhamedov E. L., Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells. Biomacromolecules 2007 8 12 3853 3859 2-s2.0-38049027787 10.1021/bm7008203
51. Kumar P., Meena K. P., Kumar P., Choudhary C., Thakur D. S., Bajpayee P., Dendrimer: a novel polymer for drug delivery. JITPS Journal 2010 1 6 252 269
52. Menjoge A. R., Kannan R. M., Tomalia D. A., Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications. Drug Discovery Today 2010 15 5-6 171 185 2-s2.0-77949275122 10.1016/j.drudis.2010.01. 009
53. McCarthy T. D., Karellas P., Henderson S. A., Giannis M., O'Keefe D. F., Heery G., Paull J. R. A., Matthews B. R., Holan G., Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for hiv and sti prevention. Molecular Pharmaceutics 2005 2 4 312 318 2-s2.0-23944434447 10.1021/mp050023q (Pubitemid 41186407)
54. Wijagkanalan W., Kawakami S., Hashida M., Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations. Pharmaceutical Research 2011 28 7 1500 1519 2-s2.0-79959874185 10.1007/s11095-010-0339-8
55. D'Emanuele A., Attwood D., Dendrimer-drug interactions. Advanced Drug Delivery Reviews 2005 57 15 2147 2162 2-s2.0-28844485107 10.1016/j.addr.2005.09. 012 (Pubitemid 41760432)
56. Jain N. K., Gupta U., Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability. Expert Opinion on Drug Metabolism and Toxicology 2008 4 8 1035 1052 2-s2.0-51049083983 10.1517/17425255.4.8.1035
57. Smith D. K., Dendritic gels: many arms make light work. Advanced Materials 2006 18 20 2773 2778 2-s2.0-33750528504 10.1002/adma.200600474 (Pubitemid 44664120)
58. Richter-Egger D. L., Tesfai A., Tucker S. A., Spectroscopic investigations of poly(propyleneimine)dendrimers using the solvatochromic probe phenol blue and comparisons to poly(amidoamine) dendrimers. Analytical Chemistry 2001 73 23 5743 5751 2-s2.0-0035579229 10.1021/ac0155355 (Pubitemid 33126733)
59. Jansen J. F. G. A., Debrabandervandenberg E. M. M., Meijer E. W., Encapsulation of guest molecules into a dendritic box. Science 1994 266 5188 1226 1229 2-s2.0-0028042356 (Pubitemid 24371278)
60. Jansen JFGA J. F. G. A., Debrabandervandenberg E. M. M., Meijer E. W., The dendritic box and bengal rose. Polymeric Materials 1995 73 123 124
61. Jansen J. F. G. A., Meijer E. W., Debrabandervandenberg E. M. M., The dendritic box: shape-selective liberation of encapsulated guests. Journal of the American Chemical Society 1995 117 15 4417 4418 2-s2.0-0010920059
62. Kojima C., Kono K., Maruyama K., Takagishi T., Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjugate Chemistry 2000 11 6 910 917 2-s2.0-0033657796 10.1021/bc0000583
63. Kono K., Liu M., Frechet J. M. J., Design of dendritic macromolecules containing folate or methotrexate residues. Bioconjugate Chemistry 1999 10 6 1115 1121 2-s2.0-0033230698 10.1021/bc990082k
64. Stevelmans S., vanHest J. C. M., Jansen J. F. G. A., vanBoxtel D. A. F. J., Vanden Berg E. M. M. D., Meijer E. W., Synthesis, characterization and guest-host properties of inverted unimolecular dendritic micelles. Journal of the American Chemical Society 1996 118 31 7398 7399 2-s2.0-0029738906 10.1021/ja954207h (Pubitemid 26270628)
65. Pan G. F., Lemmouchi Y., Akala E. O., Bakare O., Studies on pegylated and drug-loaded pamam dendrimers. Journal of Bioactive and Compatible Polymers 2005 20 1 113 128 2-s2.0-12444289540 10.1177/0883911505049656 (Pubitemid 40144216)
66. Greenwald R. B., Choe Y. H., McGuire J., Conover C. D., Effective drug delivery by pegylated drug conjugates. Advanced Drug Delivery Reviews 2003 55 2 217 250 2-s2.0-0037428969 10.1016/S0169-409X(02)00180-1 (Pubitemid 36135917)
67. Wendland M. S., Zimmerman S. C., Synthesis of cored dendrimers. Journal of the American Chemical Society 1999 121 6 1389 1390
68. Schultz L. G., Zhao Y., Zimmerman S. C., Synthesis of cored dendrimers with internal cross-links. Angewandte Chemie International Edition 2001 40 10 1962 1966 (Pubitemid 32525110)
69. Kim T., Seo H. J., Choi J. S., Jang H. S., Baek J., Kim K., Park J. S., Pamam-peg-pamam: novel triblock copolymer as a biocompatible and efficient gene delivery carrier. Biomacromolecules 2004 5 6 2487 2492 2-s2.0-9744281157 10.1021/bm049563j (Pubitemid 39585305)
70. Boas U., Heegaard P. M., Dendrimers in drug research. Chemical Society Reviews 2004 33 1 43 63 2-s2.0-1642414039 (Pubitemid 38376610)
71. El Kazzouli S., Mignani S., Bousmina M., Majoral J. P., Dendrimer therapeutics: covalent and ionic attachments. New Journal of Chemistry 2012 36 2 227 240 2-s2.0-84856704956 10.1039/c1nj20459a
72. Patri A. K., Kukowska-Latallo J. F., Baker J. R., Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Advanced Drug Delivery Reviews 2005 57 15 2203 2214 2-s2.0-28744437107 10.1016/j.addr.2005.09.014 (Pubitemid 41759393)
73. Kaminskas L. M., McLeod V. M., Porter C. J., Boyd B. J., Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation. Molecular Pharmaceutics 2012 9 3 355 373 2-s2.0-84858064291 10.1021/mp2005966
74. Hoare T. R., Kohane D. S., Hydrogels in drug delivery: progress and challenges. Polymer 2008 49 8 1993 2007 2-s2.0-41549148288 10.1016/j.polymer. 2008.01.027
75. Nirmal H. B., Bakliwal S. R., Pawar S. P., In-situ gel: new trends in controlled and sustained drug delivery system. International Journal of PharmTech Research 2010 2 2 1398 1408 2-s2.0-77954735684
76. Navath R. S., Menjoge A. R., Dai H., Romero R., Kannan S., Kannan R. M., Injectable pamam dendrimer-peg hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation. Molecular Pharmaceutics 2011 8 4 1209 1223 2-s2.0-79961084368 10.1021/mp200027z
77. Sontjens S. H. M., Nettles D. L., Carnahan M. A., Setton L. A., Grinstaff M. W., Biodendrimer-based hydrogel scaffolds for cartilage tissue repair. Biomacromolecules 2006 7 1 310 316 2-s2.0-31544453046 10.1021/bm050663e (Pubitemid 43154508)
78. Jang W. D., Aida T., Dendritic physical gels: structural parameters for gelation with peptide-core dendrimers. Macromolecules 2003 36 22 8461 8469 2-s2.0-0345411949 10.1021/ma034221b
79. Marco Zarbin A., James Leary F., Montemagno C., Ritch R., Humayun M. S., Ryan S. J., Nanomedicine in ophthalmology. Retina 2013 689 711
80. Perumal O. P., Inapagolla R., Kannan S., Kannan R. M., The effect of surface functionality on cellular trafficking of dendrimers. Biomaterials 2008 29 24-25 3469 3476 2-s2.0-46549084447 10.1016/j.biomaterials.2008.04.038
81. Kambhampati S. P., Kannan R. M., Dendrimer nanoparticles for ocular drug delivery. Journal of Ocular Pharmacology and Therapeutics 2013 29 2 151 165 10.1089/jop.2012.0232
82. Vandamme T. F., Brobeck L., Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. Journal of Controlled Release 2005 102 1 23 38 2-s2.0-11844250522 10.1016/j.jconrel.2004. 09.015 (Pubitemid 40093773)
83. Spataro G. G., Malecaze F., Turrin C.-O., Soler V., Duhayon C., Elena P.-P., Majoral J.-P., Caminade A.-M., Designing dendrimers for ocular drug delivery. European Journal of Medicinal Chemistry 2010 45 1 326 334 2-s2.0-72149094058 10.1016/j.ejmech.2009.10.017
84. Durairaj C., Kadam R. S., Chandler J. W., Hutcherson S. L., Kompella U. B., Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability and delivery of gatifloxacin. Investigative Ophthalmology and Visual Science 2010 51 11 5804 5816 2-s2.0-77957357722 10.1167/iovs.10-5388
85. Marano R. J., Toth I., Wimmer N., Brankov M., Rakoczy P. E., Dendrimer delivery of an anti-vegf oligonucleotide into the eye: a long-term study into inhibition of laser-induced cnv, distribution, uptake and toxicity. Gene Therapy 2005 12 21 1544 1550 2-s2.0-27544499791 10.1038/sj.gt.3302579 (Pubitemid 41541772)
86. Duan X., Sheardown H., Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 2006 27 26 4608 4617 2-s2.0-33646886616 10.1016/j.biomaterials.2006.04.022 (Pubitemid 43783215)
87. Duan X. D., McLaughlin C., Griffith M., Sheardown H., Biofunctionalization of collagen for improved biological response: scaffolds for corneal tissue engineering. Biomaterials 2007 28 1 78 88 2-s2.0-33748916876 10.1016/j.biomaterials.2006.08.034 (Pubitemid 44427909)
88. Grinstaff M. W., Designing hydrogel adhesives for corneal wound repair. Biomaterials 2007 28 35 5205 5214 2-s2.0-34948840023 10.1016/j.biomaterials. 2007.08.041 (Pubitemid 47532199)
89. Sugisaki K., Usui T., Nishiyama N., Jang W. D., Yanagi Y., Yamagami S., Amano S., Kataoka K., Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins. Investigative Ophthalmology and Visual Science 2008 49 3 894 899 2-s2.0-41949092444 10.1167/iovs.07-0389
90. Makky A., Michel J. P., Maillard P., Rosilio V., Biomimetic liposomes and planar supported bilayers for the assessment of glycodendrimeric porphyrins interaction with an immobilized lectin. Biochimica et Biophysica Acta 2011 1808 3 656 666 2-s2.0-78650570160 10.1016/j.bbamem.2010.11.028
91. Nishiyama N., Stapert H. R., Zhang G. D., Takasu D., Jiang D. L., Nagano T., Aida T., Kataoka K., Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate Chemistry 2003 14 1 58 66 2-s2.0-0037254696 10.1021/bc025597h (Pubitemid 36169017)
92. Nishiyama N., Morimoto Y., Jang W. D., Kataoka K., Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy. Advanced Drug Delivery Reviews 2009 61 4 327 338 2-s2.0-64149094876 10.1016/j.addr.2009.01.004
93. Nishiyama N., Iriyama A., Jang W. D., Miyata K., Itaka K., Inoue Y., Takahashi H., Yanagi Y., Tamaki Y., Koyama H., Kataoka K., Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nature Materials 2005 4 12 934 941 2-s2.0-33344455281
94. Bravo-Osuna I., Herrero-Vanrell R., Molina Martínez I. T., Girón N., Gómez R., de la Mata F., Navarro M. G., In vitro and in vivo tolerance studies of carbosilane dendrimers for ophthalmic administration. Investigative Ophthalmology and Visual Science 2010 51 E-Abstract 437
95. Yao W. J., Sun K. X., Mu H. J., Liang N., Liu Y., Yao C., Liang R. C., Wang A. P., Preparation and characterization of puerarindendrimer complexes as an ocular drug delivery system. Drug Development and Industrial Pharmacy 2010 36 9 1027 1035 2-s2.0-77956408400 10.3109/03639041003610799
96. Iezzi R., Guru B. R., Glybina I. V., Mishra M. K., Kennedy A., Kannan R. M., Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012 33 3 979 988 2-s2.0-81155152766 10.1016/j.biomaterials.2011.10.010
97. Holden C. A., Tyagi P., Thakur A., Kadam R., Jadhav G., Kompella U. B., Yang H., Polyamidoamine dendrimer hydrogel for enhanced delivery of antiglaucoma drugs. Nanomedicine 2012 8 5 776 783 2-s2.0-80054075203
98. Yang H., Tyagi P., Kadam R. S., Holden C. A., Kompella U. B., Hybrid dendrimer hydrogel/plga nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration. ACS Nano 2012 6 9 7595 7606
99. Wathier M., Jung P. J., Carnahan M. A., Kim T., Grinstaff M. W., Dendritic macromers as in situ polymerizing biomaterials for securing cataract incisions. Journal of the American Chemical Society 2004 126 40 12744 12745 2-s2.0-5644254184 (Pubitemid 39372281)