Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration

ACS Nano

Volumn 6, Issue 9, 2012, Pages 7595-7606

  Yang, Hu ^a,b   Tyagi, Puneet ^c   Kadam, Rajendra S ^c   Holden, Christopher A ^a   Kompella, Uday B ^c  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

controlled release; dendrimer; glaucoma; nanotechnology; ophthalmic solution; PLGA

Indexed keywords

AQUEOUS HUMOR; BRIMONIDINE; CELLULAR UPTAKE; CONTROLLED RELEASE; CYTOTOXIC; DOSAGE FORMS; DOSING FREQUENCY; ECONOMIC COSTS; EYE DROPS; GLAUCOMA; HISTOLOGICAL ANALYSIS; HUMAN CORNEAL EPITHELIAL CELLS; IN-VITRO; LONG LASTING; OCULAR DISEASE; PATIENT COMPLIANCE; PLGA; PLGA NANOPARTICLES; POLYAMIDOAMINE DENDRIMERS; RESIDENCE TIME; STRUCTURAL CHANGE; TIMOLOL MALEATE; TOPICAL FORMULATIONS;

BODY FLUIDS; COPOLYMERS; CYTOTOXICITY; DRUG DELIVERY; HYDROGELS; NANOPARTICLES; NANOTECHNOLOGY;

DENDRIMERS;

ANTIHYPERTENSIVE AGENT; DENDRIMER; LACTIC ACID; NANOCAPSULE; PAMAM STARBURST; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL; ARTICLE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECT; HYDROGEL; INTRAOCULAR PRESSURE; MATERIALS TESTING; PARTICLE SIZE; RABBIT; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME; ULTRASTRUCTURE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; DELAYED-ACTION PREPARATIONS; DENDRIMERS; HYDROGELS; INTRAOCULAR PRESSURE; LACTIC ACID; MATERIALS TESTING; NANOCAPSULES; PARTICLE SIZE; POLYGLYCOLIC ACID; RABBITS; TREATMENT OUTCOME;

EID: 84866656642     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn301873v     Document Type: Article

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