Cationic PAMAM dendrimers disrupt key platelet functions

Molecular Pharmaceutics

Volumn 9, Issue 6, 2012, Pages 1599-1611

  Jones, Clinton F ^a   Campbell, Robert A ^b   Franks, Zechariah ^b   Gibson, Christopher C ^b,c   Thiagarajan, Giridhar ^a,c   Vieira De Abreu, Adriana ^b,d   Sukavaneshvar, Sivaprasad ^e   Mohammad, S Fazal ^a,b,e   Li, Dean Y ^b   Ghandehari, Hamidreza ^a,c   Weyrich, Andrew S ^b   Brooks, Benjamin D ^a   Grainger, David W ^a,c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Department of Electrical and Computer Engineering   (United States)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e Thrombodyne Inc   (United States)

Author keywords

biocompatibility; nanotoxicity; PAMAM dendrimers; platelet activation; thrombin generation

Indexed keywords

AMINE; DENDRIMER; FLUORESCEIN ISOTHIOCYANATE; NANOMATERIAL; NANOPARTICLE; POLYAMIDOAMINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD COMPONENT; CELL AGGREGATION; CELL DISRUPTION; CELL STRUCTURE; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MEDICAL TECHNOLOGY; MOLECULAR SIZE; MOUSE; NANOTOXICOLOGY; NONHUMAN; NORMAL HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; THROMBOCYTE FUNCTION; THROMBOCYTE STRUCTURE;

BLOOD PLATELETS; CELLS, CULTURED; DENDRIMERS; FLOW CYTOMETRY; HUMANS; MICROSCOPY, CONFOCAL; NANOPARTICLES; NANOTECHNOLOGY; PLATELET ACTIVATION; PLATELET FUNCTION TESTS; THROMBIN;

EID: 84862001474     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2006054     Document Type: Article

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