Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 9, 2010, Pages 4311-4316

  Olson, Emilia S ^a   Jiang, Tao ^a   Aguilera, Todd A ^a   Nguyen, Quyen T ^a   Ellies, Lesley G ^a   Scadeng, Miriam ^a   Tsien, Roger Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dendrimeric nanoparticles; Molecular amplification; Molecular navigation; Targeted imaging agent; Transgenic tumor model

Indexed keywords

ACTIVATABLE CELL PENETRATING PEPTIDE; CELL PENETRATING PEPTIDE; CYANINE DYE 5; DENDRIMER; FLUORESCENT DYE; GADOLINIUM PENTETATE; GADOTERIC ACID; GELATINASE A; GELATINASE B; MMPSENSE 680; NANOPARTICLE; PROSENSE 680; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSENSOR; CANCER DIAGNOSIS; CONTROLLED STUDY; ENZYME ACTIVATION; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFRARED RADIATION; ISOTOPE LABELING; MATERIAL COATING; METASTASIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARENCHYMA; PRIORITY JOURNAL;

ANIMALS; FLUORESCENT DYES; MAGNETIC RESONANCE IMAGING; MASS SPECTROMETRY; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; PEPTIDE HYDROLASES; PEPTIDES;

EID: 77749297971     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910283107     Document Type: Article

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