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Volumn 66, Issue 4, 2014, Pages 542-556

Dendrimers for gene delivery - A potential approach for ocular therapy?

Author keywords

dendrimers; gene therapy; non viral vectors; ocular diseases

Indexed keywords

DENDRIMERS; GENE THERAPY; NON-VIRAL VECTORS; OCULAR DISEASES;

EID: 84899085765     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12104     Document Type: Review
Times cited : (83)

References (118)
  • 1
    • 84989581991 scopus 로고
    • 'Cascade'- and 'Nonskid-Chain-like' syntheses of molecular cavity topologies
    • etal.
    • Buhleier E, etal. 'Cascade'- and 'Nonskid-Chain-like' syntheses of molecular cavity topologies. Synthesis 1978; 2: 155-158.
    • (1978) Synthesis , vol.2 , pp. 155-158
    • Buhleier, E.1
  • 3
    • 33845378981 scopus 로고
    • Micelles. Part 1. Cascade molecules: A new approach to micelles. A [27]-arborol
    • etal.
    • Newkome GR, etal. Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol. J Org Chem 1985; 50: 2003-2004.
    • (1985) J Org Chem , vol.50 , pp. 2003-2004
    • Newkome, G.R.1
  • 5
    • 4544300716 scopus 로고    scopus 로고
    • Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic organic chemistry
    • Tomalia DA,. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic organic chemistry. Aldrichim Acta 2004; 37: 39-57.
    • (2004) Aldrichim Acta , vol.37 , pp. 39-57
    • Tomalia, D.A.1
  • 6
    • 75149167354 scopus 로고    scopus 로고
    • Dendrimer nanocarriers as versatile vectors in gene delivery
    • etal.
    • Dutta T, etal. Dendrimer nanocarriers as versatile vectors in gene delivery. Nanomed-Nanotechnol 2010; 6: 25-34.
    • (2010) Nanomed-Nanotechnol , vol.6 , pp. 25-34
    • Dutta, T.1
  • 8
    • 18444392735 scopus 로고    scopus 로고
    • Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry
    • Tomalia DA,. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci 2005; 30: 294-324.
    • (2005) Prog Polym Sci , vol.30 , pp. 294-324
    • Tomalia, D.A.1
  • 9
    • 70349129495 scopus 로고    scopus 로고
    • Dendrimers: Emerging polymers for drug-delivery systems
    • etal.
    • Nanjwade BK, etal. Dendrimers: emerging polymers for drug-delivery systems. Eur J Pharm Sci 2009; 38: 185-196.
    • (2009) Eur J Pharm Sci , vol.38 , pp. 185-196
    • Nanjwade, B.K.1
  • 10
    • 68949088286 scopus 로고    scopus 로고
    • Dendritic peptide-based carriers for gene delivery
    • Coles DJ, Toth I,. Dendritic peptide-based carriers for gene delivery. Curr Drug Deliv 2009; 6: 338-342.
    • (2009) Curr Drug Deliv , vol.6 , pp. 338-342
    • Coles, D.J.1    Toth, I.2
  • 11
    • 84863012364 scopus 로고    scopus 로고
    • Dendrimers as non-viral vectors for siRNA delivery
    • etal.
    • Liu X, etal. Dendrimers as non-viral vectors for siRNA delivery. New J Chem 2012; 36: 256-263.
    • (2012) New J Chem , vol.36 , pp. 256-263
    • Liu, X.1
  • 12
    • 28744443398 scopus 로고    scopus 로고
    • Dendrimers in biomedical applications - Reflections on the field
    • Svenson S, Tomalia DA,. Dendrimers in biomedical applications-reflections on the field. Adv Drug Deliv Rev 2005; 57: 2106-2129.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2106-2129
    • Svenson, S.1    Tomalia, D.A.2
  • 13
    • 84885386826 scopus 로고    scopus 로고
    • Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview
    • etal.
    • Mignani S, etal. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Adv Drug Deliv Rev 2013; 65: 1316-1330.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1316-1330
    • Mignani, S.1
  • 14
  • 15
    • 5844259443 scopus 로고    scopus 로고
    • Starburst dendrimers-nanoscopic macromolecules according to dendritic rules and principles
    • Tomalia DA,. Starburst dendrimers-nanoscopic macromolecules according to dendritic rules and principles. Macromol Symp 1996; 101: 243-255.
    • (1996) Macromol Symp , vol.101 , pp. 243-255
    • Tomalia, D.A.1
  • 16
    • 0038817081 scopus 로고
    • Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules
    • Hawker CJ, Fréchet JMJ,. Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. J Am Chem Soc 1990; 112: 7638-7647.
    • (1990) J Am Chem Soc , vol.112 , pp. 7638-7647
    • Hawker, C.J.1    Fréchet, J.M.J.2
  • 17
    • 34548527384 scopus 로고    scopus 로고
    • Dendrimers and their applications in immunoassays and clinical diagnostics
    • Singh P,. Dendrimers and their applications in immunoassays and clinical diagnostics. Biotechnol Appl Biochem 2007; 48: 1-9.
    • (2007) Biotechnol Appl Biochem , vol.48 , pp. 1-9
    • Singh, P.1
  • 18
    • 0032321246 scopus 로고    scopus 로고
    • Dendrimers - Branching out from curiosities into new technologies
    • etal.
    • Matthews OA, etal. Dendrimers-branching out from curiosities into new technologies. Prog Polym Sci 1998; 23: 1-56.
    • (1998) Prog Polym Sci , vol.23 , pp. 1-56
    • Matthews, O.A.1
  • 20
    • 0038715066 scopus 로고    scopus 로고
    • 'Lego' chemistry for the straightforward synthesis of dendrimers
    • etal.
    • Maraval V, etal. 'Lego' chemistry for the straightforward synthesis of dendrimers. J Org Chem 2003; 68: 6043-6046.
    • (2003) J Org Chem , vol.68 , pp. 6043-6046
    • Maraval, V.1
  • 21
    • 4444233074 scopus 로고    scopus 로고
    • Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes
    • etal.
    • Wu P, etal. Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes. Angew Chem Int Ed Engl 2004; 43: 3928-3932.
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 3928-3932
    • Wu, P.1
  • 22
    • 0001353467 scopus 로고
    • Values and limits of adenoviral vectors for gene transfer in vivo
    • [in German].
    • Briand P, Kahn A,. [Values and limits of adenoviral vectors for gene transfer in vivo]. Pathol Biol (Paris) 1993; 41: 663-671 [in German].
    • (1993) Pathol Biol (Paris) , vol.41 , pp. 663-671
    • Briand, P.1    Kahn, A.2
  • 23
    • 70449646908 scopus 로고    scopus 로고
    • Dendrimers in gene transfection
    • etal.
    • Shcharbin DG, etal. Dendrimers in gene transfection. Biochemistry (Moscow) 2009; 74: 1070-1079.
    • (2009) Biochemistry (Moscow) , vol.74 , pp. 1070-1079
    • Shcharbin, D.G.1
  • 24
    • 84861031974 scopus 로고    scopus 로고
    • Liposomes for intravitreal drug delivery: A state of the art
    • Bochot A, Fattal E,. Liposomes for intravitreal drug delivery: a state of the art. J Control Release 2012; 161: 628-634.
    • (2012) J Control Release , vol.161 , pp. 628-634
    • Bochot, A.1    Fattal, E.2
  • 25
    • 33751172532 scopus 로고    scopus 로고
    • Ocular delivery of nucleic acids: Antisense oligonucleotides, aptamers and siRNA
    • Fattal E, Bochot A,. Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA. Adv Drug Deliv Rev 2006; 58: 1203-1223.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1203-1223
    • Fattal, E.1    Bochot, A.2
  • 26
    • 84878374151 scopus 로고    scopus 로고
    • Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules
    • Vigderman L, Zubarev ER,. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules. Adv Drug Deliv Rev 2013; 65: 663-676.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 663-676
    • Vigderman, L.1    Zubarev, E.R.2
  • 27
    • 46749123819 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    • etal.
    • Slowing II, etal. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 2008; 60: 1278-1288.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1278-1288
    • Slowing, I.I.1
  • 28
    • 84863951245 scopus 로고    scopus 로고
    • Peptide vectors for the nonviral delivery of nucleic acids
    • Hoyer J, Neundorf I,. Peptide vectors for the nonviral delivery of nucleic acids. Accounts Chem Res 2012; 45: 1048-1056.
    • (2012) Accounts Chem Res , vol.45 , pp. 1048-1056
    • Hoyer, J.1    Neundorf, I.2
  • 29
    • 84864508341 scopus 로고    scopus 로고
    • Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
    • Shim MS, Kwon YJ,. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Adv Drug Deliv Rev 2012; 64: 1046-1059.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1046-1059
    • Shim, M.S.1    Kwon, Y.J.2
  • 30
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam J, Labhasetwar V,. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 2003; 55: 329-347.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 329-347
    • Panyam, J.1    Labhasetwar, V.2
  • 31
    • 84858013364 scopus 로고    scopus 로고
    • Biological applications of dendrimers
    • Patri AK, Simanek E,. Biological applications of dendrimers. Mol Pharm 2012; 9: 341-341.
    • (2012) Mol Pharm , vol.9 , pp. 341-341
    • Patri, A.K.1    Simanek, E.2
  • 32
    • 85047685009 scopus 로고    scopus 로고
    • Dendrimers as therapeutic agents: A systematic review
    • etal.
    • Gajbhiye V, etal. Dendrimers as therapeutic agents: a systematic review. J Pharm Pharmacol 2009; 61: 989-1003.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 989-1003
    • Gajbhiye, V.1
  • 33
    • 84875021801 scopus 로고    scopus 로고
    • Dendrimer nanoparticles for ocular drug delivery
    • Kambhampati SP, Kannan RM,. Dendrimer nanoparticles for ocular drug delivery. J Ocul Pharmacol Ther 2013; 29: 151-165.
    • (2013) J Ocul Pharmacol Ther , vol.29 , pp. 151-165
    • Kambhampati, S.P.1    Kannan, R.M.2
  • 34
    • 28744440082 scopus 로고    scopus 로고
    • Dendrimers in gene delivery
    • etal.
    • Dufes C, etal. Dendrimers in gene delivery. Adv Drug Deliv Rev 2005; 57: 2177-2202.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2177-2202
    • Dufes, C.1
  • 35
    • 77953702051 scopus 로고    scopus 로고
    • Dendrimer toxicity: Let's meet the challenge
    • etal.
    • Jain K, etal. Dendrimer toxicity: let's meet the challenge. Int J Pharm 2010; 394: 122-142.
    • (2010) Int J Pharm , vol.394 , pp. 122-142
    • Jain, K.1
  • 36
    • 28744445460 scopus 로고    scopus 로고
    • Dendrimer biocompatibility and toxicity
    • Duncan R, Izzo L,. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 2005; 57: 2215-2237.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2215-2237
    • Duncan, R.1    Izzo, L.2
  • 37
    • 35748935107 scopus 로고    scopus 로고
    • The advance of dendrimers - A versatile targeting platform for gene/drug delivery
    • Parekh HS,. The advance of dendrimers-a versatile targeting platform for gene/drug delivery. Curr Pharm Des 2007; 13: 2837-2850.
    • (2007) Curr Pharm des , vol.13 , pp. 2837-2850
    • Parekh, H.S.1
  • 38
    • 15544367914 scopus 로고    scopus 로고
    • Polymers for DNA delivery
    • etal.
    • Eliyahu H, etal. Polymers for DNA delivery. Molecules 2005; 10: 34-64.
    • (2005) Molecules , vol.10 , pp. 34-64
    • Eliyahu, H.1
  • 39
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • etal.
    • Fischer D, etal. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003; 24: 1121-1131.
    • (2003) Biomaterials , vol.24 , pp. 1121-1131
    • Fischer, D.1
  • 40
    • 28644434579 scopus 로고    scopus 로고
    • Designing dendrimers for biological applications
    • etal.
    • Lee CC, etal. Designing dendrimers for biological applications. Nat Biotech 2005; 23: 1517-1526.
    • (2005) Nat Biotech , vol.23 , pp. 1517-1526
    • Lee, C.C.1
  • 41
    • 11844250522 scopus 로고    scopus 로고
    • Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide
    • Vandamme TF, Brobeck L,. Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release 2005; 102: 23-38.
    • (2005) J Control Release , vol.102 , pp. 23-38
    • Vandamme, T.F.1    Brobeck, L.2
  • 42
    • 51649131354 scopus 로고    scopus 로고
    • Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery
    • etal.
    • Nam HY, etal. Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Int J Pharm 2008; 363: 199-205.
    • (2008) Int J Pharm , vol.363 , pp. 199-205
    • Nam, H.Y.1
  • 43
    • 56749185962 scopus 로고    scopus 로고
    • Folate and folate-PEG-PAMAM dendrimers: Synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice
    • etal.
    • Singh P, etal. Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice. Bioconjug Chem 2008; 19: 2239-2252.
    • (2008) Bioconjug Chem , vol.19 , pp. 2239-2252
    • Singh, P.1
  • 44
    • 0034915353 scopus 로고    scopus 로고
    • Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins
    • etal.
    • Arima H, etal. Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins. Bioconjug Chem 2001; 12: 476-484.
    • (2001) Bioconjug Chem , vol.12 , pp. 476-484
    • Arima, H.1
  • 45
    • 0036899037 scopus 로고    scopus 로고
    • Biological applications of dendrimers
    • Cloninger MJ,. Biological applications of dendrimers. Curr Opin Chem Biol 2002; 6: 742-748.
    • (2002) Curr Opin Chem Biol , vol.6 , pp. 742-748
    • Cloninger, M.J.1
  • 46
    • 0036177932 scopus 로고    scopus 로고
    • Peptide dendrimers: Applications and synthesis
    • Sadler K, Tam JP,. Peptide dendrimers: applications and synthesis. J Biotechnol 2002; 90: 195-229.
    • (2002) J Biotechnol , vol.90 , pp. 195-229
    • Sadler, K.1    Tam, J.P.2
  • 47
    • 20044385983 scopus 로고    scopus 로고
    • Peptide and amide bond-containing dendrimers
    • etal.
    • Crespo L, etal. Peptide and amide bond-containing dendrimers. Chem Rev 2005; 105: 1663-1682.
    • (2005) Chem Rev , vol.105 , pp. 1663-1682
    • Crespo, L.1
  • 48
    • 1642442463 scopus 로고    scopus 로고
    • From production of peptides in milligram amounts for research to multi-tons quantities for drugs of the future
    • etal.
    • Bruckdorfer T, etal. From production of peptides in milligram amounts for research to multi-tons quantities for drugs of the future. Curr Pharm Biotechnol 2004; 5: 29-43.
    • (2004) Curr Pharm Biotechnol , vol.5 , pp. 29-43
    • Bruckdorfer, T.1
  • 49
    • 34848840969 scopus 로고    scopus 로고
    • Lysine dendrimers as vectors for delivering genetic constructs to eukaryotic cells
    • etal.
    • Kiselev AV, etal. Lysine dendrimers as vectors for delivering genetic constructs to eukaryotic cells. Genetika 2007; 43: 725-733.
    • (2007) Genetika , vol.43 , pp. 725-733
    • Kiselev, A.V.1
  • 50
    • 33750423606 scopus 로고    scopus 로고
    • Cationic poly-L-lysine dendrimers: Pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats
    • etal.
    • Boyd BJ, etal. Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Mol Pharm 2006; 3: 614-627.
    • (2006) Mol Pharm , vol.3 , pp. 614-627
    • Boyd, B.J.1
  • 51
    • 1642588217 scopus 로고    scopus 로고
    • Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multiblock copolymers for nonviral gene delivery
    • etal.
    • Bikram M, etal. Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g- histidine multiblock copolymers for nonviral gene delivery. Macromolecules 2004; 37: 1903-1916.
    • (2004) Macromolecules , vol.37 , pp. 1903-1916
    • Bikram, M.1
  • 52
    • 62849107517 scopus 로고    scopus 로고
    • Cellular uptake of self-assembled cationic peptide-DNA complexes: Multifunctional role of the enhancer chloroquine
    • etal.
    • Yang S, etal. Cellular uptake of self-assembled cationic peptide-DNA complexes: multifunctional role of the enhancer chloroquine. J Control Release 2009; 135: 159-165.
    • (2009) J Control Release , vol.135 , pp. 159-165
    • Yang, S.1
  • 53
    • 84857033178 scopus 로고    scopus 로고
    • Measurement of mucosal biomarkers in a phase 1 trial of intravaginal 3% StarPharma LTD 7013 gel (VivaGel) to assess expanded safety
    • etal.
    • Moscicki AB, etal. Measurement of mucosal biomarkers in a phase 1 trial of intravaginal 3% StarPharma LTD 7013 gel (VivaGel) to assess expanded safety. J Acquir Immune Defic Syndr 2012; 59: 134-140.
    • (2012) J Acquir Immune Defic Syndr , vol.59 , pp. 134-140
    • Moscicki, A.B.1
  • 54
    • 23944434447 scopus 로고    scopus 로고
    • Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention
    • etal.
    • McCarthy TD, etal. Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention. Mol Pharm 2005; 2: 312-318.
    • (2005) Mol Pharm , vol.2 , pp. 312-318
    • McCarthy, T.D.1
  • 55
    • 80052844387 scopus 로고    scopus 로고
    • SPL7013 Gel (VivaGel(R)) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans
    • etal.
    • Price CF, etal. SPL7013 Gel (VivaGel(R)) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans. PLoS ONE 2011; 6: e24095.
    • (2011) PLoS ONE , vol.6
    • Price, C.F.1
  • 56
    • 0036181219 scopus 로고    scopus 로고
    • Design and synthesis of glycodendrimers
    • Turnbull WB, Stoddart JF,. Design and synthesis of glycodendrimers. J Biotechnol 2002; 90: 231-255.
    • (2002) J Biotechnol , vol.90 , pp. 231-255
    • Turnbull, W.B.1    Stoddart, J.F.2
  • 57
    • 19444368751 scopus 로고    scopus 로고
    • Improvement of gene delivery mediated by mannosylated dendrimer/alpha-cyclodextrin conjugates
    • etal.
    • Wada K, etal. Improvement of gene delivery mediated by mannosylated dendrimer/alpha-cyclodextrin conjugates. J Control Release 2005; 104: 397-413.
    • (2005) J Control Release , vol.104 , pp. 397-413
    • Wada, K.1
  • 58
    • 0034027294 scopus 로고    scopus 로고
    • Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice
    • etal.
    • Nishikawa M, etal. Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice. J Drug Target 2000; 8: 29-38.
    • (2000) J Drug Target , vol.8 , pp. 29-38
    • Nishikawa, M.1
  • 59
    • 84884288092 scopus 로고    scopus 로고
    • Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors
    • etal.
    • Arima H, etal. Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors. Adv Drug Deliv Rev 2013; 65: 1204-1214.
    • (2013) Adv Drug Deliv Rev , vol.65 , pp. 1204-1214
    • Arima, H.1
  • 60
    • 80052140404 scopus 로고    scopus 로고
    • Polymers in small-interfering RNA delivery
    • etal.
    • Singha K, etal. Polymers in small-interfering RNA delivery. Nucleic Acid Ther 2011; 21: 133-147.
    • (2011) Nucleic Acid Ther , vol.21 , pp. 133-147
    • Singha, K.1
  • 61
    • 49749152440 scopus 로고    scopus 로고
    • Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo
    • Intra J, Salem AK,. Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. J Control Release 2008; 130: 129-138.
    • (2008) J Control Release , vol.130 , pp. 129-138
    • Intra, J.1    Salem, A.K.2
  • 62
    • 10044278222 scopus 로고    scopus 로고
    • Preferential liver gene expression with polypropylenimine dendrimers
    • etal.
    • Schatzlein AG, etal. Preferential liver gene expression with polypropylenimine dendrimers. J Control Release 2005; 101: 247-258.
    • (2005) J Control Release , vol.101 , pp. 247-258
    • Schatzlein, A.G.1
  • 63
    • 78649709559 scopus 로고    scopus 로고
    • Poly (propyleneimine) dendrimers as potential siRNA delivery nanocarrier: From structure to function
    • etal.
    • Taratula O, etal. Poly (propyleneimine) dendrimers as potential siRNA delivery nanocarrier: from structure to function. Int J Nanotechnol 2011; 8: 36-52.
    • (2011) Int J Nanotechnol , vol.8 , pp. 36-52
    • Taratula, O.1
  • 64
    • 56649086656 scopus 로고    scopus 로고
    • Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery
    • etal.
    • Russ V, etal. Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery. J Control Release 2008; 132: 131-140.
    • (2008) J Control Release , vol.132 , pp. 131-140
    • Russ, V.1
  • 65
    • 33645863164 scopus 로고    scopus 로고
    • Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes (DNAzymes)
    • etal.
    • Tack F, etal. Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes (DNAzymes). J Drug Target 2006; 14: 69-86.
    • (2006) J Drug Target , vol.14 , pp. 69-86
    • Tack, F.1
  • 66
    • 58149484922 scopus 로고    scopus 로고
    • Ocular gene therapy: Current progress and future prospects
    • etal.
    • Colella P, etal. Ocular gene therapy: current progress and future prospects. Trends Mol Med 2009; 15: 23-31.
    • (2009) Trends Mol Med , vol.15 , pp. 23-31
    • Colella, P.1
  • 67
    • 78649448567 scopus 로고    scopus 로고
    • Protein delivery for retinal diseases: From basic considerations to clinical applications
    • etal.
    • El Sanharawi M, etal. Protein delivery for retinal diseases: from basic considerations to clinical applications. Prog Retin Eye Res 2010; 29: 443-465.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 443-465
    • El Sanharawi, M.1
  • 68
    • 61649106233 scopus 로고    scopus 로고
    • Gene delivery to the retina: Focus on non-viral approaches
    • etal.
    • Naik R, etal. Gene delivery to the retina: focus on non-viral approaches. Drug Discov Today 2009; 14: 306-315.
    • (2009) Drug Discov Today , vol.14 , pp. 306-315
    • Naik, R.1
  • 69
    • 84871388247 scopus 로고    scopus 로고
    • Clinical applications of retinal gene therapy
    • etal.
    • Lipinski DM, etal. Clinical applications of retinal gene therapy. Prog Retin Eye Res 2013; 32: 22-47.
    • (2013) Prog Retin Eye Res , vol.32 , pp. 22-47
    • Lipinski, D.M.1
  • 70
    • 79952450877 scopus 로고    scopus 로고
    • Drug delivery to the posterior segment of the eye
    • etal.
    • Thrimawithana TR, etal. Drug delivery to the posterior segment of the eye. Drug Discov Today 2011; 16: 270-277.
    • (2011) Drug Discov Today , vol.16 , pp. 270-277
    • Thrimawithana, T.R.1
  • 71
    • 79955022978 scopus 로고    scopus 로고
    • Ophthalmic drug delivery systems for the treatment of retinal diseases: Basic research to clinical applications
    • etal.
    • Edelhauser HF, etal. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Invest Ophthalmol Vis Sci 2010; 51: 5403-5420.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 5403-5420
    • Edelhauser, H.F.1
  • 72
    • 33646663892 scopus 로고    scopus 로고
    • Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an in vitro bovine eye model
    • etal.
    • Pitkanen L, etal. Neural retina limits the nonviral gene transfer to retinal pigment epithelium in an in vitro bovine eye model. AAPS J 2004; 6: e25.
    • (2004) AAPS J , vol.6
    • Pitkanen, L.1
  • 73
    • 0036015940 scopus 로고    scopus 로고
    • Transscleral drug delivery to the retina and choroid
    • Ambati J, Adamis AP,. Transscleral drug delivery to the retina and choroid. Prog Retin Eye Res 2002; 21: 145-151.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 145-151
    • Ambati, J.1    Adamis, A.P.2
  • 74
    • 0034031474 scopus 로고    scopus 로고
    • Diffusion of high molecular weight compounds through sclera
    • etal.
    • Ambati J, etal. Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci 2000; 41: 1181-1185.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 1181-1185
    • Ambati, J.1
  • 75
    • 84863766409 scopus 로고    scopus 로고
    • Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye
    • etal.
    • Patel SR, etal. Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye. Invest Ophthalmol Vis Sci 2012; 53: 4433-4441.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 4433-4441
    • Patel, S.R.1
  • 76
    • 84867320524 scopus 로고    scopus 로고
    • Gene therapy in age related macular degeneration and hereditary macular disorders
    • Kinnunen K, Yla-Herttuala S,. Gene therapy in age related macular degeneration and hereditary macular disorders. Front Biosci 2012; 4: 2546-2557.
    • (2012) Front Biosci , vol.4 , pp. 2546-2557
    • Kinnunen, K.1    Yla-Herttuala, S.2
  • 77
    • 84857134544 scopus 로고    scopus 로고
    • Gene therapy in the Cornea: 2005-present
    • etal.
    • Mohan RR, etal. Gene therapy in the Cornea: 2005-present. Prog Retin Eye Res 2012; 31: 43-64.
    • (2012) Prog Retin Eye Res , vol.31 , pp. 43-64
    • Mohan, R.R.1
  • 78
    • 80052876653 scopus 로고    scopus 로고
    • Nano-vectors for the ocular delivery of nucleic acid-based therapeutics
    • etal.
    • Khar RK, etal. Nano-vectors for the ocular delivery of nucleic acid-based therapeutics. Indian J Pharm Sci 2010; 72: 675-688.
    • (2010) Indian J Pharm Sci , vol.72 , pp. 675-688
    • Khar, R.K.1
  • 79
    • 33751272909 scopus 로고    scopus 로고
    • Non-viral ocular gene therapy: Potential ocular therapeutic avenues
    • etal.
    • Bloquel C, etal. Non-viral ocular gene therapy: potential ocular therapeutic avenues. Adv Drug Deliv Rev 2006; 58: 1224-1242.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1224-1242
    • Bloquel, C.1
  • 80
    • 33847055478 scopus 로고    scopus 로고
    • Challenges in non-viral ocular gene transfer
    • etal.
    • Peeters L, etal. Challenges in non-viral ocular gene transfer. Biochem Soc Trans 2007; 35 (Pt 1): 47-49.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 1 , pp. 47-49
    • Peeters, L.1
  • 81
    • 34548623989 scopus 로고    scopus 로고
    • Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer
    • etal.
    • Sanders NN, etal. Wanted and unwanted properties of surface PEGylated nucleic acid nanoparticles in ocular gene transfer. J Control Release 2007; 122: 226-235.
    • (2007) J Control Release , vol.122 , pp. 226-235
    • Sanders, N.N.1
  • 82
    • 33751187547 scopus 로고    scopus 로고
    • Challenges and obstacles of ocular pharmacokinetics and drug delivery
    • Urtti A,. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 2006; 58: 1131-1135.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1131-1135
    • Urtti, A.1
  • 83
    • 33646692939 scopus 로고    scopus 로고
    • Sustained release of nanosized complexes of polyethylenimine and anti-TGF-beta 2 oligonucleotide improves the outcome of glaucoma surgery
    • etal.
    • Gomes Dos Santos AL, etal. Sustained release of nanosized complexes of polyethylenimine and anti-TGF-beta 2 oligonucleotide improves the outcome of glaucoma surgery. J Control Release 2006; 112: 369-381.
    • (2006) J Control Release , vol.112 , pp. 369-381
    • Gomes Dos Santos, A.L.1
  • 84
    • 84861127428 scopus 로고    scopus 로고
    • Nanoparticle-mediated delivery of shRNA.VEGF-A plasmids regresses corneal neovascularization
    • etal.
    • Qazi Y, etal. Nanoparticle-mediated delivery of shRNA.VEGF-A plasmids regresses corneal neovascularization. Invest Ophthalmol Vis Sci 2012; 53: 2837-2844.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 2837-2844
    • Qazi, Y.1
  • 85
    • 34249666727 scopus 로고    scopus 로고
    • Human serum albumin nanoparticles for efficient delivery of Cu, Zn superoxide dismutase gene
    • etal.
    • Mo Y, etal. Human serum albumin nanoparticles for efficient delivery of Cu, Zn superoxide dismutase gene. Mol Vis 2007; 13: 746-757.
    • (2007) Mol Vis , vol.13 , pp. 746-757
    • Mo, Y.1
  • 86
    • 78650798166 scopus 로고    scopus 로고
    • Cationic nano-copolymers mediated IKKbeta targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery
    • etal.
    • Ye H, etal. Cationic nano-copolymers mediated IKKbeta targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery. Mol Vis 2010; 16: 2502-2510.
    • (2010) Mol Vis , vol.16 , pp. 2502-2510
    • Ye, H.1
  • 87
    • 21644468948 scopus 로고    scopus 로고
    • Nanoparticles for gene delivery to retinal pigment epithelial cells
    • etal.
    • Bejjani RA, etal. Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 2005; 11: 124-132.
    • (2005) Mol Vis , vol.11 , pp. 124-132
    • Bejjani, R.A.1
  • 88
    • 0037251511 scopus 로고    scopus 로고
    • Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres
    • etal.
    • Carrasquillo KG, etal. Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. Invest Ophthalmol Vis Sci 2003; 44: 290-299.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 290-299
    • Carrasquillo, K.G.1
  • 89
    • 44649113307 scopus 로고    scopus 로고
    • Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy
    • etal.
    • De La Fuente M, etal. Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy. Invest Ophthalmol Vis Sci 2008; 49: 2016-2024.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 2016-2024
    • De La Fuente, M.1
  • 90
    • 84856545175 scopus 로고    scopus 로고
    • A new tool for the transfection of corneal endothelial cells: Calcium phosphate nanoparticles
    • etal.
    • Hu J, etal. A new tool for the transfection of corneal endothelial cells: calcium phosphate nanoparticles. Acta Biomater 2012; 8: 1156-1163.
    • (2012) Acta Biomater , vol.8 , pp. 1156-1163
    • Hu, J.1
  • 91
    • 21344438178 scopus 로고    scopus 로고
    • Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer
    • etal.
    • Mannermaa E, etal. Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer. Curr Eye Res 2005; 30: 345-353.
    • (2005) Curr Eye Res , vol.30 , pp. 345-353
    • Mannermaa, E.1
  • 92
    • 34547666993 scopus 로고    scopus 로고
    • Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells
    • etal.
    • Peeters L, etal. Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. J Control Release 2007; 121: 208-217.
    • (2007) J Control Release , vol.121 , pp. 208-217
    • Peeters, L.1
  • 93
    • 2942583144 scopus 로고    scopus 로고
    • In vivo gene transfection via intravitreal injection of cationic liposome/plasmid DNA complexes in rabbits
    • etal.
    • Kawakami S, etal. In vivo gene transfection via intravitreal injection of cationic liposome/plasmid DNA complexes in rabbits. Int J Pharm 2004; 278: 255-262.
    • (2004) Int J Pharm , vol.278 , pp. 255-262
    • Kawakami, S.1
  • 94
    • 0036139020 scopus 로고    scopus 로고
    • Intravitreal delivery of oligonucleotides by sterically stabilized liposomes
    • etal.
    • Bochot A, etal. Intravitreal delivery of oligonucleotides by sterically stabilized liposomes. Invest Ophthalmol Vis Sci 2002; 43: 253-259.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 253-259
    • Bochot, A.1
  • 95
    • 4544332801 scopus 로고    scopus 로고
    • Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide
    • etal.
    • Marano RJ, etal. Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp Eye Res 2004; 79: 525-535.
    • (2004) Exp Eye Res , vol.79 , pp. 525-535
    • Marano, R.J.1
  • 96
    • 27544499791 scopus 로고    scopus 로고
    • Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity
    • etal.
    • Marano RJ, etal. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther 2005; 12: 1544-1150.
    • (2005) Gene Ther , vol.12 , pp. 1544-1150
    • Marano, R.J.1
  • 97
    • 33646809712 scopus 로고    scopus 로고
    • Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
    • etal.
    • Parekh HS, etal. Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorg Med Chem 2006; 14: 4775-4780.
    • (2006) Bioorg Med Chem , vol.14 , pp. 4775-4780
    • Parekh, H.S.1
  • 98
    • 0033406402 scopus 로고    scopus 로고
    • Polyplex-mediated gene transfer into human retinal pigment epithelial cells in vitro
    • etal.
    • Chaum E, etal. Polyplex-mediated gene transfer into human retinal pigment epithelial cells in vitro. J Cell Biochem 1999; 76: 153-160.
    • (1999) J Cell Biochem , vol.76 , pp. 153-160
    • Chaum, E.1
  • 99
    • 0033016739 scopus 로고    scopus 로고
    • Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
    • etal.
    • Hudde T, etal. Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Gene Ther 1999; 6: 939-943.
    • (1999) Gene Ther , vol.6 , pp. 939-943
    • Hudde, T.1
  • 100
    • 0037130553 scopus 로고    scopus 로고
    • Structure-activity relationships of poly(L-lysines): Effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery
    • etal.
    • Mannistö M, etal. Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery. J Control Release 2002; 83: 169-182.
    • (2002) J Control Release , vol.83 , pp. 169-182
    • Mannistö, M.1
  • 101
    • 33646427165 scopus 로고    scopus 로고
    • Oligonucleotide-polyethylenimine complexes targeting retinal cells: Structural analysis and application to anti-TGFbeta-2 therapy
    • etal.
    • Gomes Dos Santos AL, etal. Oligonucleotide-polyethylenimine complexes targeting retinal cells: structural analysis and application to anti-TGFbeta-2 therapy. Pharm Res 2006; 23: 770-781.
    • (2006) Pharm Res , vol.23 , pp. 770-781
    • Gomes Dos Santos, A.L.1
  • 102
    • 77950520123 scopus 로고    scopus 로고
    • Cell penetrating peptide POD mediates delivery of recombinant proteins to retina, cornea and skin
    • etal.
    • Johnson LN, etal. Cell penetrating peptide POD mediates delivery of recombinant proteins to retina, cornea and skin. Vision Res 2010; 50: 686-697.
    • (2010) Vision Res , vol.50 , pp. 686-697
    • Johnson, L.N.1
  • 104
    • 84861657127 scopus 로고    scopus 로고
    • Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: An in-vivo study in rats and mice
    • etal.
    • Hagigit T, etal. Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: an in-vivo study in rats and mice. J Control Release 2012; 160: 225-231.
    • (2012) J Control Release , vol.160 , pp. 225-231
    • Hagigit, T.1
  • 105
    • 84865027958 scopus 로고    scopus 로고
    • Cationic core-shell liponanoparticles for ocular gene delivery
    • etal.
    • Jiang M, etal. Cationic core-shell liponanoparticles for ocular gene delivery. Biomaterials 2012; 33: 7621-7630.
    • (2012) Biomaterials , vol.33 , pp. 7621-7630
    • Jiang, M.1
  • 106
    • 33644913381 scopus 로고    scopus 로고
    • Plasmid electrotransfer of eye ciliary muscle: Principles and therapeutic efficacy using hTNF-alpha soluble receptor in uveitis
    • etal.
    • Bloquel C, etal. Plasmid electrotransfer of eye ciliary muscle: principles and therapeutic efficacy using hTNF-alpha soluble receptor in uveitis. FASEB J 2006; 20: 389-391.
    • (2006) FASEB J , vol.20 , pp. 389-391
    • Bloquel, C.1
  • 107
    • 53949093002 scopus 로고    scopus 로고
    • Can ultrasound solve the transport barrier of the neural retina?
    • etal.
    • Peeters L, etal. Can ultrasound solve the transport barrier of the neural retina? Pharm Res 2008; 25: 2657-2665.
    • (2008) Pharm Res , vol.25 , pp. 2657-2665
    • Peeters, L.1
  • 108
    • 84866005644 scopus 로고    scopus 로고
    • Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds
    • etal.
    • Ormonde S, etal. Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds. J Membr Biol 2012; 245: 381-388.
    • (2012) J Membr Biol , vol.245 , pp. 381-388
    • Ormonde, S.1
  • 109
    • 82955169666 scopus 로고    scopus 로고
    • Ion-activated in situ gelling systems for antisense oligodeoxynucleotide delivery to the ocular surface
    • etal.
    • Rupenthal ID, etal. Ion-activated in situ gelling systems for antisense oligodeoxynucleotide delivery to the ocular surface. Mol Pharm 2011; 8: 2282-2290.
    • (2011) Mol Pharm , vol.8 , pp. 2282-2290
    • Rupenthal, I.D.1
  • 110
    • 84857831601 scopus 로고    scopus 로고
    • Improved corneal wound healing through modulation of gap junction communication using connexin43-specific antisense oligodeoxynucleotides
    • etal.
    • Grupcheva CN, etal. Improved corneal wound healing through modulation of gap junction communication using connexin43-specific antisense oligodeoxynucleotides. Invest Ophthalmol Vis Sci 2012; 53: 1130-1138.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 1130-1138
    • Grupcheva, C.N.1
  • 111
    • 84866711965 scopus 로고    scopus 로고
    • Connexin43 modulation inhibits scarring in a rabbit eye glaucoma trabeculectomy model
    • etal.
    • Deva NC, etal. Connexin43 modulation inhibits scarring in a rabbit eye glaucoma trabeculectomy model. Inflammation 2012; 35: 1276-1286.
    • (2012) Inflammation , vol.35 , pp. 1276-1286
    • Deva, N.C.1
  • 112
    • 80053906389 scopus 로고    scopus 로고
    • In-vitro and in-vivo evaluation of carrageenan/methylcellulose polymeric systems for transscleral delivery of macromolecules
    • etal.
    • Thrimawithana TR, etal. In-vitro and in-vivo evaluation of carrageenan/methylcellulose polymeric systems for transscleral delivery of macromolecules. Eur J Pharm Sci 2011; 44: 399-409.
    • (2011) Eur J Pharm Sci , vol.44 , pp. 399-409
    • Thrimawithana, T.R.1
  • 113
    • 13244295409 scopus 로고    scopus 로고
    • An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization
    • etal.
    • Bhisitkul RB, etal. An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization. Arch Ophthalmol 2005; 123: 214-219.
    • (2005) Arch Ophthalmol , vol.123 , pp. 214-219
    • Bhisitkul, R.B.1
  • 114
    • 3542993234 scopus 로고    scopus 로고
    • Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
    • etal.
    • Shaunak S, etal. Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nat Biotechnol 2004; 22: 977-984.
    • (2004) Nat Biotechnol , vol.22 , pp. 977-984
    • Shaunak, S.1
  • 115
    • 81155152766 scopus 로고    scopus 로고
    • Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
    • etal.
    • Iezzi R, etal. Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012; 33: 979-988.
    • (2012) Biomaterials , vol.33 , pp. 979-988
    • Iezzi, R.1
  • 116
    • 33646886616 scopus 로고    scopus 로고
    • Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: Mechanical properties and corneal epithelial cell interactions
    • Duan X, Sheardown H,. Dendrimer crosslinked collagen as a corneal tissue engineering scaffold: mechanical properties and corneal epithelial cell interactions. Biomaterials 2006; 27: 4608-4617.
    • (2006) Biomaterials , vol.27 , pp. 4608-4617
    • Duan, X.1    Sheardown, H.2
  • 117
    • 0037119744 scopus 로고    scopus 로고
    • Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides
    • etal.
    • Wimmer N, etal. Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorg Med Chem Lett 2002; 12: 2635-2637.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 2635-2637
    • Wimmer, N.1
  • 118
    • 35348970844 scopus 로고    scopus 로고
    • The synthesis and characterisation of a novel dendritic system for gene delivery
    • Coles DJ, etal. The synthesis and characterisation of a novel dendritic system for gene delivery. Tetrahedron 2007; 63: 12207-12214.
    • (2007) Tetrahedron , vol.63 , pp. 12207-12214
    • Coles, D.J.1


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