Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: In vitro and in vivo studies

International Journal of Cancer

Volumn 105, Issue 3, 2003, Pages 419-429

  Vincent, Loïc ^a,b   Varet, Julia ^a   Pille, Jean Yves ^a   Bompais, Heidi ^c   Opolon, Paule ^d   Maksimenko, Andrei ^d,e   Malvy, Claude ^d   Mirshahi, Manouchehr ^f   Lu, He ^g   Vannier, Jean Pierre ^a   Soria, Claudine ^a,g   Li, Hong ^a,d  

^a UNIVERSITÉ DE ROUEN   (France)

^b INSERM   (France)

^c HÔPITAL PAUL BROUSSE   (France)

^d CNRS   (France)

^e BioAlliance Pharma   (France)

^f TARBIAT MODARES UNIVERSITY   (Iran)

^g SAINT LOUIS HOSPITAL   (France)

Author keywords

Angiogenesis; Angiostatin; Cancer; Dendrimer; Gene therapy; TIMP 2

Indexed keywords

ANGIOSTATIN; DENDRIMER; GREEN FLUORESCENT PROTEIN; MATRIGEL; OLIGOMER; OLIGOMER ON36; PLASMID DNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER INHIBITION; CAPILLARY PROLIFERATION; CELL PROLIFERATION; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; ENDOTHELIUM CELL; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; KRINGLE DOMAIN; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; ONCOGENE; PARACRINE SIGNALING; PLASMID; PRIORITY JOURNAL; PROTEIN SECRETION; TARGET CELL; TIMP2 GENE; TUMOR GROWTH; TUMOR VASCULARIZATION; WESTERN BLOTTING; WOUND HEALING;

ANGIOSTATINS; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; COLLAGEN; CYTOKINES; DRUG COMBINATIONS; ENDOTHELIUM; FLOW CYTOMETRY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; LAMININ; LUMINESCENT PROTEINS; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDE FRAGMENTS; PLASMIDS; PLASMINOGEN; PROTEOGLYCANS; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFECTION; TUMOR CELLS, CULTURED; WOUND HEALING;

EID: 0037544228     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11105     Document Type: Article

References (31)

1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
2. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992;267:10931-4.
3. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
4. Gately S, Kerbel R. Antiangiogenic scheduling of lower dose cancer chemotherapy. Cancer J 2001;7:427-436.
5. Heymach JV. Angiogenesis and antiangiogenic approaches to sarcomas. Curt Opin Oncol 2001;13:261-9.
6. Li H, Lu H, Griscelli F, Opolon P, Sun LQ, Ragot T, Legrand Y, Belin D, Soria J, Soria C, Perricaudet M, Yeh P. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Ther 1998;5:1105-13.
7. Werb Z, Vu TH, Rinkenberger JL, Coussens LM. Matrix-degrading proteases and angiogenesis during development and tumor formation. APMIS 1999;107:11-8.
8. Itoh T, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H, Itohara S. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res 1998;58:1048-51.
9. Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. Tissues inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol 1997;74:111-22.
10. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994;79:315-28.
11. Cao Y, Ji RW, Davidson D, Schaller J, Marti D, Sohndel S, McCance SG, O'Reilly MS, Llinas M, Folkman J. Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. J Biol Chem 1996;271:29461-7.
12. Griscelli F, Li H, Bennaceur-Griscelli A, Soria J, Opolon P, Soria C, Perricaudet M, Yeh P, Lu H. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc Natl Acad Sci USA 1998;95:6367-72.
13. Indraccolo T, Minuzzo S, Gola E, Habeler W. Carrozzino F, Noonan D, Albini A, Santi L, Amadori A, Chieco-Bianchi L. Generation of expression plasmids for angiostatin, endostatin and TIMP-2 for cancer gene therapy. Int J Biol Markers 1999;14:251-6.
14. Li H, Lindenmeyer F, Grenet C, Opolon P, Menashi S, Soria C, Yeh P, Perricaudet M, Lu H. AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice. Hum Gene Ther 2001;12:515-26.
15. Hudde T, Rayner SA, Comer RM, Weber M, Isaacs JD, Waldmann H, Larkin DF, George AJ. Activated polyamidoamine dendrimers, non-viral vectors for gene transfer to the corneal endothelium. Gene Ther 1999;6:939-43.
16. Sato N, Kobayashi H, Saga T, Nakamoto Y, Ishimori T, Togashi K, Fujibayashi Y, Konishi J, Brechbiel MW. Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed dendrimers and/or avidin in mice. Clin Cancer Res 2001;7:3606-212.
17. Lewis JG, Lin KY, Kothavale A, Flanagan WM, Matteucci MD, DePrince RB, Mook RA Jr, Hendren RW, Wagner RW. A serumresistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. Proc Natl Acad Sci USA 1996;93:3176-81.
18. Qin L, Pahud DR, Ding Y, Bielinska AU, Kukowska-Latallo JF, Baker JR Jr, Bromberg JS. Efficient transfer of genes into murine cardiac grafts by Starburst polyamidoamine dendrimers. Hum Gene Ther 1998;9:553-60.
19. Delong R, Stephenson K, Loftus T, Fisher M, Alahari S, Nolting A, Juliano RL. Characterization of complexes of oligonucleotides with polyamidoamine Starburst dendrimers and effects on intracellular delivery. J Pharm Sci 1997;86:762-4.
20. Maksimenko A, Mandrouguine V, Gottikh MB, Bertrand JR, Majoral JP, Malvy C. Optimisation of dendrimer-mediated gene transfer by anionic oligomers. J Gene Med 2003;5:61-71.
21. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ. HMEC-I: establishment of an immortalized human endothelial cell line. J Invest Dermatol 1992;99:683-90.
22. 2-terminal region of native human plasminogen induces a modification of its functional properties. Fibrinol Prot 1997;11:155-63.
23. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
24. Buchsbaum DJ, Raben D, Stackhouse MA, Khazaeli MB, Rogers BE, Rosenfeld ME, Liu T, Curiel DT. Approaches to enhance cancer radiotherapy employing gene transfer methods. Gene Ther 1996;3:1042-68.
25. Dachs GU, Dougherty GJ, Stratford IJ.Chaplin DJ. Targeting gene therapy to cancer: a review. Oncol Res 1997;9:313-25.
26. Liu J, Razani B, Tang S, Terman BI, Ware JA, Lisanti MP. Angiogenesis activators and inhibitors differentially regulate caveolin-I expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1. J Biol Chem 1999;274:15781-5.
27. Yip D, Ahmad A, Karapetis CS, Hawkins CA, Harper PG. Matrix metalloproteinase inhibitors: applications in oncology. Invest New Drugs 1999;17:387-99.
28. Brown PD. Clinical studies with matrix metalloproteinase inhibitors. APMIS 1999;107:174-80.
29. Deplanque G, Harris AL. Anti-angiogenic agents: clinical trial design and therapies in development. Eur J Cancer 2000;36:1713-24.
30. Hajitou A, Sounni NE, Devy L, Grignet-Debrus C, Lewalle JM, Li H, Deroanne CF, Lu H, Colige A, Nusgens BV, Frankenne F, Maron A, et al. Down-regulation of vascular endothelial growth factor by tissue inhibitor of metalloproteinase-2: effect on in vivo mammary tumor growth and angiogenesis. Cancer Res 2001;61:3450-7.
31. Kisker O, Becker CM, Prox D, Fannon M, D'Amato R, Flynn E, Fogler WE, Sim BK, Alfred EN, Pirie-Shepherd SR, Folkman J. Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model. Cancer Res 2001;61:7669-74.