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Volumn 7, Issue 2, 2013, Pages 1108-1119

Single-walled carbon nanotube surface control of complement recognition and activation

Author keywords

carbon nanotubes; complement system; l ficolin; methoxy(polyethylene glycol) phospholipid; poly(maleic anhydride alt 1 octadecene)

Indexed keywords

ANAPHYLATOXINS; COMPLEMENT SYSTEMS; CONVERTASES; HUMAN SERUM ALBUMINS; INNATE IMMUNITY; INTEGRAL PART; L -FICOLIN; MANNAN-BINDING LECTINS; METHOXY; NANOMATERIAL; NUCLEIC ACID DELIVERIES; OCTADECENE; SINGLE-WALLED; SINGLE-WALLED CARBON; SITE-SPECIFIC; SURFACE COATINGS;

EID: 84874403157     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn3055175     Document Type: Article
Times cited : (106)

References (60)
  • 1
    • 0342819025 scopus 로고
    • Helical Microtubules of Graphitic Carbon
    • Iijima, S. Helical Microtubules of Graphitic Carbon Nature 1991, 354, 56-58
    • (1991) Nature , vol.354 , pp. 56-58
    • Iijima, S.1
  • 2
    • 0346304911 scopus 로고    scopus 로고
    • Nanotubes from Carbon
    • Ajayan, P. M. Nanotubes from Carbon Chem. Rev. 1999, 99, 1787-1799
    • (1999) Chem. Rev. , vol.99 , pp. 1787-1799
    • Ajayan, P.M.1
  • 3
    • 49649113099 scopus 로고    scopus 로고
    • Carbon Nanotubes as Functional Excipients for Nanomedicines: I. Pharmaceutical Properties
    • Foldvari, M.; Bagonluri, M. Carbon Nanotubes as Functional Excipients for Nanomedicines: I. Pharmaceutical Properties Nanomedicine 2008, 4, 173-182
    • (2008) Nanomedicine , vol.4 , pp. 173-182
    • Foldvari, M.1    Bagonluri, M.2
  • 4
    • 80053942384 scopus 로고    scopus 로고
    • PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead
    • Bottini, M.; Rosato, N.; Bottini, N. PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead Biomacromolecules 2011, 12, 3381-3393
    • (2011) Biomacromolecules , vol.12 , pp. 3381-3393
    • Bottini, M.1    Rosato, N.2    Bottini, N.3
  • 5
    • 33846845060 scopus 로고    scopus 로고
    • In Vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice
    • Liu, Z.; Cai, W.; He, L.; Nakayama, N.; Chen, K.; Sun, X.; Chen, X.; Dai, H. In Vivo Biodistribution and Highly Efficient Tumour Targeting of Carbon Nanotubes in Mice Nat. Nanotechnol. 2007, 2, 47-52
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 47-52
    • Liu, Z.1    Cai, W.2    He, L.3    Nakayama, N.4    Chen, K.5    Sun, X.6    Chen, X.7    Dai, H.8
  • 6
    • 31044442114 scopus 로고    scopus 로고
    • Carbon Nanotubes as Intracellular Transporters for Proteins and DNA: An Investigation of the Uptake Mechanism and Pathway
    • Kam, N. W. S.; Liu, Z.; Dai, H. Carbon Nanotubes as Intracellular Transporters for Proteins and DNA: An Investigation of the Uptake Mechanism and Pathway Angew. Chem., Int. Ed. 2006, 45, 577-581
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 577-581
    • Kam, N.W.S.1    Liu, Z.2    Dai, H.3
  • 9
    • 53049104252 scopus 로고    scopus 로고
    • Drug Delivery with Carbon Nanotubes for in Vivo Cancer Treatment
    • Liu, Z.; Chen, K.; Davis, C.; Sherlock, S.; Cao, Q.; Chen, X.; Dai, H. Drug Delivery with Carbon Nanotubes for In Vivo Cancer Treatment Cancer Res. 2008, 68, 6652-666
    • (2008) Cancer Res. , vol.68 , pp. 6652-6666
    • Liu, Z.1    Chen, K.2    Davis, C.3    Sherlock, S.4    Cao, Q.5    Chen, X.6    Dai, H.7
  • 12
    • 65249178345 scopus 로고    scopus 로고
    • Carbon Nanotubes in Biology and Medicine: In Vitro and in Vivo Detection, Imaging and Drug Delivery
    • Liu, Z.; Tabakman, S.; Welsher, K.; Dai, H. Carbon Nanotubes in Biology and Medicine: In Vitro and In Vivo Detection, Imaging and Drug Delivery Nano Res. 2009, 2, 85-120
    • (2009) Nano Res. , vol.2 , pp. 85-120
    • Liu, Z.1    Tabakman, S.2    Welsher, K.3    Dai, H.4
  • 13
    • 79952674714 scopus 로고    scopus 로고
    • High Performance in Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes
    • Robinson, J. T.; Welsher, K.; Tabakman, S. M.; Sherlock, S. P.; Wang, H.; Luong, R.; Dai, H. High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes Nano Res. 2010, 3, 779-793
    • (2010) Nano Res. , vol.3 , pp. 779-793
    • Robinson, J.T.1    Welsher, K.2    Tabakman, S.M.3    Sherlock, S.P.4    Wang, H.5    Luong, R.6    Dai, H.7
  • 14
    • 79959355547 scopus 로고    scopus 로고
    • Deep-Tissue Anatomical Imaging of Mice Using Carbon Nanotube Fluorophores in the Second Near-Infrared Window
    • Welsher, K.; Sherlock, S. P.; Dai, H. Deep-Tissue Anatomical Imaging of Mice Using Carbon Nanotube Fluorophores in the Second Near-Infrared Window Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 8943-8948
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 8943-8948
    • Welsher, K.1    Sherlock, S.P.2    Dai, H.3
  • 17
    • 0345529822 scopus 로고    scopus 로고
    • Sidewall Carboxylic Acid Functionalization of Single-Walled Carbon Nanotubes
    • Peng, H.; Alemany, L. B.; Margrave, J. L.; Khabashesku, V. N. Sidewall Carboxylic Acid Functionalization of Single-Walled Carbon Nanotubes J. Am. Chem. Soc. 2003, 125, 15174-15182
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 15174-15182
    • Peng, H.1    Alemany, L.B.2    Margrave, J.L.3    Khabashesku, V.N.4
  • 18
    • 0000129211 scopus 로고    scopus 로고
    • Water Solubilization of Single-Walled Carbon Nanotubes by Functionalization with Glucosamine
    • Pompeo, F.; Resasco, D. E. Water Solubilization of Single-Walled Carbon Nanotubes by Functionalization with Glucosamine Nano Lett. 2002, 2, 369-373
    • (2002) Nano Lett. , vol.2 , pp. 369-373
    • Pompeo, F.1    Resasco, D.E.2
  • 20
    • 20444391762 scopus 로고    scopus 로고
    • Synthesis and Characterization of Water Soluble Single-Walled Carbon Nanotube Graft Copolymers
    • Zhao, B.; Hu, H.; Yu, A.; Perea, D.; Haddon, R. C. Synthesis and Characterization of Water Soluble Single-Walled Carbon Nanotube Graft Copolymers J. Am. Chem. Soc. 2005, 127, 8917-8203
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 8917-8203
    • Zhao, B.1    Hu, H.2    Yu, A.3    Perea, D.4    Haddon, R.C.5
  • 21
    • 4644338372 scopus 로고    scopus 로고
    • Dispersing Single-Walled Carbon Nanotubes with Surfactants: A Small Angle Neutron Scattering Study
    • Wang, H.; Zhou, W.; Ho, D. L.; Winey, K. I.; Fischer, J. E.; Glinka, C. J.; Hobbie, E. K. Dispersing Single-Walled Carbon Nanotubes with Surfactants: A Small Angle Neutron Scattering Study Nano Lett. 2004, 4, 1789-1793
    • (2004) Nano Lett. , vol.4 , pp. 1789-1793
    • Wang, H.1    Zhou, W.2    Ho, D.L.3    Winey, K.I.4    Fischer, J.E.5    Glinka, C.J.6    Hobbie, E.K.7
  • 23
    • 40349112868 scopus 로고    scopus 로고
    • Circulation and Long-Term Fate of Functionalized, Biocompatible Single-Walled Carbon Nanotubes in Mice Probed by Raman Spectroscopy
    • Liu, Z.; Davis, C.; Cai, W.; He, L.; Chen, X.; Dai, H. Circulation and Long-Term Fate of Functionalized, Biocompatible Single-Walled Carbon Nanotubes in Mice Probed by Raman Spectroscopy Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 1410-1415
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 1410-1415
    • Liu, Z.1    Davis, C.2    Cai, W.3    He, L.4    Chen, X.5    Dai, H.6
  • 25
    • 81855198887 scopus 로고    scopus 로고
    • Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective
    • Moghimi, S. M.; Hunter, A. C.; Andresen, T. L. Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective Annu. Rev. Pharmacol. Toxicol. 2012, 52, 481-503
    • (2012) Annu. Rev. Pharmacol. Toxicol. , vol.52 , pp. 481-503
    • Moghimi, S.M.1    Hunter, A.C.2    Andresen, T.L.3
  • 26
    • 0141927263 scopus 로고    scopus 로고
    • Stealth Liposomes and Long Circulating Nanoparticles: Critical Issues in Pharmacokinetics, Opsonization and Protein-Binding Properties
    • Moghimi, S. M.; Szebeni, J. Stealth Liposomes and Long Circulating Nanoparticles: Critical Issues in Pharmacokinetics, Opsonization and Protein-Binding Properties Prog. Lipid Res. 2003, 42, 463-478
    • (2003) Prog. Lipid Res. , vol.42 , pp. 463-478
    • Moghimi, S.M.1    Szebeni, J.2
  • 27
    • 14644396096 scopus 로고    scopus 로고
    • Nanomedicine: Current Progress and Future Prospects
    • Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Nanomedicine: Current Progress and Future Prospects FASEB J. 2005, 19, 311-330
    • (2005) FASEB J. , vol.19 , pp. 311-330
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 28
    • 0030012929 scopus 로고    scopus 로고
    • Poloxamer-188 Revisited: A Potentially Valuable Immune Modulator?
    • Moghimi, S. M.; Murray, J. C. Poloxamer-188 Revisited: A Potentially Valuable Immune Modulator? J. Natl. Cancer Inst. 1996, 88, 766-768
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 766-768
    • Moghimi, S.M.1    Murray, J.C.2
  • 29
    • 84555197147 scopus 로고    scopus 로고
    • Interaction of Nanoparticles with Immunocompetent Cells: Nanosafety Considerations
    • Boraschi, D.; Costantino, L.; Italiani, P. Interaction of Nanoparticles with Immunocompetent Cells: Nanosafety Considerations Nanomedicine 2012, 7, 121-131
    • (2012) Nanomedicine , vol.7 , pp. 121-131
    • Boraschi, D.1    Costantino, L.2    Italiani, P.3
  • 30
    • 81855218204 scopus 로고    scopus 로고
    • Reshaping the Future of Nanopharmaceuticals: Ad Iudicium
    • Moghimi, S. M.; Peer, D.; Langer, R. Reshaping the Future of Nanopharmaceuticals: Ad Iudicium ACS Nano 2011, 5, 8454-8458
    • (2011) ACS Nano , vol.5 , pp. 8454-8458
    • Moghimi, S.M.1    Peer, D.2    Langer, R.3
  • 31
    • 33845639957 scopus 로고    scopus 로고
    • Methylation of the Phosphate Oxygen Moiety of Phospholipid- Methoxy(polyethylene glycol) Conjugate Prevents PEGylated Liposome-Mediated Complement Activation and Anaphylatoxin Production
    • Moghimi, S. M.; Hamad, I.; Andresen, T. L.; Jørgensen, K.; Szebeni, J. Methylation of the Phosphate Oxygen Moiety of Phospholipid- Methoxy(polyethylene glycol) Conjugate Prevents PEGylated Liposome-Mediated Complement Activation and Anaphylatoxin Production FASEB J. 2006, 20, 2591-2593
    • (2006) FASEB J. , vol.20 , pp. 2591-2593
    • Moghimi, S.M.1    Hamad, I.2    Andresen, T.L.3    Jørgensen, K.4    Szebeni, J.5
  • 33
    • 84864273268 scopus 로고    scopus 로고
    • PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Towards Engineering of Functional Nanomedicines for Alzheimer's Disease
    • Brambilla, D.; Verpillot, R.; Le Droumaguet, B.; Nicolas, J.; Taverna, M.; Kona, J.; Lettiero, B.; Hashemi, S. H.; De Kempe, L.; Canovi, M. et al. PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Towards Engineering of Functional Nanomedicines for Alzheimer's Disease ACS Nano 2012, 6, 5897-5908
    • (2012) ACS Nano , vol.6 , pp. 5897-5908
    • Brambilla, D.1    Verpillot, R.2    Le Droumaguet, B.3    Nicolas, J.4    Taverna, M.5    Kona, J.6    Lettiero, B.7    Hashemi, S.H.8    De Kempe, L.9    Canovi, M.10
  • 34
    • 80052141850 scopus 로고    scopus 로고
    • Complement Activation by Carbon Nanotubes
    • Rybak-Smith, M. J.; Sim, R. B. Complement Activation by Carbon Nanotubes Adv. Drug Delivery Rev. 2011, 63, 1031-1041
    • (2011) Adv. Drug Delivery Rev. , vol.63 , pp. 1031-1041
    • Rybak-Smith, M.J.1    Sim, R.B.2
  • 35
    • 48049083322 scopus 로고    scopus 로고
    • Complement Activation by PEGylated Single-Walled Carbon Nanotubes is Independent of C1q and Alternative Pathway Turnover
    • Hamad, I.; Hunter, A. C.; Rutt, K. J.; Liu, Z.; Dai, H.; Moghimi, S. M. Complement Activation by PEGylated Single-Walled Carbon Nanotubes is Independent of C1q and Alternative Pathway Turnover Mol. Immunol. 2008, 45, 3797-3803
    • (2008) Mol. Immunol. , vol.45 , pp. 3797-3803
    • Hamad, I.1    Hunter, A.C.2    Rutt, K.J.3    Liu, Z.4    Dai, H.5    Moghimi, S.M.6
  • 36
    • 78649538085 scopus 로고    scopus 로고
    • Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere-Serum Interface: Implications for Stealth Nanoparticle Engineering
    • Hamad, I.; Al-Hanbali, O.; Hunter, A. C.; Rutt, K. J.; Andresen, T. L.; Moghimi, S. M. Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere-Serum Interface: Implications for Stealth Nanoparticle Engineering ACS Nano 2010, 4, 6629-6638
    • (2010) ACS Nano , vol.4 , pp. 6629-6638
    • Hamad, I.1    Al-Hanbali, O.2    Hunter, A.C.3    Rutt, K.J.4    Andresen, T.L.5    Moghimi, S.M.6
  • 37
    • 77955213471 scopus 로고    scopus 로고
    • Complement Monitoring of Carbon Nanotubes
    • Moghimi, S. M.; Hunter, A. C. Complement Monitoring of Carbon Nanotubes Nat. Nanotechnol. 2010, 5, 382
    • (2010) Nat. Nanotechnol. , vol.5 , pp. 382
    • Moghimi, S.M.1    Hunter, A.C.2
  • 38
  • 41
    • 54849408545 scopus 로고    scopus 로고
    • Poly(ethylene glycol)s Generate Complement Activation Products in Human Serum through Increased Alternative Pathway Turnover and a MASP-2-Dependent Process
    • Hamad, I.; Hunter, A. C.; Szebeni, J.; Moghimi, S. M. Poly(ethylene glycol)s Generate Complement Activation Products in Human Serum through Increased Alternative Pathway Turnover and a MASP-2-Dependent Process Mol. Immunol. 2008, 46, 225-232
    • (2008) Mol. Immunol. , vol.46 , pp. 225-232
    • Hamad, I.1    Hunter, A.C.2    Szebeni, J.3    Moghimi, S.M.4
  • 42
    • 84987534991 scopus 로고
    • Studies of Protein Adsorption on Polystyrene Latex Surfaces
    • Fair, B. D.; Jamieson, A. M. Studies of Protein Adsorption on Polystyrene Latex Surfaces J. Colloid Interface Sci. 1980, 77, 525-534
    • (1980) J. Colloid Interface Sci. , vol.77 , pp. 525-534
    • Fair, B.D.1    Jamieson, A.M.2
  • 43
    • 0037132508 scopus 로고    scopus 로고
    • PEGylation of Microspheres Generates a Heterogeneous Population of Particles with Differential Surface Characteristics and Biological Performance
    • Gbadamosi, J. K.; Hunter, A. C.; Moghimi, S. M. PEGylation of Microspheres Generates a Heterogeneous Population of Particles with Differential Surface Characteristics and Biological Performance FEBS Lett. 2002, 532, 338-344
    • (2002) FEBS Lett. , vol.532 , pp. 338-344
    • Gbadamosi, J.K.1    Hunter, A.C.2    Moghimi, S.M.3
  • 44
    • 0036584407 scopus 로고    scopus 로고
    • Evolution of Lectin-Complement Pathway and Its Role in Innate Immunity
    • Fujita, T. Evolution of Lectin-Complement Pathway and Its Role in Innate Immunity Nat. Rev. Immunol. 2002, 2, 346-353
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 346-353
    • Fujita, T.1
  • 45
    • 34250800861 scopus 로고    scopus 로고
    • Antibody Against Poly(ethylene glycol) Adversely Affects PEG-Asparginase Therapy in Acute Lymphoblastic Leukemia Patients
    • Armstrong, J. K.; Hempel, G.; Koling, S.; Chan, L. S.; Fisher, T.; Meiselman, H. J.; Garratty, G. Antibody Against Poly(ethylene glycol) Adversely Affects PEG-Asparginase Therapy in Acute Lymphoblastic Leukemia Patients Cancer 2007, 110, 103-111
    • (2007) Cancer , vol.110 , pp. 103-111
    • Armstrong, J.K.1    Hempel, G.2    Koling, S.3    Chan, L.S.4    Fisher, T.5    Meiselman, H.J.6    Garratty, G.7
  • 48
    • 0036748175 scopus 로고    scopus 로고
    • The Lectin-Pathway of Complement Activation: MBL, Other Collectins and Ficolins
    • Wallis, R. The Lectin-Pathway of Complement Activation: MBL, Other Collectins and Ficolins Immunobiology 2002, 205, 433-445
    • (2002) Immunobiology , vol.205 , pp. 433-445
    • Wallis, R.1
  • 49
    • 38049004310 scopus 로고    scopus 로고
    • Ficolins: Innate Immune Recognition Proteins for Danger Sensing
    • Thielens, N. M.; Gaboriaud, C.; Arlaud, G. J. Ficolins: Innate Immune Recognition Proteins for Danger Sensing Immunologia 2007, 26, 145-156
    • (2007) Immunologia , vol.26 , pp. 145-156
    • Thielens, N.M.1    Gaboriaud, C.2    Arlaud, G.J.3
  • 50
    • 28344454827 scopus 로고    scopus 로고
    • M-Ficolin, an Innate Immune Defence Molecule, Binds Patterns of Acetyl Groups and Activates Complement
    • Frederiksen, P. D.; Thiel, S.; Larsen, C. B.; Jensenius, J. C. M-Ficolin, an Innate Immune Defence Molecule, Binds Patterns of Acetyl Groups and Activates Complement Scand. J. Immunol. 2005, 62, 462-473
    • (2005) Scand. J. Immunol. , vol.62 , pp. 462-473
    • Frederiksen, P.D.1    Thiel, S.2    Larsen, C.B.3    Jensenius, J.C.4
  • 52
    • 84856811307 scopus 로고    scopus 로고
    • Effect of Functionalization of Carbon Nanotubes with Psychosine on Complement Activation and Protein Adsorption
    • Rybak-Smith, M. J.; Tripisciano, C.; Borowiak-Palen, E.; Lamprecht, C.; Sim, R. B. Effect of Functionalization of Carbon Nanotubes with Psychosine on Complement Activation and Protein Adsorption J. Biomed. Nanotechnol. 2011, 7, 830-839
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 830-839
    • Rybak-Smith, M.J.1    Tripisciano, C.2    Borowiak-Palen, E.3    Lamprecht, C.4    Sim, R.B.5
  • 53
    • 77952300688 scopus 로고    scopus 로고
    • Properdin: Emerging Roles of a Pattern-Recognition Molecule
    • Kemper, C.; Atkinson, J. P.; Hourcade, D. E. Properdin: Emerging Roles of a Pattern-Recognition Molecule Annu. Rev. Immunol. 2010, 28, 131-155
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 131-155
    • Kemper, C.1    Atkinson, J.P.2    Hourcade, D.E.3
  • 56
    • 0024386370 scopus 로고
    • Complement Proteins C5b-9 Induce Secretion of High Molecular-Weight Multimers of Endothelial von Willebrand-Factor and Translocation of Granule Membrane-Protein GMP-140 to the Cell-Surface
    • Hattori, R.; Hamilton, K. K.; McEver, R. P.; Sims, P. J. Complement Proteins C5b-9 Induce Secretion of High Molecular-Weight Multimers of Endothelial von Willebrand-Factor and Translocation of Granule Membrane-Protein GMP-140 to the Cell-Surface J. Biol. Chem. 1989, 264, 9053-9060
    • (1989) J. Biol. Chem. , vol.264 , pp. 9053-9060
    • Hattori, R.1    Hamilton, K.K.2    McEver, R.P.3    Sims, P.J.4
  • 58
    • 34547690726 scopus 로고    scopus 로고
    • Immunological Properties of Engineered Nanomaterials
    • Dobrovolskaia, M. A.; McNeil, S. E. Immunological Properties of Engineered Nanomaterials Nat. Nanotechnol. 2007, 2, 469-478
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 469-478
    • Dobrovolskaia, M.A.1    McNeil, S.E.2
  • 59
    • 43949091153 scopus 로고    scopus 로고
    • Optical Properties of Ultrashort Semiconducting Single-Walled Carbon Nanotube Capsules Down to Sub-10 nm
    • Sun, X.; Zaric, S.; Daranciang, D.; Welsher, K.; Lu, Y.; Li, X.; Dai, H. Optical Properties of Ultrashort Semiconducting Single-Walled Carbon Nanotube Capsules Down to Sub-10 nm J. Am. Chem. Soc. 2008, 130, 6551-6555
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 6551-6555
    • Sun, X.1    Zaric, S.2    Daranciang, D.3    Welsher, K.4    Lu, Y.5    Li, X.6    Dai, H.7


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