Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice

Molecular Therapy

Volumn 19, Issue 12, 2011, Pages 2228-2238

  Zhou, Jiehua ^a   Neff, C Preston ^b   Liu, Xiaoxuan ^c,d   Zhang, Jane ^a   Li, Haitang ^a   Smith, David D ^a   Swiderski, Piotr ^a   Aboellail, Tawfik ^b   Huang, Yuanyu ^e   Du, Quan ^e   Liang, Zicai ^e   Peng, Ling ^d   Akkina, Ramesh ^b   Rossi, John J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c WUHAN UNIVERSITY   (China)

^d AIX MARSEILLE UNIVERSITÉ   (France)

^e PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATORIAL DICER SUBSTRATE SMALL INTERFERING RNA; LACTATE DEHYDROGENASE; NANOPARTICLE; POLYAMIDOAMINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; FOLLOW UP; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VIVO GENE TRANSFER; LIVER; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTECTION; RNA INTERFERENCE; VIRUS INHIBITION; VIRUS LOAD;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

EID: 82955237641     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.207     Document Type: Article

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