Adenosine receptor neurobiology: Overview

International Review of Neurobiology

Volumn 119, Issue , 2014, Pages 1-49

  Chen, Jiang Fan ^a   Lee, Chien fei ^b   Chern, Yijuang ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Accessory protein; Adenosine; Adenosine receptors; Crystal structure; Glia; Knockout; Noncanonical signaling; Receptor heterodimerization

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ALPHA ACTININ; BETA ARRESTIN; BETA ARRESTIN 2; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CALCIUM BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE; FIBROBLAST GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLUTAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHOLIPASE C; PROTEIN KINASE C;

A2AR GENE; AGGRESSION; ANGIOGENESIS; ANXIETY; ARTICLE; BEHAVIOR CONTROL; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN DISEASE; DEPRESSION; DRUG TARGETING; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HOMEOSTASIS; HUMAN; MOLECULAR PATHOLOGY; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NEUROBIOLOGY; NEUROMODULATION; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PSYCHOMOTOR ACTIVITY; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR GENE; SIGNAL TRANSDUCTION; SLEEP WAKING CYCLE; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION; ANIMAL; PHYSIOLOGY;

ANIMALS; HUMANS; NEUROBIOLOGY; RECEPTORS, PURINERGIC P1;

EID: 84906776396     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-801022-8.00001-5     Document Type: Chapter

References (332)

1. Abbracchio M.P., Brambilla R., Ceruti S., Kim H.O., von Lubitz D.K., Jacobson K.A., et al. G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. Molecular Pharmacology 1995, 48:1038-1045.
2. Aherne C.M., Kewley E.M., Eltzschig H.K. The resurgence of A2B adenosine receptor signaling. Biochimica et Biophysica Acta 2011, 1808:1329-1339.
3. Alsene K., Deckert J., Sand P., de Wit H. Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 2003, 28:1694-1702.
4. Augusto E., Matos M., Sevigny J., El-Tayeb A., Bynoe M.S., Muller C.E., et al. Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. The Journal of Neuroscience 2013, 33:11390-11399.
5. Baldwin H.A., File S.E. Caffeine-induced anxiogenesis: The role of adenosine, benzodiazepine and noradrenergic receptors. Pharmacology, Biochemistry, and Behavior 1989, 32:181-186.
6. Ballarin M., Fredholm B.B., Ambrosio S., Mahy N. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: Inhibition of uptake and metabolism. Acta Physiologica Scandinavica 1991, 142:97-103.
7. Basheer R., Porkka-Heiskanen T., Stenberg D., McCarley R.W. Adenosine and behavioral state control: Adenosine increases c-Fos protein and AP1 binding in basal forebrain of rats. Brain Research. Molecular Brain Research 1999, 73:1-10.
8. Basheer R., Strecker R.E., Thakkar M.M., McCarley R.W. Adenosine and sleep-wake regulation. Progress in Neurobiology 2004, 73:379-396.
9. Bastia E., Xu Y.H., Scibelli A.C., Day Y.J., Linden J., Chen J.F., et al. A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization. Neuropsychopharmacology 2005, 30:891-900.
10. Benington J.H., Kodali S.K., Heller H.C. Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Brain Research 1995, 692:79-85.
11. Bergmayr C., Thurner P., Keuerleber S., Kudlacek O., Nanoff C., Freissmuth M., et al. Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. The Journal of Biological Chemistry 2013, 288:28831-28844.
12. Biber K., Klotz K.N., Berger M., Gebicke-Harter P.J., van Calker D. Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression. The Journal of Neuroscience 1997, 17:4956-4964.
13. Bjorklund O., Shang M.M., Tonazzini I., Dare E., Fredholm B.B. Adenosine A(1) and A(3) receptors protect astrocytes from hypoxic damage. European Journal of Pharmacology 2008, 596:6-13.
14. Blum D., Galas M.C., Pintor A., Brouillet E., Ledent C., Muller C.E., et al. A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: Implications for the neuroprotective potential of A2A antagonists. The Journal of Neuroscience 2003, 23:5361-5369.
15. Blum D., Hourez R., Galas M.C., Popoli P., Schiffmann S.N. Adenosine receptors and Huntington's disease: Implications for pathogenesis and therapeutics. Lancet Neurology 2003, 2:366-374.
16. Borroto-Escuela D.O., Romero-Fernandez W., Tarakanov A.O., Ciruela F., Agnati L.F., Fuxe K. On the existence of a possible A2A-D2-beta-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced beta-arrestin2 recruitment. Journal of Molecular Biology 2011, 406:687-699.
17. Burgueno J., Blake D.J., Benson M.A., Tinsley C.L., Esapa C.T., Canela E.I., et al. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. The Journal of Biological Chemistry 2003, 278:37545-37552.
18. Burnstock G., Fredholm B.B., Verkhratsky A. Adenosine and ATP receptors in the brain. Current Topics in Medicinal Chemistry 2011, 11:973-1011.
19. Canas P.M., Duarte J.M., Rodrigues R.J., Kofalvi A., Cunha R.A. Modification upon aging of the density of presynaptic modulation systems in the hippocampus. Neurobiology of Aging 2009, 30:1877-1884.
20. Canas P.M., Porciuncula L.O., Cunha G.M., Silva C.G., Machado N.J., Oliveira J.M., et al. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. The Journal of Neuroscience 2009, 29:14741-14751.
21. Canela L., Lujan R., Lluis C., Burgueno J., Mallol J., Canela E.I., et al. The neuronal Ca(2+)-binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Molecular and Cellular Neurosciences 2007, 36:1-12.
22. Carman A.J., Mills J.H., Krenz A., Kim D.G., Bynoe M.S. Adenosine receptor signaling modulates permeability of the blood-brain barrier. The Journal of Neuroscience 2011, 31:13272-13280.
23. Carriba P., Ortiz O., Patkar K., Justinova Z., Stroik J., Themann A., et al. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 2007, 32:2249-2259.
24. Carruthers A.M., Sellers L.A., Jenkins D.W., Jarvie E.M., Feniuk W., Humphrey P.P. Adenosine A(1) receptor-mediated inhibition of protein kinase A-induced calcitonin gene-related peptide release from rat trigeminal neurons. Molecular Pharmacology 2001, 59:1533-1541.
25. Cassada D.C., Tribble C.G., Long S.M., Kaza A.K., Linden J., Rieger J.M., et al. Adenosine A2A agonist reduces paralysis after spinal cord ischemia: Correlation with A2A receptor expression on motor neurons. The Annals of Thoracic Surgery 2002, 74:846-849. discussion 849-850.
26. Che J., Chan E.S., Cronstein B.N. Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Molecular Pharmacology 2007, 72:1626-1636.
27. Chekeni F.B., Elliott M.R., Sandilos J.K., Walk S.F., Kinchen J.M., Lazarowski E.R., et al. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature 2010, 467:863-867.
28. Chen Y., Corriden R., Inoue Y., Yip L., Hashiguchi N., Zinkernagel A., et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science 2006, 314:1792-1795.
29. Chen J.F., Eltzschig H.K., Fredholm B.B. Adenosine receptors as drug targets-What are the challenges?. Nature Reviews Drug Discovery 2013, 12:265-286.
30. Chen X., Gawryluk J.W., Wagener J.F., Ghribi O., Geiger J.D. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. Journal of Neuroinflammation 2008, 5:12.
31. Chen J.F., Huang Z., Ma J., Zhu J., Moratalla R., Standaert D., et al. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. The Journal of Neuroscience 1999, 19:9192-9200.
32. Chen X., Lan X., Roche I., Liu R., Geiger J.D. Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. Journal of Neurochemistry 2008, 107:1147-1157.
33. Chen J.F., Pedata F. Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors. Current Pharmaceutical Design 2008, 14:1490-1499.
34. Chen J.F., Sonsalla P.K., Pedata F., Melani A., Domenici M.R., Popoli P., et al. Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Progress in Neurobiology 2007, 83:310-331.
35. Chen B.S., Thomas E.V., Sanz-Clemente A., Roche K.W. NMDA receptor-dependent regulation of dendritic spine morphology by SAP102 splice variants. The Journal of Neuroscience 2011, 31:89-96.
36. Chen J.F., Xu K., Petzer J.P., Staal R., Xu Y.H., Beilstein M., et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. The Journal of Neuroscience 2001, 21:RC143.
37. Cheng H.C., Shih H.M., Chern Y. Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. The Journal of Biological Chemistry 2002, 277:33930-33942.
38. Cheong S.L., Federico S., Venkatesan G., Mandel A.L., Shao Y.M., Moro S., et al. The A3 adenosine receptor as multifaceted therapeutic target: Pharmacology, medicinal chemistry, and in silico approaches. Medicinal Research Reviews 2013, 33:235-335.
39. Chern Y., Chiou J.Y., Lai H.L., Tsai M.H. Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: Role for protein phosphatase 2A. Molecular Pharmacology 1995, 48:1-8.
40. Chern Y., King K., Lai H.L., Lai H.T. Molecular cloning of a novel adenosine receptor gene from rat brain. Biochemical and Biophysical Research Communications 1992, 185:304-309.
41. Chiang M.C., Chen H.M., Lai H.L., Chen H.W., Chou S.Y., Chen C.M., et al. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system. Human Molecular Genetics 2009, 18:2929-2942.
42. Chou S.Y., Lee Y.C., Chen H.M., Chiang M.C., Lai H.L., Chang H.H., et al. CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. Journal of Neurochemistry 2005, 93:310-320.
43. Ciccarelli R., D'Alimonte I., Ballerini P., D'Auro M., Nargi E., Buccella S., et al. Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. Molecular Pharmacology 2007, 71:1369-1380.
44. Ciccarelli R., Di Iorio P., Ballerini P., Ambrosini G., Giuliani P., Tiboni G.M., et al. Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes. Journal of Neuroscience Research 1994, 39:556-566.
45. Cirera S., Fredholm M. Isolation and mapping the pig homologs survivin (BIRC5) and effector cell protease receptor 1 (EPR1) genes. Cytogenetics and Cell Genetics 2001, 92:351-352.
46. Ciruela F., Casado V., Rodrigues R.J., Lujan R., Burgueno J., Canals M., et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. The Journal of Neuroscience 2006, 26:2080-2087.
47. Ciruela F., Gomez-Soler M., Guidolin D., Borroto-Escuela D.O., Agnati L.F., Fuxe K., et al. Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain. Biochimica et Biophysica Acta 2011, 1808:1245-1255.
48. Cunha R.A. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors. Neurochemistry International 2001, 38:107-125.
49. Cunha R.A. Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade. Purinergic Signalling 2005, 1:111-134.
50. Cunha G.M., Canas P.M., Melo C.S., Hockemeyer J., Muller C.E., Oliveira C.R., et al. Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. Experimental Neurology 2008, 210:776-781.
51. Cunha G.M., Canas P.M., Oliveira C.R., Cunha R.A. Increased density and synapto-protective effect of adenosine A(2A) receptors upon sub-chronic restraint stress. Neuroscience 2006, 141:1775-1781.
52. Cunha R.A., Constantino M.C., Sebastiao A.M., Ribeiro J.A. Modification of A1 and A2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport 1995, 6:1583-1588.
53. Dai S.S., Zhou Y.G., Li W., An J.H., Li P., Yang N., et al. Local glutamate level dictates adenosine A2A receptor regulation of neuroinflammation and traumatic brain injury. The Journal of Neuroscience 2010, 30:5802-5810.
54. d'Alcantara P., Ledent C., Swillens S., Schiffmann S.N. Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission. Neuroscience 2001, 107:455-464.
55. D'Alimonte I., Ballerini P., Nargi E., Buccella S., Giuliani P., Di Iorio P., et al. Staurosporine-induced apoptosis in astrocytes is prevented by A1 adenosine receptor activation. Neuroscience Letters 2007, 418:66-71.
56. Dall'Igna O.P., Fett P., Gomes M.W., Souza D.O., Cunha R.A., Lara D.R. Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Experimental Neurology 2007, 203:241-245.
57. Daly J.W., Butts-Lamb P., Padgett W. Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines. Cellular and Molecular Neurobiology 1983, 3:69-80.
58. Daly J.W., Padgett W.L. Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase. Biochemical Pharmacology 1992, 43:1089-1093.
59. Deckert J., Nothen M.M., Bryant S.P., Ren H., Wolf H.K., Stiles G.L., et al. Human adenosine A1 receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 1q31-32.1 using a silent polymorphism in the coding region. Biochemical and Biophysical Research Communications 1995, 214:614-621.
60. Delacretaz E. Clinical practice. Supraventricular tachycardia. The New England Journal of Medicine 2006, 354:1039-1051.
61. Delaney S.M., Geiger J.D. Levels of endogenous adenosine in rat striatum. II. Regulation of basal and N-methyl-d-aspartate-induced levels by inhibitors of adenosine transport and metabolism. The Journal of Pharmacology and Experimental Therapeutics 1998, 285:568-572.
62. de Mendonça A., Ribeiro J.A. Adenosine and neuronal plasticity. Life Sciences 1997, 60:245-251.
63. de Mendonça A., Sebastião A.M., Ribeiro J.A. Adenosine: Does it have a neuroprotective role after all?. Brain Research. Brain Research Reviews 2000, 33:258-274.
64. Desai A., Victor-Vega C., Gadangi S., Montesinos M.C., Chu C.C., Cronstein B.N. Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Molecular Pharmacology 2005, 67:1406-1413.
65. Diaz-Cabiale Z., Vivo M., Del Arco A., O'Connor W.T., Harte M.K., Muller C.E., et al. Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors. Neuroscience Letters 2002, 324:154-158.
66. Dickenson J.M., Hill S.J. Involvement of G-protein betagamma subunits in coupling the adenosine A1 receptor to phospholipase C in transfected CHO cells. European Journal of Pharmacology 1998, 355:85-93.
67. Diogenes M.J., Fernandes C.C., Sebastiao A.M., Ribeiro J.A. Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices. The Journal of Neuroscience 2004, 24:2905-2913.
68. Dirnagl U., Niwa K., Lindauer U., Villringer A. Coupling of cerebral blood flow to neuronal activation: Role of adenosine and nitric oxide. The American Journal of Physiology 1994, 267:H296-H301.
69. Dixon A.K., Gubitz A.K., Sirinathsinghji D.J., Richardson P.J., Freeman T.C. Tissue distribution of adenosine receptor mRNAs in the rat. British Journal of Pharmacology 1996, 118:1461-1468.
70. Dore A.S., Robertson N., Errey J.C., Ng I., Hollenstein K., Tehan B., et al. Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Structure 2011, 19:1283-1293.
71. Duarte J.M., Carvalho R.A., Cunha R.A., Gruetter R. Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. Journal of Neurochemistry 2009, 111:368-379.
72. Duarte J.M., Oliveira C.R., Ambrosio A.F., Cunha R.A. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Neurochemistry International 2006, 48:144-150.
73. Dumont J.E., Pecasse F., Maenhaut C. Crosstalk and specificity in signalling. Are we crosstalking ourselves into general confusion?. Cellular Signalling 2001, 13:457-463.
74. Dunwiddie T.V., Fredholm B.B. Adenosine neuromodulation. Purinergic approaches in experimental therapeutics 1997, 359-382. Wiley-Liss, New York, NY. K.A. Jacobson, M.F. Jarvis (Eds.).
75. Dunwiddie T.V., Masino S.A. The role and regulation of adenosine in the central nervous system. Annual Review of Neuroscience 2001, 24:31-55.
76. Elliott M.R., Chekeni F.B., Trampont P.C., Lazarowski E.R., Kadl A., Walk S.F., et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 2009, 461:282-286.
77. Eltzschig H.K. Adenosine: An old drug newly discovered. Anesthesiology 2009, 111:904-915.
78. Eltzschig H.K., Carmeliet P. Hypoxia and inflammation. The New England Journal of Medicine 2011, 364:656-665.
79. Eltzschig H.K., Eckle T. Ischemia and reperfusion-From mechanism to translation. Nature Medicine 2011, 17:1391-1401.
80. El Yacoubi M., Ledent C., Menard J.F., Parmentier M., Costentin J., Vaugeois J.M. The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors. British Journal of Pharmacology 2000, 129:1465-1473.
81. El Yacoubi M., Ledent C., Parmentier M., Bertorelli R., Ongini E., Costentin J., et al. Adenosine A2A receptor antagonists are potential antidepressants: Evidence based on pharmacology and A2A receptor knockout mice. British Journal of Pharmacology 2001, 134:68-77.
82. Faigle M., Seessle J., Zug S., El Kasmi K.C., Eltzschig H.K. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS One 2008, 3:e2801.
83. Fedele D.E., Gouder N., Güttinger M., Gabernet L., Scheurer L., Rulicke T., et al. Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation. Brain 2005, 128:2383-2395.
84. Fedele D.E., Koch P., Brüstle O., Scheurer L., Simpson E.M., Mohler H., et al. Engineering embryonic stem cell derived glia for adenosine delivery. Neuroscience Letters 2004, 370:160-165.
85. Fedorova I.M., Jacobson M.A., Basile A., Jacobson K.A. Behavioral characterization of mice lacking the A3 adenosine receptor: Sensitivity to hypoxic neurodegeneration. Cellular and Molecular Neurobiology 2003, 23:431-447.
86. Fenton R.A., Shea L.G., Doddi C., Dobson J.G. Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27. American Journal of Physiology. Heart and Circulatory Physiology 2010, 298:H1671-H1678.
87. Feoktistov I., Biaggioni I. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. The Journal of Clinical Investigation 1995, 96:1979-1986.
88. Feoktistov I., Goldstein A.E., Ryzhov S., Zeng D., Belardinelli L., Voyno-Yasenetskaya T., et al. Differential expression of adenosine receptors in human endothelial cells: Role of A2B receptors in angiogenic factor regulation. Circulation Research 2002, 90:531-538.
89. Feoktistov I., Murray J.J., Biaggioni I. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells. Molecular Pharmacology 1994, 45:1160-1167.
90. Fideu M.D., Arce A., Esquifino A.I., Miras-Portugal M.T. Thyroid hormones modulate both adenosine transport and adenosine A1 receptors in rat brain. The American Journal of Physiology 1994, 267:C1651-C1656.
91. Fields R.D., Burnstock G. Purinergic signalling in neuron-glia interactions. Nature Reviews Neuroscience 2006, 7:423-436.
92. Fink J.S., Kalda A., Ryu H., Stack E.C., Schwarzschild M.A., Chen J.F., et al. Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage. Journal of Neurochemistry 2004, 88:538-544.
93. Fink J.S., Weaver D.R., Rivkees S.A., Peterfreund R.A., Pollack A.E., Adler E.M., et al. Molecular cloning of the rat A2 adenosine receptor: Selective co-expression with D2 dopamine receptors in rat striatum. Brain Research. Molecular Brain Research 1992, 14:186-195.
94. Fishman P., Bar-Yehuda S., Liang B.T., Jacobson K.A. Pharmacological and therapeutic effects of A3 adenosine receptor agonists. Drug Discovery Today 2012, 17:359-366.
95. Flajolet M., Wang Z., Futter M., Shen W., Nuangchamnong N., Bendor J., et al. FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity. Nature Neuroscience 2008, 11:1402-1409.
96. Florio C., Prezioso A., Papaioannou A., Vertua R. Adenosine A1 receptors modulate anxiety in CD1 mice. Psychopharmacology 1998, 136:311-319.
97. Fontinha B.M., Diogenes M.J., Ribeiro J.A., Sebastiao A.M. Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine. Neuropharmacology 2008, 54:924-933.
98. Fredduzzi S., Moratalla R., Monopoli A., Cuellar B., Xu K., Ongini E., et al. Persistent behavioral sensitization to chronic l-DOPA requires A2A adenosine receptors. The Journal of Neuroscience 2002, 22:1054-1062.
99. Fredholm B.B. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death and Differentiation 2007, 14:1315-1323.
100. Fredholm B.B., Arslan G., Halldner L., Kull B., Schulte G., Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn-Schmiedeberg's Archives of Pharmacology 2000, 362:364-374.
101. Fredholm B.B., Battig K., Holmen J., Nehlig A., Zvartau E.E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews 1999, 51:83-133.
102. Fredholm B., Chen J.-F., Masino S.A., Vaugeois J.-M. Actions of adeosine at its receptors in the CNS: Insights from knckouts and drugs. Annual Review of Pharmacology and Toxicology 2005, 45:385-412.
103. Fredholm B.B., Chern Y., Franco R., Sitkovsky M. Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology 2007, 83:263-276.
104. Fredholm B.B., Cunha R.A., Svenningsson P. Pharmacology of adenosine A(2A) receptors and therapeutic applications. Current Topics in Medicinal Chemistry 2003, 3:413-426.
105. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.N., Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacological Reviews 2001, 53:527-552.
106. Fredholm B.B., IJzerman A.P., Jacobson K.A., Linden J., Muller C.E. International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors-An update. Pharmacological Reviews 2011, 63:1-34.
107. Fredholm B.B., Irenius E., Kull B., Schulte G. Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochemical Pharmacology 2001, 61:443-448.
108. Freeman J.L., Pitcher J.A., Li X., Bennett V., Lefkowitz R.J. Alpha-actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. FEBS Letters 2000, 473:280-284.
109. Fuxe K., Ferre S., Canals M., Torvinen M., Terasmaa A., Marcellino D., et al. Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function. Journal of Molecular Neuroscience 2005, 26:209-220.
110. Gao Z.G., Jacobson K.A. Translocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: Comparison with G protein-dependent pathways. Pharmacological Research 2008, 57:303-311.
111. Gao Z.G., Verzijl D., Zweemer A., Ye K., Goblyos A., Ijzerman A.P., et al. Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers. Biochemical Pharmacology 2011, 82:658-668.
112. Genovese T., Melani A., Esposito E., Mazzon E., Di Paola R., Bramanti P., et al. The selective adenosine A2A receptor agonist CGS 21680 reduces JNK MAPK activation in oligodendrocytes in injured spinal cord. Shock 2009, 32:578-585.
113. Gianfriddo M., Melani A., Turchi D., Giovannini M.G., Pedata F. Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow. Neurobiology of Disease 2004, 17:77-88.
114. Gimenez-Llort L., Fernandez-Teruel A., Escorihuela R.M., Fredholm B.B., Tobena A., Pekny M., et al. Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. The European Journal of Neuroscience 2002, 16:547-550.
115. Gimenez-Llort L., Masino S.A., Diao L., Fernandez-Teruel A., Tobena A., Halldner L., et al. Mice lacking the adenosine A(1) receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly. Synapse 2005, 57:8-16.
116. Gimenez-Llort L., Schiffmann S.N., Shmidt T., Canela L., Camon L., Wassholm M., et al. Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiology of Learning and Memory 2007, 87:42-56.
117. Gines S., Hillion J., Torvinen M., Le Crom S., Casado V., Canela E.I., et al. Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:8606-8611.
118. Gomes C.V., Kaster M.P., Tome A.R., Agostinho P.M., Cunha R.A. Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration. Biochimica et Biophysica Acta 2011, 1808:1380-1399.
119. Gomes C.A., Vaz S.H., Ribeiro J.A., Sebastiao A.M. Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner. Brain Research 2006, 1113:129-136.
120. Gsandtner I., Charalambous C., Stefan E., Ogris E., Freissmuth M., Zezula J. Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. The Journal of Biological Chemistry 2005, 280:31898-31905.
121. Gsandtner I., Freissmuth M. A tail of two signals: The C terminus of the A(2A)-adenosine receptor recruits alternative signaling pathways. Molecular Pharmacology 2006, 70:447-449.
122. Gubitz A.K., Widdowson L., Kurokawa M., Kirkpatrick K.A., Richardson P.J. Dual signalling by the adenosine A2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. Journal of Neurochemistry 1996, 67:374-381.
123. Gutierrez-de-Teran H., Massink A., Rodriguez D., Liu W., Han G.W., Joseph J.S., et al. The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure 2013, 21:2175-2185.
124. 1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Experimental Neurology 2005, 193:53-64.
125. Halassa M.M., Fellin T., Haydon P.G. The tripartite synapse: Roles for gliotransmission in health and disease. Trends in Molecular Medicine 2007, 13:54-63.
126. Halassa M.M., Fellin T., Takano H., Dong J.H., Haydon P.G. Synaptic islands defined by the territory of a single astrocyte. The Journal of Neuroscience 2007, 27:6473-6477.
127. Halassa M.M., Florian C., Fellin T., Munoz J.R., Lee S.Y., Abel T., et al. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 2009, 61:213-219.
128. Ham J., Rees D.A. The adenosine a2b receptor: Its role in inflammation. Endocrine, Metabolic & Immune Disorders: Drug Targets 2008, 8:244-254.
129. Hamilton S.P., Slager S.L., De Leon A.B., Heiman G.A., Klein D.F., Hodge S.E., et al. Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Neuropsychopharmacology 2004, 29:558-565.
130. Hammarberg C., Schulte G., Fredholm B.B. Evidence for functional adenosine A3 receptors in microglia cells. Journal of Neurochemistry 2003, 86:1051-1054.
131. Hasko G., Linden J., Cronstein B., Pacher P. Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases. Nature Reviews Drug Discovery 2008, 7:759-770.
132. Hasko G., Pacher P., Vizi E.S., Illes P. Adenosine receptor signaling in the brain immune system. Trends in Pharmacological Sciences 2005, 26:511-516.
133. Haydon P.G., Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiological Reviews 2006, 86:1009-1031.
134. Hernandez-Deviez D.J., Roth M.G., Casanova J.E., Wilson J.M. ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Molecular Biology of the Cell 2004, 15:111-120.
135. Hettinger B.D., Lee A., Linden J., Rosin D.L. Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum. The Journal of Comparative Neurology 2001, 431:331-346.
136. Hillion J., Canals M., Torvinen M., Casado V., Scott R., Terasmaa A., et al. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. The Journal of Biological Chemistry 2002, 277:18091-18097.
137. Hong Z.Y., Huang Z.L., Qu W.M., Eguchi N., Urade Y., Hayaishi O. An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. Journal of Neurochemistry 2005, 92:1542-1549.
138. Huang N.K., Lin Y.W., Huang C.L., Messing R.O., Chern Y. Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells. The Journal of Biological Chemistry 2001, 276:13838-13846.
139. Huang Z.L., Qu W.M., Eguchi N., Chen J.F., Schwarzschild M.A., Fredholm B.B., et al. Adenosine A(2A), but not A(1), receptors mediate the arousal effect of caffeine. Nature Neuroscience 2005, 8:858-859.
140. Huang Q.Y., Wei C., Yu L., Coelho J.E., Shen H.Y., Kalda A., et al. Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. The Journal of Neuroscience 2006, 26:11371-11378.
141. Huang L., Wu D.D., Zhang L., Feng L.Y. Modulation of A(2)a receptor antagonist on D(2) receptor internalization and ERK phosphorylation. Acta Pharmacologica Sinica 2013, 34:1292-1300.
142. Huber A., Padrun V., Deglon N., Aebischer P., Mohler H., Boison D. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:7611-7616.
143. Ikeda K., Kurokawa M., Aoyama S., Kuwana Y. Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease. Journal of Neurochemistry 2002, 80:262-270.
144. Iliff J.J., D'Ambrosio R., Ngai A.C., Winn H.R. Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. American Journal of Physiology. Heart and Circulatory Physiology 2003, 284:H1631-H1637.
145. Ivanov A.A., Barak D., Jacobson K.A. Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure. Journal of Medicinal Chemistry 2009, 52:3284-3292.
146. Ivanov A.A., Jacobson K.A. Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer. Bioorganic & Medicinal Chemistry Letters 2008, 18:4312-4315.
147. Jaakola V.P., Griffith M.T., Hanson M.A., Cherezov V., Chien E.Y., Lane J.R., et al. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008, 322:1211-1217.
148. Jaakola V.P., Lane J.R., Lin J.Y., Katritch V., Ijzerman A.P., Stevens R.C. Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: Identification and characterization of essential amino acid residues. The Journal of Biological Chemistry 2010, 285:13032-13044.
149. Jacobson K.A. Crystal structures of the A adenosine receptor and their use in medicinal chemistry. In Silico Pharmacology 2013, 1:22.
150. Jain N., Kemp N., Adeyemo O., Buchanan P., Stone T.W. Anxiolytic activity of adenosine receptor activation in mice. British Journal of Pharmacology 1995, 116:2127-2133.
151. Jajoo S., Mukherjea D., Kumar S., Sheth S., Kaur T., Rybak L.P., et al. Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery. American Journal of Physiology. Cell Physiology 2010, 298:C56-C65.
152. Jeong H.J., Jang I.S., Nabekura J., Akaike N. Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. Journal of Neurophysiology 2003, 89:1214-1222.
153. Johansson B., Halldner L., Dunwiddie T.V., Masino S.A., Poelchen W., Gimenez-Llort L., et al. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:9407-9412.
154. Johnston J.B., Silva C., Gonzalez G., Holden J., Warren K.G., Metz L.M., et al. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Annals of Neurology 2001, 49:650-658.
155. Jones P.A., Smith R.A., Stone T.W. Protection against kainate-induced excitotoxicity by adenosine A2A receptor agonists and antagonists. Neuroscience 1998, 85:229-237.
156. Jones P.A., Smith R.A., Stone T.W. Protection against hippocampal kainate excitotoxicity by intracerebral administration of an adenosine A2A receptor antagonist. Brain Research 1998, 800:328-335.
157. Josselyn S.A., Nguyen P.V. CREB, synapses and memory disorders: Past progress and future challenges. Current Drug Targets. CNS and Neurological Disorders 2005, 4:481-497.
158. Kachroo A., Orlando L.R., Grandy D.K., Chen J.F., Young A.B., Schwarzschild M.A. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. The Journal of Neuroscience 2005, 25:10414-10419.
159. Kamiya T., Saitoh O., Yoshioka K., Nakata H. Oligomerization of adenosine A2A and dopamine D2 receptors in living cells. Biochemical and Biophysical Research Communications 2003, 306:544-549.
160. Kaster M.P., Rosa A.O., Rosso M.M., Goulart E.C., Santos A.R., Rodrigues A.L. Adenosine administration produces an antidepressant-like effect in mice: Evidence for the involvement of A1 and A2A receptors. Neuroscience Letters 2004, 355:21-24.
161. Keuerleber S., Gsandtner I., Freissmuth M. From cradle to twilight: The carboxyl terminus directs the fate of the A(2A)-adenosine receptor. Biochimica et Biophysica Acta 2011, 1808:1350-1357.
162. Khoa N.D., Montesinos M.C., Reiss A.B., Delano D., Awadallah N., Cronstein B.N. Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. Journal of Immunology 2001, 167:4026-4032.
163. Khoa N.D., Postow M., Danielsson J., Cronstein B.N. Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane. Molecular Pharmacology 2006, 69:1311-1319.
164. Kim Y., Hechler B., Klutz A.M., Gachet C., Jacobson K.A. Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers. Bioconjugate Chemistry 2008, 19:406-411.
165. King A.E., Ackley M.A., Cass C.E., Young J.D., Baldwin S.A. Nucleoside transporters: From scavengers to novel therapeutic targets. Trends in Pharmacological Sciences 2006, 27:416-425.
166. Kirsch G.E., Codina J., Birnbaumer L., Brown A.M. Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. The American Journal of Physiology 1990, 259:H820-H826.
167. Kobayashi S., Millhorn D.E. Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection. The Journal of Biological Chemistry 1999, 274:20358-20365.
168. Kowaluk E.A., Jarvis M.F. Therapeutic potential of adenosine kinase inhibitors. Expert Opinion on Investigational Drugs 2000, 9:551-564.
169. Kreitzer A.C., Malenka R.C. Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models. Nature 2007, 445:643-647.
170. Kreitzer A.C., Malenka R.C. Striatal plasticity and basal ganglia circuit function. Neuron 2008, 60:543-554.
171. Kull B., Svenningsson P., Fredholm B.B. Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum. Molecular Pharmacology 2000, 58:771-777.
172. Lai H.L., Yang T.H., Messing R.O., Ching Y.H., Lin S.C., Chern Y. Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response. The Journal of Biological Chemistry 1997, 272:4970-4977.
173. Lang U.E., Lang F., Richter K., Vallon V., Lipp H.P., Schnermann J., et al. Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice. Behavioural Brain Research 2003, 145:179-188.
174. Langemeijer E.V., Verzijl D., Dekker S.J., Ijzerman A.P. Functional selectivity of adenosine A1 receptor ligands?. Purinergic Signal 2013, 9:91-100.
175. Lazarus M., Huang Z.L., Lu J., Urade Y., Chen J.F. How do the basal ganglia regulate sleep-wake behavior?. Trends in Neurosciences 2012, 35:723-732.
176. Lazarus M., Shen H.Y., Cherasse Y., Qu W.M., Huang Z.L., Bass C.E., et al. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. The Journal of Neuroscience 2011, 31:10067-10075.
177. Lebon G., Warne T., Edwards P.C., Bennett K., Langmead C.J., Leslie A.G., et al. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 2011, 474:521-525.
178. Ledent C., Vaugeois J.M., Schiffmann S.N., Pedrazzini T., El Yacoubi M., Vanderhaeghen J.J., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 1997, 388:674-678.
179. Lee F.S., Chao M.V. Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:3555-3560.
180. Lee C.F., Lai H.L., Lee Y.C., Chien C.L., Chern Y. The A2A adenosine receptor is a dual coding gene: A novel mechanism of gene usage and signal transduction. The Journal of Biological Chemistry 2014, 289:1257-1270.
181. Leibovich S.J., Chen J.F., Pinhal-Enfield G., Belem P.C., Elson G., Rosania A., et al. Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. The American Journal of Pathology 2002, 160:2231-2244.
182. Li W., Dai S., An J., Xiong R., Li P., Chen X., et al. Genetic inactivation of adenosine A2A receptors attenuates acute traumatic brain injury in the mouse cortical impact model. Experimental Neurology 2009, 215:69-76.
183. Li X.X., Nomura T., Aihara H., Nishizaki T. Adenosine enhances glial glutamate efflux via A2a adenosine receptors. Life Sciences 2001, 68:1343-1350.
184. Li Y., Oskouian R.J., Day Y.J., Rieger J.M., Liu L., Kern J.A., et al. Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells. Neuroscience 2006, 141:2029-2039.
185. Linden J. Purinergic chemotaxis. Science 2006, 314:1689-1690.
186. Linden J. Regulation of leukocyte function by adenosine receptors. Advances in Pharmacology 2011, 61:95-114.
187. Liu W., Chun E., Thompson A.A., Chubukov P., Xu F., Katritch V., et al. Structural basis for allosteric regulation of GPCRs by sodium ions. Science 2012, 337:232-236.
188. Liu Z.W., Gao X.B. Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: A possible sleep-promoting effect. Journal of Neurophysiology 2007, 97:837-848.
189. Liu A.M., Wong Y.H. G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling. The Journal of Biological Chemistry 2004, 279:53196-53204.
190. Liu X.L., Zhou R., Pan Q.Q., Jia X.L., Gao W.N., Wu J., et al. Genetic inactivation of the adenosine A2A receptor attenuates pathologic but not developmental angiogenesis in the mouse retina. Investigative Ophthalmology & Visual Science 2010, 51:6625-6632.
191. Londos C., Cooper D.M., Wolff J. Subclasses of external adenosine receptors. Proceedings of the National Academy of Sciences of the United States of America 1980, 77:2551-2554.
192. Lopes L.V., Cunha R.A., Kull B., Fredholm B.B., Ribeiro J.A. Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience 2002, 112:319-329.
193. Lopes L.V., Cunha R.A., Ribeiro J.A. Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. Journal of Neurochemistry 1999, 73:1733-1738.
194. MacDonald P.E., Braun M., Galvanovskis J., Rorsman P. Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metabolism 2006, 4:283-290.
195. Mahan L.C., McVittie L.D., Smyk-Randall E.M., Nakata H., Monsma F.J., Gerfen C.R., et al. Cloning and expression of an A1 adenosine receptor from rat brain. Molecular Pharmacology 1991, 40:1-7.
196. Malaga-Dieguez L., Yang Q., Bauer J., Pankevych H., Freissmuth M., Nanoff C. Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum. Molecular Pharmacology 2010, 77:940-952.
197. Martin E.D., Fernandez M., Perea G., Pascual O., Haydon P.G., Araque A., et al. Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission. Glia 2007, 55:36-45.
198. Martire A., Tebano M.T., Chiodi V., Ferreira S.G., Cunha R.A., Kofalvi A., et al. Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission. Journal of Neurochemistry 2011, 116:273-280.
199. Matharu A.L., Mundell S.J., Benovic J.L., Kelly E. Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus. The Journal of Biological Chemistry 2001, 276:30199-30207.
200. Matos M., Augusto E., Agostinho P., Cunha R.A., Chen J.F. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-alpha2 controlling glutamate uptake in astrocytes. The Journal of Neuroscience 2013, 33:18492-18502.
201. Matos M., Augusto E., Santos-Rodrigues A.D., Schwarzschild M.A., Chen J.F., Cunha R.A., et al. Adenosine A(2A) receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia 2012, 60:702-716.
202. Mayne M., Fotheringham J., Yan H.J., Power C., Del Bigio M.R., Peeling J., et al. Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage. Annals of Neurology 2001, 49:727-735.
203. Mayne M., Shepel P.N., Jiang Y., Geiger J.D., Power C. Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients. Annals of Neurology 1999, 45:633-639.
204. Melani A., Cipriani S., Vannucchi M.G., Nosi D., Donati C., Bruni P., et al. Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia. Brain 2009, 132:1480-1495.
205. Millan M.J. The neurobiology and control of anxious states. Progress in Neurobiology 2003, 70:83-244.
206. Milojevic T., Reiterer V., Stefan E., Korkhov V.M., Dorostkar M.M., Ducza E., et al. The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Molecular Pharmacology 2006, 69:1083-1094.
207. Montesinos M.C., Desai A., Chen J.F., Yee H., Schwarzschild M.A., Fink J.S., et al. Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. The American Journal of Pathology 2002, 160:2009-2018.
208. Montesinos M.C., Gadangi P., Longaker M., Sung J., Levine J., Nilsen D., et al. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors. The Journal of Experimental Medicine 1997, 186:1615-1620.
209. Moore K.A., Nicoll R.A., Schmitz D. Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:14397-14402.
210. Muller C.E., Jacobson K.A. Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochimica et Biophysica Acta 2011, 1808:1290-1308.
211. Mundell S.J., Loudon R.P., Benovic J.L. Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels. Biochemistry 1999, 38:8723-8732.
212. Mundell S.J., Matharu A.L., Kelly E., Benovic J.L. Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking. Biochemistry 2000, 39:12828-12836.
213. Munshi R., Pang I.H., Sternweis P.C., Linden J. A1 adenosine receptors of bovine brain couple to guanine nucleotide-binding proteins Gi1, Gi2, and Go. The Journal of Biological Chemistry 1991, 266:22285-22289.
214. Murphree L.J., Sullivan G.W., Marshall M.A., Linden J. Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: Role of NF-kappaB in A(2A) adenosine receptor induction. The Biochemical Journal 2005, 391:575-580.
215. Navarro G., Aymerich M.S., Marcellino D., Cortes A., Casado V., Mallol J., et al. Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors. The Journal of Biological Chemistry 2009, 284:28058-28068.
216. Navarro G., Hradsky J., Lluis C., Casado V., McCormick P.J., Kreutz M.R., et al. NCS-1 associates with adenosine A(2A) receptors and modulates receptor function. Frontiers in Molecular Neuroscience 2012, 5:53.
217. Nie Z., Mei Y., Ramkumar V. Short term desensitization of the A1 adenosine receptors in DDT1MF-2 cells. Molecular Pharmacology 1997, 52:456-464.
218. Nikbakht M.R., Stone T.W. Suppression of presynaptic responses to adenosine by activation of NMDA receptors. European Journal of Pharmacology 2001, 427:13-25.
219. Nishizaki T., Nagai K., Nomura T., Tada H., Kanno T., Tozaki H., et al. A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors. Glia 2002, 39:133-147.
220. Norenberg W., Wirkner K., Assmann H., Richter M., Illes P. Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons. Amino Acids 1998, 14:33-39.
221. Norenberg W., Wirkner K., Illes P. Effect of adenosine and some of its structural analogues on the conductance of NMDA receptor channels in a subset of rat neostriatal neurones. British Journal of Pharmacology 1997, 122:71-80.
222. Ohata H., Cao S., Koehler R.C. Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2006, 291:R728-R735.
223. Oishi Y., Huang Z.L., Fredholm B.B., Urade Y., Hayaishi O. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:19992-19997.
224. Ongini E., Adami M., Ferri C., Bertorelli R. Adenosine A2A receptors and neuroprotection. Annals of the New York Academy of Sciences 1997, 825:30-48.
225. O'Regan M.H., Simpson R.E., Perkins L.M., Phillis J.W. The selective A2 adenosine receptor agonist CGS 21680 enhances excitatory transmitter amino acid release from the ischemic rat cerebral cortex. Neuroscience Letters 1992, 138:169-172.
226. Othman T., Yan H., Rivkees S.A. Oligodendrocytes express functional A1 adenosine receptors that stimulate cellular migration. Glia 2003, 44:166-172.
227. Pak M.A., Haas H.L., Decking U.K.M., Schrader J. Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices. Neuropharmacology 1994, 33:1049-1053.
228. Palmer T.M., Gettys T.W., Stiles G.L. Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor. The Journal of Biological Chemistry 1995, 270:16895-16902.
229. Palmer T.M., Stiles G.L. Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor. Molecular Pharmacology 2000, 57:539-545.
230. Pankevych H., Korkhov V., Freissmuth M., Nanoff C. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. The Journal of Biological Chemistry 2003, 278:30283-30293.
231. Pascual O., Casper K.B., Kubera C., Zhang J., Revilla-Sanchez R., Sul J.Y., et al. Astrocytic purinergic signaling coordinates synaptic networks. Science 2005, 310:113-116.
232. Peakman M.C., Hill S.J. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. British Journal of Pharmacology 1994, 111:191-198.
233. Pedata F., Corsi C., Melani A., Bordoni F., Latini S. Adenosine extracellular brain concentrations and role of A2A receptors in ischemia. Annals of the New York Academy of Sciences 2001, 939:74-84.
234. Pereira G.S., Rossato J.I., Sarkis J.J., Cammarota M., Bonan C.D., Izquierdo I. Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat. Neurobiology of Learning and Memory 2005, 83:217-223.
235. Phillis J.W. The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Research 1995, 705:79-84.
236. Phillis J.W. Adenosine and adenine nucleotides as regulators of cerebral blood flow: Roles of acidosis, cell swelling, and KATP channels. Critical Reviews in Neurobiology 2004, 16:237-270.
237. Pin J.P., Neubig R., Bouvier M., Devi L., Filizola M., Javitch J.A., et al. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological Reviews 2007, 59:5-13.
238. Pinhal-Enfield G., Ramanathan M., Hasko G., Vogel S.N., Salzman A.L., Boons G.J., et al. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. The American Journal of Pathology 2003, 163:711-721.
239. Popoli P., Blum D., Domenici M.R., Burnouf S., Chern Y. A critical evaluation of adenosine A2A receptors as potentially "druggable" targets in Huntington's disease. Current Pharmaceutical Design 2008, 14:1500-1511.
240. Popoli P., Blum D., Martire A., Ledent C., Ceruti S., Abbracchio M.P. Functions, dysfunctions and possible therapeutic relevance of adenosine A(2A) receptors in Huntington's disease. Progress in Neurobiology 2007, 81:331-348.
241. Popoli P., Pintor A., Domenici M.R., Frank C., Tebano M.T., Pezzola A., et al. Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: Possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. The Journal of Neuroscience 2002, 22:1967-1975.
242. Prediger R.D., Batista L.C., Takahashi R.N. Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice. European Journal of Pharmacology 2004, 499:147-154.
243. Prediger R.D., Batista L.C., Takahashi R.N. Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors. Neurobiology of Aging 2005, 26:957-964.
244. Prediger R.D., Fernandes D., Takahashi R.N. Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats. Behavioural Brain Research 2005, 159:197-205.
245. Prediger R.D., Pamplona F.A., Fernandes D., Takahashi R.N. Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD)-The spontaneously hypertensive rat (SHR). The International Journal of Neuropsychopharmacology 2005, 8:583-594.
246. Prediger R.D., Takahashi R.N. Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors. Neuroscience Letters 2005, 376:160-165.
247. Quiroz C., Lujan R., Uchigashima M., Simoes A.P., Lerner T.N., Borycz J., et al. Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. ScientificWorldJournal 2009, 9:1321-1344.
248. Rainnie D.G., Grunze H.C., McCarley R.W., Greene R.W. Adenosine inhibition of mesopontine cholinergic neurons: Implications for EEG arousal. Science 1994, 263:689-692.
249. Ramkumar V., Stiles G.L., Beaven M.A., Ali H. The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. The Journal of Biological Chemistry 1993, 268:16887-16890.
250. Rebola N., Canas P.M., Oliveira C.R., Cunha R.A. Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat. Neuroscience 2005, 132:893-903.
251. Rebola N., Pinheiro P.C., Oliveira C.R., Malva J.O., Cunha R.A. Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Brain Research 2003, 987:49-58.
252. Rebola N., Porciuncula L.O., Lopes L.V., Oliveira C.R., Soares-da-Silva P., Cunha R.A. Long-term effect of convulsive behavior on the density of adenosine A1 and A2A receptors in the rat cerebral cortex. Epilepsia 2005, 46(Suppl. 5):159-165.
253. Rebola N., Rodrigues R.J., Lopes L.V., Richardson P.J., Oliveira C.R., Cunha R.A. Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus. Neuroscience 2005, 133:79-83.
254. Rebola N., Sebastiao A.M., de Mendonça A., Oliveira C.R., Ribeiro J.A., Cunha R.A. Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Journal of Neurophysiology 2003, 90:1295-1303.
255. Rees D.A., Lewis B.M., Lewis M.D., Francis K., Scanlon M.F., Ham J. Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. British Journal of Pharmacology 2003, 140:764-772.
256. Ren G., Li T., Lan J.Q., Wilz A., Simon R.P., Boison D. Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control. Experimental Neurology 2007, 208:26-37.
257. Ren H., Stiles G.L. Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance. Molecular Pharmacology 1995, 48:975-980.
258. Ren H., Stiles G.L. Dexamethasone stimulates human A1 adenosine receptor (A1AR) gene expression through multiple regulatory sites in promoter B. Molecular Pharmacology 1999, 55:309-316.
259. Ribeiro J.A., Sebastiao A.M., de Mendonça A. Adenosine receptors in the nervous system: Pathophysiological implications. Progress in Neurobiology 2002, 68:377-392.
260. Robledo P., Ursu G., Mahy N. Effects of adenosine and gamma-aminobutyric acid A receptor antagonists on N-methyl-d-aspartate induced neurotoxicity in the rat hippocampus. Hippocampus 1999, 9:527-533.
261. Rosin D.L., Hettinger B.D., Lee A., Linden J. Anatomy of adenosine A2A receptors in brain: Morphological substrates for integration of striatal function. Neurology 2003, 61:S12-S18.
262. Rosin D.L., Robeva A., Woodard R.L., Guyenet P.G., Linden J. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. The Journal of Comparative Neurology 1998, 401:163-186.
263. Rudich N., Ravid K., Sagi-Eisenberg R. Mast cell adenosine receptors function: A focus on the A3 adenosine receptor and inflammation. Frontiers in Immunology 2012, 3:134.
264. Salvatore C.A., Jacobson M.A., Taylor H.E., Linden J., Johnson R.G. Molecular cloning and characterization of the human A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America 1993, 90:10365-10369.
265. Satoh S., Matsumura H., Hayaishi O. Involvement of adenosine A2A receptor in sleep promotion. European Journal of Pharmacology 1998, 351:155-162.
266. Satoh S., Matsumura H., Koike N., Tokunaga Y., Maeda T., Hayaishi O. Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor agonist. The European Journal of Neuroscience 1999, 11:1587-1597.
267. Saura J., Angulo E., Ejarque A., Casado V., Tusell J.M., Moratalla R., et al. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. Journal of Neurochemistry 2005, 95:919-929.
268. Scammell T.E., Gerashchenko D.Y., Mochizuki T., McCarthy M.T., Estabrooke I.V., Sears C.A., et al. An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience 2001, 107:653-663.
269. Schiffmann S.N., Fisone G., Moresco R., Cunha R.A., Ferre S. Adenosine A2A receptors and basal ganglia physiology. Progress in Neurobiology 2007, 83:277-292.
270. Schiffmann S.N., Jacobs O., Vanderhaeghen J.J. Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: An in situ hybridization histochemistry study. Journal of Neurochemistry 1991, 57:1062-1067.
271. Schiffmann S.N., Libert F., Vassart G., Vanderhaeghen J.J. Distribution of adenosine A2 receptor mRNA in the human brain. Neuroscience Letters 1991, 130:177-181.
272. Schulte G., Fredholm B.B. Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2. Molecular Pharmacology 2002, 62:1137-1146.
273. Schulte G., Fredholm B.B. Signalling from adenosine receptors to mitogen-activated protein kinases. Cellular Signalling 2003, 15:813-827.
274. Schulte G., Fredholm B.B. The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38. Experimental Cell Research 2003, 290:168-176.
275. Schwarzschild M.A., Agnati L., Fuxe K., Chen J.F., Morelli M. Targeting adenosine A2A receptors in Parkinson's disease. Trends in Neurosciences 2006, 29:647-654.
276. Schwarzschild M.A., Chen J.F., Ascherio A. Caffeinated clues and the promise of adenosine A(2A) antagonists in PD. Neurology 2002, 58:1154-1160.
277. Schwarzschild M.A., Xu K., Oztas E., Petzer J.P., Castagnoli K., Castagnoli N., et al. Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease. Neurology 2003, 61:S55-S61.
278. Sebastiao A.M., Ribeiro J.A. Adenosine A2 receptor-mediated excitatory actions on the nervous system. Progress in Neurobiology 1996, 48:167-189.
279. Sebastiao A.M., Ribeiro J.A. Adenosine receptors and the central nervous system. Handbook of Experimental Pharmacology 2009, 193:471-534.
280. Sebastiao A.M., Ribeiro J.A. Triggering neurotrophic factor actions through adenosine A2A receptor activation: Implications for neuroprotection. British Journal of Pharmacology 2009, 158:15-22.
281. Shen H.Y., Coelho J.E., Ohtsuka N., Canas P.M., Day Y.J., Huang Q.Y., et al. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. The Journal of Neuroscience 2008, 28:2970-2975.
282. Shen W., Flajolet M., Greengard P., Surmeier D.J. Dichotomous dopaminergic control of striatal synaptic plasticity. Science 2008, 321:848-851.
283. Sitaraman S.V., Wang L., Wong M., Bruewer M., Hobert M., Yun C.H., et al. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. The Journal of Biological Chemistry 2002, 277:33188-33195.
284. Soriano A., Ventura R., Molero A., Hoen R., Casado V., Cortes A., et al. Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. Journal of Medicinal Chemistry 2009, 52:5590-5602.
285. Studer F.E., Fedele D.E., Marowsky A., Schwerdel C., Wernli K., Vogt K., et al. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience 2006, 142:125-137.
286. Sun C.N., Cheng H.C., Chou J.L., Lee S.Y., Lin Y.W., Lai H.L., et al. Rescue of p53 blockage by the A2A adenosine receptor via a novel interacting protein, Translin-associated protein X. Molecular Pharmacology 2006, 70:454-466.
287. Sun C.N., Chuang H.C., Wang J.Y., Chen S.Y., Cheng Y.Y., Lee C.F., et al. The A2A adenosine receptor rescues neuritogenesis impaired by p53 blockage via KIF2A, a kinesin family member. Developmental Neurobiology 2010, 70:604-621.
288. Sun Y., Duan Y., Eisenstein A.S., Hu W., Quintana A., Lam W.K., et al. A novel mechanism of control of NFkappaB activation and inflammation involving A2B adenosine receptors. Journal of Cell Science 2012, 125:4507-4517.
289. Svenningsson P., Hall H., Sedvall G., Fredholm B.B. Distribution of adenosine receptors in the postmortem human brain: An extended autoradiographic study. Synapse 1997, 27:322-335.
290. Svenningsson P., Le Moine C., Kull B., Sunahara R., Bloch B., Fredholm B.B. Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience 1997, 80:1171-1185.
291. Tanaka K. Alteration of second messengers during acute cerebral ischemia-Adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein. Progress in Neurobiology 2001, 65:173-207.
292. Tebano M.T., Martire A., Potenza R.L., Gro C., Pepponi R., Armida M., et al. Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus. Journal of Neurochemistry 2008, 104:279-286.
293. Thakkar M.M., Winston S., McCarley R.W. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: Effects of antisense to the A1 receptor in the cholinergic basal forebrain. The Journal of Neuroscience 2003, 23:4278-4287.
294. Thurner P., Gsandtner I., Kudlacek O., Choquet D., Nanoff C., Freissmuth M., et al. A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: Agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102). The Journal of Biological Chemistry 2014, 289:9263-9274.
295. Ticho S.R., Radulovacki M. Role of adenosine in sleep and temperature regulation in the preoptic area of rats. Pharmacology, Biochemistry, and Behavior 1991, 40:33-40.
296. Torvinen M., Kozell L.B., Neve K.A., Agnati L.F., Fuxe K. Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor. Journal of Molecular Neuroscience 2004, 24:173-180.
297. Torvinen M., Marcellino D., Canals M., Agnati L.F., Lluis C., Franco R., et al. Adenosine A2A receptor and dopamine D3 receptor interactions: Evidence of functional A2A/D3 heteromeric complexes. Molecular Pharmacology 2005, 67:400-407.
298. Tozzi A., Tscherter A., Belcastro V., Tantucci M., Costa C., Picconi B., et al. Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission. Neuropharmacology 2007, 53:783-789.
299. Trincavelli M.L., Costa B., Tuscano D., Lucacchini A., Martini C. Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells. Biochemical Pharmacology 2002, 64:625-631.
300. Trincavelli M.L., Tuscano D., Marroni M., Falleni A., Gremigni V., Ceruti S., et al. A3 adenosine receptors in human astrocytoma cells: Agonist-mediated desensitization, internalization, and down-regulation. Molecular Pharmacology 2002, 62:1373-1384.
301. Urade Y., Eguchi N., Qu W.M., Sakata M., Huang Z.L., Chen J.F., et al. Sleep regulation in adenosine A2A receptor-deficient mice. Neurology 2003, 61:S94-S96.
302. van Calker D., Muller M., Hamprecht B. Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. Journal of Neurochemistry 1979, 33:999-1005.
303. Ventura R., Harris K.M. Three-dimensional relationships between hippocampal synapses and astrocytes. The Journal of Neuroscience 1999, 19:6897-6906.
304. Vidi P.A., Chemel B.R., Hu C.D., Watts V.J. Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Molecular Pharmacology 2008, 74:544-551.
305. Virus R.M., Ticho S., Pilditch M., Radulovacki M. A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors. Neuropsychopharmacology 1990, 3:243-249.
306. Von Lubitz D.K., Lin R.C., Jacobson K.A. Cerebral ischemia in gerbils: Effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist. European Journal of Pharmacology 1995, 287:295-302.
307. Waltereit R., Weller M. Signaling from cAMP/PKA to MAPK and synaptic plasticity. Molecular Neurobiology 2003, 27:99-106.
308. Weaver D.R. A2a adenosine receptor gene expression in developing rat brain. Brain Research. Molecular Brain Research 1993, 20:313-327.
309. Wei C.J., Augusto E., Gomes C.A., Singer P., Wang Y., Boison D., et al. Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain. Biological Psychiatry 2014, 75:855-863.
310. Wei C.J., Li W., Chen J.F. Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies. Biochimica et Biophysica Acta 2011, 1808:1358-1379.
311. Wei C.J., Singer P., Coelho J., Boison D., Feldon J., Yee B.K., et al. Selective inactivation of adenosine A2A receptors in striatal neurons enhances working memory and reversal learning. Learning & Memory 2011, 18:459-474.
312. Wiese S., Jablonka S., Holtmann B., Orel N., Rajagopal R., Chao M.V., et al. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:17210-17215.
313. Wirkner K., Assmann H., Koles L., Gerevich Z., Franke H., Norenberg W., et al. Inhibition by adenosine A(2A) receptors of NMDA but not AMPA currents in rat neostriatal neurons. British Journal of Pharmacology 2000, 130:259-269.
314. Woods A.S., Marcellino D., Jackson S.N., Franco R., Ferre S., Agnati L.F., et al. How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors. Journal of Proteome Research 2008, 7:3428-3434.
315. Wu Y.C., Lai H.L., Chang W.C., Lin J.T., Liu Y.J., Chern Y. A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. Biochimica et Biophysica Acta 2013, 1833:3145-3154.
316. Xaus J., Valledor A.F., Cardo M., Marques L., Beleta J., Palacios J.M., et al. Adenosine inhibits macrophage colony-stimulating factor-dependent proliferation of macrophages through the induction of p27kip-1 expression. Journal of Immunology 1999, 163:4140-4149.
317. Xiao D., Bastia E., Xu Y.H., Benn C.L., Cha J.H., Peterson T.S., et al. Forebrain adenosine A2A receptors contribute to l-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice. The Journal of Neuroscience 2006, 26:13548-13555.
318. Xu K., Bastia E., Schwarzschild M. Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacology & Therapeutics 2005, 105:267-310.
319. Xu H.L., Mao L., Ye S., Paisansathan C., Vetri F., Pelligrino D.A. Astrocytes are a key conduit for upstream signaling of vasodilation during cerebral cortical neuronal activation in vivo. American Journal of Physiology. Heart and Circulatory Physiology 2008, 294:H622-H632.
320. Xu H.L., Pelligrino D.A. ATP release and hydrolysis contribute to rat pial arteriolar dilatation elicited by neuronal activation. Experimental Physiology 2007, 92:647-651.
321. Xu F., Wu H., Katritch V., Han G.W., Jacobson K.A., Gao Z.G., et al. Structure of an agonist-bound human A2A adenosine receptor. Science 2011, 332:322-327.
322. Yu L., Frith M.C., Suzuki Y., Peterfreund R.A., Gearan T., Sugano S., et al. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Research 2004, 1000:156-173.
323. Yu C., Gupta J., Chen J.F., Yin H.H. Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation. The Journal of Neuroscience 2009, 29:15100-15103.
324. Yu L., Huang Z., Mariani J., Wang Y., Moskowitz M., Chen J.F. Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nature Medicine 2004, 10:1081-1087.
325. Yu L., Shen H.Y., Coelho J.E., Araujo I.M., Huang Q.Y., Day Y.J., et al. Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms. Annals of Neurology 2008, 63:338-346.
326. Zezula J., Freissmuth M. The A(2A)-adenosine receptor: A GPCR with unique features?. British Journal of Pharmacology 2008, 153(Suppl. 1):S184-S190.
327. Zhang Z., Chen G., Zhou W., Song A., Xu T., Luo Q., et al. Regulated ATP release from astrocytes through lysosome exocytosis. Nature Cell Biology 2007, 9:945-953.
328. Zhou Q.Y., Li C., Olah M.E., Johnson R.A., Stiles G.L., Civelli O. Molecular cloning and characterization of an adenosine receptor: The A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:7432-7436.
329. Zhou S.J., Zhu M.E., Shu D., Du X.P., Song X.H., Wang X.T., et al. Preferential enhancement of working memory in mice lacking adenosine A(2A) receptors. Brain Research 2009, 1303:74-83.
330. Cunha R.A. Caffeine, adenosine receptors, memory and Alzheimer disease. Medicina Clínica (Barcelona) 2008, 131:790-795.
331. Cunha R.A., Ferre S., Vaugeois J.M., Chen J.F. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Current Pharmaceutical Design 2008, 14:1512-1524.
332. Ferre S., Quiroz C., Woods A.S., Cunha R., Popoli P., Ciruela F., et al. An update on adenosine A2A-dopamine D2 receptor interactions: Implications for the function of G protein-coupled receptors. Current Pharmaceutical Design 2008, 14:1468-1474.