Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

Biochemical Pharmacology

Volumn 82, Issue 6, 2011, Pages 658-668

  Gao, Zhan Guo ^a   Verzijl, Dennis ^b   Zweemer, Annelien ^b   Ye, Kai ^b   Göblyös, Anikó ^b   Ijzerman, Adriaan P ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

G protein coupled receptors; Nucleoside; Positive allosteric modulator; Purines; Second messenger

Indexed keywords

2 CHLORO N6 (3 IODOBENZYL)ADENOSINE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; BETA ARRESTIN 2; CYCLIC AMP; IMIDAZOQUINOLINE DERIVATIVE; LUF 5999; LUF 6000; LUF 6001; MITOGEN ACTIVATED PROTEIN KINASE 3; N (3,4 DICHLORO PHENYL) 2 CYCLOBUTYL 1H IMIDAZO[4,5 C]QUINOLIN 4 AMINE; N (3,4 DICHLORO PHENYL) 2 CYCLOHEXYL 1H IMIDAZO[4,5 C]QUINOLIN 4 AMINE; N (3,4 DICHLORO PHENYL)1H IMIDAZO[4,5 C]QUINOLIN 4 AMINE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; HUMAN; HYPERPOLARIZATION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

ADENOSINE A3 RECEPTOR AGONISTS; ALLOSTERIC REGULATION; AMINOQUINOLINES; ANIMALS; ARRESTINS; CALCIUM; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; CYCLIC AMP; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; MEMBRANE POTENTIALS; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A3; TRANSFECTION;

EID: 80051544311     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.06.017     Document Type: Article

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