Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate

European Journal of Neuroscience

Volumn 16, Issue 3, 2002, Pages 547-550

  Giménez Llort, Lydia ^a   Fernández Teruel, Alberto ^a   Escorihuela, Rosa Maria ^a   Fredholm, Bertil B ^b   Tobeña, Adolf ^a   Pekny, Milos ^c   Johansson, Björn ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Circadian cycle; Exploration; Knockout mice; Learning and memory

Indexed keywords

ADENOSINE A1 RECEPTOR;

AGGRESSION; AGING; ANIMAL BEHAVIOR; ANXIETY; CONFERENCE PAPER; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEMALE; LEARNING; LIGHT DARK CYCLE; MALE; MAZE TEST; MOTOR ACTIVITY; MOUSE; MUSCLE STRENGTH; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SURVIVAL RATE; WORKING MEMORY;

ADENOSINE; AGGRESSION; ANIMALS; ANXIETY; BRAIN; BRAIN CHEMISTRY; CIRCADIAN RHYTHM; FEMALE; LEARNING; MALE; MAZE LEARNING; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE WEAKNESS; RECEPTORS, PURINERGIC P1; SURVIVAL RATE;

EID: 0036460099     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02122.x     Document Type: Conference Paper

References (24)

1. Arai, A., Kessler, M. & Lynch, G. (1990) The effects of adenosine on the development of long-term potentiation. Neurosci. Lett., 119, 41-44.
2. Brown, R., Ollerstam, A., Johansson, B., Skott, O., Gebre-Medhin, S., Fredholm, B.B. & Persson, A.E. (2001) Abolished tubuloglomerular feedback and increased plasma renin in adenosine A (1) receptor-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol., 281, R1362-R1367.
3. Bruns, R.F. (1991) Role of adenosine in energy supply/demand balance. Nucleoside Nucleotides, 10, 931-943.
4. Costall, B., Jones, B.J., Kelly, M.E., Naylor, R.J. & Tomkins, D.M. (1989) Exploration of mice in a black and white test box: Validation as a model of anxiety. Pharmacol. Biochem. Behav., 32, 777-785.
5. Crawley, J.N., Belknap, J.K., Collins, A., Crabbe, J.C., Frankel, W., Henderson, N., Hitzemann, R.J., Maxson, S.C., Miner, L.L., Silva, A.J., Wynshaw-Boris, A. & Paylor, R. (1997) Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies. Psychopharmacology, 132, 107-124.
6. Daly, J.W. & Fredholm, B.B. (1998) Caffeine - An atypical drug of dependence. Drug Alcohol Depart., 51, 199-206.
7. Dunwiddie, T. & Masino, S.A. (2001) The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci., 24, 31-35.
8. Elliot, K.J., Weber, E.T. & Rea, M.A. (2001) Adenosine A1 receptors regulate the response of the hamster circadian clock to light. Eur. J. Pharmacol., 414, 45-53.
9. Escorihuela, R.M., Fernández-Teruel, A., Vallina, I.F., Baamonde, C., Lumbreras, M.A., Diersen, M., Tobeña, A. & Flórez, J.A. (1995) Behavioral assessment of Ts65Dn mice: A putative Down syndrome model. Neurosci. Lett., 199, 143-146.
10. Ferré, S., Popoli, P., Giménez-Llort, L., Rimondini, R., Müller, C.E., Strömberg, I., Ögren, S.O. & Fuxe, K. (2001) Adenosine/dopamine interaction. Implications for the treatment of Parkinson's disease. Park. Rel. Dis., 7, 235-241.
11. Florio, C., Prezioso, A., Papaioannou, A. & Bertua, R. (1998) Adenosine A1 receptors modulate anxiety in CD1 mice. Psychopharmacology, 136, 311-319.
12. Fredholm, B.B. (1996) In Green, A.R. & Cross, A.J. (eds), Neuroprotective Agents and Cerebral Ischemia. Academic Press, London, pp. 259-280.
13. Fredholm, B.B., Bätig, K., Holmén, J., Nehlig, A. & Zvartau, E. (1999) Action of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev., 51, 83-133.
14. Hooper, N., Fraser, C. & Stone, T.W. (1996) Effects of purine analogues on spontaneous alternation in mice. Psychopharmacology, 123, 250-257.
15. 1 receptor. Proc. Natl. Acad. Sci. USA, 98, 9407-9412.
16. 2a receptor. Nature, 388, 674-678.
17. Navarro, J.F., Romero, C. & Maldonado, E. (2000) Effects of N6-cyclohexyl adenosine (CHA) on isolation-induced aggression in male mice. Meth. Find. Exp. Clin. Pharmacol., 22, 43-46.
18. Palmour, R.M., Lipowski, C.J., Simon, C.K. & Ervin, R.R. (1989) Adenosine analogs inhibit fighting in isolated male mice. Life Sci., 44, 1293-1301.
19. Reading, S.A. & Barclay, J.K. (2001) A1 recepor activation decreases fatigue in mammalian slow-twitch skeletal muscle in vitro. Can. J. Physiol. Pharmacol., 79, 496-501.
20. Strecker, R.E., Morairty, S., Thakkar, M.M., Porkka-Heiskanen, T., Basheer, R., Dauphin, L.J., Rainnie, D.G., Portas, C.M., Greene, R.W. & McCarley, R.W. (2000) Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav. Brain Res., 115, 183-204.
21. Suzuki, F., Shimada, J., Shiozaki, S., Ichikawa, S., Ishii, A., Nakamura, J., Nonaka, H., Kobayashi, H. & Fuse, E. (1993) Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-(R.) -phenylisopropyl) adenosine-induced cognitive disturbance. J. Med. Chem., 36, 2508-2518.
22. VonLubitz, D.K.J.E., Paul, I.A., Bartus, R.T. & Jacobson, K.A. (1993) Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory. Eur. J. Pharmacol., 249, 271-280.
23. Whishaw, I.Q. (1985) Formation of a place learning-set by the rat: A new paradigm for neurobehavioral studies. Physiol. Behav., 35, 139-143.
24. Zarrindast, M.R. & Shafaghi, B. (1994) Effects of adenosine receptor agonists and antagonists on acquisition of passive avoidance learning. Eur. J. Pharmacol., 256, 233-239.