Adenosine and adenine nucleotides as regulators of cerebral blood flow: Roles of acidosis, cell swelling, and KATP channels

Critical Reviews in Neurobiology

Volumn 16, Issue 4, 2004, Pages 237-270

  Phillis, John W ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acidosis; Adenosine; ATP; Cerebral blood flow; Coronary blood flow; Hypercapnia; Hypotension; Hypoxia ischemia; KATP and KCa channels

Indexed keywords

2 (4 BROMOPHENYL) 7,8 DIHYDRO 4 PROPYL 1H IMIDAZO[2,1 L]PURIN 5(4H) ONE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO N 6 (3 IODOBENZYL)ADENOSINE 5' METHYLURONAMIDE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 PHENYLETHYLPYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLOHEXYLADENOSINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; N (4 CYANOPHENYL) 2 [4 (2,6 DIOXO 1,3 DIPROPYL 2,3,5,6,7 HEXAHYDRO 1H PURIN 8 YL)PHENOXY]ACETAMIDE; N [2 [2 PHENYL 6 [4 (3 PHENYLPROPYL)PIPERAZINE 1 CARBONYL] 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]AMINO]ETHYLACETAMIDE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL; PURINE; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ACIDOSIS; ARTERIOLE; ARTERY DIAMETER; AUTOREGULATION; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL SWELLING; CORONARY ARTERY BLOOD FLOW; EXTRACELLULAR SPACE; GLIA CELL; HYPERCAPNIA; HYPOTENSION; MEAN ARTERIAL PRESSURE; METABOLISM; NERVE CELL STIMULATION; NONHUMAN; RAT; RECEPTOR OCCUPANCY; REGULATORY MECHANISM; REVIEW; SMOOTH MUSCLE RELAXATION; TECHNIQUE;

ACIDOSIS; ADENINE NUCLEOTIDES; ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL SIZE; CEREBRAL ARTERIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; HUMANS; POTASSIUM CHANNELS; WATER-ELECTROLYTE BALANCE;

EID: 20344374724     PISSN: 08920915     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevNeurobiol.v16.i4.20     Document Type: Review

References (328)

1. Busija DW, Heistad DD. Factors involved in the physiological regulation of the cerebral circulation. Rev Physiol Biochem Pharmacol. 1984; 101:162-211.
2. Bevan JA. Autonomic pharmacologist's guide to the cerebral circulation. Trends Pharmacol Sci 1984; 5:234-236.
3. Edvinsson L, MacKenzie ET, McCulloch J. Cerebral Blood Flow and Metabolism. New York: Raven Press, 1993.
4. Phillis JW. The Regulation of Cerebral Blood Flow. Boca Raton, FL: CRC Press, 1993.
5. Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B. Primer on Cerebrovascular Diseases. San Diego, CA: Academic Press, 1997.
6. Drury AN, Szent-Gyorgyi A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 1929; 68:213-237.
7. Berne RM, Winn HR, Knabb RM, Ely SW, Rubio R. Blood flow regulation by adenosine in heart, brain and skeletal muscle. In: Berne RM, Rall TW, Rubio R, editors. Regulatory Function of Adenosine. Boston: Martinus Nijhoff, 1983.
8. Winn HR, Rubio R, Berne RM. Brain adenosine production in the rat during 60 seconds of ischemia. Circ Res 1979; 45:486-492.
9. Hardebo JE, Edvinsson L. Adenine compounds: Cerebrovascular effects in vitro with reference to their possible involvement in migraine. Stroke 1979; 10:58-62.
10. Forrester T, Harper AM, MacKenzie ET, Thomson EM. Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism. J Physiol 1979; 296:343-355.
11. Hardebo JE, Kahrstrom J, Owman C. P1- and P2-purine receptors in brain circulation. Eur J Pharmacol 1987; 144:343-352.
12. Muramatsu I, Fujiwara M, Miura A, Shibata S. Reactivity of isolated canine cerebral arteries to adenine nucleotides and adenosine. Pharmacology 1980; 21:198-205.
13. Torregrosa G, Miranda FJ, Salom JB, Alabadi JA, Alvarez C, Alborch E. Heterogeneity of P2- purinoceptors in brain circulation. J Cereb Blood Flow Metab 1990; 10:572-579.
14. Burnstock G. The role of adenosine triphosphate in migraine. Biomed Pharmacother 1989; 43:727-736.
15. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998; 50:413-492.
16. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K-N, Linden J. International Union of Pharmacology XXV Nomenclature and Classification of Adenosine Receptors. Pharmacol Rev 2001; 53:527-552.
17. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, et al. International Union of Pharmacology XXIV Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits. Pharmacol Rev 2001; 53:107-118.
18. Webb TE, Barnard EA. Molecular biology of P2Y receptors expressed in the nervous system. Progr Brain Res 1999; 120:23-31.
19. Sak K, Webb TE. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch Biochem Biophys 2002; 397:131-136.
20. Saki M, Tsumuki H, Nonaka H, Shimada J, Ichimura M. KF 26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1-imidazo[2,1-i] purin-5(4H)-one dihydrochloride), a new potent and selective adenosine AS receptor antagonist. Eur J Pharmacol 2002; 444:133-141.
21. Baraldi PG, Cacciari B, Moro S, Spalluto G, Pastorin G, Da Ros T, et al. Synthesis, biological activity and molecular modeling investigation of new pyrazolo [4,3-e]-1,2,4-triazolo [1,5-c] pyrimidine derivatives as human AS adenosine receptor antagonists. J Med Chem 2002; 45:770-780.
22. 2B receptors. Biochem Pharmacol 2004; 68:305-312.
23. 2A adenosine receptor deficiency attenuates brain injury induced by focal ischemia in mice. J Neurosci 1999; 19:9192-9200.
24. 2A knockout mice. Stroke 2003; 34:739-744.
25. 3 adenosine receptor: sensitivity to hypoxic neurodegeneration. Cell Mol Neurobiol 2003; 23:431-447.
26. 3 receptors augments adenosine-induced coronary flow in isolated mouse heart. Am J Physiol 2002; 282:H2183-H2189.
27. Evans RJ, Lewis C, Virginio C, Lundstrom K, Buell G, Surprenant A, et al. Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol 1996; 497:413-422.
28. Vial C, Roberts JA, Evans RJ. Molecular properties of ATP-gated P2X receptor ion channels. Trends Pharmacol Sci 2004; 25:487-493.
29. 3 receptors. Nature 2000; 407:1015-1017.
30. 1 receptors. Nature 2000; 403:86-89.
31. 3 deficient mice. Eur J Neurosci 2001; 14:1784-1792.
32. 7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 2002; 168:6436-6445.
33. 3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Tner Targets 2003; 7:513-522.
34. 1 cation channel in thrombosis of small arteries in vivo. J Exp Med 2003; 198:661-667.
35. 1 receptor null mice. J Clin Invest 1999; 104:1663-1665.
36. 2 receptor of MDCK cells: cloning, expression and cell-specific signaling. Am J Physiol 2000; 279:F1045-F1052.
37. 4-null mice. Mol Pharmacol 2003; 63:777-783.
38. Lazarowski ER, Rochelle LG, O'Neal WK, Ribeiro CM, Grubb BR, Zhang V, et al. Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gall-bladder. J Pharmacol Exp Ther 2001; 297:43-49.
39. Mendoza-Fernandez V, Andrew RD, Barajas-Lopez C. ATP inhibits glutamate synaptic release by acting at P2Y receptors in pyramidal neurons of hippocampal slices. J Pharmacol Exp Ther 2000; 293:172-179.
40. 1 receptors in rat brains. FEBS Lett 2002; 531:299-303.
41. Yoshioka K, Saitoh O, Nakata H. Heteromeric association creates a P2Y-like adenosine receptor. Proc Natl Acad Sci 2001; 18:7617-7622.
42. Yoshioka K, Nakata H. ATP- and adenosine-mediated signaling in the central nervous system: purinergic receptor complex: generating adenine nucleotide-sensitive adenosine receptors. J Pharmacol Sci 2004; 94:88-94.
43. Palmer GC, Ghai G. Adenosine receptors in capillaries and pia-arachnoid of rat cerebral cortex. Eur J Pharmacol 1982; 81:129-132.
44. Kalaria RN, Harik SI. Adenosine receptors of cerebral microvessels and choroid plexus. J Cereb Blood Flow Metab 1986; 6:463-470.
45. Rivkees SA, Price SL, Zhou FC. Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum and basal ganglia. Brain Res 1995; 677:193-203.
46. 2A receptors in the rat central nervous system. J Comp Neurol 1998; 401:163-186.
47. Ochiishi T, Chen L, Yukawa A, Saitoh Y, Sekino Y, Arai T, et al. Cellular localization of adenosine A1 receptors in rat forebrain: immunohistochemical analysis using adenosine A1 receptor-specific monoclonal antibody. J Comp Neurol 1999; 411:301-316.
48. 3 receptors are located in neurons of the rat hippocampus. Neuroreport 2003; 14:1645-1448.
49. Di Tullio MA, Tayebati SK, Amenta F. Identification of adenosine A1 and A3 receptor subtypes in rat pial and intracerebral arteries. Neurosci Lett 2004; 366:48-52.
50. Ngai AC, Coyne EF, Meno JR, West GA, Winn HR. Receptor subtypes mediating adenosine induced dilation of cerebral arterioles. Am J Physiol 2001; 280:H2329-H2335.
51. 2A receptors in hypotension-induced vasodilation and cerebral blood flow autoregulation in rat pial arteries. Life Sci 2000; 67:1435-1445.
52. 2B receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol 2000; 278:H339-H344.
53. Hein TW, Wang W, Zoghi B, Muthuchamy M, Kuo L. Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 2001; 33:271-282.
54. Lewis CJ, Ennion SJ, Evans RJ. P2 purinoceptor-mediated control of rat cerebral (pial) microvasculature; contribution of P2X and P2Y receptors. J Physiol 2000; 527:315-324.
55. Lewis CJ, Evans RJ. P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations. J Vasc Res 2001; 38:332-340.
56. Loesch A, Burnstock G. Ultrastructural localization of ATP-gated P2X2 receptor immunoreactivity in vascular endothelial cells in brain. Endothelium 2000; 7:93-98.
57. Horiuchi T, Dietrich HH, Hongo K, Dacey RG. Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. 2003; 34:1473-1478.
58. Anwar Z, Albert JL, Gubby SE, Boyle JP, Roberts JA, Webb TE, et al. Regulation of cyclic AMP by extracellular ATP in cultured brain capillary endothelial cells. Br J Pharmacol 1999; 128:465-471.
59. Berne RM, Rubio R, Curnish RR. Release of adenosine from ischemic brain. Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 1974; 35:262-271.
60. Eells JT, Spector R. Determination of ribonucleosides, deoxyribonucleosides, and purine and pyrimidine bases in adult rabbit cerebrospinal fluid and plasma. Neurochem Res 1983; 8:1307-1320.
61. Parks TS, Van Wylen DG, Rubio R, Berne RM. Increased brain interstitial fluid adenosine concentration during hypoxia in newborn piglet. J Cereb Blood Flow Metab 1987; 7:178-183.
62. Walter GA, Phillis JW, O'Regan MH. Determination of rat cerebrospinal fluid concentrations of adenosine, inosine, hypoxanthine, xanthine and uric acid by high performance liquid chromatography. J Pharm Pharmacol 1988; 40:140-142.
63. Barraco RA, Walter GA, Polasek M, Phillis JW. Purine concentrations in the cerebrospinal fluid of unanesthetized rats during and after hypoxia. Neurochem Int 1991; 18:243-248.
64. Sollevi A. Cardiovascular effects of adenosine in man: possible clinical implications. Progr Neurobiol 1986; 27:319-349.
65. Weigand MA, Michel A, Eckstein HH, Martin E, Bardenheuer HJ. Adenosine: a sensitive indicator of cerebral ischemia during carotid endarterectomy. Anesthesiology 1999; 91:414-421.
66. Rodriguez-Nunez A, Cid E, Rodriguez-Garcia J, Camina F, Rodriguez-Segade S, Castro-Gago M. Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. J Child Neurol 2001; 16:704-706.
67. Laghi Pasini F, Guideri F, Picano E, Parenti G, Petersen C, Varga A, et al. Increase in plasma adenosine during brain ischemia in man: a study during transient ischemic attacks, and stroke. Brain Res Bull 2000; 51:327-330.
68. Clark RS, Carcillo JA, Kochanek PM, Obrist WD, Jackson EK, Mi Z, et al. Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans. Neurosurgery 1997; 41:1284-1292.
69. Bell MJ, Robertson CS, Kochanek PM, Goodman JC, Gopinath SP, Carcillo JA, et al. Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury. Crit Care Med 2001; 29:399-404.
70. Robertson CL, Bell MJ, Kochanek PM, Adelson PD, Ruppel RA, Carcillo JA, et al. Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity. Crit Care Med 2001; 29:2287-2293.
71. During MJ, Spencer DD. Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 1992; 32:618-624.
72. Zetterstrom T, Vernet L, Ungerstedt U, Tossman U, Fredholm BB. Purine levels in the intact brain, studies with an implanted perfused hollow fibre. Neurosci Lett 1982; 29:111-115.
73. Van Wylen DGL, Park TS, Rubio R, Berne RM. Increases in interstitial fluid adenosine concentration during hypoxia, local potassium infusion, and ischemia. J Cereb Blood Flow Metab 1986; 6:522-528.
74. Ballarin M, Fredholm BB, Ambrosio S, Mahy N. Extracellular levels of adenosine and its metabolites in the striatum of awake rats: inhibition of uptake and metabolism. Acta Physiol Scand 1991; 142:97-103.
75. + depolarization, tetrodotoxin, and NMDA receptor inhibition on extracellular adenosine levels in rat striatum. Eur J Pharmacol 1993; 234:61-65.
76. Melani A, Pantoni L, Corsi C, Blanchi L, Monopoli A, Bertorelli R, et al. Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion. Correlations with neurological deficit and histopathological damage. Stroke 1999; 30:2448-2455.
77. Pazzagli M, Corsi C, Latini S, Pedata F, Pepeu G. In vivo regulation of extracellular adenosine levels in the cerebral cortex by NMDA and muscarinic receptors. Eur J Pharmacol 1994; 254:277-282.
78. Latini S, Pedata F. Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem 2001; 79:463-484.
79. Phillis JW, Walter GA, O'Regan MH, Stair RE. Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia. J Cereb Blood Flow Metab 1987; 7:679-686.
80. Fredholm BB, Abbracchio M, Burnstock G, Daly JW, Harden TK, Jacobson KA, et al. Nomenclature and classification of purinoceptors. Pharmacol Rev 1994; 46:143-156.
81. Phillis JW, O'Regan MH, Walter GA. Effects of deoxycoformycin on adenosine, inosine, hypoxanthine, xanthine and uric acid release from the hypoxemic rat cerebral cortex. J Cereb Blood Flow Metab 1988; 8:733-741.
82. Phillis JW, O'Regan MH, Walter GA. Effect of two nucleoside transport inhibitors, dipyridamole and soluflazine, on purine release from the rat cerebral cortex. Brain Res 1989; 481:309-316.
83. Phillis JW, Walter GA, O'Regan MH. A purine nucleoside phosphorylase inhibitor, 8-amino-9-(2-thienylmethyl) guanine, enhances purine release from the rat cerebral cortex. Int J Purine Pyrimidine Res 1990; 1:19-23.
84. O'Regan MH, Phillis JW, Walter GA. The effects of the xanthine oxidase inhibitors, allopurinol and oxypurinol, on the pattern of purine release from hypoxic rat cerebral cortex. Neurochem Int 1989; 14:91-99.
85. Phillis JW, O'Regan MH. Evidence for swelling-induced adenosine and adenine nucleotide release in rat cerebral cortex exposed to monocarboxylate-containing or hypotonic artificial cerebrospinal fluids. Neurochem Int 2002; 40:629-635.
86. Meno JR, Ngai AC, Ibayashi S, Winn HR. Adenosine release and changes in pial arteriolar diameter during transient cerebral ischemia and reperfusion. J Cereb Blood Flow Metab 1991; 11:986-993.
87. Meno JR, Ngai AC, Winn HR. Changes in pial arteriolar diameter and CSF adenosine concentrations during hypoxia. J Cereb Blood Flow Metab 1993; 13:214-220.
88. Dale N, Pearson T, Frenguelli BG. Direct measurement of adenosine release during hypoxia in the CAI region of the rat hippocampal slice. J Physiol 2000; 526:143-155.
89. Llaudet E, Botting NP, Crayston JA, Dale N. A three-enzyme microelectrode sensor for detecting purine release from central nervous system. Biosens Bioelectron 2003; 18:43-52.
90. Dale N, Gourine AV, Llaudet E, Bulmer D, Thomas T, Spyer KM. Rapid adenosine release in the nucleus tractus solitarii during defense response in rats: real-time measurement in vivo. J Physiol 2002; 544:149-160.
91. Frenguelli BG, Llaudet E, Dale N. High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat brain slices. J Neurochem 2003; 86:1506-1515.
92. Pearson T, Currie AJ, Etherington LA, Gadalla AE, Damian K, Llaudet E, et al. Plasticity of purine release during cerebral ischemia: clinical implications? J Cell Mol Med 2003; 7:362-375.
93. Meghji P, Turtle JB, Rubio R. Adenosine formation and release by embryonic chick neurons and glia in cell culture. J Neurochem 1989; 53:1852-1860.
94. Northington FJ, Matherne GP, Coleman SD, Berne RM. Sciatic nerve stimulation does not increase endogenous adenosine production in sensory-motor cortex. J Cereb Blood Flow Metab 1992; 12:835-843.
95. Zimmerman H. Signaling via ATP in the nervous system. Trends Neurosci. 1994; 17:420-426.
96. Zimmerman H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog Neurobiol 1996; 49:589-618.
97. Bodin P, Burnstock G. Purinergic signaling: ATP release. Neurochem Res 2001; 26:959-969.
98. Matsuoka I, Ohkubo S. ATP- and adenosine-mediated signaling in the central nervous system: adenosine receptor activation by ATP through rapid and localized generation of adenosine by ecto-nucleotidases. J Pharmacol Sci. 2004; 94:95-99.
99. Wierasko A, Goldsmith G, Seyfried TN. Stimulation-dependent release of adenosine triphosphate from hippocampal slices. Brain Res 1989; 485:244-250.
100. Wu PH, Phillis JW. Distribution and release of adenosine triphosphate in rat brain. Neurochem Res 1978; 3:563-571.
101. Phillis JW, Edstrom JP, Kostopoulos GL, Kirkpatrick JR. Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex. Can J Physiol Pharmacol 1979; 57:1289-1312.
102. Zimmerman H. Ectonucleotidases: some recent developments and a note on nomenclature. Drug Devel Res 2001; 52:44-56.
103. Westfall DP, Todorov LD, Mihaylova-Todorova ST. ATP as a cotransmitter in sympathetic nerves and its inactivation by releasable enzymes. J Pharmacol Exp Ther 2002; 303:439-444.
104. Mihaylova-Todorova ST, Todorov LD, Westfall DP. Enzyme kinetics and pharmacological characterization of nucleotidases released from guinea pig isolated vas deferens during nerve stimulation: evidence for a soluble ecto-nucleoside triphosphate diphosphohydrolase-like ATPase and a soluble ecto-5′-nucleotidase-like AMPase. J Pharmacol Exp Ther 2002; 302:992-1001.
105. Dunwiddie TV, Diao L, Proctor WR. Adenosine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J Neurosci 1997; 17:7673-7682.
106. Liu GJ, Bennett MR. ATP secretion from nerve trunks and Schwann cells mediated by glutamate. Neuroreport 2003; 14:2079-2083.
107. Bodin P, Bailey D, Burnstock G. Increased flow-induced ATP release from isolated vascular endothelial cells but not smooth muscle cells. Br J Pharmacol 1991; 103:1203-1205.
108. Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 1994; 263:1768-1771.
109. Cotrina ML, Lin JH, Nedergaard M. Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. J Neurosci 1998; 18:8794-8804.
110. Cotrina ML, Lin JH, Lopez-Garcia JC, Naus CCG, Nedergaard M. ATP-mediated glial signaling. J Neurosci 2000; 20:2835-2844.
111. Joseph SM, Buchakjian MR, Dubyak GR. Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem 2003; 278:23331-23342.
112. Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M. Signaling at the gliovascular interface. J Neurosci 2003; 23:9254-9262.
113. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 2003; 6:43-50.
114. Zonta M, Sebelin A, Gobbo S, Fellin T, Pozzan T, Carmignoto G. Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol 2003; 553:407-414.
115. Ballerini P, DiIorio P, Ciccarelli R, Nargi E, D'Alimonte I, Traversa U, et al. Glial cells express multiple ATP binding cassette proteins which are involved in ATP release. Neuroreport 2002; 13:1789-1792.
116. - channel: fresh start to the molecular identity and volume sensor. Am J Physiol 1997; 273:C755-C789.
117. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, et al. Functional significance of volume regulatory mechanisms. Physiol Rev 1998; 78:247-306.
118. Wang Y, Roman R, Lidofsky SD, Fitz JG. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Nat Acad Sci USA 1996; 93:12020-12025.
119. Koyama T, Oike M, Ito Y. Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells. J Physiol 2001; 532:759-769.
120. Iwasa K, Tasaki I, Gibbons RC. Swelling nerve fibers associated with action potentials. Science 1980; 210:338-339.
121. Tasaki I, Iwasa K. Further studies of rapid mechanical changes in squid axon associated with action potential production. Jpn J Physiol 1982; 32:505-518.
122. Holton P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 1959; 145:494-504.
123. Abood LG, Koketsu K, Miyamoto S. Outflux of various phosphates during membrane depolarization of excitable tissues. Am J Physiol 1962; 202:469-474.
124. 3H-adenosine and its derivatives from cat sensorimotor cortex. Life Sci 1975; 17:551-556.
125. Andrew RD, MacVicar BA. Imaging cell volume changes and neuronal excitation in the hippocampal slice. Neuroscience 1994; 62:371-383.
126. - and cell volume. J Neurochem 1998; 71:1396-1404.
127. + uptake via NKCC1 and swelling of astrocytes. Glia 2002; 37:114-123.
128. Schneider GH, Baethmann A, Kempski O. Mechanisms of glial swelling induced by glutamate. Can J Physiol Pharmacol 1992; 70(Suppl):S334-343.
129. Darby M, Kuzmiski JB, Panenka W, Feighan D, MacVicar BA. ATP released from astrocytes during swelling activates chloride channels. J Neurophysiol 2003; 89:1870-1877.
130. Jakubowicz DE, Grinstein S, Klip A. Cell swelling following recovery from acidification in C6 glioma cells: an in vitro model of postischemic brain edema. Brain Res 1987; 435:138-146.
131. Solis JM, Herranz AS, Herreras O, Menedez N, Martin Del Rio R. Weak organic acids induce taurine release through an osmotic-sensitive process in the in vivo rat hippocampus. J Neurosci Res 1990; 26:159-167.
132. Phillis JW, O'Regan MH. Evidence for swelling-induced adenosine and adenine nucleotide release in rat cerebral cortex exposed to monocarboxylate-containing or hypotonic cerebrospinal fluids. Neurochem Int 2002; 40:629-635.
133. Chesler M. Regulation and modulation of pH in the brain. Physiol Rev 2003; 83:1183-1221.
134. Hartley Z, Dubinsky JM. Changes in intracellular pH associated with glutamate excitotoxicity. J Neurosci 1993; 13:4690-4699.
135. Irwin RP, Lin SZ, Long RT, Paul SM. N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons. J Neurosci 1994; 14:1352-1357.
136. 2+ loads. J Neurophysiol 1994; 72:2563-2569.
137. Meyer TM, Munsch T, Pape HC. Activity related changes in intracellular pH in rat thalamic relay neurons. Neuroreport 2000; 11:33-37.
138. Willoughby D, Schweining CJ. Electrically evoked dendritic pH transients in rat cerebellar Purkinje cells. J Physiol 2002; 544:487-499.
139. Chesler M, Kraig RP. Intracellular pH of astrocytes increases rapidly with cortical stimulation. Am J Physiol 1989; 253:R666-R670.
140. Boyarsky G, Ransom B, Schlue WR, Davis MB, Boron WF. Intracellular pH regulation in single cultured astrocytes from rat forebrain. Glia 1993; 8:241-248.
141. - cotransport. Am J Physiol 1994; 267:C1633-C1640.
142. Grichtchenko II, Chesler M. Depolarization-induced alkalinization of astrocytes in gliotic hippocampal slices. Neuroscience 1994; 62:1071-1078.
143. Chesler M, Kraig RP. Intracellular pH transients of mammalian astrocytes. J Neurosci 1989; 9:2011-2019.
144. + changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes. J Neurosci 1996; 16:5393-5404.
145. 2+ transients in cultured rat cerebellar astrocytes evoked by glutamate agonists and noradrenaline. Glia 1995; 14:153-161.
146. Kraig RP, Ferreira-Filho CR, Nicholson C. Alkaline and acid transients in cerebellar microenvironment. J Neurophysiol 1983; 49:831-850.
147. Walz W. pH shifts evoked by neuronal stimulation in slices of rat hippocampus. Can J Physiol Pharmacol 1989; 67:577-581.
148. Roy CS, Sherrington CS. The regulation of the blood supply of the brain. J Physiol 1890; 11:85-108.
149. 2 and bicarbonate on pial vessels. Stroke 1977; 8:358-360.
150. Shalit MN, Shimojyo S, Reinmuth OM, Lockhart WS, Scheinberg P. The mechanism of action of carbon dioxide in the regulation of cerebral blood flow. Progr Brain Res 1968; 30:103-106.
151. Ponte J, Purves MJ. The role of carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels. J Physiol 1973; 237:315-340.
152. Harper AM, Bell RA. The effects of metabolic acidosis and alkalosis on the blood flow through the cerebral cortex. J Neurol Neurosurg Psychiatry 1963; 26:341-344.
153. Tian R, Vogel P, Lassen NA, Mulvany MJ, Andreasen F, Aalkjaer C. Role of extracellular and intercellular acidosis for hypercapnia-induced inhibition of tension of isolated rat cerebral arteries. Circ Res 1995; 76:269-275.
154. + channels in rabbit myogenic cerebral arteries. Am J Physiol 1995; 269:H348-H355.
155. Kitazono T, Faraci FM, Taguchi H, Heistad DD. Role of potassium in cerebral blood vessels. Stroke 1995; 26:1713-1723.
156. + channels in the vertebrobasilar system of the rabbit. Circ Res 1996; 78:238-243.
157. Faraci FM, Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev 1998; 78:53-97.
158. Faraci FM, Sobey CG. Role of potassium channels in regulation of cerebral vascular tone. J Cereb Blood Flow Metab 1998; 18:1047-1063.
159. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268:C799-C822.
160. Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev 1997; 77:1165-1232.
161. + channels. Trends Neurosci 1998; 21:288-294.
162. + channels in pancreatic, cardiac, and vascular smooth muscle cells. Am J Physiol 1998; 274:C25-C37.
163. + channel currents expressed in Xenopus oocytes: a reinterpretation. J Physiol 1997; 504:35-45.
164. ATP channels. Science 1998; 282:1141-1144.
165. ATP channels. Science 1998; 282:1138-1141.
166. ATP: an inward rectification subunit plus the sulfonylurea receptor. Science 1995; 270:1166-1170.
167. + channel openers. Pharmacol Ther 2000; 85:39-53.
168. + channel. J Biol Chem 1996; 271:24321-24324.
169. + channels clarified by Kir 6.2-knockout mice. Circ Res 2001; 88:570-577.
170. ATP channels by intracellular acidosis. J Biol Chem 2001; 276:12898-12902.
171. ATP channels. Gene. 2000; 256:261-270.
172. Kinoshita H, Katusic ZS. Role of potassium channels in relaxation of isolated canine basilar arteries to acidosis. Stroke 1997; 28:433-438.
173. + and ATP. J Physiol 2002; 543:495-504.
174. Wu J, Xu H, Yang Z, Wang Y, Mao J, Jiang C. Protons activate homomeric Kir 6.2 channels by selective suppression of long and intermediate closures. J Memb Biol 2002; 190:105-116.
175. Reid JM, Paterson DJ, Ashcroft FM, Bergel DH. The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat. Pflugers Arch 1993; 425:362-364.
176. + channels in rat aorta and brain microvascular endothelial cells. Am J Physiol 1993; 265:C812-C821.
177. + channels in arterial smooth muscle. Science 1989; 245:177-180
178. Fahrenkrug J. Neural regulation of cerebral blood flow: vasoactive intestinal peptide. In: The Regulation of Cerebral Blood Flow. Phillis JW, editor. Boca Raton, FL: CRC Press, 1993.
179. + channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol 1993; 265:H581-H585.
180. Suzuki Y. Calcitonin gene-related peptide (CGRP). In: The Regulation of Cerebral Blood Flow. Phillis JW, editor. Boca Raton, FL: CRC Press, 1993.
181. Kitazono T, Faraci FM, Heistad DO. Effect of norepinephrine on rat basilar artery in vivo. Am J Physiol 1993; 264:H178-H182.
182. + channels by cyclic AMP-dependent protein kinase in cultured smooth muscle cells of porcine coronary artery. Biochem Biophys Res Commun 1993; 193:240-247.
183. Phillis JW. Adenosine in the control of the cerebral circulation. Cerebrovasc Brain Metab Rev 1989; 1:26-54.
184. 2 receptor mediated coronary vasodilation in the dog. Cardiovasc Res 1994; 28:906-911.
185. 2 receptors and cAMP-dependent protein kinase. Proc Nat Acad Sci USA 1995; 92:12441-12445.
186. + channels in the contribution of adenosine to hypoxia-induced pial artery dilation. J Cereb Blood Flow Metab 1997; 17:100-108.
187. Bari F, Louis TM, Busija DW. Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. Stroke 1998; 29:222-227.
188. Dietrich HH, Dacey RG. Effects of extravascular acidification and extravascular alkalmization on constriction and depolarization in rat cerebral arterioles in vitro. J Neurosurg 1994; 81:437-442.
189. Tian R, Vogel P, Lassen NA, Mulvany MJ, Andreasen F, Aalkjaer C. Role of extracellular and intracellular acidosis for hypercapnia-induced inhibition of tension of isolated rat cerebral arteries. Circ Res 1995; 76:269-275.
190. Santa N, Kitazono T, Ago T, Ooboshi H, Kamouchi M, Wakisaka M, et al. ATP-sensitive potassium channel mediate dilation of basilar artery in response to intracellular acidification in vivo. Stroke 2003; 34:1276-1280.
191. Faraci FM, Breese KR, Heistad DD. Cerebral vasodilation during hypercapnia. Role of glibenclamide-sensitive potassium channels and nitric oxide. Stroke 1994; 25:1679-1683.
192. + channels in parenchymal microvessels of the rat cerebral cortex. Anesthesiology 2003; 99:1333-1339.
193. 2+-activated potassium channels. J Cereb Blood Flow Metab 2003; 23:1227-1238.
194. Philip S, Armstead WM. NMDA dilates pial arteries by K-ATP and K-Ca channel activation. Brain Res Bull 2004; 63:127-131.
195. Holland M, Langton PD, Standen NB, Boyle JP. Effects of the BKCa channel activator, NS 1619, on rat cerebral artery smooth muscle. Br J Pharmacol 1996; 117:119-129.
196. + channels in smooth muscle cells from basilar artery of guinea pig. Pflugers Arch 1995; 430:984-993.
197. + channels in cerebral vasodilation induced by increases in cyclic GMP and cydic AMP in the rat. Stroke 1996; 27:1603-1608.
198. Ca channel activation and cAMP to hypoxic cerebrovasodilation. Brain Res 2000; 853:330-337.
199. Sobey CG, Faraci FM. Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter. Am J Physiol 1997; 272:H256-H262.
200. Horiuchi T, Dietrich HH, Tsugane S, Dacey RG. Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum verses brain stem. Stroke 2001; 32:218-224.
201. + channels. Am J Physiol 1994; 267:H1455-1460.
202. + currents in mesenteric arterial smooth muscle cells by adenosine. Eur J Pharmacol 2000; 394:35-40.
203. + current in freshly dispersed cerebral arterial muscle cells. Pflugers Arch 1991; 418:292-296.
204. Stockbridge N, Zhang J, Weir B. Potassium currents of rat basilar artery smooth muscle cells. Pflugers Arch 1992; 421:37-42.
205. Edwards FR, Hirst GDS, Silverberg GD. Inward rectification in rat cerebral arterioles: involvement of potassium ions in autoregulation. J Physiol 1988; 404:455-466.
206. Quayle JM, McCarron JG, Brayden JE, Nelson MT. Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries. Am J Physiol 1993; 265:C1363-C1370.
207. Johnson TD, Marrelli AP, Steenberg ML, Childres WF, Bryan RM. Inward rectifier potassium channels in the rat cerebral artery. Am J Physiol 1998; 274: R541-R547.
208. + channels. J Physiol 1996; 492:419-430.
209. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 1994; 14:175-192.
210. Cholet N, Bonvento G, Seylaz J. Effect of neuronal NO synthase inhibition on the cerebral vasodilatory response to somatosensory stimulation. Brain Res 1996; 708:197-200.
211. Dirnagl U, Niwa K, Lindauer U, Villringer A. Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am J Physiol 1994; 267:H296-H301.
212. Ngai AC, Meno JR, Winn HR. L-NNA suppresses cerebrovascular response and evoked potentials during somatosensory stimulation in rats. Am J Physiol 1995; 269:H1803-H1810.
213. Buchanan JE, Phillis JW. The role of nitric oxide in the regulation of cerebral blood flow. Brain Res 1993; 610:248-255.
214. Bonvento G, Seylaz J, Lacombe P. Widespread attenuation of the cerebrovascular reactivity to hypercapnia following inhibition of nitric oxide synthase in the conscious rat. J Cereb Blood Flow Metab 1994; 14:699-703.
215. Reid JM, Davis AG, Ashcroft FM, Paterson DJ. Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. Am J Physiol 1995; 269:H916-H922.
216. Wang Q, Pelligrino DA, Baughman VL, Koenig HM, Albrecht RF. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J Cereb Blood Flow Metab 1995; 15:774-778.
217. Horiuchi T, Dietrich HH, Hongo K, Goto T, Dacey RG. Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis. Stroke 2002; 33:844-849.
218. + channels. Am J Physiol 1996; 271:H1498-H1506.
219. ATP channels activators need L-lysine or L-arginine. Am J Physiol 1998; 274:H974-H981.
220. ATP ion channel link in the inhibition of hypercapnic dilation of pial arterioles by 7-nitroindazole and tetrodotoxin. Europ J Pharmacol 2001; 417:203-215.
221. Rosenblum WI. ATP-sensitive potassium channels in the cerebral circulation. Stroke 2003; 34:1547-1552.
222. Irikura K, Huang PL, Ma J, Lee WS, Dalkara T, Fishman MC, et al. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc Nat Acad Sci USA 1995; 92:6823-6827.
223. 2A receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 1999; 291:655-664.
224. ATP channels. Circ Res 1999; 85:634-642.
225. Flood A, Headrick JP. Functional characterization of coronary vascular adenosine receptors in the mouse. Brit J Pharmacol 2001; 133:1063-1072.
226. ATP channels in endothelium. Am J Physiol 1995; 269:H541-H549.
227. Winn HR, Welsh JE, Rubio R, Berne RM. Brain adenosine production during sustained alteration in systemic blood pressure. Am J Physiol 1980; 239:H636-H641.
228. Van Wylen DG, Park TS, Rubio R, Berne RM. Cerebral blood flow and interstitial fluid adenosine during hemorrhagic hypotension. Am J Physiol 1988; 255:H1211-H1218.
229. Park TS, Van Wylen DG, Rubio R, Berne RM. Brain interstitial adenosine and sagittal sinus blood flow during systemic hypotension in piglet. J Cereb Blood Flow Metab 1988; 8:822-828.
230. Wei EP, Kontos HA. Cerebrovascular flow regulation by adenosine. In: The Regulation of Cerebral Blood Flow. Phillis JW, editor. Boca Raton, FL: CRC Press, 1993, 281-295.
231. Phillis JW, DeLong RE. The role of adenosine in cerebral vascular regulation during reductions in perfusion pressure. J Pharm Pharmacol 1986; 38:460-462.
232. Ko KR, Ngai AS, Winn HR. Role of adenosine in regulation of regional cerebral blood flow in sensory cortex. Am J Physiol 1990; 259:H1703-H1708.
233. Meno JR, Crum AV, Winn HR. Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Am J Physiol 2001; 281:H2018-H2027.
234. Li J, Iadecola C. Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 1994; 33:1453-1461.
235. Faraci FM, Breese KR. Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res 1993; 72:476-480.
236. Meng W, Tobin JR, Busija DW. Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors. Stroke 1995; 26:857-863.
237. Pelligrino DA, Gay RL, Baughman VL, Wang Q. NO synthase inhibition modulates NMDA-induced changes in cerebral blood flow and EEG activity. Am J Physiol 1996; 271:H990-H995.
238. Bhardwaj A, Northington FJ, Ichord RN, Hanley DF, Traystman RJ, Koehler RC. Characterization of ionotropic glutamate receptor-mediated nitric oxide production in vivo in rats. Stroke 1997; 28:850-856.
239. Bari F, Thore GR, Louis TM, Busija DW. Inhibitory effects of hypoxia and adenosine on N-methyl-D-aspartate-induced pial arteriolar dilation in piglets. Brain Res 1998; 780:237-244.
240. Iliff JJ, D'Ambrosio R, Ngai AC, Winn HR. Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. Am J Physiol 2003; 284:H1631-H1637.
241. Alkayed NJ, Birks EK, Narayanan J, Petrie KA, Kohler-Cabot AE, Harder DR. Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Stroke 1997; 28:1066-1072.
242. Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, et al. P-450 epoxygenase and NO synthase inhibitors reduce cerebral flow response to N-methyl-D-aspartate. Am J Physiol 2000; 279:H1616-H1624.
243. Kuschinsky W. Coupling of blood flow and metabolism in the brain. In: The Regulation of Cerebral Blood Flow. Phillis JW, editor. Boca Raton, FL: CRC Press, 1993.
244. Leffler CW, Armstead WM, Shibata M. Role of eicosanoids in cerebral hemodynamics. In: The Regulation of Cerebral Blood Flow. Phillis JW, editor. Boca Raton, FL: CRC Press, 1993.
245. Ilch CP, Golanav EV. Cerebrovasodilation evoked by stimulation of subthalamic vasodilator area and hypoxia depends upon the integrity of cortical neurons in the rat. Neurosci Lett 2004; 368:92-95.
246. Nakai M, Iadecola C, Ruggiero DA, Tucker LW, Reis DJ. Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: evidence for an intrinsic system in brain for primary vasodilation. Brain Res 1983; 260:35-49.
247. Golanov EV, Reis DJ. Contribution of oxygen-sensitive neurons of the rostral ventrolateral medulla to hypoxic cerebral vasodilatation in the rat. J Physiol 1996; 495:201-216.
248. Winn HR, Rubio R, Berne RM. Brain adenosine concentration during hypoxia in the rat. Am J Physiol 1981; 241:H235-H242.
249. Hagberg H, Andersson P, Lacarewicz J, Jacobson I, Butcher S, Sandberg M. Extracellular adenosine, inosine, hypoxanthine and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J Neurochem 1987; 49:227-231.
250. Emerson TE, Raymond RM. Involvement of adenosine in cerebral hypoxic hyperemia in the dog. Am J Physiol 1981; 241:H134-H138.
251. Hoffman WE, Albrecht RF, Miletich DJ. The role of adenosine in CBF increases during hypoxia in young rats. Stroke 1984; 15:124-129.
252. Phillis JW, Preston G, DeLong RE. Effects of anoxia on cerebral blood flow in the rat brain: evidence for a role of adenosine in autoregulation. J Cereb Blood Flow Metab 1984; 4:586-592.
253. Morii S, Ngai AC, Ko KR, Winn HR. Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. Am J Physiol 1987; 253:H165-H175.
254. Pinard E, Puiroud S, Seylaz J. Role of adenosine in cerebral hypoxic hyperemia in the unanesthetized rabbit. Brain Res 1989; 481:124-130.
255. Laudignon N, Farri E, Beharry K, Rex J, Aranda JV. Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. J Appl Physiol 1990; 68:1534-1541.
256. Bowton DL, Haddon WS, Prough DS, Adair N, Alford PT, Stump DA. Theophylline effect on cerebral blood flow response to hypoxemia. Chest 1988; 94:371-375.
257. McDonnell M, Ives NK, Hope PL. Intravenous aminophylline and cerebral blood flow in preterm infants. Arch Disease Childhood 1992; 67:416-418.
258. Nishimura M, Yoshioka A, Yamamoto M, Akiyama Y, Miyamoto K, Kawakami Y. Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans. J Appl Physiol 1993; 74:2724-2728.
259. Robel-Tillig E, Vogtmann C. Aminophylline influences cerebral hyperperfusion after severe birth hypoxia. Acta Paediatr 2000; 89:971-974.
260. Kontos HA, Wei EP. Oxygen-dependent mechanisms in cerebral autoregulation. Ann Biomed Eng 1985; 13:329-334.
261. Simpson RE, Phillis JW. Adenosine deaminase reduces hypoxic and hypercapnic dilatation of rat pial arterioles: evidence for mediation by adenosine. Brain Res 1991; 553:305-308.
262. Haller C, Kuschinsky W. Moderate hypoxia: reactivity of pial arteries and local effect of theophylline. J Appl Physiol 1987; 63:2208-2215.
263. Dora E. Effect of theophylline treatment on the functional hyperaemic and hypoxic responses of cerebrocortical microcirculation. Acta Physiol Hung 1986; 68:183-197.
264. Dora E, Koller A, Kovach AGB. Effect of topical adenosine deaminase treatment on the functional hyperemic and hypoxic responses of the cerebral cortical microcirculation. J Cereb Blood Flow Metab 1984; 4:447-457.
265. Ray CJ, Abbas MR, Coney AM, Marshall JM. Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. J Physiol 2002; 544:195-209.
266. Phillis JW, DeLong RE, Towner JK. The effects of lidoflazine and flunarizine on cerebral reactive hyperemia. Eur J Pharmacol 1985; 112:323-329.
267. Phillis JW, DeLong RE, Towner JK. Adenosine deaminase inhibitors enhance cerebral anoxic hyperemia in the rat. J Cereb Blood Flow Metab 1985; 5:295-299.
268. Coney AM, Marshall JM. Role of adenosine and its receptors in the vasodilation induced in the cerebral cortex of the rat by systemic hypoxia. J Physiol 1998; 509:507-518.
269. Heistad DD, Kontos HA. Cerebral circulation. In: Shepherd JT, Abboud FM, editors. The Cardiovascular System. Vol. 3. Peripheral Circulation and Organ Blood Flow, Part 1. Washington DC, American Physiological Society, 1983, 137-182.
270. Gelhorn E. On the physiological action of carbon dioxide on cortex and hypothalamus. EEG Clin Neurophysiol 1953; 5:401-413.
271. Ingvar DH. Cortical state of excitability and cortical circulation. In: Jasper HH, Proctor LD, Knighton RS, Noshay WC, Costello RT, editors. Reticular Formation of the Brain. Boston, Little Brown, 1958 381-408.
272. 2 tension and neuronal excitability. J Physiol 1965; 176:105-122.
273. Phillis JW, DeLong RE. An involvement of adenosine in cerebral blood flow regulation during hypercapnia. Gen Pharmacol 1987; 18:133-139.
274. Estevez AY, Phillis JW. Hypercapnia induced increases in cerebral blood flow: roles of adenosine, nitric oxide and cortical arousal. Brain Res 1997; 758:1-8.
275. Phillis JW, O'Regan MH. Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation. Eur J Pharmacol 2003; 476:211-219.
276. Wolk R, Nowicki D, Sieminska J, Trzebski A. Role of endogenous nitric oxide in the vasodilatory tone and carbon dioxide responsiveness of the ventrolateral medulla microcirculation in the rat. J Physiol Pharmacol 1995; 46:127-139.
277. Phillis JW, Lungu CL, Barbu DE, O'Regan MH. Adenosine's role in hypercapnia-evoked cerebral vasodilation in the rat. Neurosci Lett 2004; 365:6-9.
278. Harada M, Fuse A, Tanaka Y. Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea. Neuroreport 1997; 8:999-1002.
279. Ma J, Ming W, Ayata C, Huang PL, Fishman MC, Moskowitz MA. L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice. Am J Physiol 1996; 271:H1717-H1719.
280. Goadsby PJ. Nitric oxide is not the sole determinant of hypercapnic or metabolically driven vasodilation in the cerebral circulation. J Auton Nerv Syst 1994; 49: Suppl. S67-S82.
281. Evans RJ, Surprenant A. Vasoconstriction of guinea-pig submucosal arterioles following sympathetic nerve stimulation is mediated by the release of ATP. Br J Pharmacol 1992; 106:242-249.
282. Hill CE, Hirst GD, Silverberg GD, Van Helden DF. Sympathetic innervation and excitability of arterioles originating from the rat middle cerebral artery. J Physiol 1986; 371:305-316.
283. Bergfeld GR, Forrester T. Release of ATP from human erythrocytes in response to hypoxia and hypercapnia. Cardiovasc Res 1992; 26:40-47.
284. Dietrich HH, Ellsworth ML, Sprague RS, Dacey RG. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol 2000; 278:H1294-H1298.
285. Buxton ILO, Kaiser RA, Oxhorn BC, Cheek DJ. Evidence supporting the Nucleotide Axis Hypothesis: ATP release and metabolism by coronary endothelium. Am J Physiol 2001; 281:H1657-H1666.
286. 2 purinoceptors in the cardiovascular tree of the rat. Am J Physiol 1999; 277:H893-H900.
287. Berne RM. Regulation of coronary blood flow. Physiol Rev 1974; 44:1-29.
288. Bacchus AN, Ely SW, Knabb RM, Rubio R, Berne RM. Adenosine and coronary blood flow in conscious dogs during normal physiologic stimuli. Am J Physiol 1982; 243:H628-H633.
289. Giles RW, Wilken, DEL. Reactive hyperaemia in the dog heart: interrelations between adenosine, ATP, and aminophylline and the effect of indomethacin. Cardiovasc Res 1977; 11:113-121.
290. Radford MJ, McHale PA, Sadick N, Schwartz GG, Greenfield JC. Effect of aminophylline on coronary reactive and functional hyperemic response in conscious dogs. Cardiovasc Res 1984; 18:377-383.
291. Bache RJ, Dai X-Z, Schwartz JS, Homans DC. Role of adenosine in coronary vasodilation during exercise. Circ Res 1988; 62:846-853.
292. Saito D, Steinhart CK, Nixon DG, Olsson RA. Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ Res 1981; 49:1262-1267.
293. Merrill GF, Downey HF, Jones CE. Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia. Am J Physiol 1986; 250:H579-H583.
294. Clancy RL, Gonzalez NC. Effects of respiratory and metabolic acidosis on coronary vascular resistance. Proc Soc Exp Biol Med 1975; 148:307-311.
295. Alexander CS, Liu SM. Effects of hypercapnia and hypocapnia on myocardial blood flow and performance in anaesthetized dog. Cardvasc Res 1976; 10:341-348.
296. Ely SW, Sawyer DC. Local vasoactivity of oxygen and carbon dioxide in the right coronary circulation in the dog and pig. J Physiol 1982; 332:427-439.
297. Merrill GF, Haddy FJ, Dabney JM. Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart. Circ Res 1978; 42:225-229.
298. Mustafa SJ, Mansour MM. Effect of perfusate pH on coronary flow and adenosine release in isolated rabbit heart. Proc Soc Exp Biol Med 1984; 176:22-26.
299. Degenring FH. The effects of acidosis and alkalosis on coronary flow and cardiac nucleotide metabolism. Basic Res Cardiol 1976; 71:287-290.
300. 2A-adenosine receptor reserve for coronary vasodilation. Circulation 1998; 98:711-718.
301. Flood A, Headrick JP. Functional characterization of coronary vascular adenosine receptors in the mouse. Br J Pharmacol 2001; 133:1063-1072.
302. 2B receptors in mice. J Cardiovasc Pharmacol 2003; 41:562-570.
303. 2A receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 1999; 291:655-664.
304. Hinschen AK, Rose'Meyer RB, Headrick JP. Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol 41:73-80.
305. ATP channels in vascular smooth muscles. Circ Res 2003; 92:1225-1232.
306. Phillis JW, Song D, O'Regan MH. Mechanisms involved in coronary artery dilatation during respiratory acidosis in the isolated perfused rat heart. Basic Res Cardiol 2000; 95:93-97.
307. Davis CA, Sherman AJ, Yaroshenko Y, Harris KR, Hedjbeli S, Parker MA, et al. Coronary vascular responsiveness to adenosine is impaired additively by blockade of nitric oxide synthesis and a sulfonylurea. J Am Coll Cardiol 1998; 31:816-822.
308. 2A-adenosine receptor activation for ATP-mediated coronary vasodilation in guinea-pig isolated heart. Br J Pharmacol 2000; 130:1065-1075.
309. Phillis JW, Song D, O'Regan MH. The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. Europ J Pharmacol 1998; 356:199-206.
310. Phillis JW, O'Regan MH, Song D. Further evidence for the role of adenosine in hypercapnia/acidosis-evoked coronary flow regulation. Gen Pharmacol 1999; 33:431-437.
311. Abebe W, Makujina SR, Mustafa SJ. Adenosine receptor-mediated relaxation of porcine coronary artery in presence and absence of endothelium. Am J Physiol 1994; 266:H2018-H2025.
312. Huckstorf C, Zanzinger J, Fink B, Bassenge E. Reduced nitric oxide formation causes coronary vasoconstriction and impaired vasodilator responses to endogenous agonists and hypoxia. Naunyn-Schmiedeberg's Arch Pharmacol 1994; 349:367-373.
313. Maekawa K, Saito D, Obayashi N, Uchida S, Haraoka S. Role of endothelium-derived nitric oxide and adenosine in functional myocardial hyperemia. Am J Physiol 1994; 267:H166-H173.
314. Zanzinger J, Bassenge E. Coronary vasodilation to acetylcholine, adenosine and bradykinin in dogs: effects of inhibition of NO-synthesis and captopril. Eur Heart J 1993; 14(Suppl. 1):164-168.
315. Li J-M, Fenton RA, Cutler BS, Dobson JG. Adenosine enhances nitric oxide production by vascular endothelial cells. Am J Physiol 1995; 269:C519-C523.
316. 2B receptors mediated nitric oxide production in coronary artery endothelial cells. Gen Pharmacol 2000; 35:171-177.
317. Song D, O'Regan MH, Phillis JW. Role of nitric oxide in rat coronary flow regulation during respiratory and metabolic acidosis. Gen Pharmacol 1999; 32:571-575.
318. ATP channels. Br J Pharmacol 1997; 120:728-734.
319. Ishizaka H, Kuo L. Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle. Circ Res 1996; 78:50-57.
320. Parkinson FE, Xiong W. Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J Neurochem 2004; 88:1305-1312.
321. Gourine AV, Llaudet E, Dale N, Spyer KM. Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response. J Neurosci 2005; 25:1211-1218.
322. Gourine AV, Llaudet E, Thomas T, Dale N, Spyer KM. Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia-induced respiratory depression in rats. J Physiol (Lond) 2002; 544:161-170.
323. Spyer KM, Dale N, Gourine AV. ATP is a key mediator of central and peripheral chemosensory transduction. Exp Physiol 2004; 89:53-59.
324. Ralevic V, Burnstock G. Effects of purines and pyrimidines on the rat mesenteric arterial bed. Circ Res 1991; 69:1583-1590.
325. Boeynaems JM, Communi D, Savi P, Herbert JM. P2Y receptors: in the middle of the road. Trends Pharmacol Sci 2000; 21:1-3.
326. Stanford SJ, Gitlin JM, Mitchell JA. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat. Br J Pharmacol 2001; 133:825-832.
327. Malmsjo M, Chu ZM, Croft K, Erlinge D, Edvinsson L, Beilin LJ. P2Y receptor-induced EDHF vasodilation is of primary importance for the regulation of perfusion pressure in the peripheral circulation in the rat. Acta Physiol Scand 2002; 174:301-309.
328. Harrington LS, Mitchell JA. Novel role for P2X receptor activation in endothelium-dependent vasodilation. Br J Pharmacol 2004; 143:611-617.