Adenosine A2A receptor antagonists are potential antidepressants: Evidence based on pharmacology and A2A receptor knockout mice

British Journal of Pharmacology

Volumn 134, Issue 1, 2001, Pages 68-77

  El Yacoubi, Malika ^a   Ledent, Catherine ^b   Parmentier, Marc ^b   Bertorelli, Rosalia ^c   Ongini, Ennio ^c   Costentin, Jean ^a   Vaugeois, Jean Marie ^a  

^a IFRMP 23   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c San Raffaele Science Park   (Italy)

Author keywords

Adenosine; Antidepressant; Forced swim test; KW 6002; Motor activity; SCH 58261; Tail suspension test; ZM 241385

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; HALOPERIDOL; ISTRADEFYLLINE; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RESERPINE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; ASSAY; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG EFFICACY; FORCED SWIMMING TEST; GENE INACTIVATION; IMMOBILIZATION; KNOCKOUT MOUSE; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCREENING TEST; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; MOUSE MUTANT; PHYSIOLOGY; PTOSIS; SWIMMING; TIME;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BLEPHAROPTOSIS; DISEASE MODELS, ANIMAL; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALOPERIDOL; IMMOBILIZATION; MALE; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; PURINES; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D2; RECEPTORS, PURINERGIC P1; RESERPINE; SWIMMING; TIME FACTORS; TRIAZOLES;

EID: 0034741713     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704240     Document Type: Article

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