Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats

Journal of Neurophysiology

Volumn 90, Issue 2, 2003, Pages 1295-1303

  Rebola, Nelson ^a   Sebastião, Ana M ^b   De Mendonca, Alexandre ^b   Oliveira, Catarina R ^a   Ribeiro, J A ^b   Cunha, Rodrigo A ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLOROADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE DEAMINASE; CHELERYTHRINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; ROLIPRAM; TRITIUM; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; XANTHINE DERIVATIVE;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MEMBRANE BINDING; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; MALE; METABOLISM; NERVE CELL; PHYSIOLOGY; RAT; SYNAPTOSOME; WISTAR RAT;

ADENOSINE; ADRENERGIC BETA-AGONISTS; AGING; ANIMALS; BLOTTING, WESTERN; CYCLIC AMP; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; ISOPROTERENOL; MALE; NEURONS; PHENETHYLAMINES; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; SYNAPTIC TRANSMISSION; TRIAZINES; TRIAZOLES; XANTHINES;

EID: 0042817860     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00896.2002     Document Type: Article

References (48)

1. Anderson WW and Collingridge GL. A data acquisition program for on-line analysis of long-term potentiation and long-term depression. Neurosci Abst 23: 665, 1997.
2. Barnes CA. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends Neurosci 17: 13-18, 1994.
3. Barnes CA, Rao G, and Orr G. Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats. Neural Plast 7: 167-178, 2000.
4. 1 adenosine receptor antagonism in rat hippocampal slices. J Neurophysiol 68: 629-638, 1992.
5. 2a-adenosine receptor of the motor nerve endings is positively coupled to adenylate cyclase. Naunyn-Schmiedeberg's Arch Pharmacol 350: 514-522, 1994.
6. 2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats. Neuroreport 11: 2591-2595, 2000.
7. 2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo. Neuroreport 10: 3933-3937, 1999.
8. Cunha RA. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem Int 38: 107-125, 2001.
9. Cunha RA, Almeida T, and Ribeiro JA. Parallel modification of adenosine extracellular metabolism and modulatory action in the hippocampus of aged rats. J Neurochem 76: 372-382, 2001.
10. 2A adenosine receptor agonist CGS21680 and HENECA in the rat hippocampus. Br J Pharmacol 122: 1279-1284, 1997.
11. 2A adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport 6: 1583-1588, 1995a.
12. 2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci Lett 196: 41-44, 1995b.
13. 2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation. Neurosci Lett 289: 127-130, 2000.
14. Dani SU, Hori A, and Walter GF. Principles of Neural Aging. Elsevier, Amsterdam, 1997.
15. de Mendonca A and Ribeiro JA. Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience 62: 385-390, 1994.
16. Dierssen M, Marmol F, Vivas NM, Clos MV, and Badia A. Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats. Brain Res 586: 117-120, 1992.
17. Dunwiddie TV and Diao L. Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses. J Pharmacol Exp Ther 268: 537-545, 1994.
18. Dunwiddie TV and Masino SA. The role and regulation of adenosine in the central nervous system. Ann Rev Neurosci 24: 31-55, 2001.
19. 2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia. Neuroscience 63: 765-773, 1994.
20. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, and Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev 46: 482-487, 1994.
21. 2A receptors and therapeutic applications. Curr Top Med Chem 3: 413-426, 2002.
22. 2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. J Neurochem 67: 374-381, 1996.
23. Gudermann T, Schöneberg T, and Schultz G. Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci 20: 399-427, 1997.
24. Herrero I and Sánchez-Prieto J. cAMP-dependent facilitation of glutamate release by β-adrenergic receptors in cerebrocortical nerve terminals. J Biol Chem 271:30554-30560, 1996.
25. 1 receptor inhibition. Neuroscience 112: 319-329, 2002.
26. 2A adenosine receptors in the hippocampus and cortex of young adult and old rats. J Neurophysiol 82: 3196-3203, 1999a.
27. 2A receptors in the limbic cortex, but not striatum, of aged rats. J Neurochem 73: 1733-1738, 1999b.
28. 1 receptor responses. Eur J Pharmacol 383: 395-398, 1999c.
29. Masoro EJ. Use of rodents as models for the study of "normal aging": conceptual and practical issues. Neurobiol Aging 12: 639-643, 1991.
30. Miller RA and Nadon NL. Principles of animal use for gerontological research. J Gerontol 55: B117-B123, 2000.
31. 2a receptors: implications for the treatment of Parkinson's disease. J Neurosci 20: 7782-7789, 2000.
32. Okada M, Nutt DJ, Murakami T, Zhu G, Kamata A, Kawata Y, and Kaneko S. Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release. J Neurosci 21: 628-640, 2001.
33. Peterson GL. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346-357, 1977.
34. Popoli P, Betto P, Rimondini R, Reggio R, Pezzola A, Ricciarello G, Fuxe K, and Ferre S. Age-related alteration of the adenosine/dopamine balance in the rat striatum. Brain Res 795: 297-300, 1998b.
35. 2A receptor antagonists stimulate motor activity: evidence for an increased effectiveness in aged rats. Neurosci Lett 251: 201-204, 1998a.
36. 2A receptors to facilitate acetylcholine release in the rat hippocampus. Eur J Pharmacol 454: 31-38, 2002.
37. Rothman S. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J Neurosci 4: 1884-1891, 1984.
38. 2A receptor agonist. Eur J Neurosci 11: 1587-1597, 1999.
39. 2 receptor in the rat striatum. Neurosci Lett 158: 121-124, 1993.
40. Sebastião AM, Cunha RA, de Mendonca A, and Ribeiro JA. Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats. Br J Pharmacol 131: 1629-1634, 2000.
41. Sebastião AM and Ribeiro JA. Fine-tuning neuromodulation by adenosine. Trends Pharmacol 21: 341-346, 2000.
42. 2A agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine. Psychopharmacology 156: 187-193, 2001.
43. Spector T. Refinement of the Coomassie blue method of protein quantification. A simple and linear spectrophotometric assay for <0.5 to 50 μg of protein. Anal Biochem 86: 142-146, 1978.
44. Sugawa M and May T. Age-related alteration in signal transduction: involvement of the cAMP cascade. Brain Res 618: 57-62, 1993.
45. 2A receptors. Prog Neurobiol 59: 355-396, 1999.
46. Young LT, Warsh JJ, Li PP, Siu KP, Becker L, Gilbert J, Hornykiewicz O, and Kish SJ. Maturational and aging effects on guanine nucleotide binding protein immunoreactivity in human brain. Dev Brain Res 61: 243-248, 1991.
47. Zimmerman ID and Berg AP. Levels of adenosine 3′, 5′ cyclic monophosphate in the cerebral cortex of the aging rats. Mech Ageing Dev 3: 33-36, 1974.
48. Zimmerman ID and Berg AP. Phosphodiesterase and adenyl-cyclase activities in the cerebral cortex of the aging rat. Mech Ageing Dev 4: 89-96, 1975.