A3 adenosine receptors in human astrocytoma cells: Agonist-mediated desensitization, internalization, and down-regulation

Molecular Pharmacology

Volumn 62, Issue 6, 2002, Pages 1373-1384

  Trincavelli, M L ^a   Tuscano, D ^a   Marroni, M ^a   Falleni, A ^a   Gremigni, V ^a   Ceruti, S ^b   Abbracchio, M P ^b   Jacobson, K A ^c   Cattabeni, F ^b   Martini, Claudia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N6 (3 IODOBENZYL) N METHYL 5' CARBAMOYLADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; ADENYLATE CYCLASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR;

ARTICLE; ASTROCYTOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOGOLD ELECTRON MICROSCOPY; INTERNALIZATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; CELL CULTURE; DRUG POTENTIATION; ENDOCYTOSIS; METABOLISM; PATHOLOGY;

ADENYLATE CYCLASE; ASTROCYTOMA; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; TUMOR CELLS, CULTURED;

EID: 0036882256     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.6.1373     Document Type: Article

References (40)

1. Abbracchio MP and Burnstock G (1998) Purinergic signalling: Pathophysiological roles. Jpn J Pharmacol 78:113-145.
2. 3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins. Ann NY Acad Sci 939:63-73.
3. 3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton and distribution of Bcl-XL: Studies in human astroglioma cells. Biochem Biophys Res Commun 241:297-304.
4. Ali H, Cunha-Melo JR, Saul WF, and Beaven MA (1990) Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor. J Biol Chem 265:745-753.
5. 3 receptor-induced apoptosis. J Mol Neurosci 17:285-292.
6. Bohm SK, Grady EF, and Bunnett NW (1997) Regulatory mechanisms that modulate signalling by G-protein coupled receptors. Biochem J 322:1-18.
7. 3 adenosine receptor affects cell cycle progression and cell growth. Naunyn-Schmiedeberg's Arch Pharmacol 361:225-234.
8. Bunemann M and Hosey MM (1999) G-protein coupled receptor kinases as modulators of G-protein signalling. J Physiol (Lond) 517:5-23.
9. 1 adenosine receptors. Mol Pharmacol 52:788-797.
10. Edwardson JM and Szekeres PG (1999) Endocytosis and recycling of muscarinic receptors. Life Sci 64:487-494.
11. Ferguson G, Watterson KR, and Palmer TM (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Mol Pharmacol 57:546-552.
12. Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling. Pharmacol Rev 53:1-24.
13. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, and Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156.
14. 1 adenosine receptor-G-protein complexes: Effects of receptor down-regulation and phosphorylation on coupling. Biochem J 338:729-736.
15. 3 adenosine receptors in Jurkat T cells. Br J Pharmacol 134:116-126.
16. Gessi S, Varani K, Merighi S, Cattabriga E, Iannotta V, Leung E, Baraldi PG, and Borea PA (2002) A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: A pharmacological and biochemical study. Mol Pharmacol 61:415-424.
17. 3 receptors: Novel ligands and paradoxical effects. Trends Pharmacol Sci 19:184-191.
18. Jacobson KA, Hoffmann C, Cattabeni F, and Abbracchio MP (1999) Adenosine-induced cell death: Evidence for receptor-mediated signalling. Apoptosis 4:197-211.
19. 3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett 336:57-60.
20. 3 adenosine receptor-selective antagonists. Neuropharmacology 36:1157-1165.
21. 3 adenosine receptors. Biochem Biophys Res Commun 203:570-576.
22. 3 adenosine receptors: Structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives. J Med Chem. 37:4020-4030.
23. 3 receptor subtype. J Med Chem 39:4142-4148.
24. Kim SG, Ravi G, Hoffmann C, Jung YJ, Kim M, Chen A, and Jacobson KA (2002) p53-independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, CI-IB-MECA. Biochem Pharmacol 63:871-880.
25. Merighi S, Varani K, Gessi S, Cattabriga E, Iannotta V, Ulouglu C, Leung E, and Borea PA (2001) Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line. Br J Pharmacol 134:1215-1226.
26. 3 adenosine receptor. Mol Pharmacol 45:978-982.
27. 3 adenosine receptors. J Biol Chem 270:29607-29613.
28. 3 adenosine receptor. J Biol Chem 271:15272-15278.
29. 3 adenosine receptors. J Biol Chem 270:16895-16902.
30. 3 adenosine receptor. Mol Pharmacol 52:632-640.
31. Palmer TM and Stiles GL (2000) Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor. Mol Pharmacol 57:539-545.
32. 3 adenosine receptor. Proc Natl Acad Sci USA 90:10365-10369.
33. Suh BC, Kim TD, Lee JU, Seong JK, and Kim KT (2001) Pharmacological characterization of adenosine receptors in PGT-β mouse pineal gland tumour cells. Br J Pharmacol 134:132-142.
34. Simon MI, Strathmann MP, and Gautam N (1991) Diversity of G proteins in signal transduction. Science (Wash DC) 252:802-808.
35. 3 adenosine receptor agonist. Exp Cell Res 243:383-397.
36. 3 adenosine receptors: Role in receptor desensitization and resensitization. J Neurochem 75:1492-1501.
37. Tsao P, Cao T, and von Zastrow M (2001) Role of endocytosis in mediating down-regulation of G-protein-coupled receptors. Trends Pharmacol Sci 22:91-96.
38. Tsao PI and von Zastrow M (2001) Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors. Pharmacol Ther 89:139-147.
39. von Lubitz DK (1999) Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept? Eur J Pharmacol 371:85-102.
40. von Zastrow M (2001) Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans 29:500-504.