Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801

Experimental Neurology

Volumn 210, Issue 2, 2008, Pages 776-781

  Cunha, Geanne M A ^a,b   Canas, Paula M ^a   Melo, Carolina S ^b   Hockemeyer, Jörg ^c   Müller, Christa E ^c   Oliveira, Catarina R ^a   Cunha, Rodrigo A ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

amyloid; A2A receptor; Adenosine; Alzheimer's disease; Locomotion; Memory; MK 801; NMDA; Scopolamine

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; AMYLOID BETA PROTEIN; DIZOCILPINE; ISTRADEFYLLINE; SCOPOLAMINE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); DIZOCILPINE MALEATE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; MAZE TEST; MEMORY DISORDER; NERVE DEGENERATION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TASK PERFORMANCE; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; MOTOR ACTIVITY; WISTAR RAT;

AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DIZOCILPINE MALEATE; DRUG INTERACTIONS; MALE; MAZE LEARNING; MEMORY DISORDERS; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PURINES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A2A; SCOPOLAMINE; TRIAZOLES;

EID: 41149136710     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2007.11.013     Document Type: Article

References (35)

1. Anisman H. Dissociation of disinhibitory effects of scopolamine: strain and task factors. Pharmacol. Biochem. Behav. 3 (1975) 613-618
2. Arendash G.W., Schleif W., Rezai-Zadeh K., Jackson E.K., Zacharia C., Cracchiolo J.R., Shippy D., and Tan J. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience 142 (2006) 941-952
3. Coleman P., Federoff H., and Kurlan R. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology 63 (2004) 1155-1162
4. Collingridge G. The role of NMDA receptors in learning and memory. Nature 330 (1987) 604-605
5. 2A receptor blockade. Purinergic Signal. 1 (2005) 111-134
6. 2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission. Neuroscience 107 (2001) 455-464
7. Dall'Igna O.P., Silva A.L., Dietrich M.O., Hoffmann A., Oliveira R.V., Souza D.O., and Lara D.R. Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-d-aspartate receptor antagonist MK-801 in mice. Psychopharmacology 166 (2003) 258-263
8. 2a receptor antagonists prevent β-amyloid (25-35)-induced cognitive deficits in mice. Exp. Neurol. 203 (2007) 241-245
9. Drew W.G., Miller L.L., and Baugh E.L. Effects of THC, LSD-25 and scopolamine on continuous, spontaneous alternation in the Y-maze. Psychopharmacology 32 (1973) 171-182
10. Ellison G. The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res. Rev. 20 (1995) 250-267
11. 2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. Parkinsonism Relat. Disord. 10 (2004) 265-271
12. Fredholm B.B., Chen J.F., Cunha R.A., Svenningsson P., and Vaugeois J.M. Adenosine and brain function. Int. Rev. Neurobiol. 63 (2005) 191-270
13. 2A receptors in the brain. Neurobiol. Learn. Mem. 87 (2007) 42-56
14. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
15. Hasselmo M.E. The role of acetylcholine in learning and memory. Curr. Opin. Neurobiol. 16 (2006) 710-715
16. 2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease. J. Org. Chem. 69 (2004) 3308-3318
17. Hooper N., Fraser C., and Stone T.W. Effects of purine analogues on spontaneous alternation in mice. Psychopharmacology 123 (1996) 250-257
18. Hughes R.N. The value of spontaneous alteration behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci. Behav. Rev. 28 (2004) 497-505
19. Johnson-Kozlow M., Kritz-Silverstein D., Barrett-Connor E., and Morton D. Coffee consumption and cognitive function among older adults. Am. J. Epidemiol. 156 (2002) 842-850
20. Koek W., Colpaert F.C., Woods J.H., and Kamenka J.M. The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801. J. Pharmacol. Exp. Ther. 250 (1989) 1019-1027
21. Lynch M.A. Long-term potentiation and memory. Physiol. Rev. 84 (2004) 87-136
22. Maia L., and de Mendonça A. Does caffeine intake protect from Alzheimer's disease?. Eur. J. Neurol. 9 (2002) 377-382
23. Pitkanen M., Sirvio J., MacDonald E., Niemi S., Ekonsalo T., and Riekkinen P.S. The effects of d-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. Eur. Neuropsychopharmacol. 5 (1995) 457-463
24. 2A receptors. Neurobiol. Aging 26 (2005) 957-964
25. 2A receptors. Neuron.
26. 2+ homeostasis. Brain Res. 1143 (2007) 11-21
27. Ritchie K., Carrière I., Portet F., de Mendonça A., Dartigues J.F., Rouaud O., Barberger-Gateau P., and Ancelin M.L. The neuro-protective effects of caffeine: a prospective population study (the Three City Study). Neurology 69 (2007) 536-545
28. 2A receptors and basal ganglia physiology. Progr. Neurobiol 83 (2007) 277-292
29. 2A receptors in Parkinson's disease. Trends Neurosci. 29 (2006) 647-654
30. Sitaram N., Weingartner H., and Gillin J.C. Human serial learning: enhancement with arecholine and choline impairment with scopolamine. Science 211 (1978) 274-276
31. 2A receptors. Annu. Rev. Immunol. 22 (2004) 657-682
32. Takahashi R.N., Pamplona F.A., and Prediger R.D.S. Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies. Front. Biosci. 13 (2008) 2614-2632
33. 2A receptors. Exp. Neurol. 199 (2006) 438-445
34. 2A receptor modulation. Neurology 61 Suppl.6 (2003) S88-S93
35. Yamada K., Noda Y., Hasegawa T., Komori Y., Nikai T., Sugihara H., and Nabeshima T. The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice. J. Pharmacol. Exp. Ther. 276 (1996) 460-466