Adenosine A2A agonist reduces paralysis after spinal cord ischemia: Correlation with A2A receptor expression on motor neurons

Annals of Thoracic Surgery

Volumn 74, Issue 3, 2002, Pages 846-850

  Cassada, David C ^a   Tribble, Curtis G ^b   Long, Stewart M ^b   Kaza, Aditya K ^b   Linden, Joel ^b   Rieger, Jayson M ^b   Rosin, Diane ^b   Kron, Irving L ^a   Kern, John A ^a,b  

^a UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT; PURINE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; AORTA CLAMPING; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOREACTIVITY; KIDNEY ARTERY; LAPAROTOMY; LUMBAR SPINAL CORD; MICROSCOPY; MOTONEURON; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; SCORING SYSTEM; SPINAL CORD ISCHEMIA; ANIMAL; DRUG POTENTIATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; SPINAL CORD; UPREGULATION;

ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; PARALYSIS; PURINES; RABBITS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; SPINAL CORD; SPINAL CORD ISCHEMIA; UP-REGULATION;

EID: 0036713818     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(02)03793-1     Document Type: Article

References (10)

1. Design, synthesis, and evaluation of novel A2A adenosine receptor agonists
2. Systemic adenosine A2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord
3. An adenosine A2A agonist, ATL-146e, reduces paralysis, and apoptosis during rabbit spinal cord reperfusion
4. Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion
5. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion
6. Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation
7. Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection
8. Spinal cord protection during aortic cross-clamping using retrograde venous perfusion
9. The role and regulation of adenosine in the central nervous system
10. Inhibition of voltage-sensitive calcium channels by the A2A adenosine receptor in PC12 cells